No work in sight for the next 5 days 🥳🥳🥳. Salcombe birthday celebrations for the legend that is @paulsquires.bsky.social #Salcombe #SalcombeHarbourHotel ##AnnualLeave #Academic #Lifeofanacadenic #Academia #England #Devon
Prof Paul E Squires
@paulsquires.bsky.social
Prof of Biomedical Science with interests in diabetes, cardiorenal & kidney disease, connexins & cell-cell contact, coupling & communication. Views are my own. 👨🔬🔬🇬🇧 #cardiosky #nephsky #diabetes #cardiorenal
This #ASNCJASN study analyzed the effects of empagliflozin, a diabetes medication, on kidney function in young people with type 2 diabetes (T2D), suggesting that empagliflozin may help prevent early diabetic kidney disease in youth with T2D. Read more: kidney.pub/CJASN0889
Mechanistic target of rapamycin complex-2 (mTORc2) mediates the effect of over-night high K+ on Kir4.1/Kir4.1 in the DCT and ENaC/ROMK in ASDN. | American Journal of Physiology-Renal Physiology | American Physiological Society journals.physiology.org/doi/abs/10.1...
Mechanistic target of rapamycin complex-2 (mTORc2) mediates the effect of over-night high K+ on Kir4.1/Kir4.1 in the DCT and ENaC/ROMK in ASDN. | American Journal of Physiology-Renal Physiology | Amer...
We examine the role of mTORc2 in mediating overnight-high-K+-(HK)-intake-induced stimulation of renal-outer-medullary-K+-channels (ROMK) in late distal-convoluted-tubule DCT2)/early connecting-tubule ...
journals.physiology.org
Power relations and role boundaries between community first responders and ambulance clinicians in England: a qualitative study - power relations, hierarchy and role boundaries, characterised by subordination of CFRs and collaborative relationships between ambulance staff and CFRs rdcu.be/eR6fK
Power relations and role boundaries between community first responders and ambulance clinicians in England: a qualitative study
rdcu.be
Our department @ucph.bsky.social is looking for a new faculty member! This is a nice environment for an ambitious PI with a research focus on cardiovascular system, metabolism and/or drug discovery! Happy to answer questions if you are interested!
164414 Tenure Track Assistant Professor or Associate Professor of Biomedical Sciences
jobportal.ku.dk
Wedding Vibes 👰🤵♂💒💍 with @paulsquires.bsky.social ..it was a hot one ☀️☀️☀️ #ArdingtonHouse #Oxfordshire #womeninSTEM #annualleave #summertime #UK #Cotswolds #wedding
Stimulating immune cells in vitro is a common experimental lab model. We profiled 150K blood immune cells treated with 11 different stimuli to compare the effects. The data are freely available for researchers. See the preprint for our findings and to access the data 🧪 doi.org/10.1101/2025...
Delighted to have contributed to this editorial diabetesjournals.org/diabetes/art...
Accelerating Medicines Partnership in Type 2 Diabetes and Common Metabolic Diseases: Collaborating to Maximize the Value of Genetic and Genomic Data
In the last two decades, significant progress has been made toward understanding the genetic basis of type 2 diabetes. An important supporter of this resea
diabetesjournals.org
Fantastic article to celebrate the contribution of our very own @chillslincoln79.bsky.social to some amazing work on #worldkidneyday, see: news.lincoln.ac.uk/2025/03/13/l...
Lincoln Professor Helping Shape the Future of Diabetic Kidney Disease Research | News and PressPrevious posts arrow navigation.Next posts arrow navigation.
Browse through a range of inspiring news stories from the University of Lincoln, featuring leading research, campus events, and student and alumni success stories.
news.lincoln.ac.uk
I have funding through at least 2031 for postdoctoral researchers with expertise in islet biology or cell-based therapies for, or modelling of, diabetes. Bring your expertise to a country that values it. 🇨🇦 Contact info on my website.
Fantastic opportunity for fellowship in an excellent T1D research training environment working in regenerative medicine and stem cells in the Breakthrough T1D Centre of Excellence at UBC. If you missed the NOI deadline, no worries, you can still apply! Reach out if you have any questions.
