our paper starts with an analysis of the dynamics of 3D chromatin in cardiac differentiation, for ventricular and atrial cardiomyocytes. They are different! And by single cell methyl-HiC we can discern subtype differences. www.science.org/doi/10.1126/...

Dose-dependent sensitivity of human three-dimensional chromatin to a heart disease–linked transcription factor

Dosage-sensitive transcription factors (TFs) underlie altered gene regulation in human developmental disorders, and cell type–specific gene regulation is linked to the reorganization of three-dimensio...

science.org

A single mushroom can release 3 BLLION spores a day at a rate of 30,000 PER SECOND. A single giant puffball can produce 7 TRILLION spores in its lifetime. Each year, fungi collectively produce 50 million TONS of them, enough to coat every square mm of Earth with 1,000 spores. Let's talk about it.

How exciting is this????? A new monkey species discovered in 2026 - what a beautiful new discovery !!!!https://www.bbc.com/news/articles/c15y5wgj4x8o

New monkey species with orange lips found 'hiding' in DRC forest

Scientists describe "amazing feeling" to look into the face of an animal that so few people knew existed.

bbc.com

Manuscripts with women as corresponding authors are less frequently sent out for review at Science. The ones reviewed receive less favorable reviews by both male and female reviewers.

Javi Ibarrondo@jibarrondo.bsky.social · 3w ago

Editorial and peer review dynamics at elite general science journals | Science Advances www.science.org/doi/10.1126/... 🧪

Each human (resting CD4+ T) cell has about 2 meters of DNA crammed into the nucleus. Therefore, the challenge is not just storing DNA but folding it in a way that preserves function. rdcu.be/fsd7v

Molecular architecture of heterochromatin at the nuclear periphery of primary human cells

Nature Communications - The 3D organisation of chromatin inside a human cell is still not fully resolved. Here the authors reveal that in situ cryo-ET resolves individual nucleosomes and predicts...

rdcu.be

Hey #nucleus nerds, the JCS Special Issue on the Cell Biology of the Nucleus is now live! This was a pleasure to co-edit with Megan King @luskinglab.bsky.social.

Journal of Cell Science@jcellsci.bsky.social · last mo.

Our Special Issue: Cell Biology of the Nucleus is complete Explore our Toc: journals.biologists.com/jcs/issue/13... Our cover image shows the posteriorly positioned nuclei (Nup50-mCherry - pink) of notochord cells in Ciona embryos. See article by Peng et al. journals.biologists.com/jcs/article/...

Scott Atlas worked in my field. His most notable study is an fMRI experiment looking at the neural correlates of erections that was so poorly designed I used to teach it in my class on the dangers of sloppy design. His opinions are about as worthless as his science.

Jeremy Berg@jeremymberg.bsky.social · last mo.

Scott Atlas, the champion of herd immunity as an Fox News commenter and the Trump Advisor during COVID, weighs in with a DEEPLY MININFORMED op-ed in the WaPo. www.washingtonpost.com/opinions/202... 1/7

Genome instability triggers intercellular DNA transfer between human cells @cellcellpress.bsky.social @peterlylab.bsky.social www.cell.com/cell/fulltex...

Peter Ly@peterlylab.bsky.social · 3mo ago

Excited to share our latest paper! We found that large pieces of the human genome can transfer between cells upon direct contact, endowing recipient cells with heritable phenotypic changes. @cp-cell.bsky.social (1/7) www.cell.com/cell/fulltex...

On this day, in 1961, two articles appeared in Nature announcing the isolation of messenger RNA (mRNA) www.cell.com/current-biol...

Who discovered messenger RNA?

Cobb looks back at the complicated series events that led to the discovery of messenger RNA, highlighting the often difficult problem of attributing credit for scientific advances.

cell.com

Sounds super interesting - hope we'll see more of these (lncRNAs linked by human genetics + mouse KOs to key phenotypes)! www.nature.com/articles/s41...

An X-linked long non-coding RNA, PTCHD1-AS, and the core features of autism - Nature

PTCHD1-AS, which encodes a long non-coding RNA, is associated with the aetiology of autism spectrum disorder in humans through striatal molecular and circuit-level dysregulation.

nature.com

Why can't we explain enhancer action despite 2 decades of chromosome conformation technologies? 😬 Our new study spearheaded by Leonid Mirny's group points to a flaw in our assumptions, and to a solution from physical principles By @timothyfoldes.bsky.social 💻& @karissalhansen.bsky.social 🧪 🧵👇

Nature research paper: HIV-1 signalling remodels nuclear pores to licence infection go.nature.com/49hjtFQ

HIV-1 signalling remodels nuclear pores to licence infection - Nature

HIV-1 capsid nuclear import at the nuclear pore complex is a bottleneck to resting T cell infection, but HIV-1 overcomes this by triggering receptor-mediated signalling during cell–cell spread to drive nuclear import and licence infection.

go.nature.com

1/ Preprint alert 🚨🚨🚨 How do cells decide where an mRNA should end? And how is that decision coordinated with splicing and transcription while the RNA is still being made? Here's what first author @hopem105.bsky.social found 👇

(1/n) Super excited to share that our preprint is out today in @natsmb.nature.com with a new name "Integrated MINFLUX tracking reveals two distinct chromatin dynamics classes across cell types" and more than 2x more data: www.nature.com/articles/s41... See also MIT News news.mit.edu/2026/how-chr...

Anders Sejr Hansen@andersshansen.bsky.social · last yr.

