Tessera
Folgen

Ludo Poiré

@ludopoire.bsky.social

PhD Student working on plasmid dynamics and defense systems in bacteria. Team Horizontal Gene Transfer in pathogenic bacteria 🦠 (CIRI, Lyon 🇫🇷) https://ludopoire.github.io/ludopoire/

3 Posts76 Follower157 Folgt
César de la Fuente@delafuentelab.bsky.social · last mo.

Biology has plenty of data—the challenge is making it usable. AllTheBacteria transforms 2.44 million public bacterial and archaeal genomes into an open, uniformly processed, searchable, AI-ready resource. www.biorxiv.org/content/10.1...

AllTheBacteria: a community resource empowers biology and discovers novel peptide antibiotics

Public microbial genomes encode an immense record of biological diversity, evolution and molecular function, but much of this information remains difficult to reuse because raw sequencing data are not...

biorxiv.org

Inga Songailiene@ingasongailiene.bsky.social · 2mo ago

Two HEPN-domain encoding systems (Ishtar) and two TM-domain containing systems (Namtar and Attar) protect bacteria against conjugation of plasmids! 👏

Xavier Charpentier@labxc.bsky.social · 2mo ago

#microsky New preprint from the lab! Widespread immune systems protect bacteria against conjugative plasmids www.biorxiv.org/content/10.6... Kudos to the extremely talented lead author Ludovic Poiré! Key contributions by @francoisrousset.bsky.social and also help from C. Lesterlin/TacC lab. 🧵⬇️

Aude Bernheim@audeber.bsky.social · 2mo ago

Fantastic study tackling a new aspect of bacterial immunity: defense against conjugation ! Added bonus: Mesopotamian deities are fascinating, a good reason to dive again into this civilisation.

Xavier Charpentier@labxc.bsky.social · 2mo ago

#microsky New preprint from the lab! Widespread immune systems protect bacteria against conjugative plasmids www.biorxiv.org/content/10.6... Kudos to the extremely talented lead author Ludovic Poiré! Key contributions by @francoisrousset.bsky.social and also help from C. Lesterlin/TacC lab. 🧵⬇️

Ludo Poiré@ludopoire.bsky.social · 2mo ago

Months (years ?) spent on species-wide screens, over 3.000 PCR reactions and an unbelievable amount of 10-uL tips : I'm glad to introduce the novel TAR family of anti-plasmid defenses ! The war between bacteria and their MGEs is far more complex than we expected ⚔️ Read Xavier's 🧵 for more details !

Xavier Charpentier@labxc.bsky.social · 2mo ago

#microsky New preprint from the lab! Widespread immune systems protect bacteria against conjugative plasmids www.biorxiv.org/content/10.6... Kudos to the extremely talented lead author Ludovic Poiré! Key contributions by @francoisrousset.bsky.social and also help from C. Lesterlin/TacC lab. 🧵⬇️

François Rousset@francoisrousset.bsky.social · 2mo ago

🚨Defense systems against conjugative plasmids can kill recipient cells, like abortive infection against phages. Massive effort from very talented Ludovic Poiré (@ludopoire.bsky.social) in the Charpentier lab at @ciri-lyon.bsky.social ! Very happy our team could contribute w @julie-bltk.bsky.social

Xavier Charpentier@labxc.bsky.social · 2mo ago

#microsky New preprint from the lab! Widespread immune systems protect bacteria against conjugative plasmids www.biorxiv.org/content/10.6... Kudos to the extremely talented lead author Ludovic Poiré! Key contributions by @francoisrousset.bsky.social and also help from C. Lesterlin/TacC lab. 🧵⬇️

Xavier Charpentier@labxc.bsky.social · 2mo ago

#microsky New preprint from the lab! Widespread immune systems protect bacteria against conjugative plasmids www.biorxiv.org/content/10.6... Kudos to the extremely talented lead author Ludovic Poiré! Key contributions by @francoisrousset.bsky.social and also help from C. Lesterlin/TacC lab. 🧵⬇️

Widespread immune systems protect bacteria against conjugative plasmids

Conjugative plasmids are a class of mobile genetic elements capable of efficient transfer between bacterial cells. Although they can introduce beneficial traits such as antibiotic resistance to recipi...

biorxiv.org

Ludo Poiré@ludopoire.bsky.social · 2mo ago

The 50th FEBS Congress started in the best way possible as I won the best oral presentation prize, sponsored by @febsopenbio.bsky.social in the YSF in Wageningen ! The science goes on in Maastricht up til Wednesday, you can find me at my poster (SP076) to discuss novel bacterial immunity systems !

