Miriam Lisci
@miriamlisci.bsky.social
Novartis Young Investigator & EMBO postdoc fellow @jourdainlab.bsky.social at @dib-unil.bsky.social diving into cancer & T cell metabolism | Previously @griffithslab.bsky.social @thecimr.bsky.social | Lausanne City Coordinator @pintofscience.ch
I couldn’t be prouder to announce that @tanmanamitra.bsky.social’s thesis work identifying how metabolic demand drives terminal T cell exhaustion is out today in @cp-immunity.bsky.social: www.sciencedirect.com/science/arti...
MEK-dependent bioenergetic demand drives terminal CD8+ T cell exhaustion
Loss of mitochondrial function promotes CD8+ T cell dysfunction during persistent antigen encounter. Here, we examined the pathways whereby chronic an…
sciencedirect.com
Congratulations @miriamlisci.bsky.social for her @fbm-unil.bsky.social Young Researcher in Basic Science award!
Miriam Lisci@miriamlisci.bsky.social · 2mo agoIt was an honour to be selected for the Young Researcher in Basic Sciences Award by the Faculty of Biology and Medicine @unil.bsky.social! A sincere thank you to my department @dib-unil.bsky.social for the support, and especially to my wonderful colleagues at the @jourdainlab.bsky.social
It was an honour to be selected for the Young Researcher in Basic Sciences Award by the Faculty of Biology and Medicine @unil.bsky.social! A sincere thank you to my department @dib-unil.bsky.social for the support, and especially to my wonderful colleagues at the @jourdainlab.bsky.social
@fbm-unil.bsky.social · 2mo ago@nikogeldner.bsky.social @miriamlisci.bsky.social @adelpanta.bsky.social @dib-unil.bsky.social @dee-unil.bsky.social @dmf-unil.bsky.social
Certain cancers are described as “glutamine addicted”. But how does this addiction arise, and how do tumors manage to bypass it? I am excited to share that the results of my postdoctoral work are finally published in @cp-molcell.bsky.social! tinyurl.com/hs7ep5sa 👇 Check the thread for more!
Functional nutrient-genetic profiling reveals biotin and FBXW7 are essential to bypass glutamine addiction
Metabolic flexibility is key to survival and growth in all living organisms. In mammals, the pathways supporting cell proliferation in nutrient-limiti…
sciencedirect.com
Check ⬇️ the latest paper from the @jourdainlab.bsky.social ab on glutamine addiction! Congratulation to @miriamlisci.bsky.social and all co-authors for the amazing work🥳
Alexis A. Jourdain@jourdainlab.bsky.social · 6mo agoOur story on #FBXW7 and #biotin in #glutamine_addiction is now peer-reviewed and published in Molecular Cell! Heroic work led by the very first postdoc of the lab @miriamlisci.bsky.social. Have a look! www.cell.com/molecular-ce...
New article in Molecular Cell by @miriamlisci.bsky.social and @jourdainlab.bsky.social!
Alexis A. Jourdain@jourdainlab.bsky.social · 6mo agoOur story on #FBXW7 and #biotin in #glutamine_addiction is now peer-reviewed and published in Molecular Cell! Heroic work led by the very first postdoc of the lab @miriamlisci.bsky.social. Have a look! www.cell.com/molecular-ce...
Our story on #FBXW7 and #biotin in #glutamine_addiction is now peer-reviewed and published in Molecular Cell! Heroic work led by the very first postdoc of the lab @miriamlisci.bsky.social. Have a look! www.cell.com/molecular-ce...
Functional nutrient-genetic profiling reveals biotin and FBXW7 are essential to bypass glutamine addiction
Lisci et al. present a unified model revealing how cells escape glutamine addiction, a metabolic vulnerability of several cancers. Combining systematic genetic and nutrient screens, they show that bio...
cell.com
We are hiring a postdoc! 🧪 ▶️ Project: nucleotide metabolism (genomics & biochemistry) ▶️ Start date: spring 2026 (flexible) ▶️ More info and application: tinyurl.com/3kjrbb2x Please share 🌏 @fbm-unil.bsky.social @dib-unil.bsky.social @unil.bsky.social @snsf.ch
Career Opportunities: Postdoctoral position in cellular metabolism (22584)
tinyurl.com
Very excited to share the published version of our #uridine #CRISPR screen in naturemetabolism.bsky.social! 🎉 Led by Abigail Strefeler with @pagliarini-lab.bsky.social @zakbaker.bsky.social and team! #NUDT5 #DMQ @dib-unil.bsky.social @fbm-unil.bsky.social 🔗 www.nature.com/articles/s42... 🧵1/17
Uridine-sensitized screening identifies demethoxy-coenzyme Q and NUDT5 as regulators of nucleotide synthesis - Nature Metabolism
A uridine-sensitized CRISPR-Cas9 screening identifies demethoxy-CoQ as an alternative electron acceptor in the absence of CoQ, and NUDT5 as a regulator of de novo pyrimidine synthesis via its interact...
nature.com
How can mitophagy be an effective quality control mechanism if mtDNA mutations reach high enough levels to cause disease? This question led us into a dark path, full of concepts of evolutionary genetics, germline stem cell biology and mito-nuclear compatibility. www.science.org/doi/10.1126/...
