#WeekendRead! #InterferonPower! Cook, Green &co show @jcb.org that macrophage cell volume controls their inflammatory response & that macrophage swelling increases IFN induction synergizing with pathogen-associated molecular pathways! doi.org/10.1083/jcb....

Disruption of macrophage cell volume drives inflammatory responses and type I interferon signaling

Cook et al. show that macrophages sense cell volume disruption as a danger signal promoting transcriptional reprogramming and inflammatory responses via ty

doi.org

📅 ACTIVIDADES SEMANA → 11-15 Mayo 2026 # WIP Seminar - MARTES. Chiranan Khantham. # SEMINARIO EXTERNO - VIERNES. Dra. Verónica I. Dodero (Bielefeld University, Germany).

I will start my own research group at @ipblncsic.bsky.social, and I am already available to support fellowship applications!! A dream come true thanks to my mentors' continuous support: J-M Ruysschaert, @ppelegrin.bsky.social, Kate @inflammasomelab.bsky.social, @clarebryant.bsky.social Thank you!

Congratulations to @jakubegan.bsky.social, @brozlab.bsky.social et al. A nice reminder that lipid acyl chains are not just defining binding interactions. They tune membrane curvature and flexibility, adding an additional layer of regulation to protein activity and cellular signalling

Jakub Began@jakubegan.bsky.social · 6mo ago

PAPER ALERT! I am excited to share that our study describing the molecular mechanism of caspase-4 activation has just been published in Immunity. www.cell.com/immunity/ful... I would like to thank all the co-authors for their valuable contributions. Well done guys! Link for short summary below👇

Ha finalizado el segundo día de Café Con Ciencia en el IPBLN, nos han visitado los institutos: IES Veleta, Instituto Diego de Siloé, IES Virgen de la Caridad, IES Emilio Muñoz e IES Virgen de las Nieves. ¡Esperamos haber despertado en vosotros nuevas vocaciones científicas! @csic.es

Check out our new publication, a collaboration with Giovanni Luchetti and Vishva Dixit @ Genentech. We show that the E.coli effector NleL inhibits intestinal epithelial cell extrusion after #inflammasome activation via degrading the kinases ROCK1 and 2!! www.nature.com/articles/s41... Explainer 1/8

Enteropathogenic bacteria evade ROCK-driven epithelial cell extrusion - Nature

The bacterial ubiquitin ligase NleL evades host defence mechanisms both by inhibiting pyroptosis and by preventing infected intestinal epithelial cells from being extruded into the lumen and expelled ...

nature.com

#InflammaZoom free Webinar is back on Monday October 20th! With James Murphy (WEHI, Melbourne, Australia) @pseudokinase.bsky.social and Jonathan Maelfait (VIB-UGent, Ghent, Belgium) Register now: bit.ly/4iXGqjw

📌 Save the Date - #EUResearchersNight returns on Friday 26/09! Join us across Europe for a night full of science, discovery & fun - connecting curious minds with brilliant researchers, including ERC grantees and their teams💡! 📍Find events near you: link.europa.eu/TbHmPP 🧪

Very cool talk today at #CABDseminars by Malvina Pizzuto. Dr. Pizzuto explained the work assessing cardiolipin control over inflammatory pathways and immune dysfunctions. Malvina was invited by Peter Askjaer. Thanks for coming @malvinapiz.bsky.social

✅Ha venido la doctora Malvina Pizzuto, a hablarnos de "Evaluación del control de la cardiolipina sobre las vías inflamatorias en situaciones de enfermedad como el shock séptico". 🦠 @ipblncsic.bsky.social @csic.es @csicandalextrem.bsky.social @universitypress.cambridge.org @malvinapiz.bsky.social

#CABDseminars "Assessing Cardiolipin Control Over Inflammatory Pathways and Immune Dysfunctions" by Malvina Pizzuto @malvinapiz.bsky.social, University of Cambridge (UK) 🗓️ September 19 th ⏰ 12 pm 📍Rosalind Franklin Auditorium at the CABD Hosted by Peter Askjaer

Still wrapping my head around the fact that it’s finally out!! 🎉 From hypothesis in 2017 to data in 2020, it took 5 more years to fully prove the story. Long road for a lipid inhibitor, but worth it. Wonder how long a Nature paper takes… maybe I’ll find out soon! 😉 #ResearchLife

🚨It’s out @embojournal.org 🚨 Cardiolipin inhibits Caspase-4/11! Huge thanks to my brilliant supervisors Kate & Pablo, to @s-burgener.bsky.social & Mercedes and all the @inflammasomelab.bsky.social, it was a joy working and laughing with you, and to @brozlab.bsky.social & Si Ming lab.

Broz Lab@brozlab.bsky.social · last yr.

