A/Prof Sam Stehbens PhD (She/Her)
@samstehbens.bsky.social
Everything microtubules, movement, and microscopy. Melanoma research focus. ARC Future Fellow, lab head University of Queensland #CatsOfAcademia advoCATe. UCSF Wittmann lab alumni.
Reconstitution of actomyosin networks in cell-sized liposomes dissects distinct mechanisms of membrane blebbing and symmetry breaking | Science Advances www.science.org/doi/10.1126/...
Reconstitution of actomyosin networks in cell-sized liposomes dissects distinct mechanisms of membrane blebbing and symmetry breaking
Actin network organization dictates how and where membrane blebs form, revealed through reconstitution and simulations.
science.org
Australian Grant assessors- can we please stop adding useless comments like ‘‘big papers from post doc in established international lab but has not proven themselves here yet”. It’s REALLY hard to move countries, set up an independent team, and produce high impact work in under 3 years.
Gru: Okay, That's Not Helping
ALT: Gru: Okay, That's Not Helping
static.klipy.com
Registration for the 2026 Triangle Cytoskeleton Meeting is NOW OPEN! Our meeting will be Monday, September 21st at the Friday Center on UNC-Chapel Hill Campus. Please fill out the Google Form below and register through the UNC Event Registration page to attend. forms.gle/zcMoubS2mavp...
LOVE!!! 🎉 The sound effects of the wind chimes with water flowing are a beautiful way to demonstrate #microtubule dynamics
Philippe Bastin's Lab@bastinlab.bsky.social · last mo.Beautiful videos nicely explaining microtubules! Congratulations to Renaud Chabrier and Casten Janke 👍 www.youtube.com/watch?v=dVbv...
🌈 At a time when progress can't be taken for granted, I 'm especially proud to share this @natcellbio.nature.com Q&A piece. I had the pleasure to discuss with @gunawanlab.bsky.social about his inspiring journey as an LGBTQIA+ immigrant. #PrideInSTEM 👉 rdcu.be/fnXQ6 www.nature.com/articles/s41...
A scientist can come from anywhere - Nature Cell Biology
This June, we celebrate Pride by discussing with Felix Gunawan, assistant professor at the University of Toronto and co-affiliate group leader at the University of Münster, about his personal and acad...
nature.com
Our latest review is out. We take a deep dive into the human mutations in microtubule motors that drive devastating neurodevelopmental and neurodegenerative diseases. Taking in motor protein biophysics, animal models of disease as well as patient phenotypes. onlinelibrary.wiley.com/doi/full/10....
Very excited to be sharing our new paper, just out in Nature Cell Biology! The big question we investigate: How do migrating cells put their front 🔴 and back 🔵 in the right place?
Registration open for the @garvaninstitute.bsky.social Signalling Symposium. linktr.ee/garvansignal...
Vote for @marcoenriquez18.bsky.social #FocalPlane entry ‘Fibroblasts & ECM’ it is a beautiful representation of his passion- cells & polymers 🥰.
FocalPlane @focalplane.bsky.social · 2mo agoVoting is now open in our image competition with #ELMI2026. Thanks to everyone that entered the competition, we received so many wonderful entries. Voting closes on 18 June, the penultimate day of #ELMI2026 @ppbioimaging.bsky.social. focalplane.biologists.com/2026/06/08/f...
1 week to start🔥 New @focalplane.bsky.social webinar series focused on #CellMigration, register & join us▶️, it will be fun! pls spread the word, in the next one, ECRs could apply to show their work ;) ▶️ to register: focalplane.biologists.com/2026/05/29/n... @dgz.bsky.social @the-node.bsky.social
Our June issue is here! rupress.org/jcb/issue/22... The cover shows a maximum intensity projection from a confocal image stack showing an angiogenic sprout emerging from an engineered microvessel. From @lakynm.bsky.social et al. of the Matthew Kutys lab: rupress.org/jcb/article/... #Cytoskeleton
Saishree S. Iyer and Anna Akhmanova @utrechtuniversity.bsky.social review the mechanisms controlling plus-end elongation of centriolar and ciliary #microtubules, revealing shared principles. rupress.org/jcb/article/... #Centrioles #Cilia #Cytoskeleton
How is NGFR expression linked to melanoma aggressiveness? Laura Nogués, Héctor Peinado @hps2022.bsky.social et al identify non-muscle myosin II as downstream NGFR target mediating invasiveness and immunotherapy resistance link.springer.com/article/10.1...
NGFR induces melanoma invasion and immunotherapy resistance through myosin light chain 2 modulation - The EMBO Journal
Immunotherapy has reshaped melanoma treatment, yet the majority of patients fail to respond or develop resistance. Nerve growth factor receptor (NGFR/p75NTR/CD271) has been linked to melanoma aggressi...
