See you at home next year!!! Please covid and allies, don’t ruin this again. #SMBE26 #SMBE

Want to learn about adapting computational pipeline from human cancer to wildlife and soon captive #penguins WGS high coverage data? Visit poster #115 at 6pm Main Hall today and chat with Isabel! #SMBE2026

Leave it to the heart to BEAT cancer: How the beating of the heart suppresses tumor proliferation through mechanical load. @science.org www.science.org/doi/10.1126/...

Mechanical load inhibits cancer growth in mouse and human hearts

The heart rarely develops cancer, and, at the same time, it lacks regenerative capacity, as cardiomyocytes stop proliferating after birth. This suggests that mechanisms limiting cardiac regeneration m...

science.org

the cancer news seems great but it is very sad for buses that this is the analogy someone would reach for. real monkey's paw outcome for "raise awareness of bus reliability and bus bunching"

koenfucius@koenfucius.bsky.social · 2mo ago

Cancer research has become like buses—you wait for a breakthrough for ages, then suddenly a whole bunch comes along over a few weeks. @salonium rounds up the harvest at this year’s annual Oncology jamboree. It’s hard not to feel insanely optimistic. buff.ly/WMSulkY

One of my dream projects, ever since joining here in Basel, out now in @nature.com : single-cells 🤝 eco-morphological proxies rdcu.be/fiyso How cells and tissues adapt to dietary niches... Thanks and congrats to Antoine, Walter, and all the other co-authors for this great collaboration!! 🙏🥳

Adaptive cellular evolution in the intestine of hyperdiverse cichlid fishes

Nature - Single-cell transcriptomics combined with morphological and ecological data show that the rapid evolutionary radiation of cichlid fishes in Lake Tanganyika was accompanied by dietary...

rdcu.be

Trump’s rollback of toxic gas rules limits EPA’s authority to protect public health, analysis says www.theguardian.com/us-news/2026... On the war against pollution, Donald Trump and Republicans are on the side of pollution, and making your family sick.

Trump’s rollback of toxic gas rules limits EPA’s authority to protect public health, analysis says

Ethylene oxide (EtO) is about 60 times more carcinogenic than believed in 2006, research finds

theguardian.com

New preprint live! www.medrxiv.org/content/10.1... Geography, Ancestry, Age and Sex Shape Somatic Autosomal Mosaic Chromosomal Alterations in Blood

Geography, Ancestry, Age and Sex Shape Somatic Autosomal Mosaic Chromosomal Alterations in Blood

Clonal hematopoiesis, through the age-associated accumulation of somatic mutations in blood, is strongly associated with hematological malignancies and other chronic diseases. These mutations have lar...

medrxiv.org

My first time awarding a PhD to a candidate, what a precious honour. Keep up the good work, students!

Now: @jsdron.bsky.social (JD): Age- and BMI-dependent genetic architecture of blood lipids in 2.5 million individuals from globally diverse populations #ASHG25 🧪🧬🖥️

We're excited to be recruiting an NIH funded postdoc to work in the Coop lab at UC Davis. We're specifically interested in candidates who are want to work at the intersection of human genetics, GWAS, and population genetics modeling. Please RT

Come join us in beautiful vibrant Montréal! Job opening for a CRC position in Applied Synthetic Biology at Concordia University. www.concordia.ca/jobs/artsci/... #ASHG25 #ASHG2025

Canada Research Chair Tier II in Applied Synthetic Biology | Faculty of Arts and Science - Concordia University

The Department of Biology in the Faculty of Arts and Science at Concordia University invites applications for a tenure track faculty position and Tier II Canada Research Chair (CRC) in Applied Synthet...

concordia.ca

I will be missing #ASHG25 but please keep posting about it! I can't wait to read all the updates of great science and people! #FOMO

Ever wondered how robust cellular identity is to external perturbations? Here we disrupt cellular environmnent in vivo and in vitro, and find cell population specific sensitivities. Environment sculpts development yes, but not all cells are made of the same wood. www.science.org/doi/10.1126/...

Cell-extrinsic controls over neocortical neuron fate and diversity

Cell-extrinsic cues are key for neocortical cell identity and diversity.

science.org

Interesting, well-written article from the Guardian. www.theguardian.com/world/2025/a...

Arctic glaciers face ‘terminal’ decline as microbes accelerate ice melt

Scientists in Svalbard in race to study polar microbes as global heating threatens fragile glacial ecosystems

theguardian.com

Music to my ears. This is brilliant. Either 90% of us can claim to be better musicians than Beethoven or… maybe just maybe polygenic scores aren’t perfect?

