Imagine testing cancer therapies on patient-derived organoids before treatment begins. At the #mdcBerlin Bioengineering Symposium, researchers will discuss how bioengineering is bringing medicine closer to that future. 🗓️ July 6 | Berlin-Buch More details: 👉 www.mdc-berlin.de/news/press/j... 👈

How do lineage-biased HSC states relate to each other? check out: rdcu.be/fkASJ in @natcellbio.nature.com Collaboration with @simonhaas.bsky.social @bihatcharite.bsky.social & MDC; Thomas Höfer & Daniel Hübschmann @dkfz.bsky.social @nct-heidelberg.bsky.social

In our new study, we identify stem cell kinetics and cellular competition as key principles underlying hematopoietic stem cell diversity. Fun collab@milsommick.bsky.social Florian Grünschläger@estherrodriguezc.bsky.social, Tamar Nizharadze, T. Höfer, D. Hübschmann(1/6) www.nature.com/articles/s41...

In aggressive #lymphomas, inflammatory messengers reprogram the ​“conductors” of the immune system, causing lymph node structure to collapse. A team led by @simonhaas.bsky.social describes this process in ​“Nature Cancer” using #singlecell and spatial analyses: www.mdc-berlin.de/news/press/c...

📢 ISCO registration is now open for registration! Everyone interested in the latest developments in single-cell approaches and their applications will enjoy our exciting lineup of speakers. 🌞 Join us in sunny Barcelona this May!

Lars Velten@larsplus.bsky.social · 8mo ago

ISCO (Innovations in Single-Cell OMICS) will be back in beautiful Barcelona! 🗓️ 28th/29th of May 2026 📍Barcelona Biomedical Research Park @prbb.org (beachfront!) Keynotes: @bartdeplancke.bsky.social and @bocklab.bsky.social Submit your abstract and present your research! www.isco-conference.eu

Interact-omics is a high-throughput cytometry-based framework for cellular interaction mapping. @simonhaas.bsky.social www.nature.com/articles/s41...

Did you ever wonder what insights hide in the multiplets that are usually discarded in flow cytometry? 🫧 Find out in the first publication of my PhD, now out in Nature Methods! www.nature.com/articles/s41... (1/4)

Ultra-high-scale cytometry-based cellular interaction mapping - Nature Methods

Interact-omics, a high-throughput cytometry-based framework, resolves the cellular interaction landscape.

nature.com

Nature Methods@natmethods.nature.com · 12mo ago

For a quick summary, read the Research Briefing here: www.nature.com/articles/s41...

Great opportunity! Up to 4 Group Leader positions at the NOVA Institute for Medical Systems Biology (NIMSB) in Computational & Experimental Medical Systems Biology 📍 Lisbon ⏳ Apply by Oct 8 🔗 nimsb.unl.pt/wp-content/u... #Job #SciencePositions #JobOffer #GroupLeaders #Innovation #systemsbiology

Excited to share our latest paper @natmethods.nature.com We present a high-throughput framework to map cellular interactions at ultra-high scale – broadly applicable from whole-organism immune response mapping to personalized therapy response prediction (1/4). www.nature.com/articles/s41...

"Innovations in Single Cell Omics" Berlin 5.12-13. Organizers: @stefaniegrosswendt.bsky.social @simonhaas.bsky.social @leifludwig.bsky.social Ashley Sanders @larsplus.bsky.social @elimereu.bsky.social @alejofraticelli.bsky.social

A group of Berlin researchers and international colleagues have found differences in heart inflammation caused by COVID-19, vaccination, and heart disease. The results pave the way for more personalized therapies, they report in "Nature Cardiovascular Research.” ➡️ www.mdc-berlin.de/news/press/n... ⬅️

Zooming in on how multiple myeloma starts to spread in the body: Single-cell analyses and spatial omics allowed international researchers, including the @simonhaas.bsky.social lab at the #mdcBerlin, to see a co-evolution of blood cancer and immune cells. #ScienceImmunology More details 👇

When blood cancer starts to spread

When blood cancer cells break through the bone and multiply, tumor cells become dangerously diverse and the immune response in the region changes, researchers from Berlin and Heidelberg report in “Sci...

mdc-berlin.de

Super intriguing findings

Simon Haas@simonhaas.bsky.social · last yr.

