The anatomy and molecular inventory of Staphylococcus aureus abscesses

The anatomy and molecular inventory of Staphylococcus aureus abscesses

Staphylococcus aureus is an opportunistic pathogen that infects practically every body site despite differences in nutritional environment, immune milieu, and mode of inoculation. S. aureus abscesses are pathophysiological structures wherein host-derived extracellular matrix and immune cells form layers surrounding a S. aureus colony. Staphylococcal abscess communities seed staphylococcal abscesses, which are associated with worse S. aureus infection outcomes. Abscesses are also an example of the host–S. aureus interface, wherein host and pathogen adaptations define the spatial and temporal features of pathogenesis as well as the outcomes of infection. This review discusses recent discoveries in abscess formation made across organ systems and highlights findings involving host and pathogen determinants of abscess formation that improve our understanding of S. aureus pathogenesis.

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Lovely work driven by Lizzie Ledger in the group: a new but druggable mechanism by which Staphs produce biofilm using components of human serum. First polysaccharides, then protein, then eDNA, now lipids too! bsky.app/profile/bior...

bioRxiv Microbiology@biorxiv-microbiol.bsky.social · 6mo ago

Human serum triglycerides promote Staphylococcus aureus biofilm formation and antibiotic tolerance https://www.biorxiv.org/content/10.64898/2026.03.05.709992v1

The incomparable Zong roped @wvschaik.bsky.social and I into a comment for Nature Comms on microbiome mediated colonisation resistance to combat Klebsiella www.nature.com/articles/s41...

Microbiome-mediated colonization resistance to and countermeasures of Klebsiella pneumoniae - Nature Communications

Yang et al. summarize that Klebsiella pneumoniae affects infectious and non-infectious disease via gut colonization; commensals provide colonization resistance, but K. pneumoniae adapts via multiple m...

nature.com

Interesting new paper on Enterococcus lactis (the species formerly known as Clade B E. faecium) 'The Mannose Phosphotransferase System in Enterococcus lactis Is Essential for Gastrointestinal Colonization' onlinelibrary.wiley.com/doi/abs/10.1...

The Mannose Phosphotransferase System in Enterococcus lactis Is Essential for Gastrointestinal Colonization

Enterococcus lactis, a recently established species that was previously classified as Enterococcus faecium clade B. Given its recent taxonomic classification, studies on this bacterium are scarce, an...

onlinelibrary.wiley.com

Happy to see our collaboration with @larocklab.com in print! Great work from @larocklab.com group to show that Staphopain A cysteine protease (ScpA) of S. aureus initiates pyroptosis in keratinocytes through proteolytic processing of Gasdermin A. www.nature.com/articles/s41...

Staphylococcus aureus induces Gasdermin A-dependent keratinocyte pyroptosis - Nature Communications

The cell death effector Gasdermin A is only known to be activated by Streptococcus pyogenes. This work discovers a mechanism for its activation by Staphylococcus aureus, and shows a conserved role in ...

nature.com

New article about how to manage Staphylococcus aureus bacteremia. Led by Hadar Mudrik-Zohar. Includes @seanong.bsky.social @drtoddlee.bsky.social #IDSky #SNAP_trial www.sciencedirect.com/science/arti...

Navigating the Challenges in Staphylococcus aureus Bloodstream Infection: A Practical Guide to Management

sciencedirect.com

😳 Reversible phenotypic resistance to phage infection via capsule downregulation in Klebsiella pneumoniae #phage #phageky www.cell.com/iscience/ful...

Reversible phenotypic resistance to phage infection via capsule downregulation in Klebsiella pneumoniae

Molecular biology; Microbiology; Cell biology

cell.com

Really excited to be part of this project! #KlebClub

AMR-kleb/staph@s-rowe-conlon.bsky.social · 9mo ago

Thrilled to share our latest paper on antibiotic treatment failure of Klebsiella pneumoniae liver abscesses www.pnas.org/doi/full/10.... @drwalkermsbanta.bsky.social

Really happy to see the final version of this published in @isme-microbes.bsky.social. We show that production of and competition for biotin shapes S. aureus fitness in the context of nasal commensals doi.org/10.1093/isme... Work lead by the amazing Kevser Bilici!

