Our manuscript on the co-option of TEs as cerebellar CREs is now officially published in @natcomms.nature.com! Huge thanks to @kaessmannlab.bsky.social @marisepp.bsky.social, and @ioansarr.bsky.social for the fantastic collaboration throughout this project! www.nature.com/articles/s41...

Gene regulatory innovations from transposable elements in primate cerebellum development - Nature Communications

The roles of transposable elements in primate brain development remain underexplored. Here, the authors identify transposable elements with ancestral regulatory potential that have been co-opted as ci...

nature.com

Kaessmann Lab@kaessmannlab.bsky.social · 10mo ago

Did transposable elements shape brain evolution — and if so, which ones, and in which cell states and lineages? Led by @tyamadat.bsky.social, we explored this question in cerebellum development using sequence-based deep learning models! www.biorxiv.org/content/10.1...

----- PLS SHARE WIDELY ----- I have 2 positions to fill asap: 1) a 3-year postdoctoral position, creating single-cell atlases across species and development. 2) a 4-year (!) PhD position, to create anatomical atlases. Both will work together on integrating these two strands of information...!

🚨 I am very happy (and relieved!) to announce that I secured Emmy Noether funding by the @dfg.de to start my own group at @unimainz.bsky.social , hosted by Marion Silies & Jakob von Engelhardt in August! 🚨 Website coming soon - open for name/logo suggestions. They better be funny tho!

Sophia Petrillo with Megaphone in Golden Girls

ALT: Sophia Petrillo with Megaphone in Golden Girls

static.klipy.com

I am starting my lab at the University of Geneva next January! Incredibly excited to soon be joining the MOCEL department as an Asst. Professor. The lab will use evolutionary cell biology to study chromosomes, centromeres & speciation 🧬🔬🌱 Intrigued, want to join or collaborate? 🔗 helsenlab.org

Helsen lab | chromosome and centromere evolution

The Helsen lab at the University of Geneva explores how centromeres and chromosomes evolve, diversify, and function across eukaryotes. Discover our latest publications, research team, and open positio...

helsenlab.org

www.cell.com/molecular-ce... I'm happy to see our work published! If you are interested in transposons, transcriptional regulation and Pol III come and check it out 👀 🧫 🧬

ChAHP silences SINE retrotransposons by inhibiting TFIIIB recruitment

SINEs are short transposable elements that make up large fractions of mammalian genomes. Known to be transcribed by RNA polymerase III, their regulation has remained largely unexplored. Schnabl-Baumga...

cell.com

This paper is now online at @currentbiology.bsky.social. This marks the end of my postdoc and I’ll be joining @imperiallifesci.bsky.social as Imperial College Research Fellow in October! 🎊 🥳🍾 www.cell.com/action/showP...

Ethan (Chee Kiang) Ewe@ethanewe.bsky.social · 12mo ago

🔥my latest paper from @odedrechavi.bsky.social lab🔥 we found small RNAs act across tissues to regulate fertlity in C. elegans 🪱. Surprisingly, we also found that O2-sensing neurons inhibit germline maintenance. Follow along our journey👇https://www.biorxiv.org/content/10.1101/2025.08.07.669182v1

Frank Grosveld has been a giant in the field of long-range gene regulation. Inspirational to me and I am sure for many others. Rest in peace.

Lluis Montoliu@lluismontoliu.bsky.social · last mo.

Frank Grosveld, born in 1948, passed away last Friday. He was a colossal scientist in the transcriptional control of gene expression during development and helped us understand the complex regulation of beta-globin genes. His work will remain as a reference. May he rest in peace.

Our evil ORFeome paper is out! In collaboration with @alex-stark.bsky.social, we screened ~4,000 viral proteins and secreted effectors from bacteria and parasites, covering hundreds of diverse pathogens, for phenotypes in human cells.

A New Open Foundation for TE Research: GIRI is transitioning the full Repbase collection to an open-access license and joining the Dfam effort to help build a unified open resource for transposable element research. Full announcement: tinyurl.com/48665xss

Noticeable underrepresentation of women as corresponding authors in the 1%. Almost as if AI has been trained on years of discriminatory behaviours and is perpetuating that bias.

