New Toettchlab paper alert! Harrison Oatman just published his beautiful work combining software design for "smart" microscopy+optogenetics and some really beautiful work understanding EGFR-driven collective cell migration. www.cell.com/cell-systems...
Nicole Repina
@nrepina.bsky.social
Studying multiscale emergence (cell -> tissue) at FMI Basel complex systems | 3D shape | morphogenesis | self-organization | philosophy of biology | systems evo-devo | image analysis | illustration ✨ always questioning, forever inspired ✨
Introduced by Bernhard Riemann in the mid-19th century, manifolds are crucial to our understanding of the universe.
What Is a Manifold? | Quanta Magazine
In the mid-19th century, Bernhard Riemann conceived of a new way to think about mathematical spaces, providing the foundation for modern geometry and physics.
quantamagazine.org
🔥 Published today, and just in time for summer conferences, here are your guidelines for presenting badly www.nature.com/articles/s41... rdcu.be/fqa92
Here the published version of our work on uncoupling different types of tissue phase transitions during development! Find out more on how contact surface tension-driven rigidity transitions trigger tricellular junction formation and initiate epithelial organization! @natphys.nature.com
⚡ Our paper is now out in @natphys.nature.com ! This version now includes a detailed molecular characterisation of the optogenetic perturbations, new insights on the relevance of tricellular junctions for tissue morphology, and beautiful light-sheet timelapses. 🔬 www.nature.com/articles/s41...
Tune in this coming Monday on zoom! I'll be presenting work from my PhD @slcuplants.bsky.social on how plants regulate their shoot branching architecture via auxin, strigolactone, and BRC1.
Next Monday, 15 June at 2:30 PM (UK time), we are excited to welcome Zoe Nahas @zoenahas.bsky.social and Toby Andrews @tobyandrews.bsky.social! This seminar will be online and will be the last one of the term. We hope to see many of you there and finish the term with great science and discussion!
Multinucleate cells challenge deeply-held assumptions about complexity, ecological success and evolution. Postdoc extraordinaire and gifted writer @mrosjac.bsky.social tackles this subject with aplomb - tell us what you think! www.sciencedirect.com/science/arti... @currentbiology.bsky.social
Multinucleation as a recurring evolutionary strategy for scaling and plasticity
Multinucleate cells — single cells containing multiple nuclei in a shared cytoplasm — are found across the eukaryotic tree of life. Having evolved ind…
sciencedirect.com
Nature research paper: A deep-learning framework reveals whole-body perturbations at cell level go.nature.com/3Pjox61
A deep-learning framework reveals whole-body perturbations at cell level - Nature
An analysis of diet-induced obesity using MouseMapper—a suite of foundation-model-based deep-learning algorithms—identifies structural alterations of the infraorbital branch of the trigeminal ganglia.
go.nature.com
Our latest: Minimal essential requirements for neural tube self-organisation How does a single cell give rise to a tissue with the right cell types in the right proportions? We deconstruct and rebuild a self-organising tissue from first principles A thread🧵 www.biorxiv.org/content/10.6...
Minimal essential requirements for neural tube self-organisation
The reliable generation of diverse cell types in precise proportions is essential for the formation of functional tissues during embryonic development. Three-dimensional organoid models derived from p...
biorxiv.org
📢📢 We are hiring a Bioimage Analyst at the BioVisionCenter! 📢📢 Join our collaboration with the Flow Cytometry Facility and contribute back to the international efforts on open standards for bioimaging data! More information here, reach out if you have any question: jobs.uzh.ch/job-vacancie...
UZH: Bioimage Analyst
The University of Zurich is the largest university in Switzerland and one of the most prominent in Europe. For research purposes the Biovision Center and Flow Cytometry Facility offer services to supp...
jobs.uzh.ch
Check out our 2026 subject collection, showcasing recent papers in @dev-journal.bsky.social on evolutionary developmental biology: journals.biologists.com/dev/collecti... It has been curated to support the 2026 Euro-Evo-Devo conference in Glasgow, UK. #EED2026
Our latest work on shape-programmable tissues is out in @science.org. By positioning topological defects in cellular nematics, we encode frustrated 2D force fields that relax into predictable 3D shapes. Collaboration with Marino Arroyo’s lab, led by @pauguillamat.bsky.social at @ibecbarcelona.eu.
Check out 2 papers and a related Perspective on tissue regeneration in @science.org this week Species-specific oxygen sensing governs the initiation of vertebrate limb regeneration | Science www.science.org/doi/10.1126/...
Species-specific oxygen sensing governs the initiation of vertebrate limb regeneration
Why mammals cannot regenerate limbs like amphibians do presents a long-standing puzzle in biology. To uncover the underlying differences, we compared amputation responses of embryonic mouse (Mus musculus) and Xenopus laevis tadpole limbs. Lowering ...
science.org
I know this tension all too well! Thank you for the highlight
Expert's Dilemma: the more specialized you become, the less open you are to creative solutions from other fields. But the more you explore other fields, the more you risk losing credibility in your home field. (Night Science recap, Day 3)
How it feels doing literally any task right now.
A question I get asked all the time by @dev-journal.bsky.social authors "Why does it cost so much to publish a paper?" We break down the finances and explain where the money goes Spoiler: quality publishing takes a village (people + infrastructure) journals.biologists.com/dev/article/...