Ever wondered what drives hematopoietic stem cell (HSC) heterogeneity? In this preprint, our collaborative team uncovered that differences in HSC reconstitution kinetics play a key role in shaping stem cell heterogeneity and lineage biases. doi.org/10.1101/2025... (1/2)

Great opportunity to learn more about the most recent possiblities on single-cell lineage tracing!!! Attend a workshop led by one of the key experts in the field @leifludwig.bsky.social Join us at the ISCO2025 conference!

Leif S. Ludwig@leifludwig.bsky.social · 2y ago

Interested in 'Mitochondrial single cell-multi-omics for lineage tracing and genetics'? Apply for our free workshop in Berlin following our #ISCO2025 conference! www.isco-conference.eu www.mdc-berlin.de/news/events/...

So pleased to have the paper out, available here: www.nature.com/articles/s41586-024-08423-8 For me this was discovery science as I had always hoped it would be. A lot of fun, and some proper detective work with plenty of twists & turns on the way. Brief thread below

Join us to connect with the vibrant #singlecell community. 📢Register for the #ISCO'25 Conference "Innovations in #SingleCell #OMICS" in Berlin! 🗓️ 12-13 May 2025 🎤 fantastic Keynote and Confirmed Speakers 🫵🏿 Many slots for talks: submit your abstract 🔗http://isco-conference.eu

Curious about the latest innovations in single-cell omics? 🔬✨ Join us at the next ISCO conference for groundbreaking insights, exciting speakers, and plenty of fun! Don't miss it! 🗓️ 12-13 May 2025 🔗http://isco-conference.eu

Leif S. Ludwig@leifludwig.bsky.social · 2y ago

Join us to connect with the vibrant #singlecell community. 📢Register for the #ISCO'25 Conference "Innovations in #SingleCell #OMICS" in Berlin! 🗓️ 12-13 May 2025 🎤 Fantastic Keynote and Invited Speakers 🫵🏿 Many slots for talks: submit your abstract 🔗http://isco-conference.eu Please spread the word!

Join us to connect with the vibrant #singlecell community. 📢Register for the #ISCO'25 Conference "Innovations in #SingleCell #OMICS" in Berlin! 🗓️ 12-13 May 2025 🎤 Fantastic Keynote and Invited Speakers 🫵🏿 Many slots for talks: submit your abstract 🔗http://isco-conference.eu Please spread the word!

Interested in 'Mitochondrial single cell-multi-omics for lineage tracing and genetics'? Apply for our free workshop in Berlin following our #ISCO2025 conference! www.isco-conference.eu www.mdc-berlin.de/news/events/...

Mitochondrial single cell-multi-omics for lineage tracing and genetics

mdc-berlin.de

How does multiple myeloma progress? In our latest Science Immunology cover story, we reveal how myeloma cells breaking through bone trigger dangerous diversity. This arises from bidirectional interactions with the immune system, fueling disease evolution. scim.ag/4hMrLHs 1/2

Be sure to check out the fantastic tweetorial by @milsommick.bsky.social on our collaborative work uncovering the sources of hematopoeitic stem cell heterogeneity 🔥

Mick Milsom@milsommick.bsky.social · last yr.

New pre-print from Thomas Höfer, Daniel Hübschmann, @haas_lab and myself, with first authors @Esther_RCorrea @FloGrunschlager and Tamar Nizharadze doi.org/10.1101/2025... @DKFZ @NCT_HD @ChariteBerlin @hi_stem_lab BIH & MDC

Ever wondered what drives hematopoietic stem cell (HSC) heterogeneity? In this preprint, our collaborative team uncovered that differences in HSC reconstitution kinetics play a key role in shaping stem cell heterogeneity and lineage biases. doi.org/10.1101/2025... (1/2)

A kinetics-based model of hematopoiesis reveals extrinsic regulation of skewed lineage output from stem cells

Residing at the top of the hematopoietic hierarchy, long-term hematopoietic stem cells (HSCs) are capable of self-renewal and sustained blood cell regeneration. Over the past decades, single-cell and ...

doi.org