New paper! 🚀 A high-affinity anti- #mNeonGreen #nanobody turns #mNG into a #multifunctional Tag. @nanotag.bsky.social decided to openly share the #nanobody for research use. Not common, but we strongly believe well-defined reagents are key for reproducible science. We hope you find it useful! 💚

Our project of ten years is finally out today @natcellbio.nature.com. Huge thanks for the tour de force to first author @nina-kozlova.bsky.social and all the co-authors, collaborators, and of course the whole Muranen lab. rdcu.be/ffBUb

Cancer-associated fibroblasts regulate DNA repair in pancreatic cancer through NDRG1-mediated R-loop processing

Nature Cell Biology - Kozlova et al. report a functional role for NDRG1 in regulating R-loops and DNA repair, thereby linking cancer-associated fibroblast-derived extracellular matrix to...

rdcu.be

Oh, I feel the pressure building up... 🧪

LINXS@linxsinstitute.bsky.social · 2y ago

Come meet our ChemLife guest researcher @petrikursula.bsky.social next month when he gives his seminar on The self-assembling proteolipid structure of myelin! Details: www.linxs.se/events/2025-...

First post over here! And it’s a link to our NDRG1 preprint!

bioRxivpreprint@biorxivpreprint.bsky.social · 2y ago

A novel DNA repair protein, N-Myc downstream regulated gene 1 (NDRG1), links stromal tumour microenvironment to chemoresistance https://www.biorxiv.org/content/10.1101/2025.01.22.634323v1

Choose 20 books that have stayed with you or influenced you. One book per day for 20 days, in no particular order. No explanations, no reviews, just covers. #BookSky #BookChallenge #Books Day #9

Choose 20 books that have stayed with you or influenced you. One book per day for 20 days, in no particular order. No explanations, no reviews, just covers. #BookSky #BookChallenge #Books Day #8

6️⃣6️⃣ Dorothy June Sutor (1929-1990) 🇳🇿 #womeninSTEM New Zealand crystallographer. She was the first to establish the existence of C - H ⋯ O hydrogen bonds in crystals in 1962. Her work was wrongly criticised by Jerry Donohue. www.chemistryworld.com/features/the...

Choose 20 books that have stayed with you or influenced you. One book per day for 20 days, in no particular order. No explanations, no reviews, just covers. #BookSky #BookChallenge #Books Day #7

Over 60 German and Austrian universities, the German Federal Court of Justice and multiple top German football clubs have announced that they will be withdrawing from Twitter (X), due to US oligarch Elon Musk's "discussion" (collaboration) with Germany's neo-Nazi party (AfD) Alice Weidl.

Choose 20 books that have stayed with you or influenced you. One book per day for 20 days, in no particular order. No explanations, no reviews, just covers. #BookSky #BookChallenge #Books Day #6

Choose 20 books that have stayed with you or influenced you. One book per day for 20 days, in no particular order. No explanations, no reviews, just covers. #BookSky #BookChallenge #Books Day #5

Näin tiede asetetaan poliittiseen kontrolliin. "Akatemian tehtävien hoitaminen ei saa olla ristiriidassa Suomen kansallisen turvallisuuden, Suomen kansainvälisten velvoitteiden tai Suomen ulko- ja turvallisuuspolitiikan kanssa." suomenkuvalehti.fi/mielipide/ku...

Kukaan ei huomannut uutista: hallitus vaatii huomioimaan ”turvallisuuteen liittyvät näkökohdat” tutkimuksen rahoituksessa

Luulisi, että esitys herättäisi uutisnälkäisessä toimittajassa kysymyksiä. Aletaanko Suomen Akatemiassa valvoa arvopohjaisen realismin noudattamista? kirjoittaa Anu Koivunen.

suomenkuvalehti.fi

Choose 20 books that have stayed with you or influenced you. One book per day for 20 days, in no particular order. No explanations, no reviews, just covers. #BookSky #BookChallenge #Books Day #4

Choose 20 books that have stayed with you or influenced you. One book per day for 20 days, in no particular order. No explanations, no reviews, just covers. #BookSky #BookChallenge #Books Day #3

Had a little holiday break but here we go again... Choose 20 books that have stayed with you or influenced you. One book per day for 20 days, in no particular order. No explanations, no reviews, just covers. #BookSky #BookChallenge #Books Day #2

Choose 20 books that have stayed with you or influenced you. One book per day for 20 days, in no particular order. No explanations, no reviews, just covers. #BookSky #BookChallenge #Books Day #1

#finland still has a lot to learn #racism www.theguardian.com/world/2024/d...

