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Edwin Antony

@professorantony.bsky.social

Professor of Biochemistry at St. Louis University School of Medicine. Passionate about mechanistic & structural enzymology, electron transfer & nucleic acid binding enzymes. Fascinated by Cryo-EM, kinetics, single molecules and student training. Golf Nut!

206 Posts2148 Follower2731 Folgt
Miloš Tišma@tismaa.bsky.social · 2w ago

I'm happy to share the first paper from my postdoc work: www.biorxiv.org/content/10.6... How does RecA find one homologous sequence in an entire chromosome -and what turns that encounter into a repair-competent one? We find that DNA topology is the gatekeeper !! 1/10

Chromosome topology gates productive RecA homology search

In homologous recombination, DNA repair depends on recombinase filaments finding homologous templates on chromosomes whose topology is continually remodeled by replication and transcription. How dynam...

biorxiv.org

@trisre.bsky.social · last mo.

1/ Happy to share our preprint! The Mtr complex catalyses the second-to-last step of the methanogenesis and is an essential bioenergetic machine in most methanogenic archaea. Anaerobic cryo-EM of Mtr reveals a nitrogenase-like metallocluster bound at its active site! www.biorxiv.org/content/10.6...

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Kathrin Lang@klanglab.bsky.social · 5mo ago

🚨 Our new paper is out! 🙌 Bioorthogonal reactions often create bulky, non-native linkages-great for labeling, but not ideal for installing natural PTMs. We combine GCE with a chemoselective amide-bond forming reaction to install site-specific acylation PTMs. www.cell.com/chem/fulltex... 1/4

A modular genetic code expansion approach to site-specific lysine acylations

A modular strategy combining genetic code expansion with a selective amide bond-forming reaction enables the site-specific installation of lysine acylations on folded proteins. Acylboronates react sel...

cell.com

Ben Larson@blarson.bsky.social · 6mo ago

If you're interested in the regulation and/or evolution of complex cell behavior, this could serve as an opportunity to join our lab as a postdoc. I would be happy to consult on proposal development if we've got a good alignment of goals, skills, and interests. DMs or emails welcome.

Colin Carlson@colincarlson.bsky.social · 6mo ago

Holy shit: it's an RFP for the NSF Postdoctoral Research Fellowship in Biology (PRFB). Hello old friend www.nsf.gov/funding/oppo...

The EMBO Journal@embojournal.org · 8mo ago

New methods article: David Fay et al integrate endogenous TurboID labeling and data-independent acquisition mass-spectrometry for in vivo proximity labeling link.springer.com/article/10.1...

Integrating endogenous TurboID and data-independent acquisition mass spectrometry for in vivo proximity labeling - The EMBO Journal

Proximity labeling has emerged as a powerful approach for identifying protein–protein interaction networks within living systems, particularly those involving weak or transient associations. Here, we ...

link.springer.com

Edwin Antony@professorantony.bsky.social · 8mo ago

What does phosphorylation do to RPA? This has been a long-standing question in the field of genome integrity. In our newest publication in Nature Communications rdcu.be/eT4z3 with @proforiganti.bsky.social , we reveal the answer. Thanks to funding from NIGMS to our groups.

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ALT: a man is sitting on a couch with his arms outstretched and making a funny face .

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Sofi Origanti@proforiganti.bsky.social · 8mo ago

This was another fun collaboration with @professorantony.bsky.social and big thanks to lead authors (Poonam Roshan, Ayush Mistry and Vikas Kaushi) and to all the co-authors. www.nature.com/articles/s41...

Edwin Antony@professorantony.bsky.social · 10mo ago

This is super cool! Congratulations on a fantastic study. Looking forward to trying out these tricks in our ncAA incorporation setup.

Kathrin Lang@klanglab.bsky.social · 10mo ago

🚨Our paper is out! 🥳 Hijacking a bacterial ABC transporter for efficient genetic code expansion. Many congrats to everyone involved - a multi-year effort led by @taruniype.bsky.social @maxfottner.bsky.social www.nature.com/articles/s41... it all started years ago with a failed experiment 🧵👇 1/9

Kathrin Lang@klanglab.bsky.social · 10mo ago

🚨Our paper is out! 🥳 Hijacking a bacterial ABC transporter for efficient genetic code expansion. Many congrats to everyone involved - a multi-year effort led by @taruniype.bsky.social @maxfottner.bsky.social www.nature.com/articles/s41... it all started years ago with a failed experiment 🧵👇 1/9

Hijacking a bacterial ABC transporter for genetic code expansion - Nature

Bacterial ATP-binding cassette (ABC) transporters can be utilized and engineered to transport non-canonical amino acids into Escherichia coli for highly efficient synthesis of proteins with novel func...

nature.com

@giovanniconsoli.bsky.social · 10mo ago

Have you ever looked at the night sky and wondered if there’s a chlorophyll f in the reaction centre of Photosystem I from far-red light adapted cyanobacteria? 🦠 Well, we did (don’t judge) and the work that followed is now out as a First Release in @science.org www.science.org/doi/10.1126/...

Locating the missing chlorophylls f in far-red photosystem I

The discovery of chlorophyll f-containing photosystems, with their long-wavelength photochemistry, represented a distinct, low-energy paradigm for oxygenic photosynthesis. Structural studies on chloro...

science.org

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Florian Roisné-Hamelin@roisnehamelinf.bsky.social · 10mo ago

Delighted to announce our latest work on how Wadjet loads onto and establishes topological entrapment of plasmid DNA prior to initiating loop extrusion. At @gruberlab.bsky.social, Dubochet Center for Imaging and BSI @igbmc.bsky.social www.cell.com/molecular-ce...

Mechanism of DNA entrapment by a loop-extruding Wadjet SMC motor

Wadjet is an SMC-based prokaryotic defense system that eliminates plasmid DNA. Roisné-Hamelin et al. present structures capturing key steps of its DNA-loading mechanism. This work reveals how Wadjet t...

cell.com

Stephan Gruber@gruberlab.bsky.social · 10mo ago

How do SMC complexes load onto DNA to get ready for loop extrusion? @roisnehamelinf.bsky.social & co discovered that Wadjet, an SMC complex involved in bacterial DNA immunity, performs some impressive molecular gymnastics 🤸‍♂️🤸‍♂️🤸‍♂️. Check out the new paper: www.cell.com/molecular-ce...

Edwin Antony@professorantony.bsky.social · 10mo ago

Spread the word if you can. We have an unused stopped flow accessory from Applied Photophysics. We traded in our Chirascan CD instrument so we have no use for this anymore. Reach out if you are interested and can find a home for this setup. Will ofcourse only work with a Chirascan!

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