1. How common is LLM use in scientific publishing, and how does it vary across field, publisher, journal prestige, author demographics etc.? @kylesiler.bsky.social has new paper in PNAS that addresses this question on a massive scale: 7.3 million papers from Elsevier, PLOS, MDPI, and Frontiers.

The diffusion of large language models in published academic articles | PNAS

Large language models (LLMs) are rapidly changing academic research, raising questions of who is adopting these tools and under what conditions. Th...

pnas.org

The Australian Academy of Science announced their 2026 fellows today, including Nicki Packer. "She is a pioneer in enabling, promoting and transforming glycoscience from an unrecognised niche research area into a high-impact international specialty field..." #glycotime science.org.au/about-us/aca...

A great paper, with multiple approaches to characterise ST8Sia IV. #glycotime Polysialylation of HEK N-glycans, O-glycans, and even plant polysialylation. It would have been nice to see a little mass spec, but I'm biased :) pubs.acs.org/doi/full/10....

Polysialic Acid Synthesis on the N- and O-Glycans of Salmonid Polysialyltransferase ST8Sia IV

Extension of N- and O-glycans with linear sialic acid polymers (polySias) was described on a limited number of mammalian glycoproteins, including the α2,8-polysialyltransferases ST8Sia II and ST8Sia IV. Previous in vitro analyses have shown that ST8Sia IV from the salmonid fish Coregonus maraena (Cma) had high polysialylation activity and broader donor substrate specificity compared to its human counterpart. In this study, we investigated whether the fish ST8Sia IV was able to polysialylate N- and O-glycans of glycoproteins with a focus on its autopolysialylation capacity. Using a combination of strategies, including plant-based glycoengineering, we found that the Cma ST8Sia IV is able to use both types of acceptors for the formation of long polySia chains with a degree of polymerization of >40 consisting of N-acetylneuraminic acid and N-glycolylneuraminic acid. Given the importance of polySias in multiple health and disease states, the Cma ST8Sia IV represents a useful biocatalyst with applications in the fields of biosafe therapeutics and glycobiology.

pubs.acs.org

As part of a special issue on "Glycosyltransferases", we are pleased that the editors allowed our glycosidase focused mini perspective data exploration article of the Allen Brain Cell Atlas to be part of the collection 😁 #glycotime @alleninstitute.org www.sciencedirect.com/science/arti...

Modulation of glycosylation in the brain: A single-cell exploration of glycosidases using the Allen Brain Cell Atlas

The mammalian brain is enveloped in a dense, charge-rich glycocalyx that orchestrates cell signalling, migration, and synaptic stability. Transcriptom…

sciencedirect.com

Sharing our new paper where we did our sssmug protocol, found differences in GAGs and sialylation, and it matched exactly the only 2 differentially expressed glycoenzymes. #glycotime onlinelibrary.wiley.com/doi/10.1002/...

Reduction of Charged Glycoconjugates in Tango2 KO Mouse Brain

The transport and Golgi organization 2 (TANGO2) gene has been identified to cause a rare recessive genetic disorder known as TANGO2-deficiency disorder (TDD). TDD is a multi-systemic disorder that ca....

onlinelibrary.wiley.com

Have you ever wondered how many N-Glycans or #glycoproteins there are on cells? The numbers are massive: calculations suggest about 20 to 200 million N-glycans per human cell! Read the full blog post: research.bidmc.org/ncfg/blog/24... #glycobiology #glycotime #cells #biology

This is a fantastic day for Australian chemistry. First Australian chemistry Nobel prize since John Cornforth in 1975, but Richard Robson's work is at least as impactful. #ozchem

Jon Beves@jonbeves.bsky.social · 11mo ago

Fantastic to see one of my chemical heroes, Richard Robson, winning the Nobel Prize for coordination frameworks (MOFs), together with Kitagawa and Yaghi. #ozchem

Super excited by our new #glycotime preprint! A long-term project from my group with awesome collaborator @elisafadda.bsky.social Regulation of N-glycosylation efficiency by eukaryotic oligosaccharyltransferase www.biorxiv.org/content/10.1... thread below 👇

a cartoon drawing of a pitcher and cup of sugar on a table

ALT: a cartoon drawing of a pitcher and cup of sugar on a table

media.tenor.com

How easy is it to fudge your scientific rank? Meet Larry, the world’s most cited cat www.science.org/content/arti... "More than 130 citations in 4 years." Meow, Larry! Oh wait. “All you have to do is put some fake papers on ResearchGate.” And buy citations. Critical: Let's clean up research!