Journal impact factors were released yesterday. In our latest @dev-journal.bsky.social Editorial, @jamesbriscoe.bsky.social and I discuss how we are all architects of impact, highlighting that measuring the influence and support journals provide goes beyond a single number. doi.org/10.1242/dev....

The elephant in the room: impact factor

Summary: This Editorial offers an honest look at impact factor trends in developmental biology, explains how Development serves its community, and makes the case that sustaining developmental biology ...

doi.org

Barbara McClintock was born #OTD in 1902. 🧪 🌽 McClintock, who spent most of her career at Cold Spring Harbor Laboratory, won a Basic Medical Research Lasker in 1981 for the discovery of transposons, genetic elements that can move from one location to another: http://ow.ly/hVNI50Jvkql #WomenInSTEM

Dfam 4.0 has been released. With over 7 million TE families spanning 6130 species, Dfam continues to grow through genome sequencing and community submissions. This release also introduces an improved FamDB format, making it easier to obtain only the data you need. Release notes: tinyurl.com/6dzwu4w8

📣 POSTDOC position available in the Feschotte Lab at Cornell to work on #TRANSPOSONS! More details below. Pls send informal application or inquiry ASAP by DM or email to cf458_at_cornell.edu. Pls spread the word 🙏 #TEsky www.thefeschottelabatcornell.com

We are thrilled to release Bambu-pipe 🧬 🚀 A Nextflow pipeline built for speed, scalability, and precision — unlocking isoform-level insights from long-read single-cell and spatial RNA-seq data💡 🔗 GitHub: github.com/GoekeLab/bambu-pipe 📄 Preprint: doi.org/10.1101/2024.12.30.630828

GitHub - GoekeLab/bambu-pipe: Transcript discovery and quantification for long read single cell and spatial transcriptomics data using Bambu

Transcript discovery and quantification for long read single cell and spatial transcriptomics data using Bambu - GoekeLab/bambu-pipe

github.com

Excited to share our @natgenet.nature.com study showing that epigenetically rewired transposable elements control AML leukemia stem cell properties and patient outcome. Grateful to the team & collaborators. www.nature.com/articles/s41...

Transposable elements shape stemness in normal and leukemic hematopoiesis - Nature Genetics

This study identifies distinct transposable element subfamilies as genetic determinants of stemness properties in normal and leukemic stem populations with clinical implications for patients with acut...

nature.com

👋 Transposon lovers: registration is now open for the CSHL TE meeting! We have a 🔥 lineup of invited speakers and many slots for short talks selected upon abstract across all areas of TE biology. 🧬➰🧬 #TEsky Abstract deadline: July 10 meetings.cshl.edu/meetings.asp...

We are pleased to welcome 8 new fellows to our Pathway to Independence programme. Welcome Maëlle Bellec, @iamzico.bsky.social, @evhealy.bsky.social, @josepmercadal.bsky.social, @nikhil-mishra.bsky.social, Jessica Perochon, Yamini Ravichandran & Margherita Zamboni. Read more⤵️ tinyurl.com/4bk4wrk7

Which transcription factors control transposable element expression during zygotic genome activation? Gain-of-function screen by @metorrespadilla.bsky.social and coworkers identifies TBP as direct regulator of mouse endogenous retrovirus-like elements link.springer.com/article/10.1...

TBP regulates transposable element expression in early mouse embryos - The EMBO Journal

The activation of the embryonic genome is a crucial step in development. In addition to thousands of genes, many transposable elements (TEs) are robustly transcribed during early mammalian development...

link.springer.com

Just out! 👀 for TFs that regulate TEs.Clara's work with @tamas-schauer.bsky.social @marliesoomen.bsky.social @palmrinmoy.bsky.social and bluesky-less lab members 🌎 identifies TBP as a regulator of specific ERVL class: MaLRs in 🐭embryos -as always -feedback welcome👍 link.springer.com/article/10.1...