Ubiquitin-mediated mitophagy regulates the inheritance of mitochondrial DNA mutations
Mitochondrial synthesis of adenosine triphosphate is essential for eukaryotic life but is dependent on the cooperation of two genomes: nuclear and mitochondrial DNA (mtDNA). mtDNA mutates ~15 times as...
science.org
Super excited to share our new preprint from @cssheehan.bsky.social on how the tumor microenvironment causes drug resistance in pancreatic cancer: www.biorxiv.org/content/10.1...
Tumor nutrient stress gives rise to a drug tolerant cell state in pancreatic cancer
Cytotoxic chemotherapy remains the standard-of-care treatment for patients with pancreatic ductal adenocarcinoma (PDAC). However, chemotherapy only has modest effects at improving patient survival due...
biorxiv.org
It was great to meet so many EMBO fellows from all around the world! Thank you EMBO for inviting us and for giving us the opportunity to discuss our projects and network with such a diverse group of scientist.
EMBO@embo.org · last yr.119 EMBO Fellows from 30+ countries attended the EMBO Fellows’ Meeting in Heidelberg, DE from 27 June–1 July. #Research was shared and connections formed – an incredible opportunity for #networking and #collaboration. Thank you to all who joined and were part of this vibrant community! 🧪
Pint of Science was again a great success in Lausanne, with >500 people attending our events! Kudos to co-coordinators @miriamlisci.bsky.social and @juliensluneau.bsky.social, and to the fantastic team of 19 volunteers at the bars 🥳! #PINT25 #scicomm
Get ready for a night full of surprises in Lausanne! With talks in both EN and FR, and topics ranging from AI & privacy, viruses and green revolution, your thirst for science in a fun and relaxed setting will be satisfied starting tonight! Time: 7-9pm Locations: Cylure, Sidewalk, On va où #Pint25
Pint of Science Switzerland 🇨🇭@pintofscience.ch · last yr.✨#pintCH is starting today!✨3 nights of fun science talks for everyone! 🗓️ 19–21 May 2025 📍12 cities 🎤58 events 🎟️free entry 🌐 pintofscience.ch #Baden #Basel #Bern #Brig #Fribourg #Geneva #Lausanne #Lugano #Neuchatel #Sion #StGallen #Zurich #Pint25 @pintsworld.bsky.social
The latest pre-print from the lab is out! 🥳 In this work led by our PhD student Abigail, the @jourdainlab.bsky.social adds a piece to the puzzle of mechanisms balancing #pyrimidines and #purine synthesis, and hints at #NUDT5 expression as a potential predictor of chemotherapy resistance.
Alexis A. Jourdain@jourdainlab.bsky.social · last yr.🚨 New preprint available! Third and final in the #CRISPR screen series!🚨 👉🏻 Uridine-sensitized screening identifies genes and metabolic regulators of #nucleotide synthesis www.biorxiv.org/content/10.1... By A. Strefeler in collaboration with Dave Pagliarini and team. @DIB_UNIL @FBM_UNIL 🧵 1/9
Check out our new pre-print from the @jourdainlab.bsky.social, featuring work led by @marcellharhai.bsky.social! How do growth and death screens compare when uncovering novel regulators of mitochondrial function? Is Ménière disease a mitochondrial disorder? Find out below 👇
Alexis A. Jourdain@jourdainlab.bsky.social · 2y agoNew preprint from the lab! 🚨 🧫 New galactose #CRISPR screening strategy 🎯 481 genes required for #OXPHOS ⚙️ #FAM136A in IMS proteostasis 👂Mito defects in #Menieres disease by @marcellharhai.bsky.social @fbm-unil.bsky.social A short thread 1/5 www.biorxiv.org/content/10.1...
Celebrating the New Year in style! Best wishes from the Jourdain Lab 🥌🫕🇨🇭
Stoked to share TWO preprints on mitochondrial pearling! 🎉 We uncover how spontaneous #mitochondria pearling drives #mtDNA nucleoid distribution (doi.org/10.1101/2024...), and @gavsturm.bsky.social et al. dissect the biophysics behind it (doi.org/10.1101/2024...). Details below! 🔬🧵🧪
Could you live without glutamine? I am delighted to share our preprint @jourdainlab.bsky.social: we employed parallel nutrient and genetic screening to tackle the mechanisms promoting survival in glutamine-limiting conditions. Check it out 👇 more details below! www.biorxiv.org/content/10.1...
Stressed mitochondrial RNA granules from our recent work on the cover of PNAS! A photo by E. Recazens illustrating our new story led by M. Foged on the cytosolic control of mitochondrial RNA processing and innate immunity by #N6AMT1. #mitochondria #dsRNA