(1/n) Thread @matteomazzocca.bsky.social @domenicnarducci.bsky.social Simon Grosse-Holz @jessematthias.bsky.social preprint Q: how does chromatin move? Using MINFLUX, SPT & SRLCI, we track chromatin dynamics across 7 orders of magnitude in time to provide answers www.biorxiv.org/content/10.1...

I've spent yesterday and today talking to researchers across the globe trying to understand the hantavirus outbreak aboard the cruise ship MV Hondius. My story in @science.org is here (and some threaded thoughts coming): www.science.org/content/arti... 🧪 #IDsky

Cruise ship’s hantavirus outbreak puts researchers in uncharted territory

Questions about the culprit virus and its route of spread remain as health officials make plans for stranded passengers

science.org

A few additional key details 👇, building on what I mentioned yesterday - human-to-human transmission on-board is the most likely explanation, but, importantly, does not mean this is likely to cause a larger outbreak. The ship’s doctor among suspected cases + reportedly, no rodents on board.

Kai Kupferschmidt@kakape.bsky.social · 3mo ago

I've spent yesterday and today talking to researchers across the globe trying to understand the hantavirus outbreak aboard the cruise ship MV Hondius. My story in @science.org is here (and some threaded thoughts coming): www.science.org/content/arti... 🧪 #IDsky

The research highlight of our recent work on nuclear speckles is online. The photo choice is eggcellent. Happy Easter! 🌸🐰🥚 www.nature.com/articles/s41...

Nuclear speckles of GC richness - Nature Reviews Molecular Cell Biology

Nuclear speckles support the splicing of levelled exon–intron architecture transcripts, and their evolution shaped genome organization in amniotes.

nature.com

www.theguardian.com/world/video/...

Inside the world's fastest-growing HIV epidemic – video

HIV infections in Fiji are growing among the most vulnerable, including babies and young children

theguardian.com

Herpes simplex virus 1 fluidizes the nucleus, enabling condensate formation

We found a viral Trojan Horse: a virus can hide inside another virus.This one surprised us: deltaviruses don’t just borrow a helper virus. They can travel inside it. A literal Trojan Horse “virus-in-a-virus” route into cells. 🤯 Kudos to 1st author @viroscope.bsky.social and co-authors !

Deltaviruses spread through a viral Trojan Horse

Hepatitis D-like satellite viruses, known as deltaviruses, have been recently discovered in a wide range of animals. These viruses are thought to expr…

sciencedirect.com

Deltaviruses don’t just borrow a helper virus, they can travel inside it to infect news. A literal Trojan Horse “virus-in-a-virus”🤯@viroscope.bsky.social @karimaj.bsky.social www.cell.com/cell/fulltex... @cellcellpress.bsky.social

Viroscope@viroscope.bsky.social · 5mo ago

The Trojan Horse is real, and it’s microscopic! 🐴🦠 Our paper is out today in @cellcellpress.bsky.social! We discovered that deltaviruses physically hide INSIDE helper viruses to sneak into new cells. And to prove it, we had to image them from every angle. 🧵👇 www.sciencedirect.com/science/arti...

Awesome new work from Jingyi Fei's lab in collaboration with Oded Regev's group. RNA localization to nuclear speckles follows splicing logic url: academic.oup.com/nar/article/...

RNA localization to nuclear speckles follows splicing logic

Abstract. Nuclear speckles are membraneless organelles implicated in multiple RNA processing steps. In this work, we systematically characterize the sequen

academic.oup.com

The richest man owns X. The second and third richest men control Google. The fourth richest man owns Facebook, Instagram, and WhatsApp. The fifth richest man owns The Washington Post. And now the sixth richest could soon take over both Paramount and Warner Bros. See the problem here?

Netflix Backs Out of Bid for Warner Bros., Paving Way for an Ellison Takeover

nytimes.com

2026 basically

Antibody cocktails derived from pediatricians cooperatively neutralize and protect rodents against RSV and hMPV by targeting conserved epitopes www.science.org/doi/10.1126/...

I started offering career advice to two junior colleagues today in separate meetings, and both times I caught myself thinking that, if I'm honest, I don't have very good advice on navigating the current funding and job climate. I think it's important to say that no one does.

"Another remarkable case is a 106-year-old woman who took up swimming at age 70 & won her first competition three decades later. Longevity runs in the family: she has two younger sisters over 100 & a 110-year-old aunt." Great story from @marilenharo.bsky.social www.nature.com/articles/d41... 🧪

Still working at 107: supercentenarian study probes genetics of extreme longevity

Scientists seek to understand the factors that have allowed people in Brazil to reach their 100th or even 110th birthdays despite facing adversities.

nature.com

📣 Please spread: we’re hiring a Lab Manager! It is a critical position in our new lab. As our lab moves to Barcelona and joins the @crg.eu, we’re looking for a Lab Manager to help build the lab and set the lab atmosphere. 🔗 Apply here 👉 recruitment.crg.eu/content/jobs...

This is the most astonishing graph of what the Trump regime has done to US science. They have destroyed the federal science workforce across the board. The negative impacts on Americans will be felt for generations, and the US might never be the same again. www.nature.com/immersive/d4...

A trial was about to launch for a vaccine that would ward off the HIV virus. It would be an incredible breakthrough. Then it looked as if it would be over before it started. n.pr/3NnYj0O

The near death -- and last-minute reprieve -- of a trial for an HIV vaccine

A trial was about to launch for a vaccine that would ward off the HIV virus. It would be an incredible breakthrough. Then it looked as if it would be over before it started.

n.pr