Michael Giolai

@michaelgiolai.bsky.social

Our Editorial in @embojournal.org ‘EMBO Press co-evolves with molecular ecology and evolutionary biology’ is available online now doi.org/10.1038/s443...

The EMBO Journal@embojournal.org · 8mo ago

Read how @embopress.org is expanding its focus on molecular ecology and evolution as central underpinnings of functions/interactions/diversification of biological systems – by @yehumoran.bsky.social, @berndpulverer.bsky.social, and our new team of Editorial Advisors link.springer.com/article/10.1...

How do bacterial pangenomes evolve, what controls their dynamics, why do they exist? Fitting a mechanistic model to 450 species from allthebacteria.org suggesting fast vs slow gene exchange (i.e. amount of MGEs) is a major differentiating factor, correlated with phylogeny rather than lifestyle

Proportion of fast genes, as a trait mapped on the bacteria-wide phylogeny
Sam Horsfield@samuelhorsfield.bsky.social · 8mo ago

At long last, my final PhD chapter is out: we developed a novel evolutionary simulator of bacterial pangenomes, Pansim, fitting it to data from >600K genomes using a likelihood-free framework, PopPUNK-mod, to explore neutral and adaptive pangenome dynamics www.biorxiv.org/content/10.6...

TF-MINDI is out! A new method to learn cis-regulatory codes through rich embeddings of TF binding sites. TF-MINDI decomposes motif neighbourhoods, and works downstream of any sequence-to-function deep learning model. We deeply study the enhancer code in human neural development, check out the thread

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Seppe De Winter@seppedewinter.bsky.social · 9mo ago

We are thrilled to share our new pre-print: “System-wide extraction of cis-regulatory rules from sequence-to-function models in human neural development”. S2F-deeplearning models can accurately encode enhancers, yet decoding these models into human-interpretable rules remains a major challenge.

Join us in Norwich this July for the TSL Summer Conference in Plant-Microbe Interactions! ☀️🌱🧬 Discuss the latest approaches & discoveries in plant health with international keynote and local speakers. APPLY by 30 March '26 ⬇️ Click link for more info www.tsl.ac.uk/tsl-summer-c...

TSL Summer Conference in Plant-Microbe Interactions, 20th – 31st July…

Inviting Early Career Researchers to join international experts in discussing the latest approaches and discoveries in Plant-Microbe Interactions …

tsl.ac.uk