The 6th New York Area Cryo-EM meeting will be held on May 27th, 2026 at NYU Langone Medical Center. This year, Dr. Jean-Paul Armache from Penn State University will be the Keynote Speaker. #cryoem #newyork There are a few spots left, if you are planning to attend register at: tinyurl.com/bdft8yx3

We are recruiting postdocs to work on antimicrobial resistance and bacterial cell envelope biology. PLEASE SHARE.

Added a little script to chimerax-trimmings to automate the creation of panels for model-map fit figures. It zones the map around (by default) 40aa parts of each chain (but doesn't cut in the middle of helices). Saves each as a png, metadata to csv. Saves each view as a scene for tweaking views.

Great day at NYSBC, thanks for having me! 😊 If anyone wants to try out the tutorial, here it is: www.dropbox.com/scl/fi/054cm... There are linked videos for each step in the PDF, or I have also prepared the whole thing as a .PPT with embedded videos (2.7GB): www.dropbox.com/scl/fi/jnl9h...

Edward T Eng@edwardteng.bsky.social · 5mo ago

Day 5 @olibclarke.bsky.social did double duty talking about model building & validation and giving a Coot/chimeraX tutorial. Also Justin Flatt from the @rcsbpdb.bsky.social shared best practices for #cryoEM deposition & validation.

The data is in: the NIH goalposts have shifted. What were once almost certain fundable scores have become coin flips and what used to be likely grants have become aspirational, leading to fewer awards. Another manifestation of how HHS policies have led to fewer awards and less science.

Looking forward to #BPS2026 in San Francisco? Come by the NIH sponsored Transformative High-Resolution Cryo-Electron Microscopy National Centers for #CryoEM at booth 410. Our mission is to broaden access to high-resolution cryo-electron microscopy and tomography technologies - cryoemcenters.org

I'm happy to share that our work describing the #cryoEM #structure of the glycosyltransferase ArnC from Salmonella enterica has been published in Nature Communications. #membrane #protein #PetrouLab The article is open access and available at: www.nature.com/articles/s41...

Structural basis of undecaprenyl phosphate glycosylation leading to polymyxin resistance in Gram-negative bacteria - Nature Communications

The study reveals the structure of ArnC, a membrane glycosyltransferase that modifies undecaprenyl phosphate with aminoarabinose (L-Ara4N), leading to polymyxin resistance. The structure of ArnC in tw...

nature.com

“NIH will not issue noncompeting continuation awards for existing projects until the SBIR/STTR program is reauthorized. “

Jeremy Berg@jeremymberg.bsky.social · 9mo ago

Notice of early expiration of NIH SBIR/STTR funding announcements. grants.nih.gov/grants/guide... If anyone knows the backstory, please share.

**Job Alert** Exciting postdoc position available: theoretical and experimental cryo-EM studies of flexible biomolecules. Competitive salary, collaborative environment at NYSBC and Flatiron Institute. Please share!! and contact: pcossio@flatironinstitute.org

🚨🧠🔬 A major breakthrough in molecular neuroscience: I am excited to share a new story from our lab, published in accelerated format today by @nature.com: "Delta-type glutamate receptors are ligand-gated ion channels" Read more here (free article link): rdcu.be/eGIKz

For non-scientists: the funding rate is somewhere between 7% to ~25% (rare) for NIH or NSF grants, depending on where you are applying. Grants are reviewed by a panel of peers who read the grants, score them, then debate the ratings for 1-2 days to rank them. It is INCREDIBLY competitive already.

Max Kozlov@maxkozlov.bsky.social · last yr.

Republican Senator Katie Britt: We need to create a system "where the beat idea wins... This is our opportunity to make a dollar go further and to make it have a greater impact." (NIH already generates $2.56 for every $1 spent it spends on research.)

Read preprints. Cite preprints. Email people and tell them you loved their preprint. Email people you hated their preprint. Embrace preprints, preprints are good.

That specifically right there is the sound of science in the US dying

Jeremy Berg@jeremymberg.bsky.social · last yr.

