Take a look at this recently published paper in LSA: The transcriptional cortical response to daily torpor in Phodopus sungorus @manuelfriese.bsky.social www.life-science-alliance.org/content/9/10...
Manuel Friese
@manuelfriese.bsky.social
Professor of Neurology | Director Institute of Neuroimmunology and Multiple Sclerosis, UKE
Transcriptomic profiling of cortical nuclei identifies neuron-specific RNA catabolic pathways during torpor and non-neuronal seasonal adaptations in the Djungarian hamster. @manuelfriese.bsky.social www.life-science-alliance.org/content/9/10...
We’re excited to introduce the new Hamburg #HertieNetwork fellows for the 3rd funding period: @felixfischbach.bsky.social, Märit Jensen, @brissiek.bsky.social & @janasonner.bsky.social. Looking forward to inspiring projects, discussions & collaboration across sites! #UKEHamburg #HertieStiftung
Check out our latest research on how a neuron-immune axis modulates peripheral immune responses during multiple sclerosis. We discovered it by exploring pregnancy-associated immune modulation in multiple sclerosis. Special thanks to Jana Sonner and Audrey Kahn: www.nature.com/articles/s41...
A GDF-15–GFRAL axis controls autoimmune T cell responses during neuroinflammation - Nature Immunology
Here the authors show that endogenous or therapeutically delivered GDF-15 activates brainstem neurons that trigger splenic β-adrenergic signaling. This, in turn, suppresses autoreactive T cells and re...
nature.com
We are hiring dedicated and motivated new members to join our basic and clinical research team at INIMS (www.inims.de), Universitätsklinikum Hamburg-Eppendorf. - Medical Scientist (Postdoc) - Clinician Scientist (Neurology) Apply here: www.uke.jobs/index.php?ac... www.uke.jobs/index.php?ac...
👉 Register now: hubs.li/Q03NdTNP0 📆 Nov 20, 2025 | 2pm GMT / 9am EST / 10pm CST Join our expert panel as they explore innate immunity’s role in neurological diseases, and therapies to prevent inflammation-driven neurodegeneration. #neurology #brainhealth #lancetwebinar
Our latest work: The immunoproteasome disturbs neuronal metabolism and drives neurodegeneration in multiple sclerosis: Cell www.cell.com/cell/fulltex...
The immunoproteasome disturbs neuronal metabolism and drives neurodegeneration in multiple sclerosis
Neuronal proteasomal dysfunction is a hallmark of neuroinflammatory and neurodegenerative diseases. This study reveals that the interferon-induced immunoproteasome drastically decreases proteasomal ac...
cell.com
Interferon-induced immunoproteasome drastically decreases proteasomal activity in neurons, leading to a switch in neuronal metabolism with increased oxidative injury and ferroptosis @cellcellpress.bsky.social @manuelfriese.bsky.social www.cell.com/cell/fulltex...
We’re looking for a physician (f/m/d) with a strong interest in neuroimmunology and research in our MS outpatient clinic and day hospital team! Join us in advancing care and science in a dynamic, interdisciplinary environment🧠 uke.jobs/index.php?ac...
Arzt/Ärztin (all genders) in Weiterbildung - Neurologie mit Schwerpunkt Neuroimmunologie
uke.jobs
Important walkthrough for newcomers in the field rdcu.be/eg58p
Recommendations for robust and reproducible research on ferroptosis
Nature Reviews Molecular Cell Biology - Ferroptosis is a non-apoptotic type of cell death that is induced by uncontrolled iron-dependent phospholipid peroxidation and has important roles in...
rdcu.be
This week in #Science #Immunology: researchers @ @helsinki.fi characterize #immune landscape of deep cervical #LymphNodes in newly diagnosed untreated patients w #MultipleSclerosis! Authors uncover several lines of evidence strengthening possible link btw #MS & Epstein–Barr virus ( #EBV ) infection!
Altered immune landscape of cervical lymph nodes reveals Epstein-Barr virus signature in multiple sclerosis
Deep cervical lymph nodes of patients with MS have an altered B cell compartment that, in part, transcriptionally resembles an EBV infection.
science.org
We are hiring (2 positions) one Postdoctoral fellow and one Clinician-Scientist (all genders) in neuroimmunological research | Universitätsklinikum Hamburg-Eppendorf uke.jobs/index.php?ac... uke.jobs/index.php?ac...
Check out our results from an academic drug development program targeting TRPM4 to protect neurons from neurodegeneration. Many years of intense collaboration between UKE Hamburg, KU Leuven, Fraunhofer ITMP, Evotec: www.cell.com/iscience/ful...