Our lab’s latest on synthetic genomics “Synthetic Combinatorial Minimisation of Cell Cycle Control” is up now on BioRxiv - covering ambitious yeast #synbio cell cycle work led by Anastasiya Malyshava and co-supervised by Matteo Barberis.
Pablo Ivan Nikel
@pabnik.bsky.social
Professor DTU Biosustain · Proud PI @labnikel.bsky.social · SynBio · Metabolic Engineering · @novo-nordisk.bsky.social Ascending Investigator & Distinguished Innovator · He/him🏳️🌈
Hello! We are a new @scienceinnovation.ec.europa.eu project building bacteria that only grow by making methanol-based chemicals instead of releasing CO2. 🌬️🦠 📈 Follow our journey and learn more at carboncare-project.eu Eight partners, six countries, one goal: Fermentation 2.0. #microsky 🧪
PntAB & SthA of #Pseudomonas are a flexible transhydrogenase system, supporting energy balance, acetate assimilation & formate tolerance, impacting redox-intensive & C1 metabolic engineering @michelepartipilo.bsky.social @labnikel.bsky.social @cp-cellsystems.bsky.social www.cell.com/cell-systems...
cell.com
Cascading recombinase memory switch for programmable and stable gene expression in Pseudomonas putida by Javier Hernández @labnikel.bsky.social #SyntheticBiology #MetabolicEngineering #GeneticCircuit #OpenAccess academic.oup.com/nar/article/... @narjournal.bsky.social
Cascading recombinase memory switch for programmable and stable gene expression in Pseudomonas putida
Abstract. Genetic circuits for model bacteria often perform poorly in non-canonical hosts, limiting the deployment of regulatory programs in industrially r
academic.oup.com
Happy Pride Month! LGBTQIA+ lives are increasingly at risk in 2026, but you'll probably see the usual 'things are better/acceptance has increased/stop shoving it in our faces' No. Love loud, continue to fight, support queer art and businesses, and stand up for your trans siblings :)
Elmo's Rainbow Pride Celebration
ALT: Elmo's Rainbow Pride Celebration
static.klipy.com
#Pseudomonas vancouverensis as a platform for one-carbon (#C1) assimilation and #polyhydroxyalkanoate accumulation, led by Emil C. Ørsted @labnikel.bsky.social #Biotechnology #MetabolicEngineering #SynBio www.sciencedirect.com/science/arti...
Pseudomonas vancouverensis as a platform for one-carbon (C1) assimilation and polyhydroxyalkanoate accumulation
Metabolic engineering calls for new bacterial chassis that combine robust metabolic and physiological traits with genetic tractability. We developed P…
sciencedirect.com
🔓Check out the #OpenAccess review by @pabnik.bsky.social & co. @labnikel.bsky.social in our latest issue exploring emergent strategies and methods for isolating, creating & characterizing enzymes optimized for bioproduction #natprod Read in full on our website🔽
Accelerating enzyme discovery and engineering with high-throughput screening
Covering: up to August 2024 Enzymes play an essential role in synthesizing value-added chemicals with high specificity and selectivity. Since enzymes utilize substrates derived from renewable…
pubs.rsc.org
💫 I am recruiting a postdoctoral candidate for a 3-year position starting in summer 2026 to work on the role of extracellular RNA (eRNA) in interspecies interactions.
Very sad news about the passing of Prof. Jeff Cole. Jeff was a central figure for biotechnology in Europe who inspired generations of researchers. R.I.P.🕊️
Institute of Microbiology and Infection @imibirmingham.bsky.social · 5mo agoIt is with deep sadness that we share the passing of Professor Jeff Cole. An esteemed academic, Jeffs research on bacterial adaptation to oxygen and nitrosative stress made a lasting impact on the field. He mentored nearly 60 doctoral students, our thoughts are with his family, friends & colleagues
#MicroSky: Plasmid vectors still underpin molecular biology, but convenience shouldn’t trump design. De Lorenzo & Martínez revisit copy number, selection & stability, and explores modular AI-assisted vector design for robust synthetic biology across the microbial world. doi.org/10.1111/1751...