How easy is it to fudge your scientific rank? Meet Larry, the world’s most cited cat

“Exercise in absurdity” reveals flaws in Google Scholar’s productivity metrics

science.org

Australian Proteomics Analysis Facility (APAF) celebrating 30 year anniversary. Had a good morning on the past, present, and future of proteomics by the pioneers in the field, including Prof. Nicki Packer @sugar-princess.bsky.social, and Prof Mark Wilkins, who famously invented the word "Proteome"

When glycan recognition is linked to immune response, you need fine tuning! 😎 Here ⬇️ we show how human Siglecs act as molecular precision tools, recognising the glycan and also the biological environment (or context) these glycans are found in. A 1/5 #glycotime🧵 ⬇️ doi.org/10.1101/2025...

By deep characterisation of 186 N-glycan standards, we @thencfg.bsky.social have made the most comprehensive targeted LC-MS glycomic assay to date. Non-reduced native glycan analysis is key. We hope this enables anyone with QqQ and interest in #glycotime to measure specific N-glycan structures.

bioRxivpreprint@biorxivpreprint.bsky.social · last yr.

N-Glycopedia: Libraries for Native N-glycan Structural Analysis https://www.biorxiv.org/content/10.1101/2025.06.09.658590v1

Resonated so well with so many speakers that it gets quoted by almost every planery talk that follows on. #Glyco27 @sugar-princess.bsky.social

Imagine if more countries fund glyco like Canada #Glyco27 #glycotime

📱 Don’t forget: our social media competition is live! Follow us and use #Glyco27 when posting on LinkedIn, X (Twitter), or Bluesky for a chance to win a prize! Let’s get the conversation going and have an amazing conference! #Glycotime #Glycoscience #Glycobiology #Canada #YEG

Congratulations to @nickescott.bsky.social on his dual MCR prize from both AGS @ozglyco.bsky.social and APS for his work on bacterial glycosylation! #glycotime

Spatial mapping of the brain metabolome lipidome and glycome #NatCommun #MassSpec www.nature.com/articles/s41...

Spatial mapping of the brain metabolome lipidome and glycome - Nature Communications

Clarke et al. presents a framework for spatial analysis of the metabolome, lipidome, and glycome from a single tissue section using mass spectrometry imaging. Applying this approach, they revealed reg...

nature.com

Nice #glycotime review that pulls together the emerging story of glycosyltransferase specificity for cellular substrates chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/...

Glycoproteins, Glycolipids, or Both: Why do Glycosyltransferases Recognize Different Acceptors?

Glycosylation is an important post-translational modification catalyzed by glycosyltransferases (GTs), which comprise a large group of enzymes with diversified specificity. Most GTs show high specifi...

chemistry-europe.onlinelibrary.wiley.com

academic.oup.com/ecco-jcc/art... Happy to share our most recent publication on how T cells glycosylation mediates #IBD progression to colorectal cancer defining the risk of colitis-associated cancer. #glycotime Great work @eduardalgomes.bsky.social @i3suporto.bsky.social @GlycanTrigger

T-cell branched glycosylation as a mediator of colitis-associated colorectal cancer progression: a potential new risk biomarker in inflammatory bowel disease

AbstractBackground and Aims. Inflammatory bowel disease (IBD) is a chronic inflammatory disorder of the gastrointestinal tract, established as a risk facto

academic.oup.com

There are great conferences and science in the US, but with the way things are right now, it’s too risky to attend.