Competitive fitness of Staphylococcus aureus against nasal commensals depends on biotin biosynthesis and acquisition

Abstract. The human nasal microbiome can serve as a reservoir for pathogens. In particular, the opportunistic pathogen Staphylococcus aureus can be a membe

doi.org

S. aureus has an intrinsic rifampicin resistance mechanism! See the recent study by M. Otto's lab with important clinical implications: Export by a quorum sensing–controlled drug exporter underlies rifampicin’s strong activity against staphylococcal biofilms | www.science.org/doi/10.1126/...

Export by a quorum sensing–controlled drug exporter underlies rifampicin’s strong activity against staphylococcal biofilms

Rifampicin is more effective against biofilm infections because it targets biofilm-forming mutants that are highly resistant to other antibiotics.

science.org

Growing Staphylococcus aureus in Synthetic Cystic Fibrosis Medium Promotes Colonization in a Murine Pneumonia Model https://www.biorxiv.org/content/10.1101/2025.10.14.682363v1

Delighted to share our latest paper - A host-directed adjuvant sensitizes intracellular bacterial persisters to antibiotics. Excellently led by Dr. Kuan-Yi Lu. We think it's a great proof-of-concept that altering immune cell behavior can make antibiotics work better www.nature.com/articles/s41...

A host-directed adjuvant sensitizes intracellular bacterial persisters to antibiotics - Nature Microbiology

The authors developed a screen to find compounds that modulate intracellular Staphylococcus aureus metabolism and discovered KL1, which sensitizes persisters to antibiotics by reversing host-induced tolerance.

nature.com

Thinking about a postdoc in microbiome science? Our lab at the MPI for Biology (Tübingen) builds on the culture I established at Cornell: collaborative, creative, and internationally diverse. Postdocs lead their own projects with secure funding. Join us! #PostdocJobs #HostMicrobe #AcademicJobs

#NewResearch Nasal colonisation by S. aureus is linked with depression in a human cohort and shown in a mouse model to cause decreased serotonin and dopamine in the brain #MicroSky #Depression www.nature.com/articles/s41...

Nasal Staphylococcus aureus carriage promotes depressive behaviour in mice via sex hormone degradation - Nature Microbiology

Nasal colonization by Staphylococcus aureus is linked with depression in a human cohort and shown in a mouse model to cause decreased serotonin and dopamine in the brain.

nature.com

Congrats, @ronimiah.bsky.social with your newly published work.

Roni Miah@ronimiah.bsky.social · last yr.

Happy to share our recently accepted research article in iScience(Cell Press). Indeed it was an excellent team work. Special thanks to project PI @christianslentz.bsky.social, co-PI @monaj66.bsky.social and excellent CRISPRi collaborator @mkjos.bsky.social. Wish to learn many more with this tool!

New in Nat Comm Pathogenic E. coli use protein FimH to grab onto the gut lining New microgels mimic the mannose binding sites—acting as “decoys” to drag bacteria away and protect the intestine in IBD Adherent-invasive E. coli (AIEC), enriched in Crohn’s disease, are a key target for this strategy

Fishing out AIEC with FimH capturing microgels for inflammatory bowel disease treatment - Nature Communications

Inflammatory bowel disease (IBD) is a chronic immune-mediated condition. This study presents a drug-free treatment strategy for IBD that targets bacterial adhesion, utilizing mannan oligosaccharide-lo...

nature.com

Good opportunity here to work with a super talented new PI.

Joe Wanford@jwanford.bsky.social · last yr.

🚨 Job alert 🚨 I’m recruiting two postdoctoral research associates to join my lab at KCL to study how #Klebsiella pneumoniae regulates virulence factor expression during infection! #klebclub Mol Micro: tinyurl.com/mtrwtx5e Infection: tinyurl.com/2s3u8ca2 Deadline: 21st September.

We’re hiring a Postdoc in Gut Microbiome Metabolomics! Help us decode microbial metabolism and its impact on human health @leibniz-hki.de , Jena 🇩🇪 🔗 jobs.hki-jena.de/jobs/Postdoc...

Job opportunity Postdoctoral Researcher (m/f/div) in Gut Microbiome Metabolomics at Leibniz HKI Jobportal

Wissenschaft/Forschung in Jena

jobs.hki-jena.de

Pleased to share our latest study @natcomms.nature.com! We show that the host metabolites fumarate and itaconate impose selective pressure on Staphylococcus aureus, driving its adaptation via the enzyme FumC. Grateful to all who contributed to this work! www.nature.com/articles/s41...