How do you react when your favorite microbe is renamed by taxonomists who are completely outside your field—and who ignore the community that actually works with it? Here is our clear answer re the case of Pseudomonas putida KT2440 👉🏻 journals.asm.org/doi/10.1128/...
The disputed identity of Pseudomonas putida KT2440: when taxonomists rename your favorite microbe | mBio
Names matter; they are not mere labels. They operate as anchors of memory, social coordinates, and references of collective identity. When a name becomes established through long-term use and broad ad...
journals.asm.org
Should an iconic #bacterial #chassis be renamed without community consensus? Our @mbio.bsky.social #article vindicates the established identity of #Pseudomonas putida KT2440 & argues for continuity, community practice & common sense in naming · @vdlorenzo.bsky.social journals.asm.org/doi/10.1128/...
The disputed identity of Pseudomonas putida KT2440: when taxonomists rename your favorite microbe | mBio
Names matter; they are not mere labels. They operate as anchors of memory, social coordinates, and references of collective identity. When a name becomes established through long-term use and broad ad...
journals.asm.org
this is also a contribution to the Scientists' Warning to Humanity series @scientistswarning.bsky.social
Ken Timmis@kentimmis.bsky.social · 8mo agoHappy to post our latest paper: doi.org/10.1111/1751... Biases accumulate with age, so it is essential to begin teaching critical thinking as early as possible. The problems are HOW, given the complexity of its theory, and IN WHAT EDUCATIONAL CONTEXT? The solutions we propose in this paper are...
Happy to post our latest paper: doi.org/10.1111/1751... Biases accumulate with age, so it is essential to begin teaching critical thinking as early as possible. The problems are HOW, given the complexity of its theory, and IN WHAT EDUCATIONAL CONTEXT? The solutions we propose in this paper are...
Microbes determine the health of all other organisms and that of the planet. They were our ancestors and are our cousins. They are life and sustain it. Microbes are life, the biological core of One Health and Health in All Policies url: academic.oup.com/microlife/ar...
Microbes are life, the biological core of One Health and Health in All Policies
The World Health Organization (WHO) is promoting the operative concept of “Health in All Policies” (HiAP; https://iris.who.int/bitstream/handle/10665/11263
academic.oup.com
So excited that the theme of LGBT+ History Month UK 2026 is 'Science and Innovation,' with super badge designed by @canopyrobin.com! 🧬🏳️⚧️🔭🏳️🌈🚆 Wonderful launch event at the Royal Society of Chemistry @rsc.org this evening. 👏 lgbtplushistorymonth.co.uk/lgbt-history... @lgbthm.bsky.social #LGBTplusHM 🌈🗃️
LGBT+ History Month 2026 - LGBT+ History Month
If you’d like to donate to support our work, click here to donate via PayPal. Free Schools Presentation For 2026 we are able to offer free LGBT+ History Month presentations for secondary schools, prid...
lgbtplushistorymonth.co.uk
Growth-coupled microbial biosynthesis of the animal pigment xanthommatin — Led by Leah Bushin, featuring M. Gracia Alvan, @danielvolke.bsky.social @oscarpuiggene.bsky.social in a fantastic collaboration w/Brad Moore @labnikel.bsky.social @natbiotech.nature.com 🦑 www.nature.com/articles/s41...
🚨 New paper in mBio! We established strict formatotrophic & methylotrophic growth in engineered Pseudomonas putida via the reductive glycine pathway (rGlyP). journals.asm.org/doi/full/10.... Here’s a teaser of how we did it 🧵👇1/5
Synthetic C1 metabolism in Pseudomonas putida enables strict formatotrophy and methylotrophy via the reductive glycine pathway | mBio
Soluble C1 feedstocks, such as formate and methanol, have gained attention as sustainable substrates for biotechnology, with the potential to reduce greenhouse gas emissions and reliance on sugar-based resources. Despite their promise, the metabolic ...
journals.asm.org
3/4 Our perspective lays out: 1️⃣ A blueprint for designing next-gen synthetic C1 microbes 2️⃣ A roadmap for engineering P. putida into an autotrophic chassis 3️⃣ A circular carbon economy vision, revalorizing CO₂ + waste streams 📊 Together, these steps connect design → engineering → sustainability.
