Luc Reym⌬nd
@lreymond.bsky.social
Organic chemistry passionate 🧪, mountain addict 🧗 & freediver 🤿. EPFL scientist and @spirochrome.com co-founder. 🇨🇭
The end of the heatwave is in sight. Good because the temperature in our living room on the ground floor is trending "to the roof"...
Spoiler: lots of 😍 SPY555-FastAct live cell movies in there.
Journal of Cell Biology@jcb.org · 2mo agoOur June issue is here! rupress.org/jcb/issue/22... The cover shows a maximum intensity projection from a confocal image stack showing an angiogenic sprout emerging from an engineered microvessel. From @lakynm.bsky.social et al. of the Matthew Kutys lab: rupress.org/jcb/article/... #Cytoskeleton
And it's not all: For an exceptional new product, an exceptional new casing! We designed new boxes that we will gradually deploy to replace our old metal boxes. 4 designs will be randomly used for each product!
Our June issue is here! rupress.org/jcb/issue/22... The cover shows a maximum intensity projection from a confocal image stack showing an angiogenic sprout emerging from an engineered microvessel. From @lakynm.bsky.social et al. of the Matthew Kutys lab: rupress.org/jcb/article/... #Cytoskeleton
Today is the Day, CenSpark650 is available! Time to get those centrioles and cilia shining under the 🔬objective! spirochrome.com/product/cens... video: 20h imaging of primary cilium formation in a single RPE-1 cell stained with CenSpark650. movie credits: @cepourroy.bsky.social
📢On June 1st, we will be launching CenSpark650, the very first selective fluorescent probe for imaging centrioles and cilia in live cells.🔬 No transfection, zero genetic manipulation. Just Add & Image 1 hour later. Learn more: spirochrome.com/12-may-2026/ #Bioimaging
Equipment check for quartz hunting. 💎 New season starts tomorrow with 8yo.
Just me again with more neurons. Happy #FluorescenceFriday. Have a great weekend.
We had such a fun ERC Synergy @erc.europa.eu kickoff workshop for our 6-year MitoContact collaborative project with our partners Kai Johnsson and Wanda Kukulski! Wonderful to share science, ideas, and play games together 💚 fantastic organization by @zimmerli.bsky.social @jclandoni.bsky.social
Excited to share our latest paper! We found that large pieces of the human genome can transfer between cells upon direct contact, endowing recipient cells with heritable phenotypic changes. @cp-cell.bsky.social (1/7) www.cell.com/cell/fulltex...
Starting materials VS products. A good yield for this afternoon!
We are very pleased to announce Prof. Paul Guichard and Dr. Virginie Hamel @centriolelab.bsky.social as joint winners of the RMS Award for Light Microscopy 🔬 👏 🏅 Huge congratulations to both! Read more about Paul and Virginie's achievements: www.rms.org.uk/resource/pro...
#FluorescenceFriday material here!
Spirochrome@spirochrome.com · 3mo agoOverly proud that Katie Holden's image won Evident Microscopy's 6th Annual Image of the Year "Global Winner" award🏆 The image shows Live iPSC-derived neurospheres. DNA (magenta) & MT (blue) were stained with our probes SiR-tubulin & SPY555-DNA probes. evidentscientific.com/en/landing/i...
Overly proud that Katie Holden's image won Evident Microscopy's 6th Annual Image of the Year "Global Winner" award🏆 The image shows Live iPSC-derived neurospheres. DNA (magenta) & MT (blue) were stained with our probes SiR-tubulin & SPY555-DNA probes. evidentscientific.com/en/landing/i...
I've been fortunate to have @marcoenriquez18.bsky.social a #materialsChemist in my team. Cytoskeletal elements are often studied on their own but in reality, the #cytoskeleton is biopolymer network that is intricately intertwined. (#Award winning movie Light Microscopy Aus). @aibnatuq.bsky.social
#microtubules in orange hot, #F-actin greyscale, Fibroblast, spinning disc. @marcoenriquez18.bsky.social @aibnatuq.bsky.social #fluorescenceFriday
Localizable fluorescent metal ion indicators galore: advanced.onlinelibrary.wiley.com/doi/10.1002/...
Localizable Fluorescent Metal Ion Indicators With Tunable Colors
A modular platform enables the generation of fluorescent metal ion indicators with tunable emission colors and precise subcellular localization. Conjugation to self-labeling proteins yields bright, c...
advanced.onlinelibrary.wiley.com
Mesmerizing light sheet imaging of neutrophils swarming at a yeast target! The neutrophils were labeled with SPY650-DNA (yellow) and a calcium dye (blue). This movie is part of the recent manuscript by @strickland-evelyn.bsky.social that we highly recommend reading! www.biorxiv.org/content/10.6...
Very cool probe to label doublet MTs and therefore centrioles across different species and set ups (from live imaging, STED and expansion)!😍 www.nature.com/articles/s41...
Development of the fluorescent probe CenSpark for labeling centrioles and cilia - Nature Chemical Biology
CenSpark is a dual-ligand fluorescent probe binding simultaneously inner and outer microtubule sites, a configuration unique to doublet and triplet microtubules, enabling selective live imaging of cen...
nature.com
What a probe! Congratulations @cepourroy.bsky.social! We're happy to share that we re working hard on making CenSpark probes available to the centriole aficionados in the coming weeks!
Cédric Pourroy@cepourroy.bsky.social · 4mo agoCenSpark story is now published in @natchembio.nature.com. We engineered a dual-ligand fluorescent probe to selectively "light up" centrioles & cilia. Massive thank to Pierre Gönczy, @lreymond.bsky.social and @ghatzopoulos.bsky.social for the guidance. Check it out 👉: doi.org/10.1038/s415...
CenSpark story is now published in @natchembio.nature.com. We engineered a dual-ligand fluorescent probe to selectively "light up" centrioles & cilia. Massive thank to Pierre Gönczy, @lreymond.bsky.social and @ghatzopoulos.bsky.social for the guidance. Check it out 👉: doi.org/10.1038/s415...
Development of the fluorescent probe CenSpark for labeling centrioles and cilia - Nature Chemical Biology
CenSpark is a dual-ligand fluorescent probe binding simultaneously inner and outer microtubule sites, a configuration unique to doublet and triplet microtubules, enabling selective live imaging of cen...
doi.org
Organoids stained with Spirochrome probes for actin and DNA! 😍
Valentin Dunsing-Eichenauer@dunsingvalentin.bsky.social · 4mo agoPainted 100+ lung organoids for Easter, stained with live-cell Cell Tracker/ @spirochrome.com dyes, imaged at our @leicamicrosystems.bsky.social Viventis Deep light-sheet 🔬 at Charité (soon @Si-M - Der Simulierte Mensch) and visualized using inverted lookup tables designed by @christlet.bsky.social
Painted 100+ lung organoids for Easter, stained with live-cell Cell Tracker/ @spirochrome.com dyes, imaged at our @leicamicrosystems.bsky.social Viventis Deep light-sheet 🔬 at Charité (soon @Si-M - Der Simulierte Mensch) and visualized using inverted lookup tables designed by @christlet.bsky.social
Mr Blackcap (Sylvia atricapilla) singing and dancing for Mrs Blackcap just under my window! Turn the sound on, this little dude is a talented singer.
Mirror mirror on the wall who is the brightest of them all? Brightness is a key parameter for choosing fluorescent reporters in bioimaging. As tricky to assess, we present a pipeline to compare chemigenetic labels and FPs in tissue culture and #zebrafish embryos. www.biorxiv.org/content/10.6...