Black woman targeted by racist abuse in Finland over festival role

Finnish PM apologises to Daniela Owusu after she received hate messages after becoming first Black woman to represent Saint Lucia

theguardian.com

One more preprint out - Santa can come now! www.biorxiv.org/content/10.1... 🧪

Paratope mapping of tilvestamab, an anti-AXL function blocking antibody, using high-throughput bacterial expression of secreted scFv-ompY fusion proteins

Targeting AXL with a highly selective antibody presents a promising approach for inhibiting AXL and potentially improving cancer treatment. An essential step in antibody optimisation is the mapping of...

biorxiv.org

...and there we have it - the first paper for 2025 😀 onlinelibrary.wiley.com/doi/10.1111/...

Nanobodies against the myelin enzyme CNPase as tools for structural and functional studies

The enzyme 2′,3′-cyclic nucleotide 3′-phosphodiesterase (CNPase) is abundant in non-compact myelin. While its in vitro catalytic activity is well understood, the in vivo function of CNPase remains un...

onlinelibrary.wiley.com

My 1st post in bsky is about our latest paper of 2024. Excellent collaboration with @petrikursula.bsky.social @myelincentric.bsky.social & Bradley Zuchero labs. We characterized a set of 🦙 #nanobodies binding myelin protein CNPase. It is online at @jneurochem.bsky.social: dx.doi.org/10.1111/jnc....

Thrilled to share our latest paper in PNAS! We enhanced SAXS with noncanonical amino acid labels to extract both RG and RE of IDPs, addressing key discrepancies in biophysical measurements. Big thanks to Lemke Lab for the amazing ASAXS-inspired T-shirt! www.pnas.org/doi/10.1073/...

Interested in structural biology, membrane proteins, biophysics and working onto understand hormone transport in plants?☘️🔬👩‍🔬🧪 We are recruiting a postdoc: - Deadline 20. Dec 2024. - 2(+2) year position. - Details and application link: tinyurl.com/y7vnewen - PM for questions Please repost 💚

Postdoctoral position in biophysical and structural characterization of auxin transport, Aarhus University, Denmark - Vacancy at Aarhus University

Vacancy at Department of Molecular Biology and Genetics - Protein Science, Aarhus University

tinyurl.com

Latest from the lab now out as a preprint 😇🧪

bioRxivpreprint@biorxivpreprint.bsky.social · 2y ago

Structural analysis of tilvestamab in complex with AXL https://www.biorxiv.org/content/10.1101/2024.12.04.626834v1

Last lecture of 2024 is DONE! 🧪🎓🤠

Well, this is unlikely to happen again any time soon...I have submitted 5 funding applications within 2 days. 🧪 #science #funding

Calling Recent PhDs! The PULSE postdoc program at SciLifeLab is opening soon, matchmaking portfolio now published! 🧪🌍🖥️🧬 The program welcomes researchers from all over the world – 48 in total, in an academic and an entrepreneurial track. #MolBiol #AcademicSky #PlantSciJobs

I can only agree! The meeting was excellent, and lots of new ideas and motivation! Who knows - maybe next time there will be more nice protein structures to show! 😇

Julia Edgar@juliae.bsky.social · 2y ago

The Myelin Network meeting in Kassel was simply terrific! Thanks to the organisers @myelincentric.bsky.social @axoglia.bsky.social @Tanya Kuhlmann. Exciting science and excellent socialising.

go.bsky.app/Lyzro3M !WELCOME! thought we might need a starter pack for all those coming over from the birdhouse - here's a GliaSky list. apologies for missing many of you - please do reply to get added and remember to repost so the newbies can find us!

So many people added to pack 1 this weekend we had to make pack 2. Makes sure you refresh for followers on pack one to see them all! 🧶🧬 go.bsky.app/DDetSBp