🚀 Thrilled to share our new Nature Communications article: “A blueprint for designing the next-generation of synthetic C1 microbes” We propose a framework to unlock sustainable, carbon-efficient biomanufacturing using non-canonical hosts. 🔗 www.nature.com/articles/s41... A short 🧵1/4
A blueprint for designing the next-generation of synthetic C1 microbes - Nature Communications
Synthetic one-carbon assimilation could contribute to a more sustainable and circular carbon economy, but much work in this field has focused on model microorganisms. Here the authors provide their perspective on the potential value of non-model microbes, and how that potential could be realised.
nature.com
A blueprint for designing the next-generation of #synthetic C1 #microbes @natureportfolio.nature.com / We outline how to engineer non-canonical hosts, apply modeling & C1-inducible promoters & integrate sustainability metrics for carbon-efficient #biomanufacturing www.nature.com/articles/s41...
A blueprint for designing the next-generation of synthetic C1 microbes - Nature Communications
Synthetic one-carbon assimilation could contribute to a more sustainable and circular carbon economy, but much work in this field has focused on model microorganisms. Here the authors provide their perspective on the potential value of non-model microbes, and how that potential could be realised.
nature.com
The very 1st #Course on #SynBio & #Metabolic #Engineering of #Pseudomonas at Cold Spring Harbor Asia successfully completed in Suzhou, #China! Excellent group of students & lecturers, w/time for culture, food & stand-up paddling alongside the science—thanks to all who participated & stay tuned 4+!
Welcome to the social media account of the International Microbiology Literacy Initiative (IMiLI). Nearly 1,000 researchers freely contribute to the IMiLI project integrating microbiology into education providing downloadable resources for all. Explore at imili.org
Who is afraid of HGT? True, antibiotic resistances disseminate through it. But we can also leverage the same channels for spreading good stuff at a very large scale and fortifying the env microbiome with beneficial activities www.biorxiv.org/content/10.1... by Victor Maull & @ricardsole.bsky.social
Synthetic Horizontal Gene Transfer for Ecosystem Restoration
Restoring endangered ecosystems has become a pressing issue as the effects of global warming continue to harm existing communities. Over the last decade, several studies have suggested the use of synt...
biorxiv.org
We are deeply saddened by the news that Andrew D. Hanson (@adhansonlab.bsky.social) is no longer with us. He was an exceptional scientist, mentor, and leader in multiple fields. He constantly reminded us that over-promising would backfire. Rest in peace, Andrew.
Delighted to join #MetabolicEngineering as Associate Editor w/Sang Yup Lee, Jay Keasling, I. Borodina, C. Maranas & C. Wittmann. I'll handle submissions in #SyntheticMetabolism, #Pseudomonas, #SynBio, new-to-nature #bioproduction & #EnvironmentalBiotechnology!
#Synthetic C1 #metabolism in #Pseudomonas putida enables strict formatotrophy and methylotrophy via the reductive glycine pathway—led by J. Turlin, M. G. Alván, @oscarpuiggene.bsky.social w/@stefanodonati.bsky.social & @sebwenk.bsky.social @mbio.bsky.social #SynBio journals.asm.org/doi/10.1128/...
Synthetic C1 metabolism in Pseudomonas putida enables strict formatotrophy and methylotrophy via the reductive glycine pathway | mBio
Soluble C1 feedstocks, such as formate and methanol, have gained attention as sustainable substrates for biotechnology, with the potential to reduce greenhouse gas emissions and reliance on sugar-based resources. Despite their promise, the metabolic ...
journals.asm.org
🔍Problems with synthetic C1 metabolism? The @pabnik.bsky.social group identifies seven major barriers limiting its deployment in microorganisms and proposes specific strategies to overcome each of them. Check out their paper 👉https://doi.org/10.1093/femsre/fuaf011