www.ualberta.ca/en/news/spot... Here’s another look at our recent publication—this time with a Folio piece into what we found and why it matters. Check out the new post highlighting the key insights from the study. People can access this data on our labs website: amsrguofa.ca/datasets/

Excited that the work from the talented Dr. Sameera Zia is now out. Blood, sweat, and tears went into this one. An amazing job. rdcu.be/ePyQm

Age-impaired remyelination is associated with dysregulated microglial transitions

Nature Communications - Microglial states throughout remyelination are incompletely understood. Here, the authors show that microglia form several states during the early stages of remyelination...

rdcu.be

Looking forward to this:

Glycomics Institute of Alberta@giaglyco.bsky.social · 9mo ago

Our first Invited Speaker to present at GIA2025 is Dr. Jason Plemel (@jrplemel.bsky.social), a Canada Research Chair in Glial Neuroimmunology and Associate Professor in the UofA Department of Medicine Neurology Division. Dr. Plemel will talk on Microglia and glycome alterations during demyelination.

CSF1R ligands promote microglial proliferation but are not the sole regulators of developmental microglial proliferation Read this #LifelongDevSI Research Article by Brady P. Hammond, Jason Plemel @jrplemel.bsky.social and colleagues: journals.biologists.com/dev/article/...

🧪

Trushar Patel, PhD, DSc, FRSC@trushar7.bsky.social · last yr.

My amazing Department of Chemistry and Biochemistry at @ulethbridge.ca is seeking a motivated & talented candidate for a tenure-track Assistant Professor position in the area of experimental chemistry. We encourage you to apply or help spread the word! uleth.peopleadmin.ca/postings/8541

Three in two weeks. Could not be more proud of the newly minded Dr. Sameera Zia after successfully defending her PhD yesterday. This bright young star will do amazing things! Also, a huge thanks to @nachoriko.bsky.social for making the trip to Edmonton to serve as an external examiner

CSF1R ligands promote microglial proliferation but are not the sole regulators of developmental microglial proliferation Read this Research Article from our special issue on lifelong development #LifelongDevSI, by Brady Hammond, @jrplemel.bsky.social & co.: journals.biologists.com/dev/article/...

Excited to get going for the 2025 #endMS_SummerSchool ! It takes a village! Look at all the welcome packages for those who make this event happen

Two in one week! An amazing MSc Defence for Rebecca John, co-supervised by Karim Fouad and myself.

Super proud of Brady Hammond for successfully defending his PhD today. Well done Brady!

Just out, recent work from the Plemel lab by the talented Brady Hammond. We sought to understand the factors that regulate microglial proliferation during development. journals.biologists.com/dev/article/...

CSF1R ligands promote microglial proliferation but are not the sole regulators of developmental microglial proliferation

Summary: In vitro and in vivo investigations indicate that CSF1 and IL34 may partially regulate the developmental proliferation of microglia in the mouse hippocampus and cortex, but an additional laye...

journals.biologists.com

Amazing work by @iammadho.bsky.social 👇 Check it out

Madelene Faye Ho@iammadho.bsky.social · last yr.

Ecstatic to post my 1st first author review! Ever wondered about the immune cell perspective on sex differences within the PNS under pain? Do I have news for you 📝🗯️🦠🔬🤕 Read it here: doi.org/10.1016/j.bb... So grateful to write this under the labs of @bradleykerr.bsky.social @jrplemel.bsky.social

Graduate student and post-doc (Neuroimmunology & High-Throughput Immunometabolic Profiling in MS) positions available in Dr. Deepak Kaushik's laboratory at Memorial University #neurojobs can-acn.org/msc-phd-posi... can-acn.org/postdoctoral...

MSc/PhD Position at the Faculty of Medicine, Memorial University of Newfoundland, St. John’s, Canada – Canadian Association for Neuroscience

Dr. Deepak Kaushik, Assistant Professor at the Faculty of Medicine, Memorial University of Newfoundland (MUN, St. John’s, Canada), is currently recruiting MSc/PhD fellows to join a CIHR-funded…

can-acn.org

Exciting work from @blurtonjoneslab.bsky.social + Spitale labs -- new examples of how iPSC-microglia can be used as a long-term, in vivo platform for a therapeutic protein payload in models of Alzheimer’s disease @cp-cellstemcell.bsky.social sciencedirect.com/science/article/pii/S1934590925000992

Harnessing human iPSC-microglia for CNS-wide delivery of disease-modifying proteins

Widespread delivery of therapeutic proteins to the brain remains challenging. To determine whether human induced pluripotent stem cell (iPSC)-microgli…

sciencedirect.com

Congratulations to all accepted SS & SPRINT applicants. The application quality was outstanding but sadly we are unable to accept everyone. A truly national🍁program. Can't wait to meet you in Edmonton. @ualberta.bsky.social, @jrplemel.bsky.social, @rimuhc.bsky.social, @healthsciences.mcgill.ca

endMS Training Program@endms.bsky.social · last yr.

