MetaMorpheus

@metamorpheus.bsky.social

The number of people using expensive, black-box software for proteomics is bewildering.

Are you curious about what steps you need to do to analyze very large multi-plex TMT datasets? This is a reanalysis of some Gygi Lab mouse liver data from 2015 and 2021 with 14.5 million MS2/MS3 scans in total. The big data needed a big discussion (kind of a long read). github.com/pwilmart/mou...

GitHub - pwilmart/mouse_liver_TMT_reanalysis: Reanalysis of large-scale TMT mouse liver studies (2015 and 2021) from the Gygi Lab.

Reanalysis of large-scale TMT mouse liver studies (2015 and 2021) from the Gygi Lab. - pwilmart/mouse_liver_TMT_reanalysis

github.com

metaproteomics?????? skeptical scientist here: but, let's say for argument sake you wanted to confidently identify an adventitious bacterial protein in human plasma, is there a "gold-standard" method? I assume the search result is merely the start point.

Referee questioned the adoption/accessibility of lc-ms to the research community. I think that's reasonable. So, realistically, how big of a problem do I need to solve to make my method worth the investment and effort? What is a thoughtful response to this critique?

"Science is an investment. We will put forward a new 500 million package for 2025-2027 to support the best and the brightest researchers and scientists from Europe and around the world." — President @vonderleyen.ec.europa.eu at the ‘Choose Europe for Science' event at La Sorbonne 🇫🇷

Some folks a whole lot smarter than me put together this white paper outlining what "open-source" means to us. I learned some new things. Come join us on the happy road. Open-source and FAIR Research Software for Proteomics | ChemRxiv - go.shr.lc/3B7rRtW

Open-source and FAIR Research Software for Proteomics

Scientific discovery relies on innovative software as much as experimental methods, especially in proteomics, where computational tools are essential for mass spectrometer setup, data analysis, and in...

go.shr.lc

Recently, We saw a discussion on the role of open-source in proteomics. Here, experienced developers & researchers maintaining OS tools for years shared this comment to guide newcomers in the field about OS and its role in the field. 💻 #Proteomics #OpenSource chemrxiv.org/engage/chemr...

Open-source and FAIR Research Software for Proteomics

Scientific discovery relies on innovative software as much as experimental methods, especially in proteomics, where computational tools are essential for mass spectrometer setup, data analysis, and in...

chemrxiv.org