Update on Wellcome LEAP's $50 million program on autism and the microbiome

Exactly five months ago, I blogged about a program entitled Foundations of a Resilient Microbiome (FORM) that Wellcome LEAP was funding to ...

deevybee.blogspot.com

Capturing Spatially Organized Oscillatory Cliques as Signatures of Neuronal Assemblies

State-of-the-art neural recording technologies now enable dense sampling of neuronal activity, demonstrating meaningful spiking variability from moment to moment. Yet spiking activity is sparse by nature and allows only partial access to collective neuronal dynamics. Local field potentials (LFPs) provide complementary information by capturing coordinated activity from large neuronal populations, but methods to characterize the fine-scale spatio-temporal organization of LFPs are lacking. Starting from the notion that neural oscillations are brief and burst-like, we introduce a framework to detect and analyze SPatially Organized Oscillatory Cliques (SPOOCs), oscillatory events that are cohesive in space, time, and frequency. SPOOCs displayed diverse dynamics in space and frequency and were differentially modulated during stimulus processing. Linking SPOOCs to local spiking, we demonstrate that these events index rapid reconfigurations of neuronal assemblies. With SPOOChunter, we provide an open-source toolbox that enables systematic detection and analysis of transient, spatially organized population dynamics in high-density electrophysiological recordings. ### Competing Interest Statement The authors have declared no competing interest.

biorxiv.org

Timing found to be crucial for spinal cord repair in zebrafish

The healing of the spinal cord depends on carefully timed interactions between injured nerve cells and their surrounding environment, according to a new study published in Science Advances by research...

news.ki.se

Honorary SWEBAGS Webinar 2026 – SWEBAGS

Swedish Basal Ganglia Society

swebags.ebrains.se

A prefrontal cortex map based on single-neuron activity - Nature Neuroscience

The authors mapped spontaneous and choice activity across mouse prefrontal cortex. The activity maps aligned with intrinsic connectivity rather than anatomical subregions, suggesting that connectivity, not cytoarchitecture, organizes prefrontal function.

go.nature.com

New brain maps challenge traditional descriptions of the brain

For more than a century, maps of the brain have been based on how brain tissue looks under the microscope. These anatomical maps divide the brain into regions according to structural variations in the...

news.ki.se

Dual cholinergic mechanisms for sculpting striatal dopamine in vivo

Striatal dopamine (DA) and acetylcholine constitute a computationally powerful neuromodulatory dyad that orchestrates action selection, motivational vigor, and reward learning. Striatal cholinergic in...

biorxiv.org

Karolinska Institutet - ett medicinskt universitet

Karolinska Institutet är ett av Europas största medicinska universitet. I Sverige har KI det största utbudet av medicinska utbildningar och står för den enskilt största andelen av den medicinska akade...

ki.se

Brain circuit controlling compulsive behavior mapped

Researchers at Karolinska Institutet in Sweden have identified a brain circuit that can drive repetitive and compulsive behaviours in mice, even when natural rewards such as food or social contact are...

eurekalert.org

A striosomal accumbens pathway drives stereotyped behavior through an aversive Esr1+ hypothalamic-habenula circuit

A brain circuit shapes competition between repetitive and goal-directed behavior.

science.org

Scientists map how the brain develops – and how it resolves inflammation

Researchers at Karolinska Institutet and Yale University have created a multidimensional, molecular map of how the mouse brain develops after birth and how it reacts to inflammation. The study, which ...

news.ki.se

A new map of the brain to reveal our thinking | Knut and Alice Wallenberg Foundation

Research on the structure of the brain has made great strides in recent years. However, Marie Carlén believes a new approach is needed to move forward. She is developing entirely new concepts and meth...

kaw.wallenberg.org

A LEAP into the future, or off a cliff: Wellcome LEAP's new $50M program

A few days ago, I saw this post on LinkedIn: How does the gut microbiome shape early brain development? That’s what FORM, a new $50 million...

deevybee.blogspot.com

Apply - Interfolio {{$ctrl.$state.data.pageTitle}} - Apply - Interfolio

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Postdoktor i Diabetes och Parkinsons sjukdom

Vill du bidra till medicinsk forskning av toppkvalitet? Det strategiska forskningsprogrammet för diabetes (SRP Diabetes) vid Karolinska Institutet finansierar ett prestigefyllt stipendieprogram för

ki.varbi.com

Postdoctoral studies in next generation single cell lineage tracing of skin (scholarship)

Do you want to contribute to top quality medical research? A postdoctoral scholarship is available in the lab of Emma R Andersson at the Department of Cell and Molecular Biology, Karolinska Institutet

ki.varbi.com

My Lab Displayed A Message of Solidarity on Our Windows. Harvard Took It Down. | Opinion | The Harvard Crimson

If we continue down this path, we risk not only Harvard’s future as an institution of free inquiry and expression but also its integrity and trustworthiness.

thecrimson.com

KI to recruit junior researchers with a focus on excellence

On 25 June, Karolinska Institutet will be starting a major recruitment drive for 20 junior researchers with a focus on excellence and mobility. As one of Europe’s leading medical universities, KI offe...

news.ki.se

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