We are recruiting a Postdoctoral Fellow in Brain Cancer Epigenomics. PDF will perform research on pediatric brain tumors at Texas Children's Hospital/Baylor College of Medicine. Informatics/computational experience is required. Apply here: jobs.bcm.edu/job/Postdoct...

#NEWS: #BCMNeurosurgery's Dr. Ben Deneen recently received the inaugural Bert O'Malley Award for Outstanding Basic Research at this year's Dan L Duncan Comprehensive Cancer Center at @bcmhouston.bsky.social annual retreat.

"A functional perspective on astrocyte heterogeneity" http://dlvr.it/TPML8T Benjamin Deneen, Wookbong Kwon & @m-r-williamson.bsky.social @cp-trendsneuro.bsky.social #SfN2025

Please share or forward to anyone interested in joining our lab as a research assistant, details can be found via the link below shorturl.at/x0cSs

a penguin wearing a red bandana and a tie looks through binoculars

Alt: a penguin wearing a red bandana and a tie looks through binoculars

media.tenor.com

Lest We Forget N'oublions Jamais

In honor of Veterans Day, Dr. Timothy Porea shares how he uses his time in the U.S. Navy and military medicine to help current military students. Watch the interview with Dr. Porea on YouTube: https://bit.ly/4p6AUi0 Thank you to all veterans who support Baylor and the community. #VeteransDay

Veterans Day 2025

In honor of Veterans Day, Dr. Timothy Porea, professor of pediatrics-hematology and oncology at Baylor College of Medicine, reflects on his time in U.S. Navy and military medicine. Thank you to all veterans who support Baylor and the community.

bit.ly

DNA replication is only half the story. Cells actually replicate their chromatin, ensuring that both the DNA sequences and the chromatin states are faithfully maintained to preserve cell identity and function after division. Here's a glimpse of how this process unfolds, courtesy of theCrux:

Epigenetic Replication during DNA Replication - Replicating histones and DNA methylation

YouTube video by theCrux

youtube.com

This week, that idea reached patients: Viral-mimicry priming + anti-PD-1 in relapsed/refractory NK/T-cell lymphoma delivered 47.6% complete responses, 66.7% ORR, and ~50% 2-year OS, even after prior PD-1 failure (Huang, Cancer Discovery 2025).

EZHIP has been puzzling us for years because of its incompletely understood role in pediatric brain tumors. Here we report new functions for EZHIP and that EZHIP is not only mutated in PFA ependymoma, but also in K27M+ HGGs with EGFR mutations. actaneurocomms.biomedcentral.com/articles/10....

EZHIP boosts neuronal-like synaptic gene programs and depresses polyamine metabolism - Acta Neuropathologica Communications

It is currently understood that the characteristic loss of the repressive histone mark H3K27me3 in PFA ependymoma and diffuse midline glioma (DMG) are caused by complementary mechanisms mediated by EZ...

actaneurocomms.biomedcentral.com

1/ Excited to share our new study with @brumbaugh-lab.bsky.social, out in @natbiotech.nature.com! P-bodies selectively sequester RNAs encoding cell fate regulators, often from the preceding developmental stage. Releasing these RNAs can drive changes in cell identity. 🧵 www.nature.com/articles/s41...

Selective RNA sequestration in biomolecular condensates directs cell fate transitions - Nature Biotechnology

Stem cell differentiation is controlled by manipulating RNA condensates.

nature.com

Scientists uncover nuclear droplets that link multiple #leukemias revealing new #therapeuticTarget. @gandhardatar.bsky.social @sciencyelmira.bsky.social @goodell-lab.bsky.social @superscijew.bsky.social et al @cellcellpress.bsky.social @bcmhouston.bsky.social www.bcm.edu/news/scienti...

Scientists uncover nuclear droplets that link multiple leukemias revealing new therapeutic target

A hidden structure inside the cell is rewriting how scientists understand leukemia. Beneath the microscope, what looked like disorder turned out to follow...

bcm.edu

(1/10) How do diverse leukemia mutations converge on the same molecular program? In #RibackLab first manuscript @cp-cell.bsky.social, collaboration with @goodell-lab.bsky.social shows that disparate mutations rewire shared protein networks to form nuclear condensates called C-bodies.

The November issue of Cancer Discovery @aacrjournals.bsky.social is online! The cover features work by Diwakar Davar, @overacrelab.bsky.social, et al. showing sucralose consumption ablates cancer immunotherapy response via microbiome disruption - read that & more: aacrjournals.org/cancerdiscov...

Our "mind captioning" paper is now published in Science Advances @science.org . The method generates descriptive text of what we perceive and recall from brain activity — a linguistic interpretation of nonverbal mental content rather than language decoding. doi.org/10.1126/scia...

Mind captioning: Evolving descriptive text of mental content from human brain activity

Nonverbal thoughts can be translated into verbal descriptions by aligning semantic representations between text and the brain.

doi.org

Our latest collaboration with @rongfan8.bsky.social, spatial triomics to investigate myelin and cortical brain development, and demyelination, spearheaded by Leslie Kirby in our lab @ki.se and Di Zhang in Rong's lab! Check it out @nature.com www.nature.com/articles/s41...

Spatial dynamics of brain development and neuroinflammation - Nature

A tri-omic atlas of the mouse brain from postnatal day 0 to P21 reveals that layer-specific projection neurons have a role in coordinating axonogenesis and myelination.

nature.com

The Pathania lab will be moving to the Ludwig Institute in Oxford in early 2026. We'll be recruiting postdocs and research assistants soon, so keep an eye out for those job ads and reach out if you want to find out more about the science we have planned! shorturl.at/thpyK

Ludwig Oxford welcomes Dr Manav Pathania

Ludwig Oxford is delighted to welcome Dr Manav Pathania as an Assistant Member of the Ludwig Institute for Cancer Research, Oxford Branch.

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