Philip Dunne
@profpipdunne.bsky.social
Phenotypic plasticity in colorectal cancer. Group leader at QUB Belfast and CRUK Scotland Institute. CRUK-SI: https://tinyurl.com/5fr9n2ew QUB: https://tinyurl.com/4b68vf56
1/ Delighted to share our paper out today in Nature: ZFP36L2 orchestrates stress-adaptive plasticity in regeneration and cancer. We found the switch that lets differentiated cells rewind into stem cells — in gut repair, and in metastasis. 🧵 doi.org/10.1038/s415...
ZFP36L2 orchestrates stress-adaptive plasticity in regeneration and cancer - Nature
The RNA-binding protein ZFP36L2 mediates stress-adaptive plasticity in intestinal regeneration and colorectal cancer metastasis.
doi.org
#EACR2026 such a disappointment, eventually an acknowledgment that they can’t cater for coeliacs, but will do better next year.. only took 2 days of misinformation Really poor setup @helloeacr.bsky.social
Philip Dunne@profpipdunne.bsky.social · 4mo agoDay 2 at #EACR2026 and still no gluten free food, been sent to 3 different places and no one wants to deal with this. Utter shambles @helloeacr.bsky.social
Day 2 at #EACR2026 and still no gluten free food, been sent to 3 different places and no one wants to deal with this. Utter shambles @helloeacr.bsky.social
Philip Dunne@profpipdunne.bsky.social · 4mo agoAbsolutely no gluten free food options available at the #EACR2026 conference, food verdors not interested and no help from anyone at help desk other than telling me to leave the conference.. Any help please @helloeacr.bsky.social ??
Absolutely no gluten free food options available at the #EACR2026 conference, food verdors not interested and no help from anyone at help desk other than telling me to leave the conference.. Any help please @helloeacr.bsky.social ??
The brilliant Raheleh presenting her work at @helloeacr.bsky.social in Budapest. Supported by @cruk-si.bsky.social @crukpolicy.bsky.social @aicri.bsky.social
What’s a bioinformaticians favourite TV station? The tSNE channel.. 🥁
Finally out! A longstanding project to explore the mechanism behind ectopic crypt formation in polyps when GREM1 is aberrantly expressed in HMPS patients. Turns out it is all to do with stromal remodelling and epithelial-mesenchymal interdependence! www.nature.com/articles/s41...
Epithelial GREMLIN1 disrupts intestinal epithelial-mesenchymal crosstalk to induce a wnt-dependent ectopic stem cell niche through stromal remodelling - Nature Communications
The authors show that aberrant epithelial GREM1 expression remodels intestinal stroma to form ectopic stem cell niches in mice. Anti-GREM1 reversed these changes, highlighting a potential strategy for...
nature.com
New review on the importance of intestinal epithelial-mesenchymal crosstalk - from development and homeostasis through to regeneration to neoplasia. Excellent collaboration with Frances England, Manquiang Lin and Michael Sigal www.nature.com/articles/s41...
Defining the mucosal ecosystem: epithelial–mesenchymal interdependence in gastrointestinal health and disease - Nature Reviews Gastroenterology & Hepatology
This Review focuses on epithelial–mesenchymal crosstalk and how these interactions shape development, health and disease in the intestinal mucosa. The dynamic nature of this ecosystem is highlighted, ...
nature.com
And the original publication is here: Uridine phosphorylase-1 supports metastasis by altering immune and extracellular matrix landscapes | EMBO reports share.google/JXMzGDRzpl0E...
Uridine phosphorylase-1 supports metastasis by altering immune and extracellular matrix landscapes | EMBO reports
imageimageMetastatic primary tumours upregulate Upp1 in neutrophils, which elevates circulating uracil. UPP1-expressing neutrophils accumulate in the lung where they inhibit CD8+ T cells, promote fibronectin deposition and support metastatic niche ...
share.google
It was a pleasure to speak to Lucy Whyte this morning on #BBCRadioScotland to discuss our recent @emboreports.org publication which has discovered how #neutrophil #metabolism facilitates #metastasis. Catch up with interview here: www.youtube.com/watch?v=tUUw...