‘Why is publishing so expensive?’
For many of us who work in scientific publishing, the title of this Editorial is a question we hear all the time when we're out talking to academics. And it's a perfectly reasonable one. After all, re...
journals.biologists.com
3 DAYS LEFT to submit your abstract!! Don’t miss your chance to present at the Cambridge Morphogenesis Symposium. 👉 Submit & register here: t.ly/YYM3u #Morpho5
📢We are excited to announce the Cambridge Morphogenesis Symposium - a full day event at SLCU @slcuplants.bsky.social (and virtually) on 5 June 2026! 🎉Come celebrate the 5th anniversary of the seminar series! 🚩Register & submit abstracts by 3 April! Check out the details: t.ly/YYM3u Please repost!🙏
We’re excited to share our latest preprint on Fractal: our approach towards FAIR bioimage analysis at scale with OME-Zarr-native workflows. Fractal defines interoperable tasks on OME-Zarr and provides a platform for TB-scale image analysis. (1 / 10🧵) www.biorxiv.org/content/10.6...
biorxiv.org
📢We are excited to announce the Cambridge Morphogenesis Symposium - a full day event at SLCU @slcuplants.bsky.social (and virtually) on 5 June 2026! 🎉Come celebrate the 5th anniversary of the seminar series! 🚩Register & submit abstracts by 3 April! Check out the details: t.ly/YYM3u Please repost!🙏
Peer Bork died yesterday 💔 which shocked me. In 2003 I did a short-term fellowship in Peer’s lab because I idolized him. I met Martin there & we wrote this paper together. Peer was great at bringing people together; a master collaborator with a rare ability to think up big ideas.
In need of a positive outlook on the future (of developmental biology)? Read our perspectives by my fellow @dev-journal.bsky.social PI fellows and myself. I'm hoping my future will contain much more TE biology and mammalian genome regulation! journals.biologists.com/dev/article/...
Pathway to Independence: a forecast for the future of developmental biology
ABSTRACT. In 2022, Development launched its Pathway to Independence (PI) programme, aimed at supporting postdocs as they transition to their first independent position. In 2025, we welcome our third c...
journals.biologists.com
How do #stemcells integrate information to coordinate fate decisions? Delighted to finally see our work showing how growth factors regulate the mechano-osmotic state of the #nucleus and #chromatin to control #pluripotency exit out! www.nature.com/articles/s41... see 🧵 👇
Mechano-osmotic signals control chromatin state and fate transitions in pluripotent stem cells - Nature Cell Biology
McCreery, Stubb et al. show that mechano-osmotic changes in the nucleus induce general transcriptional repression and prime chromatin for cell fate transitions by relieving repression of specific differentiation genes.
nature.com
The reality in science is that creativity is not treated as a core skill while hypothesis testing is, and that is the imbalance that we want correct through the Night Science Institute! www.technologynetworks.com/genomics/art... www.night-science.org
The Night Science Institute Is Changing How Science Teaches Creativity
In this interview with Professors Itai Yanai and Martin Lercher, explore how night science brings creativity, ideation and collaboration back into the heart of modern science.
technologynetworks.com
Hydra body axis balance: a fight between two transcription factors This Research Highlight showcases the work from Jaroslav Ferenc, Marylène Bonvin, Panagiotis Papasaikas, Jacqueline Ferralli, Clara Nuninger and Charisios D. Tsiairis: journals.biologists.com/dev/article/...
Out in @science.org! We found that the intestine doesn’t just push out cells when crowded. Instead, cells are in a mechanical tug-of-war, and weaker ones are extruded. A new view of how our gut keeps its balance and stays healthy. www.science.org/doi/10.1126/...
Epithelial tension controls intestinal cell extrusion
Cell extrusion is essential for homeostatic self-renewal of the intestinal epithelium. Extrusion is thought to be triggered by crowding-induced compression of cells at the intestinal villus tip. In th...
science.org
What a week! A huge thank you to all the students and teachers for the for the engaged discussions, thoughtful questions, and good vibes. Rock on, and stay curious! 🤓 ✨ #VeniceEvoDevo #levels #morphogenesis #sysbio #evodevo
We are all super happy and proud to see our work on the function and evolution of the #cephalic #furrow published in @nature.com. Let me say a few things about the background and history of this work on the #Evolution_of_Morphogenesis (1/12)
BIG NEWS!! We will be hiring a new professor with 25 years of endowed funding at the @biozentrum.unibas.ch @unibas.ch, focused on using biophysics and structural biology to explore climate-related fundamental science topics. Come start an innovative research cluster with us! 🧪🔬🧶🧬🌾🌍
The University of Basel is setting up a new endowed professorship at the @biozentrum to make fundamental discoveries at the interface between biophysics and climate-relevant environmental biology. This will be made possible by the Georg H. Endress Foundation.
We're happy to announce the 2025 International OME-NGFF workshop 🎉 📅 Dates: - Symposium: Nov 10–11, 2025 - Hackathon: Nov 12–14, 2025 📍 Location: Zurich, Switzerland Full details & registration: www.biovisioncenter.uzh.ch/en/events/Up... #bioimaging #openscience #OMENGFF #OMEZarr (1/x 🧵)
A closed feedback between tissue phase transitions and morphogen gradients drives patterning dynamics https://www.biorxiv.org/content/10.1101/2025.06.06.658228v1