Stem Cell Network@stemcellnetwork.ca · 2y agoAre you applying for the J. Andrew McKee Fellowship in Type 1 Diabetes? Supported by SCN and Breakthrough T1D (formerly JDRF), this is your chance to join UBC’s Breakthrough T1D Centre of Excellence. Submit your application by February 27, 2025. ➡️ stemcellnetwork.ca/training/exc...
Effect of #sotagliflozin on major adverse cardiovascular events: a prespecified secondary analysis of the SCORED randomised trial 👩🔬🥼🧪👨🔬 #cardiosky #SGLT2i #SGLT1/2 #cardiovascular #womeninstem #NephSky 👇👇👇 www.thelancet.com/journals/lan...
Effect of sotagliflozin on major adverse cardiovascular events: a prespecified secondary analysis of the SCORED randomised trial
Sotagliflozin reduced MACE, with independent reductions in myocardial infarction and stroke, among patients with type 2 diabetes, chronic kidney disease, and additional cardiovascular risk. The ischae...
thelancet.com
A sunday night worth celebrating with @paulsquires.bsky.social after a busy, busy week 🥂🍾. Hopeful that good news will follow 👩🔬👨🔬🧪 #justbecause #cardiosky #NephSky #womeninSTEM #academic #weekendvibes #champagne ##KidneyResearch #CardioRenal #Cardiovascular
Birthday boy cotswolds celebrations 🥳🥳 @DoubleRedDuke with @paulsquires.bsky.social 🥰🥰 #birthday #cotswolds #England #annualleave #womeninSTEM
📣 Novo Nordisk announces that the FDA has granted approval to its blockbuster drug Ozempic (semaglutide) to treat chronic kidney disease (CKD) in adults with type 2 diabetes. 👩🔬🥼🧪👨🔬 #Semaglutide #diabetes #type2diabetes #nephropathy #GLP-1 👇👇 docwirenews.com/post/fda-app...
FDA Approves Ozempic for Kidney Disease | Docwire News
Based on FLOW trial results, the FDA has approved Ozempic (semaglutide) to treat chronic kidney disease (CKD) in adults with type 2 diabetes.
docwirenews.com
📣 Semaglutide in patients with overweight or obesity and chronic kidney disease without diabetes: a randomized double-blind placebo-clinical trial @naturemedicine.bsky.social 👩🔬🥼🧪👨🔬 #Semaglutide #KidneyDisease #Obesity #kidney #NephroSky #CardioSky #NephSky 👇👇👇 pubmed.ncbi.nlm.nih.gov/39455729/
Semaglutide in patients with overweight or obesity and chronic kidney disease without diabetes: a randomized double-blind placebo-controlled clinical trial - PubMed
Semaglutide reduces albuminuria and the risk of kidney disease progression in patients with type 2 diabetes and chronic kidney disease (CKD). We conducted a randomized placebo-controlled double-blind ...
pubmed.ncbi.nlm.nih.gov
BBC News - Meon Vale mother of three who needs kidney makes donor appeal - BBC News www.bbc.co.uk/news/article...
Meon Vale mother of three who needs kidney makes donor appeal
Amber Simmonds, 29, has lived with hereditary polycystic kidney disease (PKD) since she was 13.
bbc.co.uk
BREAKING NEWS: The FDA has approved Ozempic for patients with chronic kidney disease. This means the popular injection can be used to reduce the risk of kidney disease worsening, kidney failure and death from cardiovascular disease in patients with chronic kidney disease and diabetes.
FDA approves Novo Nordisk's Ozempic to treat chronic kidney disease in those with diabetes, expanding its use
Expanded Ozempic approval in the U.S. could transform how doctors treat patients with chronic kidney disease, which involves a gradual loss of kidney function.
cnbc.com
Congratulations @cardiacshah.bsky.social & co-author @jo-ward08.bsky.social from team #CardioRenal on publication of this all important review - incorporating clinical guidelines with latest evidence & experience in the management of T2DM in patients with ASCVD 🥳🥳🥳🥳. #diabetes #CardioSky #NephSky
Usman@cardiacshah.bsky.social · 2y agowww.frontiersin.org/journals/end... Pleased to see this review article getting published where we incorporate clinical guidelines with latest evidence and experience in the management of T2DM in patients with ASCVD. Very grateful to all the coauthors for the help and input.