Dr Cassie Clarke CRUK Scotland Institute - breast cancer research
YouTube video by Fiona MacLeod
youtube.com
✨Thrilled to announce an exciting opportunity to work on our project exploring WNT-driven cell competition as a novel preventative strategy in CRC 🧬 We’re hiring a Senior Scientific Officer to join me in @owen_sansom’s lab. Great science and lots of room to make an impact! 👩🏽🔬
Cancer Research UK Scotland Institute@cruk-si.bsky.social · last yr.We are recruiting a Senior Scientific Officer to work with @nadianasreddin.bsky.social in the Sansom lab on the project WNT-driven cell competition: a target for novel preventative strategies against colorectal adenoma formation 📅Apply by 15 August 2025 www.crukscotlandinstitute.ac.uk/careers/
Excellent opportunity to work with a wonderful team 👇👇💥
Nadia Nasreddin@nadianasreddin.bsky.social · last yr.✨Thrilled to announce an exciting opportunity to work on our project exploring WNT-driven cell competition as a novel preventative strategy in CRC 🧬 We’re hiring a Senior Scientific Officer to join me in @owen_sansom’s lab. Great science and lots of room to make an impact! 👩🏽🔬
We are recruiting a Senior Scientific Officer to work with @nadianasreddin.bsky.social in the Sansom lab on the project WNT-driven cell competition: a target for novel preventative strategies against colorectal adenoma formation 📅Apply by 15 August 2025 www.crukscotlandinstitute.ac.uk/careers/
Sunshine and science in Glasgow today at the CRC-STARS kick off meeting Excellent presention from Raheleh in our team charting phenotypic evolution during cancer development and progression, and how best we can use preclinical models of cancer to improve patient outcomes
AACR.. over and out! Great couple of days in Chicago, brilliant to catch up with so many collaborators and make new connections. Coming home brimming with new ideas to take into our @cruk-si.bsky.social early detection, @incise-research.bsky.social, & CRC-STARS programmes #AACR25
Philip Dunne@profpipdunne.bsky.social · last yr.If you are Chicago bound watch out for Natalie & Sid presenting at #AACR2025 & come say hello! Natalie's @theaacr.bsky.social Women in Cancer Research award talk covers how we can use biology to improve early detection of polyps Sid's poster is on early tumour transcriptional landscapes
Incredibly proud to see Dr Fisher presenting her research at the @theaacr.bsky.social annual conference. Understanding precancer biology is crucial for improving early detection, and preventing early cancer development and progression. #AACR25 @nataliefisher.bsky.social
Philip Dunne@profpipdunne.bsky.social · last yr.If you are Chicago bound watch out for Natalie & Sid presenting at #AACR2025 & come say hello! Natalie's @theaacr.bsky.social Women in Cancer Research award talk covers how we can use biology to improve early detection of polyps Sid's poster is on early tumour transcriptional landscapes
Session with Natalie’s talk starting shortly in room E351
Philip Dunne@profpipdunne.bsky.social · last yr.If you are Chicago bound watch out for Natalie & Sid presenting at #AACR2025 & come say hello! Natalie's @theaacr.bsky.social Women in Cancer Research award talk covers how we can use biology to improve early detection of polyps Sid's poster is on early tumour transcriptional landscapes
Sarah Aitken@s-j-aitken.bsky.social · 2y agoMy lab at hiring! - we have TWO postdoc positions (one computational, one wet lab focussed) at Yale @yaleschoolofmed.bsky.social, working closely with our group members at University of Cambridge, UK @cambridgeuni.bsky.social Please help to spread the word! Adverts with full details below ⬇️
If you are Chicago bound watch out for Natalie & Sid presenting at #AACR2025 & come say hello! Natalie's @theaacr.bsky.social Women in Cancer Research award talk covers how we can use biology to improve early detection of polyps Sid's poster is on early tumour transcriptional landscapes
Network members secure new #funding aimed at developing new and personalised #therapeutic approaches for #ColorectalCancer nmgn.mrc.ukri.org?p=1808&previ... @drpipdunne.bsky.social @cancerresearchuk.org @cruk-si.bsky.social
Bowel Cancer in the Spotlight as Network Members Lead New Research Towards Personalised Treatment | National Mouse Genetics Network
MRC National Mouse Genetics Network (NMGN) members from the Cancer Cluster and the new Data Platform initiative are at the centre of a new project announced on the 31st of […]
nmgn.mrc.ukri.org
Members of IMPACT span wet-lab scientists, pathologists, bioinformaticians, patient involvement managers, image analysts, technicians, clinicians, students, project managers, and lecturers among others, to ensure a wide range of expertise and optimum resource management!
With 5 distinct research groups led by @joedwardswwcrc.bsky.social, Campbell Roxburgh, Nigel Jamieson, Colin Steele, and @mcsorleystephen.bsky.social, IMPACT provides a human tissue-based translational research infrastructure in Glasgow, in collaboration with @drpipdunne.bsky.social and Xiao Fu! 🤝
Last week, the 1st Annual IMPACT conference took place on the shores of Loch Lomond 📍🤩
An absolutely brilliant few days in sunny Loch Lomond with my Glasgow colleagues 🏴☘️☀️
Edwards Lab@labedwards.bsky.social · 2y agoLast week, the 1st Annual IMPACT conference took place on the shores of Loch Lomond 📍🤩
Many thanks WntUK ECR rep @nadianasreddin.bsky.social from @cruk-si.bsky.social for chairing the Future Generation session! #WNTUK2025
Congrats to @zanivanlab.bsky.social for this very interesting review: www.cell.com/cell-reports...
The tumor microenvironment is an ecosystem sustained by metabolic interactions
Cancer-associated fibroblasts and immune cells are known to interact within the tumor microenvironment and influence each other to impact on tumor progression. Here, Kay et al. discuss how they can al...
cell.com
A St Patrick’s Day treat ☘️ More excellent work from @aideenryan.bsky.social and her team, teasing apart the importance of stromal & immune communication networks in colorectal cancer 👇
bioRxiv Cancer Bio@biorxiv-cancer.bsky.social · 2y agoStromal cells modulate innate immune cell phenotype and function in colorectal cancer via the Sialic acid/Siglec axis https://www.biorxiv.org/content/10.1101/2025.03.14.642985v1
Stromal cells modulate innate immune cell phenotype and function in colorectal cancer via the Sialic acid/Siglec axis https://www.biorxiv.org/content/10.1101/2025.03.14.642985v1