F mechanisms (New and Competitive renewals) Oof! 3/n

🚨 Amazing Opportunity 🚨 U Alberta is looking for a director for their new #cryoEM facility Support excellent researchers (who are really nice people) using state-of-the-art infrastructure. + reasonable cost of living + near some of most beautiful places in world + 🇨🇦 apps.ualberta.ca/careers/post...

Registration is now open for the 4th Structural Biology Symposium. Poster abstract submission is due on 4/15/2025. isb.med.upenn.edu/4th-structur... 🧬@Structuralbiology

Wondering if your PO, SRO, or other NIH official is still at NIH? Tara pointed out this useful search tool. Unfortunately my MIRA PO, who just took over this portfolio in December, is no longer listed. 💔

Tara Fischer@tarafisch.bsky.social · last yr.

Check ned.nih.gov/search/

openRxiv has arrived! We’re thrilled to announce the launch of openRxiv as an independent, researcher-led nonprofit to oversee bioRxiv and medRxiv, the world’s leading preprint servers for life and health sciences. openrxiv.org/introducing-... #openRxiv #OpenScience #Preprints #bioRxiv #medRxiv

🎉 bioRxiv & medRxiv are now managed by openRxiv, a new independent nonprofit. This transition allows for more flexibility and innovation. Our mission remains being a free service to authors ensuring rapid sharing of scientific information before peer review. ℹ️ openrxiv.org/introducing-...

Introducing openRxiv: a new independent home for preprint sharing in the life sciences - openRxiv

We’re thrilled to announce the launch of openRxiv as an independent nonprofit to oversee bioRxiv and medRxiv, the world’s leading preprint servers for life and health sciences. openRxiv ensures that r...

openrxiv.org

I keep receiving these emails full of enthusiasm about the 50 alleged NIH study sections that will be (but really are not yet) on the federal register. Folks, council meetings are on an INDEFINITE hold. There is no grant happening. Let's focus on the issue at hand.

Jeremy Berg@jeremymberg.bsky.social · last yr.

Extending my grant update this morning. Here are data limited to new and competitive renewal applications. The Pause is dead, Long live the Pause...

Leaders have been saying "let's make every scientists a communicator" for decades. I'd say we have evidence that isn't the answer. It's an example of the scholastic fallacy - which says scientists think everyone thinks about things the same way we do.

Jess Hardie@jesshardie.bsky.social · last yr.

I am pretty tired of this argument. Journal articles and books are sometimes not widely accessible (although some are), but academics speak much more often to the public now, through the media, op eds, trade books, and public lectures, than in the past and anti-intellectualism has grown.

There are many reasons for anti-intellectualism, but in the current moment, much of it is political. We’re in a rightwing, segregationist backlash & colleges are viewed as bastions of progressiveness and integration AND sources of an alternative form of authority, making them dangerous to fascists.

Our new preprint is out! We report the #cryoEM #structure of the glycosyltransferase ArnC from Salmonella enterica and identify key structural elements that enable the glycosylation of bacterial lipid undecaprenyl phosphate. #membrane #protein #PetrouLab 🧵1/n https://buff.ly/3EvRyFy

Structural basis of undecaprenyl phosphate glycosylation leading to polymyxin resistance in Gram-negative bacteria

In Gram-negative bacteria, the enzymatic modification of Lipid A with aminoarabinose (L-Ara4N) leads to resistance against polymyxin antibiotics and cationic antimicrobial peptides. ArnC, an integral…

buff.ly

1/ Thrilled to announce Dr. Elizabeth Wright as the inaugural winner of the June Almeida Award for #cryoem! 🎉Elizabeth’s pioneering work in both cryo-ET methods and structural virology made her a perfect fit for this award. Congrats, Elizabeth!

Hello everyone! I joined Bluesky some months back but I finally decided to become more active here. I am a structural biologist studying membrane enzymes and ion channels. I am a newish PI, having started my lab in 2019. In Newark we operate a Tundra cryo-TEM. Here is a recent picture of our team: