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Maria Dilia Palumbieri

@mariapalumbieri.bsky.social

Passionate about science. Interested in DNA repair and ADP ribosylation Postdoc at the MaxPlanck for biology of ageing @maticlab.bsky.social

6 Posts60 Follower71 Folgt
The Matić Lab@maticlab.bsky.social · 6mo ago

The paper describing our sensitive poly-ADPr antibodies and a few other things is now out in Nature Communications. Congrats to all the authors!! www.nature.com/articles/s41...

Versatile and sensitive detection of mono- and poly(ADP-ribosyl)ation reveals XRCC1-dependent remodelling of PARP1 signalling - Nature Communications

ADP-ribosylation regulates DNA repair, but its distinct forms have been difficult to distinguish. Here, the authors develop sensitive, modular antibodies to precisely detect mono- and poly-ADP-ribosyl...

nature.com

The Matić Lab@maticlab.bsky.social · 8mo ago

We’ve made the poly-ADPr antibody AbD64138 available in a SpyTag HRP-conjugated format (TZA0117P): www.bio-rad-antibodies.com/monoclonal/h... This sophisticated format enables detection of very low poly-ADPr levels while simplifying and reducing the cost of detecting abundant poly-ADPr.

Maria Dilia Palumbieri@mariapalumbieri.bsky.social · 11mo ago

Had lots of fun yesterday at the first edition of the Wissenschaftsfestival Köln with CECAD Cologne and Max Planck Institute for Biology of Ageing at the Rautenstrauch Museum 🔬 🧬 Great to see so many people interested in science! #science4all

#bazaar #science #wissenschaftsfestival #köln #outreach #science4all | Dr. Tanio Calabrese

🎪🔬🧪 The #bazaar of #science is in full swing today at the first edition of the #Wissenschaftsfestival #Köln. Come by and discover the world of science with us! Whether you want tips on how to promot...

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Nature Chemical Biology@natchembio.nature.com · last yr.

RNF114 is an E3 ligase that can recognize ADP-ribose (ADPr) and ubiquitin with separate domains. A proteomics approach is developed using these domains to map ADP-ribosyl-ubiquitylation sites www.nature.com/articles/s41...

Serine ADPr on histones and PARP1 is a cellular target of ester-linked ubiquitylation - Nature Chemical Biology

RNF114 is an E3 ligase that can recognize ADP-ribose (ADPr) and ubiquitin with separate domains. Using these domains, Kolvenbach and Palumbieri et al. developed a proteomics approach to map ADP-ribosy...

nature.com

Andrii Gorelik@andriigorelik.bsky.social · last yr.

An amazing paper from van der Heden and Ahel groups! They use clever chemistry to identify RNF114 as a dual ADP-ribose-Ubiquitin reader involved in the DNA damage response! Congratulations to first authors Max, @chatrin-c.bsky.social and Rishov. Happy to have a small contribution in this story

Identification of RNF114 as ADPr-Ub reader through non-hydrolysable ubiquitinated ADP-ribose - Nature Communications

Deltex E3s modify ADP-ribosylated targets with ubiquitin, creating a hybrid modification whose readers remains unknown. Here, the authors synthesise a non-hydrolysable probe that mimics the modificati...

nature.com

Maria Dilia Palumbieri@mariapalumbieri.bsky.social · last yr.

Thrilled to share my first first-author postdoc publication — a team effort with @aklvnbch.bsky.social. We present the first MS-based evidence of ADP-ribosylation–linked ubiquitin (ADPrUb) in cells after DNA damage. Grateful for all I’ve learned and looking forward to uncovering more about ADPrUb

The Matić Lab@maticlab.bsky.social · last yr.

Our latest study on ADP-ribosyl-linked serine ubiquitylation in the context of PARP1 signaling and the DNA damage response is out today in Nature Chemical Biology www.nature.com/articles/s41...

Andreas Kolvenbach@aklvnbch.bsky.social · last yr.

Really happy that our paper is finally released. We show that PARP1 and histones are targets of ADP-ribosyl-linked ubiquitylation during DNA damage and describe how to detect the dual modification. Great teamwork with @mariapalumbieri.bsky.social & thanks to everyone involved @maticlab.bsky.social !

The Matić Lab@maticlab.bsky.social · last yr.

Our latest study on ADP-ribosyl-linked serine ubiquitylation in the context of PARP1 signaling and the DNA damage response is out today in Nature Chemical Biology www.nature.com/articles/s41...