😱🤩 wow! Shining light on lipid-protein interactions #lipidtime Monumental work and awesome skytorial @nadlerlab.bsky.social Very excited to dig through the preprint. Congratulations already 🎉

André Nadler@nadlerlab.bsky.social · last wk.

Lipids build the membranes of all cells, but identifying their precise functions is extremely challenging. Here’s our attempt to change that: How to find and understand lipid-protein interactions, by Katelyn Cook & company. www.biorxiv.org/content/10.6...

Long time in the making and finally out. Great work by Lucas and @haosha.bsky.social who wrote the code, Maxime and Nestor for the beautiful samples and @zacsimile.bsky.social for helping to wrap this up. Try it out!

Hao Sha@haosha.bsky.social · last wk.

[0/1] Excited to share our new preprint DECODE-Plex! After many people efforts, we developed a deep-learning framework for multi-channel SMLM, enabling simultaneous localization and color assignment of densely packed emitters across multiple channels. biorxiv.org/content/10.6...

The first 22 hours of #zebrafish development in under one minute. Credit to @zebrafish007.bsky.social in #WeinsteinLab at NIH. #ZebrafishZunday 🧪

Recently we were trying to change the colour of superfolder GFP and accidentally engineered a great probe for expansion microscopy! Read about it in our first micropublication - lnkd.in/eCxYcCJZ

CMU biophysicists are flipping the script on cell membrane dynamics. They’ve developed a new theoretical framework that links membrane stress to lipid flip-flop, uncovering a key driver of membrane asymmetry. 🧪⚛️ www.cmu.edu/mcs/news-eve...

CMU Researchers Capture the Randomness of Lipid Flip-Flopping

Cell membranes are dynamic, two-sided structures made of asymmetric lipid layers. While lipids can randomly flip-flop from one layer to the other, membrane proteins sort lipids between the two sides. ...

cmu.edu

FreeCAD 1.1.2 is out. Bugfix release only, no new features, but 32% of the patches fix BIM and core issues, and 12% are security fixes. Recommended update for everyone! blog.freecad.org/2026/07/23/freecad-1-1-2-released/ Support the project: wiki.freecad.org/Donate #FreeCAD #CAD #OpenSource

FreeCAD 1.1.2 released

We are pleased to announce the release of version 1.1.2. This release pulls important fixes from the current development branch without adding any new features. 32% of the backported patches fix is…

blog.freecad.org

Free and open-source images, icons, and tools for creating scientific illustrations doi.org/10.59350/5zt... 🧪

Free and open-source images, icons, and tools for creating scientific illustrations

Phylopic, NIH Bioart, Bioicons, Scidraw, Open Science Art, Health Icons, Servier Medical Art, Biodiversity Heritage Library, the Noun Project, Segment Anything, Excalidraw, draw.io, Biographics

doi.org

@wsctt.bsky.social and Nimo Abdullah from @sporemohan.bsky.social lab demonstrate the potential of 3-iodotyrosine containing FPs for expansion microscopy 🔬🐟🌈 Happy to have played a small role in this exciting project Findings available @micropub7n.bsky.social micropublication.org/journals/bio...

Here is our one figure paper in micropublications. A new tool for protein expansion microscopy. First time in @micropub7n.bsky.social and loved the experience Please let me know if you have some feedback and how this may be incorporated into other work micropublication.org/journals/bio...

3-iodotyrosine fluorescent proteins for improved expansion microscopy #micropublication #biology #data #caltechlibrary #Zebrafish #Escherichiacoli #Biochemistry #Methods #NewFinding #Methodology https://micropublication.org/journals/biology/micropub-biology-002234

Come join us! 🔬🐣 The Piacentino Lab at Johns Hopkins @hopkinsmedicine.bsky.social is recruiting a postdoc to study membrane lipids, cell migration, and invasion in neural crest and embryonic models! @socdevbio.bsky.social @ascbiology.bsky.social #devbiol #cellbio #lipids

What’s the focus of UKRI’s new strategy? Watch Stian Westlake, ESRC Executive Chair, talk about the strategy’s goals and how they will be delivered. He highlights the importance of the strategy for social science and describes some of the ways we will measure its success and impact.

The focus of UKRI’s new strategy

YouTube video by UK Research and Innovation

youtu.be

We developed a new approach for mapping absolute membrane voltage, based on dynamic photocycle control in Voltron2. www.biorxiv.org/content/10.6... Here's my favorite example: human iPSC colonies break into electrical domains as they begin to differentiate.

I love these PIP3 biosensors because it labels the plasma membrane so well. You can see the cell's edge so clearly along with any intracellular vesicles. Also, this cell is so blebby. This video was taken when I was still working on endocytosis :D Good old times! #FluorescenceFriday

Fluorescence cross-correlation spectroscopy quantifies affinity, cooperativity, and kinetic stability in ternary protein complexes https://www.biorxiv.org/content/10.64898/2026.07.16.738902v1

Microscopy beautifully reveals the dynamic nature of biology but quantifying that motion can be tricky! In the latest paper from @aicjanelia.bsky.social, out now in @jcellsci.bsky.social, we present a tool for measuring amorphous motion: OpticalFlow3D journals.biologists.com/jcs/article/... (1/7)

OpticalFlow3D – a tool for measuring amorphous motion in three-dimensional fluorescence microscopy images

Summary: Biological motion can be difficult to define and measure. Optical flow is uniquely suited to this challenge. We provide tools for 3D optical flow and illustrate its use in extracting biologic...

journals.biologists.com

www.biorxiv.org/content/10.6...