Australian academics refuse to attend US conferences for fear of being detained

‘When academics fear travelling or partnering with US institutions, the impacts ripple through the entire global knowledge ecosystem,’ one says

theguardian.com

Just out by Shelley Jager: rdcu.be/edEnO. One of the fastest & deepest plasma glycoproteomics studies. Take home message; we even detect glycosylated cytokines and chemokines, but also still need better software. #glycotime @utrechtuniversity.bsky.social @bijvoet-centre.bsky.social

In-depth plasma N-glycoproteome profiling using narrow-window data-independent acquisition on the Orbitrap Astral mass spectrometer

Nature Communications - While DIA has advanced standard proteomics, its application in glycoproteomics has remained limited. Here, the authors present an optimized narrow-window DIA method for...

rdcu.be

Happy to share this new #glycotime work with collaborator Tony Wyss-Coray, led by grad student Sophia Shi, mucin loss at the BBB is associated with aging and cognitive decline, can be reversed by restoration with with gene therapy. Aging is a mucinopathy! www.nature.com/articles/s41...

Glycocalyx dysregulation impairs blood–brain barrier in ageing and disease - Nature

Disruption of mucin-domain glycoprotein expression and function in the endothelial glycocalyx are associated with ageing and Alzheimer’s disease, leading to dysregulated blood–brain barrier function.

nature.com

Picture this: your fav protein-protein interaction is *entirely* dependent on, 1) glycans 💥 2) the type of glycans 🤯💜 Check out this doi.org/10.1016/j.jb... 🔝 #glycotime fresh off the press in JBC led by Nicki Packer and Len Harrison 🇦🇺 + us 🇮🇪🇬🇧 + @ethangbaus.bsky.social 🇦🇺 🧵1/5

Glycomics-Guided Glycoproteomics Facilitates Comprehensive Profiling of the Glycoproteome in Complex Tumor Microenvironments #JVisExp #MassSpec app.jove.com/t/67405/glyc...

A POGase is a huge advance in the glycomics field, which has typically relied on chemical or incomplete enzymatic releases (no Sia). Expect a lot of multi-omic studies enabled by this (N-glycomics, O-glycomics, and proteomics) since the peptide backbone is left intact. www.nature.com/articles/s41...

🎉Announcing our ANZSMS 2025 Medalists 🎉 Congratulations to Prof Nicki Packer from Macquarie University and A/Prof Shane Ellis from University of Wollongong! Join us at AUS-omics from May 18 - 21 to celebrate this wonderful achievement! 🏆 Read about our medalists here 👉 mailchi.mp/6c90f3d41712...

A robust glycomic study, can’t critique any aspect of the sample QC or methods used. Really nice work. #glycotime #TeamMassSpec

BioMassSpec@realbiomassspec.bsky.social · 2y ago

Blood N-glycomics reveals individuals at risk for cognitive decline and Alzheimer's disease #EBioMedicine #MassSpec www.thelancet.com/journals/ebi...

Had a great time at GlycoBioTec2025 (www.mpi-magdeburg.mpg.de/glycobiotec2...), held once every 2 years, with a good amount of industry participants. Furthermore, food at Harnack Haus is fabulous!

GlycoBioTec2025

mpi-magdeburg.mpg.de

Check it out, powerful new method for optical imaging of the live ECM, from @hhmijanelia.bsky.social Group Leader Kayvon Pedram #proudofalumni #glycotime www.nature.com/articles/s41...

Live imaging of the extracellular matrix with a glycan-binding fluorophore - Nature Methods

Rhobo6 is a cell-impermeable small-molecule fluorophore that displays reversible fluorogenic binding to glycans, making it a general, wash-free, and non-perturbative label for the extracellular matrix...

nature.com

Our latest work on Siglec binding to sulfated glycans. Great help: @khookh.bsky.social, @pengwu.bsky.social ,@raflynn5.bsky.social. Fom 1st PhD graduate of the lab (Jaesoo Jung) and help from Edward, Zeinab, Jhon, Kelli, @tayloregray.bsky.social, and Chris from my lab. pubs.acs.org/doi/10.1021/...

Understanding the Glycosylation Pathways Involved in the Biosynthesis of the Sulfated Glycan Ligands for Siglecs

Carbohydrate sulfation plays a pivotal role in modulating the strength of Siglec–glycan interactions. Recently, new aspects of Siglec binding to sulfated cell surface carbohydrates have been discovere...

pubs.acs.org