Excited to share this month's #endMS newsletter unveiling the list of successful #endMS_SummerSchool and #endMS_SPRINT applicants, achievements, publications and more! View the full issue here: bit.ly/endMS_Newsle...

Check out this exciting work by @philgrossphd.bsky.social in the @jkhuang.bsky.social lab! Thanks for asking us to be a part of it

Phil Gross, PhD@philgrossphd.bsky.social · last yr.

Excited to finally have this published! Out today in @naturecomms.bsky.social, we show that following demyelination in a mouse model of Multiple Sclerosis, treatment of senescent microglia with senolytics leads to improved remyelination. www.nature.com/articles/s41... 1/3

Bye bye 👋🏽 🇺🇸 beer, wine, & liquor The scene at our local LCBO #capoli

💪

I knew this would happen, but it's still surreal to hear another nation's leader talk to us in a televised address the way US presidents have historically spoken to the citizens of countries led by dictators and despots.

Aaron Rupar@atrupar.com · last yr.

Trudeau: "I want to speak first directly to the American people. We don't want this. We want to work with you as a friend and ally. We don't want to see you hurt either. But your government has chosen to do this to you. As of this morning, markets are down and inflation is set to rise dramatically."

I hope you haven’t missed this awesome new study by @caromenard666.bsky.social’s team, where the dreamy keys worlds #astrocyte and #BloodBrainBarrier coexist 🤩🥰

Astrocytic cannabinoid receptor 1 promotes resilience by dampening stress-induced blood–brain barrier alterations - Nature Neuroscience

The mechanisms of neurovascular adaptations underlying stress resilience remain unclear. Here the authors show that the astrocytic endocannabinoid system modulates the blood–brain barrier changes duri...

nature.com

Check out a recent paper by Karim Fouad and my groups examining how reawakening inflammation in the chronically injured spinal cord using lipopolysaccharide induces diverse microglial states

Oligodendrocyte precursor cells facilitate neuronal lysosome release

Oligodendrocyte precursor cells facilitate neuronal lysosome release - Nature Communications

Oligodendrocyte precursor cells (OPCs) play a multifaceted role in the brain. Here, the authors show that OPCs regulate neuronal metabolism by forming contacts with neuronal somata, facilitating lysos...

nature.com

Wise words from another Nobel laureate.

Maximiliano José Nigro@maxnigro.bsky.social · 2y ago

Take a look at this passage from the autobiography of Van Essen from the same SfN series

Cool new manuscript from the Huang lab!!

bioRxiv Neuroscience@biorxiv-neursci.bsky.social · 2y ago

Dissecting the evolving cellular landscape of a remyelinating microenvironment https://www.biorxiv.org/content/10.1101/2024.12.25.630253v1

Old article but poignant as ever. Success in science is far more than science alone.

Channa Prakash@agbioworld.bsky.social · 2y ago

The discoverer of GFP gene for a glowing protein 
was driving a van for a car dealership in Huntsville, Alabama, when he learned that former colleagues 
had won science's greatest honor. www.discovermagazine.com/mind/how-bad...

Extrasinusoidal macrophages are a distinct subset of immunologically active dural macrophages www.science.org/doi/full/10....

congratulations to @pryprk.bsky.social for her recent review article in #GLIA on the role of lipids in microglial function. onlinelibrary.wiley.com/doi/full/10....

How to make the most out of PostDoc time? www.cell.com/trends/cell-... "In summary, start early, do research, build a network, establish your niche, and apply for funding of your own."

Homeostatic microglia initially seed and activated microglia later reshape amyloid plaques in Alzheimer’s Disease This further adds to the mounting evidence that microglia are perhaps much better at Aβ plaque formation than plaque clearance. What a fantastic study 🤩

Homeostatic microglia initially seed and activated microglia later reshape amyloid plaques in Alzheimer’s Disease - Nature Communications

The role of microglia in Alzheimer’s disease is debated. This paper shows that homeostatic microglia seed amyloid plaques in early disease stages and activated microglia compact plaques at later stage...

nature.com

⬆️ Updated ⬆️ Oligodendroglia starter pack! If you are interested in Oligos, OPCs, myelin, and more check out these awesome folx and their cool findings! Please share, nominate, and comment below to be added. Go team Oligo 🧠🦋! go.bsky.app/JgL2evN