BildBildBild
Michael Baym@baym.lol · 9mo ago

Hot off the press! Our latest paper led by @fernpizza.bsky.social, understanding how plasmids evolve inside cells. These small, self-replicating DNA circles live inside bacteria and carry antibiotic resistance genes, but also compete with one another to replicate. 1/ www.science.org/doi/10.1126/...

Intracellular competition shapes plasmid population dynamics

From populations of multicellular organisms to selfish genetic elements, conflicts between levels of biological organization are central to evolution. Plasmids are extrachromosomal, self-replicating g...

science.org

Nature Structural & Molecular Biology@natsmb.nature.com · 11mo ago

New online: Structure and activation mechanism of a Lamassu phage and plasmid defense system

Structure and activation mechanism of a Lamassu phage and plasmid defense system

Nature Structural & Molecular Biology, Published online: 14 October 2025; doi:10.1038/s41594-025-01677-4Li et al. show that a Lamassu defense system protects bacteria from phage infection by activating a lethal tetrameric DNA-cutting enzyme. In the absence of phages, a protein clamp holds the enzyme as an inactive monomer, preventing self-damage.

go.nature.com

Anne Chevallereau@annechevallereau.bsky.social · 12mo ago

Happy to see our paper out! Functional assessment of anti-phage defence systems in their native clinical E. coli host royalsocietypublishing.org/doi/10.1098/... Thread in previous post 👇

Systematic functional assessment of anti-phage systems in their native host | Philosophical Transactions of the Royal Society B: Biological Sciences

Bacterial resistance to bacteriophages (phages) relies on two primary strategies: preventing phage attachment and blocking post-attachment steps. These post-attachment mechanisms are mediated by diverse defence systems, including DNA-degrading systems ...

royalsocietypublishing.org

Anne Chevallereau@annechevallereau.bsky.social · 2y ago

Finishing the year with a paper submission always feels good! 🛡 🦠 (1/5) www.biorxiv.org/content/10.1... Happy holidays everyone! ⭐️🎄

François Rousset@francoisrousset.bsky.social · 12mo ago

Super excited to receive the ERC starting grant to explore what phage-bacteria interactions can teach us on host-pathogen conflicts 🤩 I'm immensely grateful to my wonderful team and to present and past mentors 🙏

European Research Council (ERC)@erc.europa.eu · 12mo ago

📣 The ERC Starting Grant call results are out! Find out which early-career researchers will receive funding this year, what they will be investigating, where they will be based... plus lots of other #ERCStG facts & figures for 2025! ➡️ buff.ly/IsafuFh #FrontierResearch 🇪🇺#EUfunded #HorizonEurope

Nature Reviews Immunology@natrevimmunol.nature.com · last yr.

NEW Review from @soreklab.bsky.social @dinahoch.bsky.social explains how immune pathways manipulate the availability of nucleotides, chemically modify nucleotides to generate immune signalling molecules, and produce altered nucleotides that poison viral replication #immunosky #microsky #phagesky

Manipulation of the nucleotide pool in human, bacterial and plant immunity - Nature Reviews Immunology

Modification of the nucleotide pool is emerging as key to innate immunity in animals, plants and bacteria. This Review explains how immune pathways conserved from bacteria to humans manipulate the nuc...

nature.com

Marjon de Vos@lizscurious.bsky.social · last yr.

When things add up: environmental structure and microbial interactions drive antibiotic-resistance plasmid evolution. New paper from the lab, and the third chapter of Lars Zandbergen’s thesis! www.biorxiv.org/cgi/content/...

When things add up: environmental structure and microbial interactions drive antibiotic-resistance plasmid evolution

Antimicrobial resistance is recognized as a major global health threat. Pathogens can rapidly evolve resistance which diminishes the impact of antimicrobial treatments. The presence of other microbes ...

biorxiv.org