Simon Fisher@profsimonfisher.bsky.social · 12mo ago

If someone you know buys into claims about "genetic optimization" of embryos using polygenic scores of cognition, just send them our 2024 paper on Beethoven & musicality. We wrote it to help communicate limits of individual-level genetic predictions & complexity of links between DNA & behaviour. 🧪👇

Nature research paper: Multigenerational cell tracking of DNA replication and heritable DNA damage https://go.nature.com/4jxWDMJ

Multigenerational cell tracking of DNA replication and heritable DNA damage - Nature

A multigenerational single-cell tracking approach provides a framework to dissect phenotypic plasticity at the single-cell level, offering insights into cellular processes that may resemble early events during cancer development.

go.nature.com

I never thought about wool as a possible route of infection. www.nature.com/articles/d41...

This ancient pathogen became deadlier when humans started wearing wool

Ancient genomes reveal that a bacterial fever jumped from human-borne ticks to lice around the time wool textiles became common.

nature.com

On parle souvent de l'importance de la fluidité automobile au centre-ville. Pourtant, seuls 21% des déplacements vers le centre-ville se font en voiture. On devrait plutôt parler de comment améliorer le transport collectif (55%) et actif (23%) si on veut attirer les clients et travailleurs au c-v.

Come join us at @mcgill.ca as an assistant professor in virus-host interactions! Please share widely. mcgill.wd3.myworkdayjobs.com/en-US/McGill...

Assistant Professor (Research), Department of Microbiology & Immunology, (C2-240724)

Please refer to the How to Apply for a Job (for External Candidates) job aid for instructions on how to apply. If you are an active McGill employee (ie: currently in an active contract or position at ...

mcgill.wd3.myworkdayjobs.com

Getting mistaken for a student at my final exam ✅ Should I have pretended and write my own exam? 😁

This morning, teaching an undergraduate class in population genetics gave me hope and confidence for the future, those students are rocking it!!

To the women in science. To the allies in science. To the ones who lift each other up. I spend my life in science, constantly trying to figure out where I fit in. At times, it feels like pushing against an invisible force-one that questions, doubts, resists. But through it all, I am never alone. 🧵

Sex determination in cephalopods: hemizygosity (ZO) in females and ZZ males, and predates the radiation of the group 480 milions years ago. Fascinating work by Andrew Kern lab!

Cephalopod sex determination and its ancient evolutionary origin

Coffing et al. assemble a chromosome-level octopus genome assembly, revealing that the female octopus has just one sex chromosome (ZO karyotype), and males have two (ZZ karyotype). They conduct genomi...

cell.com

Our blood tests are interpreted by average reference values. That's missing a lot of rich information! Each person has their own tightly regulated setpoints. One healthy person's complete blood count setpoint can be differentiated from 98% of other healthy adults. www.nature.com/articles/s41...

When even your office phone knows you only as per your initials. #LongNameProblems

Hybridization lead to a reduced rate of LOH and influence adaptation - Very cool work by the Landry lab!

Christian Landry@christianlandry.bsky.social · 2y ago

For her PhD work, Carla Bautista in our group discovered that yeast hybrids adapted slower to stressful conditions, and she figured out why. See what she found here. #evolution www.nature.com/articles/s41...

Scientists, academics, researchers: We’re excited to share that @altmetric.com is now tracking mentions of your research on Bluesky! 🧪

Altmetric@altmetric.com · 2y ago

There are already many articles for which there is more attention on Bluesky than on other comparable micro-blogging sites, meaning the academic community and the general public have clearly adopted Bluesky as one of its core places to disseminate and discuss new research. A Place of Joy.

Does my mutation have the same impact as yours? Population genetics 🤠 🥸 🤓 🤡 meets single cell CRISPRi ⚡ ! www.biorxiv.org/content/10.1... Led by Claudia Feng, Oliver Stegle, Britta Velten, @sangerinstitute.bsky.social .

#RStats that DeLorean though!

LoF and duplications correlated effects on phenotypes lead to an interesting paradox:

Jonathan Pritchard@jkpritch.bsky.social · 2y ago

In a new preprint led by @TheNikhilMilind, we explored a fascinating paradox: For many traits the number of duplications or loss-of-function (LoF) mutations is correlated with phenotype. Curiously, for most traits, the AVERAGE direction of LoFs and Dups is the SAME. Why?