Fialho et al. find that neuropilin-1 drives nerve growth factor-dependent sensitization in trigeminal nociceptors and oral cancer pain. Targeting neuropilin-1 blocks tumor-derived algogens, offering a safer, nonopioid therapeutic strategy #PAIN bit.ly/4wCwhzq

NEW PRC PAPER 🚨: The Bunnett lab identified Neuropilin-1 (NRP1) as a key mediator of NGF signaling driving oral cancer pain. Targeting NRP1 disrupts NGF/TrkA signaling, reduces nociceptor sensitization, and alleviates pain without directly blocking NGF! buff.ly/NmyrTLy

📣Excited to share our new preprint! We identify synaptic vesicle endocytosis in nociceptors as a key driver of ongoing pain, and show that LNP‑delivered CRISPR/dCas9 repression of this pathway produces durable analgesia across multiple pain models. www.biorxiv.org/content/10.6...

Targeting Synaptic Vesicle Endocytosis in Nociceptors Provides Sustained Pain Relief

Endocytosis replenishes synaptic vesicle (SV) pools that are required for persistent transmission of chronic pain signals within nociceptive spinal circuits. The nociceptor-specific contribution of SV...

biorxiv.org

Amazing day so far at the PRC symposium! So much exciting science from our research community and awesome keynote speakers. @karapedsgastrodoc.bsky.social @jimr-1.bsky.social @sarahanajjar.bsky.social @tonelloraquel.bsky.social @elisadamo.bsky.social @pazduran.bsky.social @badrsokrat.bsky.social

📢🔬Check out our latest study on the specific role of endocytic mediators in pain-related synaptic transmission, now out in PAIN. @mariafialho.bsky.social #PainResearch #Neuroscience #SynapticTransmission

PAIN@painthejournal.bsky.social · 11mo ago

Fialho et al. find that synaptojanin 1, endophilin A1, dynamin 1, and adaptor-associated protein kinase-1 mediate synaptic vesicle recycling and neurotransmission in nociceptive circuits in the spinal cord. Learn more in #PAIN bit.ly/3WIf08B

My first postdoc paper published 🎉🥳, and Raquel’s first as first senior author! Happy to be part of this! @nyupainresearch.bsky.social @tonelloraquel.bsky.social

Raquel Tonello@tonelloraquel.bsky.social · last yr.

Excited to share my first senior author paper in Pain! 🎉 We identify Synaptojanin 1 & Endophilin A1 as key endocytic mediators of nociception. Silencing them blocks spinal synaptic transmission and relieves pain in cancer & postoperative models, without affecting normal behavior. buff.ly/caKMGY3

Kicked off the USASP meeting last night with a mega pretzel at the NYU Pain Research Center dinner. Great start to a great week! #USASP2025 #PainResearch #NYUPRC #NetworkingAndPretzels

@nyupainresearch.bsky.social Shoutout 📢 to The NYU Molecular Pathobiology for #hosting an amazing tea time #Mardi #Gras style! #Brazil #Zamba #Turnupthursdays #Happymardigras 🪅🎉🎊🪩💃🕺🏼 #NYUDental #newyorkuniversity

A non-opioid alternative in the treatment of chronic pain! Chloe J. Peach @tonelloraquel.bsky.social & team discover inhibition of Neuropilin-1 suppresses NGF-evoked pain in preclinical models: https://www.jci.org/articles/view/183873

@tedpricethepainguy.bsky.social @utdpaincenter.bsky.social Great visit today from Dr. Ted Price! Thank you for wowing us with your team’s exciting data on human DRG tissue, very inspiring and insightful seminar! #painresearch #dorsalrootganglia #humanDRG #nyudental #nyuniversity #nyupainresearch