Beautiful #Salcombe, it never disappoints. The perfect place to switch off and unwind with @paulsquires.bsky.social 🥰🥰 #Lifeofanacademic #AcademicSky ##CardioSky #WomeninSTEM #England #Devon #SalcombeHarbour #Coastal #Coastline #NephroSky
📣 Congratulations to my PhD student @cardiacshah.bsky.social on his review 'Diagnosis & management of type 2 diabetes mellitus in patients with ischaemic heart disease & acute coronary syndromes - a review of evidence & recommendations' 👇👇 #CardioSky #diabetes www.frontiersin.org/journals/end...
Frontiers | Diagnosis and management of type 2 diabetes mellitus in patients with ischaemic heart disease and acute coronary syndromes - a review of evidence and recommendations
frontiersin.org
Checking out of all things work for the next 9 days with @paulsquires.bsky.social. Heading to Salcombe for sea air, coastal walks and yummy food and wine 🫒🍲🥖🥂🍷. Stay tuned for glorious pictures of the English Coast 🌊🌊 #FancyPants are on 😉 #WomeninSTEM #Weekend #Salcombe #England #Coastal
Bracing but beautiful day in Salcombe with @paulsquires.bsky.social ❤️ #Salcombe #Devon #AnnualLeave #womeninSTEM #CardioSky #NephroSky
Our special issue for DiabeticMedicine entitled 'From Bench to Bedside: An integrated and multi-disciplinary approach to tackling diabetic kidney disease' is available online now. 👇👇 #KidneyDisease #Diabetes #NephSky #KidneyResearch #Diabetes #CardioSky onlinelibrary.wiley.com/toc/14645491...
<em>Diabetic Medicine</em> | Diabetes UK Journal | Wiley Online Library
Click on the title to browse this issue
onlinelibrary.wiley.com
A glorious walk today, albeit a slightly freezing day in Kenilworth. ❄️❄️❄️ #academicsky #cardiosky #nephsky #Warwickshire #saturday #countrylife #womeninSTEM
3 days back at work. Let's just say this wine is well deserved 🤣🤣. Thank heavens I have @paulsquires.bsky.social by my side to keep me sane 😬 #WomeninStem #cardiosky #Nephsky #academiclife #drama #womeninnephro
Metabolite-mediated inter-tissue signalling. Led by Jane Luk & Mark Kearney @unileedsnews.bsky.social in @naturecomms.bsky.social we identify malonic acid as an IGF1R-regulated endothelial-to-adipocyte metabokine mediating adipose metabolism. Great start to 2025. www.nature.com/articles/s41...
Paracrine role of endothelial IGF-1 receptor in depot-specific adipose tissue adaptation in male mice - Nature Communications
Here the authors show that lowering IGF-1R levels in endothelial cells improves insulin sensitivity, boosts energy use, and supports beneficial changes in adipose tissue, offering insights into potent...
nature.com
Interested in #GLP-1 , #Semaglutide #cardiovascular and #kidneydisease ? 👩🔬🥼🧪🧪Just out @thelancet.bsky.social 👇👇. Thanks for sharing @paulsquires.bsky.social 👍 #CardioSky #NephSky #diabetes #kidneys #womeninSTEM
Prof Paul E Squires@paulsquires.bsky.social · 2y agoGreat read to start 2025 #GLP1 #semaglutide #diabetes #diabetesuk #cardiorenal #GLP1RA www.thelancet.com/journals/lan...
Great read to start 2025 #GLP1 #semaglutide #diabetes #diabetesuk #cardiorenal #GLP1RA www.thelancet.com/journals/lan...
Effects of GLP-1 receptor agonists on kidney and cardiovascular disease outcomes: a meta-analysis of randomised controlled trials
We found evidence that GLP-1 receptor agonists significantly reduce clinically important kidney events, kidney failure, and cardiovascular events.
thelancet.com
#BHF #diabetes #T2DM #trials #DUK Exciting use of #AI in diabetes diagnosis. BBC News - Hospitals trial AI to spot type 2 diabetes risk www.bbc.com/news/article...
Hospitals trial AI to spot type 2 diabetes risk
The system checks patients' ECG heart traces for subtle early warning signs.
bbc.com