Regulation of airway fumarate by host and pathogen promotes Staphylococcus aureus pneumonia - Nature Communications

This study reveals how the pathogen Staphylococcus aureus adapts to the lung microenvironment, rich in host metabolites fumarate and itaconate, by using a key enzyme, FumC, to support its metabolic fi...

nature.com

"Among all bacterial species, S. aureus ranks second only to E. coli in the number of scientific publications." It was a pleasure to contribute to this review, with @pinholab.bsky.social and Friedrich Götz journals.asm.org/doi/10.1128/...

Staphylococcus aureus: a model for bacterial cell biology and pathogenesis | Journal of Bacteriology

When talking about Staphylococcus aureus, one usually has in mind the diseases that can be caused by this bacterium, ranging from mild skin and soft tissue infections, such as abscesses and furuncles,...

journals.asm.org

Staphylococcus aureus exhibits spatiotemporal heterogeneity in Sae activity during kidney abscess development https://www.biorxiv.org/content/10.1101/2025.07.08.663646v1

I am delighted that our manuscript 'Staphylococcus haemolyticus is a reservoir of antibiotic resistance genes in the preterm infant gut' is now published. www.tandfonline.com/doi/full/10.... Big thank you to all co-authors, particularly @lisalamberte.bsky.social and @halllab.bsky.social

Staphylococcus haemolyticus is a reservoir of antibiotic resistance genes in the preterm infant gut

Staphylococcus haemolyticus is an important cause of sepsis in preterm infants, with gut colonization being recognized as a risk factor for infection. To better understand the diversity of S. haemo...

tandfonline.com

www.biorxiv.org/content/10.1.... New pre-print of the lab in which we dive deep into Klebsiella-macrophage interface. High structural resolution of the lipid A produced by Klebsiella within the Klebsiella containing vacuole governed bt TLR4 signaling. Superb job led PhD student Toby Bartholomew

(1/6) 🌟 Excited to share our new paper! Advancing microbiome safety assessments: opportunities, challenges & recommendations 🧫🦠 This work came out of an academic–industry workshop hosted by @microbiologysociety.org in early 2024. 🔗 www.microbiologyresearch.org/content/jour...

Assessing the safety of microbiome perturbations

Everyday actions such as eating, tooth brushing or applying cosmetics inherently modulate our microbiome. Advances in sequencing technologies now facilitate detailed microbial profiling, driving inten...

microbiologyresearch.org

Great news for postdocs! 🎉 Looking for your next big career move in microbiology? Explore a range of exciting postdoctoral positions now available on the #FEMSOpportunitiesBoard. Find your perfect fit and advance your research journey. Apply today👇 buff.ly/CSwBDPl #CareerOpportunity

Powerful new tool against Malaria (𝘕𝘢𝘵𝘶𝘳𝘦) Instead of killing mosquitoes, bed nets coated with ELQs (endochin-like quinolones) KILL THE MALARIA PARASITES INSIDE THE INSECTS. Infected mosquitoes land, absorb the drug through their legs, and are rendered parasite-free www.nature.com/articles/s41...

🚨 Out now! Rainbow trout with depleted IgM reveals interesting insights into its role in maintaining the gut microbiota 🐟 #MicroSky #IgM #MicrobiomeSky 🦠 www.nature.com/articles/s41...

Secretory IgM regulates gut microbiota homeostasis and metabolism - Nature Microbiology

Rainbow trout with depleted secretory IgM reveal interesting insights into the elusive role of this immunoglobulin in maintaining gut microbiota.

nature.com

I am happy to share our latest preprint, spearheaded by Laura Camus. We show that tyrosin-dependent interactions can foster integration of S. aureus into the nasal microbiome. @cmfi.bsky.social @lmumuenchen.bsky.social www.biorxiv.org/content/10.1...

Important stuff Microbes that weather chemo may help cancer patients do the same Turnbaugh Lab (UCSF) find preTA+ bacteria detoxify 5-FU, reduce side effects Probiotic supplements to protect patients during cancer therapy? Works in mouse colorectal cancer model www.science.org/doi/10.1126/...

Yeah! 7 more years for @cmfi.bsky.social So many people to thank... We are a fantastic team!

Cluster of Excellence CMFI@cmfi.bsky.social · last yr.

🎉 Fantastic News 🎉 Our CMFI Cluster of Excellence @unituebingen.bsky.social receives funding extension for the next seven years. Spokesperson Andreas Peschel @andreaspeschel.bsky.social: "We can now advance our research into resistance mechanisms and new antimicrobial agents!" shorturl.at/rcK1A