Protein-based, live-cell PAINT microscopy with fluorogenic exchangeable HaloTag ligands

We report a generalizable method for single-molecule localization super-resolution microscopy in living cells. Live-cell protein-based PAINT (points accumulation for imaging in nanoscale topography) i...

biorxiv.org

Excited to see this collaboration now in print. Dye chemistry meets AI-designed proteins. Three small, orthogonal tags; lifetime modulation; split versions. Request the free dyes at dyes.janelia.org www.science.org/doi/10.1126/...

De novo design of orthogonal far-red, orange, and green fluorophore-binding proteins for multiplexed imaging

Fluorescent proteins and small-molecule dyes offer complementary advantages for biological imaging: proteins are amenable to genetic tagging, whereas dyes provide superior brightness and photostabilit...

science.org

De novo design of orthogonal far-red, orange, and green fluorophore-binding proteins for multiplexed imaging | Science www.science.org/doi/10.1126/...

De novo design of orthogonal far-red, orange, and green fluorophore-binding proteins for multiplexed imaging

Fluorescent proteins and small-molecule dyes offer complementary advantages for biological imaging: proteins are amenable to genetic tagging, whereas dyes provide superior brightness and photostabilit...

science.org

Our AI-guided design of RNA-guided nucleases is now out in @science.org 💻🧬 We used structure and evolutionary data to generate minimal, active and divergent gene editors! www.science.org/doi/10.1126/... Congrats to @petrskopintsev.bsky.social @isabelesain.bsky.social @evandeturk.bsky.social & team!

Structure and evolution-guided design of minimal RNA-guided nucleases

The design of RNA-guided nucleases with properties not limited by evolution can expand programmable genome-editing capabilities. However, generating diverse multidomain proteins with robust enzymatic ...

science.org

'There has been a 12 percentage point leap in the number of UK universities reporting cutbacks to research, according to a survey carried out this year by Universities UK.' Being a global research power when you're reducing research by 12% in a year may prove a wee bit of a challenge.

Proportion of universities cutting research increases - Research Professional News

Universities UK survey shows worsening picture but more optimism about future backing for research

researchprofessionalnews.com

A list of exit strategies (or pipe dreams) that colleagues have mentioned in the case of further HE crisis. - tea/coffee shop - bike shop - book/record shop - bed & breakfast - taxi driver - climate activism/social campaigning Tea/coffee shop seems to be the most popular dream. What's yours?

A cell videoed through a DIC microscope. The nucleus spins around. Why would it do that? #CellBiology

Already out for a while as the final version: Our @elife.bsky.social paper presenting an experimental and computational pipeline for whole mount deep imaging and multi-scale analysis of organoid systems: elifesciences.org/articles/107... A great collaboration during my postdoc in Marseille.

A quantitative pipeline for whole-mount deep imaging and analysis of multi-layered organoids across scales

The Tapenade pipeline enables single-cell, whole-mount 3D quantification in dense multilayer organoids, linking spatial gene co-expression and nuclear deformation to emerging tissue-scale organization...

elifesciences.org

Biomedical Picture of the Day BPoD@bpodaily.bsky.social · 2mo ago

User-friendly pipeline Tapenade quantifies spatial patterns of gene expression & nuclear morphology in 3D cell assembly '...oids' 📹 @alicegros.bsky.social, @jules-vanaret.bsky.social, @dunsingvalentin.bsky.social et al @centuri-ls.bsky.social in @elife.bsky.social ➡️ bpod.org.uk/archive/2026...

New paper! 🚀 A high-affinity anti- #mNeonGreen #nanobody turns #mNG into a #multifunctional Tag. @nanotag.bsky.social decided to openly share the #nanobody for research use. Not common, but we strongly believe well-defined reagents are key for reproducible science. We hope you find it useful! 💚

1/ 🧬🔬 How does one cell become an entire animal? We can now film it in 3D 🐟, but turning those movies into accurate cell tracks is brutally hard. Enter our new #Kaggle challenge: $60K prize pool, to help crack 3D+time cell tracking at scale! 🧵👇 www.kaggle.com/competitions... @biohub.org

🚨Open call to the Cell Tracking crowd out there🚨! Loïc's team at @biohub.org opened our Kaggle Challenge for 3D cell tracking, with $60k of prize money💰. Spread the news, delve into our gigabytes of imaging (zarr3) and cell tracking (geff) data of developing zebrafish embryos, and start tracking 🤩

Loïc A. Royer 💻🔬🧪@loicaroyer.bsky.social · last mo.

1/ 🧬🔬 How does one cell become an entire animal? We can now film it in 3D 🐟, but turning those movies into accurate cell tracks is brutally hard. Enter our new #Kaggle challenge: $60K prize pool, to help crack 3D+time cell tracking at scale! 🧵👇 www.kaggle.com/competitions... @biohub.org

Galvanin (TMEM154) is an electric-field sensor for directed cell migration: Cell www.cell.com/cell/fulltex...

Galvanin (TMEM154) is an electric-field sensor for directed cell migration

Galvanin is an electric-field sensor that links electrical cues to directed migration in rapidly moving cells.

cell.com

This AI stuff.... Anyone else feel like they're one of the remaining unbitten characters in a zombie movie?

By sampling sequential nanosecond delays we capture phasor plots at up to 500 Hz (individual gated images at 2500 Hz). Here is a fast phasor video of dye quenching: