I am very pleased to share the latest article from the PHYBAC team, which shows that 1) the loss of function of certain PRC1 subunits leads to the development of a new type of intestinal tumor, and 2) the NF-κB immune pathways act as a brake on tumor progression. journals.plos.org/plosgenetics...
A tumor-suppressive role of the PRC1 Polycomb epigenetic complex in the maintenance of adult Drosophila intestinal stem cell identity
Author summary Our research explores how stem cells in the adult intestine stay healthy and avoid becoming cancerous. We focused on a group of proteins called Polycomb Repressive Complex 1 (PRC1), whi...
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