Congrats to @malvinapiz.bsky.social and @inflammasomelab.bsky.social on their new paper on the role of cardiolipin in non canonical inflammasome activation. We’re happy to have contributed to the story 🎉🦠!! www.embopress.org/doi/full/10....

www.open.online/2025/06/06/d...

La battaglia dei ricercatori italiani finisce a Bruxelles. L'esposto alla Commissione Ue contro i nuovi contratti: «Viola gli impegni Pnrr»

Raffaele Vitolo (Adi) spiega a Open perché i dottorandi considerano «incompatibile» con le direttive Ue l’emendamento Occhiuto alla legge Pnrr, che introduce due nuovi contratti

open.online

(1/3) 🏆 Applications are now open for the 2025 ACDS Professional Development Award! A $2,000 grant for a PhD student or ECR to support national or international professional development 🌍✈️ Conference? Lab visit? Data training? This one's for you. More info below

#celldeathresearch #careerdevelopment | Australasian Cell Death Society (ACDS)

🥇2025 ACDS Professional Development Award 🥇 Applications are now open! Are you a PhD student or early-career researcher in the cell death field? Don’t miss your chance to apply for our $2,000 travel ...

linkedin.com

Streaming tomorrow morning in Europe! Don't miss it

Australasian Cell Death Society (ACDS)@auscelldeathsoc.bsky.social · last yr.

(1/3) 🌍 We're kicking off our 2025 International Cell Death Seminar Series with @ecdo & @CDDpress on Wed 7 May! 🕓 4:30pm AEST / 8:30am CEST 📍 Online (Zoom link in poster) A fantastic international line-up awaits... 🧵👇

The last three weeks before leaving my current lab 😅 you are never done with experiments!

PHD Comics@phdcomics.com · 2y ago

"Done"

My 1st post in bluesky goes for🚨phagocyte lovers🚨 send ABSTRACT & REGISTER NOW!!! phagocytes2025.com 📌Madrid @CNIC_CARDIO 📆 26-28 March '25 20 🔝🌍speakers 28 short talks + posters Support by www.inmunologia.org www.embo.org CRC_TRR332 & TRR359_PILOT Travel bursaries by www.efis.org & EurJImmunol

#NoTimeToDie! @inflammasomelab, Holley, Monteleone &co show @natimmunol.bsky.social that cells that die by #pyroptosis, or #necroptosis, are crowned with F-actin filopodia that makes them visible by dendritic cells via CLEC9A to initiate adaptive immunity! www.nature.com/articles/s41...

Pyroptotic cell corpses are crowned with F-actin-rich filopodia that engage CLEC9A signaling in incoming dendritic cells - Nature Immunology

Pyroptotic cell death results in inflammation. Here the authors find that F-actin-rich structures formed during macrophage pyroptosis persist after cell death to activate dendritic cells.

nature.com

Imagine cells bursting into tiny fireworks to alert the immune system and spark a powerful defense. @carolinelholley.bsky.social @inflammasomelab.bsky.social @jkagan.bsky.social @samstehbens.bsky.social @doktrnick.bsky.social t.co/dE9wPARavh #ImmunoSky 🧪

How do macrophages sense SARS-CoV-2 infection to drive inflammation (protective or disease causing) in COVID-19? Our 2023 paper in Science Signalling helps explain 🧵 www.science.org/doi/10.1126/...

Macrophage ACE2 is necessary for SARS-CoV-2 replication and subsequent cytokine responses that restrict continued virion release

ACE2 in macrophages promotes infection that enables an intrinsic antiviral response to SARS-CoV-2.

science.org

Grateful to be part of the amazing team behind our student and postdoc associations @SIMBAatUQ @EMCRA_IMB @IMBatUQ. We've worked hard to support our community. I'm also honored to receive recognition for my contribution. Still so much to do, best of luck to next year’s committees

Have you ever wondered whether pyroptotic corpses have functions beyond the grave? We made the surprising discovery that pyroptotic corpses are flagged by #filopodia to alert #DendriticCells they need autopsy. A short Bluetorial (1/13)👇with movies! Link: rdcu.be/d2mjm

Pyroptotic cell corpses are crowned with F-actin-rich filopodia that engage CLEC9A signaling in incoming dendritic cells

Nature Immunology - Pyroptotic cell death results in inflammation. Here the authors find that F-actin-rich structures formed during macrophage pyroptosis persist after cell death to activate...

rdcu.be

Hi all! My name is Cornelius, and I'm an assistant professor in the Department of Biochemistry and Biophysics @pennmedicine.bsky.social @upenn.bsky.social. My lab is interested in host-pathogen interactions with a focus on how the host responds to infections. I'm passionate about mentoring, too!

Hi all, my name is Malvina. I am a senior postdoctoral researcher trying my best to start my lab and study the regulation of the immune system by cardiolipin and mitochondria. I am passionate about #inflammasome #caspases and #mitochondria, and I advocate #equity #diversity and #inclusion in science