Have you ever wondered how cells in developing embryos manage to squeeze through tiny spaces? And how do they cope with mechanical stresses imposed by surrounding tissues? Check out our paper, now out @natcellbio.nature.com : www.nature.com/articles/s41...

In vivo DNA damage protection during cell migration across confining embryonic tissue environments - Nature Cell Biology

Häkkinen et al. show that zebrafish neural crest cells encounter increased tissue-scale confinement along the body axis. Despite nuclear deformation, migrating neural crest cells experience neither nu...

nature.com

BREAKING NEWS The 2026 Nobel Prize in Physiology or Medicine has been awarded to Karl Deisseroth, Peter Hegemann and Georg Nagel “for their discoveries concerning light-gated ion channels and optogenetics.”

Only one week left to apply ! Check below for more details but the course will be great. Please spread the word 🙏

Levayer Lab@levayerr.bsky.social · 2mo ago

📢master or PhD student interested in cell biology ? There are spots left for the Molecular Biology of the Cell course @pasteur.fr. Check the amazing list of lecturers + 1 week practical pocking choano cytokeleton with @thibautbrunet.bsky.social team. Registration 👇 www.pasteur.fr/fr/nous-conn...

A funded postdoctoral position is available at the IBPS, Sorbonne University/CNRS/INSERM in Paris, to investigate the formation of the olfactory organ in zebrafish. We are looking for an postdoctoral researcher with expertise in transcriptomics and bioinformatics, (scRNAseq analysis).

📢Call for Group Leader in our unit within the Institut de Biologie Paris Seine in Paris @ibps.bsky.social www.ibps.sorbonne-universite.fr/fr/Recherche...

🚨 New preprint from the lab! 🚨 Transcriptomic profiling identifies cellular and molecular transitions during Merkel cell regeneration www.biorxiv.org/content/10.6...

Transcriptomic profiling identifies cellular and molecular transitions during Merkel cell regeneration

Skin exhibits a remarkable capacity for regeneration, which requires the coordinated reconstitution of diverse cell types and structures. Merkel cells are mechanosensory cells that detect gentle touch...

biorxiv.org

We've just released StressNET: a machine-learning method that infers the mechanical state of tissues! Check it out! (1/8)

bioRxiv Bioinfo@biorxiv-bioinfo.bsky.social · last mo.

StressNET: an adaptable deep-learning model for mechanical stress inference in tissues https://www.biorxiv.org/content/10.64898/2026.09.14.751456v1

A happy update to this preprint: our work is now published in Nature Communications! Fair and transparent peer review genuinely made the paper stronger – many thanks to the reviewers for pushing us to go deeper into the mechanics 🔩⚙️ www.nature.com/articles/s41...

Goblet cells mechanically breach the epithelial barrier in gut homeostasis - Nature Communications

This study shows that goblet cells physically compress neighboring intestinal cells, creating fractures in cell–cell junctions that weaken epithelial cohesion, increase gut permeability and reveal how...

nature.com

Denis Krndija@deniskrndija.bsky.social · 2y ago

🥳 Thrilled to share our lab's first preprint, led by our talented postdoc Justine Creff! 👩🏻‍🔬 We tackled a fundamental question: how the epithelium withstands mechanical stress at the interface of cells with distinct geometries and mechanics, such as enterocytes (E) and goblet cells (G) (1/9)

More reasons to use your F2s!

Adam Ameur@adameur.bsky.social · 2mo ago

What happens after genome editing? Using PacBio PureTarget sequencing (>1000× coverage), we resolved CRISPR-Cas9 on-target and off-target outcomes at high resolution. In zebrafish, this revealed widespread mosaicism and edits transmitted to the offspring 🧬 🧪 link.springer.com/article/10.1...

Great speakers, great science, great location = great meeting! EMBO workshop Forces across scale April 27-30, 2027 in Porto. meetings.embo.org/event/27-for...

Happy to share our new study @ijmonod.bsky.social on how surface curvature shapes multicellular organization and function. How curvature controls tissue chirality, patterns distinct architectures, and influences myogenic differentiation? www.biorxiv.org/content/10.6...

Happy to share our new preprint! We uncover how local force imbalances drive keratinocyte delamination and upward motion, while neighboring cells close the basal layer below. Amazing work from @andreasschoenit.bsky.social! www.biorxiv.org/content/10.6...

🧵 What if one reason fertility declines with age isn’t just genetic-but mechanical? Thrilled to share our new paper in @NatureCellBio : Elevated contractility drives implantation failure in mouse embryos from aged females… here’s what we found 👇 www.nature.com/articles/s41... 1/11

Elevated contractility drives implantation failure in mouse embryos from aged females - Nature Cell Biology

Cavanaugh et al. show that embryos from aged mice have increased contractility and tissue viscosity on embryonic day 4.5, which leads to poor spreading and attachment. Similar age-associated mechanica...

nature.com

Happy to share our new paper @natcomms.nature.com on the role of active nematics on myoblast fusion and myotube growth! www.nature.com/articles/s41... Amazinf work from @dubey837.bsky.social, @yoannletoquin.bsky.social and Aleksandra Ardaševa!

New preprint from the lab 🥳 We made new knock-in zebrafish 🐟 that fluorescently tag endogenous neurofascins. So now, we can live-image neuronal nfasca/NF186 and glial nfascb/NF155 non-invasively, as nerves, nodes of Ranvier and paranodes develop in vivo 🧵👇 www.biorxiv.org/content/10.6...