link.springer.com
Colchicine, disrupting microtubules & inhibiting NLRP3 inflammasome, shows promise in treating atherosclerosis in recent studies. PMID:42045490, Nat Cardiovasc Res 2026 https://doi.org/10.1038/s44161-026-00807-5 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪
Mechanisms and therapeutic potential of colchicine in atherosclerotic cardiovascular disease | Nature Cardiovascular Research
Over the past decade, colchicine has re-emerged as a promising therapeutic candidate for atherosclerotic cardiovascular disease. Here we review evidence from large randomized controlled trials together with advances in mechanistic research that have clarified how colchicine modulates vascular inflammation and plaque stability. Canonically, colchicine disrupts microtubule dynamics and suppresses NOD-like receptor family pyrin domain-containing 3 (NLRP3) inflammasome activation. Beyond these actions, it limits oxidative stress, modulates cytoskeletal cross-talk, attenuates cholesterol crystal formation and reprograms inflammatory and metabolic proteomic networks. Colchicine influences multiple vascular and immune cell types, including neutrophils, monocytes, macrophages, endothelial cells, smooth muscle cells and platelets, collectively reducing vascular inflammation and promoting plaque stability. Notably, while colchicine has demonstrated benefit in coronary artery disease, several rec
doi.org
A day in the life of a growing hiPSC spheroid expressing endogenously mStayGold-tagged histone 3.3 for #FluorescenceFriday and the #Snouty aficionados. 28 hours (and >50,000 exposures) later and they are still going! Home-brewed volume projection.
Tell me a funding scheme is not ‘fit for purpose’ without telling me a funding scheme is not ‘fit for purpose’…. If Science careers were unstable in the older systems - then this is non functional
ARC Tracker@arc-tracker.bsky.social · 3mo agoAnd the newly announced Future Fellowships scheme for 2027 (FT27) will take a full 12 months … BAD!
After so many #notthecover one of @probablycarmen.bsky.social of a CAR T cell engaging with a cancer cell made it to the front of @embojournal.org! Want to know more about the function of protrusions in early #Tcell activation? Check out how we became accidental immunologists!
The EMBO Journal@embojournal.org · 3mo agoIn issue 10: Convergent evolution of aerobic fermentation CIN promotes migration & invasion via EFEMP1 secretion SenSet resource defines cell-type specific senescence signatures ... Cover: @franbottanelli.bsky.social and colleagues link.springer.com/journal/4431...
‘When asked who currently runs radioligand binding assays, Roberts paused for several seconds before saying “the point is that they could.” 😆
Anthony Dornan@dornan.bsky.social · 3mo agoThe system is capable of performing Northern & Southern blots, manual Edman degradation, and a form of 2D gel electrophoresis that one observer described as “something my PhD advisor mentioned once.” … “We’re very close to full automation of the entire 1990s,” … “The 2000s are next.”
it's #FluorescenceFriday !! Australia always gets in first.... #cytoskeleton #cellBiology #STEM (Movie by @marcoenriquez18.bsky.social from my team #AIBN #UQ @aibnatuq.bsky.social
Happy #FluorescenceFriday. I feel so lucky to get to work with these weird and curious primary macrophages from 🐸. They exhibit myriad different morphologies and behaviours, including spinning endlessly and stationary, kinda like progenitor cells under compression from 🐟. Also actomyosin is strong!
Reviews don't fund research. If, like me, you hope for more research funding in tomorrow's Budget, here's a cold shower from a Minister responsible for Australia's currently shambolic R&D system, Tim Ayres 👇 'We hear your concerns' 'We did a review' But…nothing else. A script from The Hollowmen.
Research funding in Australia falters - ABC listen
Australia lags behind most OECD countries when it comes to percentage of GDP spent on scientific research. Belinda Smith speaks to scientists impacted with a response from science minister Tim Ayres.
abc.net.au
www.instagram.com/reel/DXzN3dP...
Wyss Institute on Instagram: "In addition to being a pioneer in the field of biologically inspired engineering, Wyss Founding Director Donald Ingber is also a cartoonist, gardener, former comedy write...
1,311 likes, 14 comments - wyssinstitute on May 1, 2026: "In addition to being a pioneer in the field of biologically inspired engineering, Wyss Founding Director Donald Ingber is also a cartoonist, g...
instagram.com
Wonderful opportunity to hear about the latest progress in fluorescent probe technology ⬇️
Janelia Conferences@janeliaconf.bsky.social · 6mo ago📢 Applications are open! Join us in October to explore next-generation fluorescent proteins, biosensors & imaging advances + machine learning and computational approaches to accelerate design. 🛏️ Meals & lodging covered; no registration fee Apply by May 21 ➡️ janelia.news/FPS26 @agtebo.bsky.social
Kalukula, Y., Ciccone, G., Mohammed, D., Procès, A., Versaevel, M., Deridoux, A., ... & Luciano, M. (2025). Unlocking the therapeutic potential of cellular mechanobiology. Science advances, 11(44), eaea6817. #EpithelialMechanicsReview buff.ly/RUcvLfF
👉ONE MONTH TIME to submit an abstract to 35th BioCity Symposium: VISION, EXPANDED bit.ly/4f6kuUR Come and see some amazing imaging here in Turku, 27-28 August! @utu.fi @turkubioimaging.bsky.social @eurobioimaging.bsky.social @inflames-flagship.bsky.social @turkubioscience.bsky.social
How does Taxol bind microtubules, and why do tubulin isoforms matter for its efficacy? In my recent commentary in @natchembio.nature.com, I discuss Luo et al.’s mechanistic insights and their implications for designing isoform-selective microtubule-targeting drugs. www.nature.com/articles/s41...
Sign up by 27 May for the EMBO Solutions #training "How to write a scientific paper" delivered by @embopress.org editors at the upcoming meeting: www.embl.org/about/info/c... 🧪 @embolableadership.bsky.social @embl.org #EESMicrotubules #EMBOevents
