Manuel Friese

@manuelfriese.bsky.social

Professor of Neurology | Director Institute of Neuroimmunology and Multiple Sclerosis, UKE

Check out our latest research on how a neuron-immune axis modulates peripheral immune responses during multiple sclerosis. We discovered it by exploring pregnancy-associated immune modulation in multiple sclerosis. Special thanks to Jana Sonner and Audrey Kahn: www.nature.com/articles/s41...

A GDF-15–GFRAL axis controls autoimmune T cell responses during neuroinflammation - Nature Immunology

Here the authors show that endogenous or therapeutically delivered GDF-15 activates brainstem neurons that trigger splenic β-adrenergic signaling. This, in turn, suppresses autoreactive T cells and re...

nature.com