Live-imaging of endogenous neurofascins reveals glial adhesion shapes developing nodes of Ranvier

The organisation of myelinated axons into specialised domains is essential for saltatory conduction and depends on the polarised distribution of neuronal and glial cell-adhesion molecules, including n...

biorxiv.org

We are thrilled to announce our new preprint from the wonderful @sorayavillaseca.bsky.social Ever wondered how cells squeeze through tiny spaces in embryos? Neural crest cells use Dynein to transport their nucleus along microtubules. Check out the preprint!! www.biorxiv.org/content/10.6...

That's right! EQDB made it all the way to Japan 🇯🇵! Many thanks to @laghalab.bsky.social @juliebatut.bsky.social @robinjournot.bsky.social @leopoldlab.bsky.social @clotilde-cadart.bsky.social Vincent, Emma, Miquel, Clara and Kai! Join us @sfbd.bsky.social for more outreach activities

Bardin Lab@bardinlab.bsky.social · 5mo ago

Fantastic outreach by @maitrejl.bsky.social et al, who have brought Biology Quest (En Quête de Bio) of the @sfbd.bsky.social to Japan! Want to bring model organisms into your primary schools? See www.eqd-bio.org or contact me or @drosopachea.bsky.social . French, English and other languages!

I'm very happy to announce that the "From Postdoc to PI Session" will be sponsored by the @biologists.bsky.social and we will be offering a $$ Prize to the best talk, so now a twofer reason to apply! www.germanfishmeeting.org/from-postoc-... Let me know if you have any question/s! 🐟

From Postoc to PI Session | German Fish Meeting

germanfishmeeting.org

Just published in @science.org 🚀 By controlling how cells align, we show that living nematic tissues can be programmed to generate forces and fold into predictable 3D shapes. A new platform for tissue engineering and the design of smart active materials! 🫆 www.science.org/doi/10.1126/...

Pau Guillamat@pauguillamat.bsky.social · last yr.

New preprint out! We show how cellular nematic order can be harnessed to program tissue-wide force fields and guide 3D shape transformations. The tissue morphogenesis logic, now engineered into living, programmable materials. www.biorxiv.org/content/10.1... #ActiveMatter #TissueEngineering

🎉 Great success for our 2nd SFBD-SBCF science outreach day in Ivry-sur-Seine, with the support of the city! Over a thousand children came to take part in our workshops, led by around fifty researchers from institutes in Paris and Gif-sur-Yvette! Thank you all for your enthusiasm! 🔬🧬

May 29th. If you're in Paris, mark your calendars. Lock your pipettes. TELL YOUR cHAIR. RUN FOR YOUR LIVES 🧪🐟

Maxim Greenberg@maxvcg.bsky.social · 7mo ago

ElmoFire.gif @mads100tist.bsky.social @nkonst4.bsky.social @ijmonod.bsky.social Looking forward to having Dr. Mad Scientist (AKA Joaquin) grace our humble institute! 🐟🧪

www.science.org/doi/10.1126/...

Happy #fluorescencefriday (and start of vacation!) to all those who are celebrating Lifeact-labeled epidermal stem cells closing a wound after in vivo adult zebrafish skin injury

🐟!JOB ALERT!Duke, Durham, NC!🐟 We are looking for a research tech (our current tech is starting grad school this Fall (Yay!)). The candidate will contribute to our ongoing research projects on tissue morphogenesis using zebrafish. Please RT🙏 www.munjallab.com/join-us

Happy to share the heroic effort of @gaellel.bsky.social to reduce our segmentation pain through EpiCure (Epithelial Curation), a napari plugin easing the curation of epithelial segmentation developed with several groups of @devstempasteur.bsky.social. www.biorxiv.org/content/10.6... See more 👇

Gaëlle Letort@gaellel.bsky.social · 7mo ago

I'm happy to present our new tool, EpiCure, a napari plugin to ease correction of segmentation and tracking of epithelia movies, developed in @devstempasteur.bsky.social

🆁🅴🅼🅸🅽🅳🅴🆁 Spread the word 📢 & mark your 🗓️!! The 1st edition of the Dev2A symposium series will be held on May 7, 2026. 👉Inspiring invited speakers & opportunities for selected talks and posters from submitted abstracts ! ➡️Registration link : lnkd.in/eUyfAbmG ➡️Abstract submission deadline : March 30th

How do tissues maintain their integrity? Let's discuss epithelial fractures! High tissue tension can cause cells to break their contacts, leading to rupture!

Spread the word 📢 & mark your calendars 🗓️!! The first edition of the Dev2A symposium series will be held on May 7, 2026. 👉Inspiring invited speakers & opportunities for selected talks and posters from submitted abstracts!! ➡️Registration: free but mandatory ➡️More information to come very soon

Offre d'emploi | Ingénieur·e d'études plateau technique iPSC – Sorbonne Université Concours externe | Affectation : Unité Dev2A – IBPS, Paris www.enseignementsup-recherche.gouv.fr/fr/recruteme... #Recrutement et #Ingénieurd’études#SorbonneUniversité #CellulesSouches #iPSC #Recherche #CNRS #Inserm

Check out our new publication @dev-journal.bsky.social! If you thought that cell divisions challenge tissue boundaries ... you got half of the story! Using in vivo quantitative microscopy and math. modelling we show that divisions fluidize tissues and facilitate boundary refinement. 🧪 #drosophila

Cell divisions both challenge and refine tissue boundaries in the Drosophila embryo

Highlighted Article: A combination of mathematical modelling, in vivo quantitative microscopy, and pharmacological and biophysical manipulations reveals that cell divisions not only challenge, but als...

journals.biologists.com