Very grateful to everyone who made this work possible. I feel incredibly lucky to have worked with such an amazing team. Special thanks to: Jakob El Kholtei, KJ Jenie, @mcolomerr.bsky.social, and of course our wonderful collaborator Bogdan Bintu and my mentor @schierlab.bsky.social

Alex Schier @schierlab.bsky.social · 5mo ago

Very happy to see this out. 👏 @yinanwan.bsky.social Bogdan Bintu and team. Whole-embryo spatial transcriptomics at subcellular resolution from gastrulation to organogenesis | free link Science www.science.org/eprint/5MHTM...

Incredibly proud to share our new preprint, lead by the Incomparable Rithika Sankar. Here we temporally dissect the role of FACT in mES cells, finding that FACT loss drives progressive deterioration of chromatin architecture, leading to transcriptional collapse. www.biorxiv.org/content/10.6...

Our internal organs are evolutionary marvels. New technologies are transforming our understanding of the evolution of vertebrate organs. You can find more by reading here: rdcu.be/e5EgU #EvoBio #EvoDevo 🐟🦎🐢🦇🐊🦜

The molecular evolution of vertebrate organs

Nature Ecology & Evolution - This Review discusses recent advances in the molecular evolution of vertebrate organs, including rates of evolution of organs and cell types, molecular mechanisms...

rdcu.be

I had a lot of fun putting this together with @suminkim.bsky.social and @andersshansen.bsky.social! Glad to have had the chance to work on it!

Anders Sejr Hansen@andersshansen.bsky.social · 6mo ago

Excited to share @suminkim.bsky.social and @mileshuseyin.bsky.social 's new Current Opinion review on how Polycomb complexes mediate 3D genome interactions including mechanistic models and potential roles in gene regulation: www.sciencedirect.com/science/arti...

I am also (i) very stressed, (ii) very thrilled and (iii) on the job market

PEOPLES OF EARTH: BE PREPARED 🧪

the Node@the-node.bsky.social · 6mo ago

📢Register for our #DevPres webinar on neurodevelopment The webinar, chaired by Polina Kameneva, features talks from Joaquín Navajas Acedo @mads100tist.bsky.social, Carlo Donato Caiaffa & Clarisse Brunet @clarissebrunet.bsky.social. 🗓️25 February, 15:00 GMT/UTC us02web.zoom.us/webinar/regi...

New preprint!! 🚨 Did you know that many vertebrate species determine sex based on environmental conditions rather than chromosomes? Some turtles, like Trachemys scripta, rely on temperature. We learned more about how this happen molecularly.👇 www.biorxiv.org/content/10.6...

The final (and my favorite) chapter of my PhD is now officially published! Extremely grateful to all our collaborators, especially to @marisepp.bsky.social and @tyamadat.bsky.social for their hard work, and to @steinaerts.bsky.social and @kaessmannlab.bsky.social for their guidance and advice!

Kaessmann Lab@kaessmannlab.bsky.social · 6mo ago

We are thrilled that our study on the evolution of gene regulation in mammalian cerebellum development – led by @ioansarr.bsky.social, @marisepp.bsky.social and @tyamadat.bsky.social, in collaboration with @steinaerts.bsky.social – is now out in @ScienceMagazine! www.science.org/doi/10.1126/...

It is finally out! If you are interested in TE-derived CREs, and newly described, but evolutionary old KZFP-TE mechanistic modalities, read it at www.cell.com/cell-reports.... Thankful to everyone who took part in this work, namely @orpsf.bsky.social and other @trono-lab.bsky.social members. 🫀🧬✨

Tissue-specific restriction of transposon-derived regulatory elements safeguards cell-type identity

Milovanović et al. uncover a mechanism by which KZFPs restrict the activity of transposon-derived cis-regulatory elements to safeguard cardiomyocyte functionality. This work extends the classical TE-K...

cell.com

Very excited to receive this award and truly grateful to the @bscb-official.bsky.social who have been supporting me throughout my postdoc since I moved to the UK!

British Society for Cell Biology@bscb-official.bsky.social · 7mo ago

We are delighted to announce that @giuliapaci.bsky.social from @ucllifesciences.bsky.social has been awarded the 2026 BSCB Postdoctoral researcher medal You can read about Giulia's work on how tissues withstand mechanical stress here: bscb.org/postdoctoral...