Micha Sam Brickman Raredon
@msbr89.bsky.social
Scientist/Engineer. Assistant Professor @ Yale School of Medicine. Tissue Biology, Lung Regeneration, Data Science. Here to learn! RaredonLab.com & GitHub.com/RaredonLab
Multi-scale modeling of human tissues from spatial transcriptomics with TERRA https://www.biorxiv.org/content/10.64898/2026.07.29.741565v1
“Contrary to the common assumption that journals reject null results, we found that most projects halt during early data analysis or presentation stages.” New work by @bartekmacka.bsky.social et al. Open Access: doi.org/10.1007/s112...
Love science, teaching genetics, and mentoring? There are some great students and faculty at @smithcollege.bsky.social and they are hiring a tenure track assistant professor! Some of my favorite folks in #DevBio are there! www.smith.edu/people/cagne... www.smith.edu/people/micha...
Pls share. Assistant Professor of Biological Sciences - Genetics/Genomics at Smith College. apply.interfolio.com/190342
Nature research paper: Intestinal stem cells count self-renewal divisions to switch multipotency go.nature.com/45uYCwn
Intestinal stem cells count self-renewal divisions to switch multipotency - Nature
In Drosophila, cell fate switching in adult intestinal stem cells is determined through an epigenetic mechanism in which these cells count divisions, switching from producing enterocytes to producing an enteroendocrine mother cell every ninth division.
go.nature.com
This epic paper, which has been a heroic 10 year journey for the lead author, Ricardo Barrientos, is finally out in Cell today! Many thanks to all co-authors, especially Billie Meadowcroft and Andela Saric for their beautiful MD simulations www.cell.com/cell/fulltex...
Basement membrane turnover controls cell shape
Basement membranes are scaffolds of proteins, like collagen, that give organs shape. During development, basement membranes must adapt to the growing organ. We infer how fast the basement membrane ada...
cell.com
Fantastic!
This epic paper, which has been a heroic 10 year journey for the lead author, Ricardo Barrientos, is finally out in Cell today! Many thanks to all co-authors, especially Billie Meadowcroft and Andela Saric for their beautiful MD simulations www.cell.com/cell/fulltex...
How do tissues safely remove cells? Join me, @marija-matejcic.bsky.social in this perspective on the past, present and future of epithelial cell extrusion 🧵 0/16
The legendary "walking bed" page from Winsor McCay's "Little Nemo in Slumberland" was published on July 26, 1908. If there’s a Mt. Rushmore for Sunday pages, this one is certainly on it.
Each generation of telescope and camera technology has built upon the outstanding legacies of those that came before, sharpening our view of the cosmos and revealing more details that were previously hidden.🔭🧪
1/ The world's songbirds sing in just 8 basic sounds. And where a bird lives decides which ones it uses. My first PhD paper is out now in @science.org (www.science.org/doi/10.1126/science.aee6239) Here is what we found:
In this Opinion article, Peter Cook looks at the impact of clusters of RNA polymerases in linking DNA sequence and cell fate. journals.biologists.com/jcs/article/...
I wish I did not have to bring up this old tweet from ‘that other place’ every now and again but here we are (again) and here it is…
There's not much I can say about Alan Turing's cryptography in WWII that Benadryl Cabbagepatch didn't already cover in "Imitation Game." But did you know he explained how the tiger got its stripes, why hair parts on one side & why your heart tilts to the left? Let's talk about Turing patterns.
This video shows wave patterns in the cell's cortex, the layer just below the outer membrane where so much signaling occurs. These waves are a self-organizing pattern that prepares an oocyte for polar body emission & cytokinesis during meiosis, using simple rules that produce complexity from chaos.
Michaud, @andrewgoryachev.bsky.social, von Dassow, @xenresearchcenter.bsky.social et al. identify a versatile cortical pattern-forming circuit based on #Rho, F-#actin, Ect2, & RGA-3/4 rupress.org/jcb/article/... 📕 In "Collective Behaviors and Self-Organization in Cells" rupress.org/jcb/collecti...
AI has made it easy to construct the form of an academic paper without any true insight, and that’s not going away. We might have to move from peer review to peer recommendation. All papers get uploaded to a server, w/ an overlay where experts point to the good ones. The rest can just be ignored.
The anatomy of an AI-supported academic article is becoming more apparent. I desk reviewed ~70 manuscripts this week for our journal. Reckon 20ish had significant AI assistance. On top of hundreds of others recently I'm starting to see patterns. Are other editors are seeing the same or similar? 1/
Out today in PNAS: We show that dynamic "4D" forces can spatially pattern angiogenesis in a PIEZO1-dependent manner. Excitingly, changing force patterns over time enables redirecting sprouting trajectories, forming complex branched geometries: www.pnas.org/doi/10.1073/... #TissueEngineering
I learned a new word and yes, everybody acedia. I will further refer to AI ennui as "the consumption."
Anyway I think the LLMs are giving people acedia, for real
journals.plos.org/plosbiology/...
The cell cloud: Adopting systems biology concepts in the era of single-cell immunology
Immune cells exist as continuous clouds, not discrete categories. In this Perspective, authors from the Immunological Genome Project reframe immune identity through systems biology, and redirect where...
journals.plos.org
Immune cells exist as continuous clouds, not discrete categories. In this Perspective, @tal-shay.bsky.social &co reframe immune identity through systems biology, and propose that immunotherapies should aim at dynamics of the cell cloud. 🧪 #AcademicSky #immunology plos.io/4oWuoLG
I've felt for a while that a mainstream method, reverse engineering, in cognitive science & AI is incompatible w computationalism‼️ So I wrote "Modern Alchemy: Neurocognitive Reverse Engineering" w the wonderful Natalia S. & @irisvanrooij.bsky.social to elaborate: philsci-archive.pitt.edu/25289/ 1/n
Nice paper from Ruppel et al. in @natphys.nature.com www.nature.com/articles/s41...
A minimal in vitro assay for cell intercalation highlights the importance of interfacial tension and migratory forces - Nature Physics
Cell intercalation is an exchange of cell neighbours. Now it is shown in a minimal system of four cells that intercalation is driven by junction tension and migratory forces.
nature.com
Fabulous work in which Martial Balland and his colleagues revealed the information hidden in fluctuations rather than mean values.
Nice paper from Ruppel et al. in @natphys.nature.com www.nature.com/articles/s41...
How mammals get their fur? New research from the Milinkovitch-Tzika lab, published in PNAS, shows that chemotaxis—cells moving toward chemical cues—drives hair follicle precursor self-organization during embryonic development, generating diverse fur patterns across mammals. doi.org/10.1073/pnas...
Chemotactic self-organization captures the dynamics of mammalian hair follicle patterning | PNAS
The spatial patterning of mammalian hair follicle precursors in embryonic skin is most commonly studied in the laboratory mouse (Mus musculus), whe...
doi.org
Absolutely insane that Cape Verde — a country of 500,000 — played Spain, Uruguay and Argentina…and lost to none of them in regulation. Easily one of the greatest performances in World Cup history.