guys I just tried googling this to find the exact Andor quote and jesus fucking christ guys what the fuck is happening here

Our latest blog walks through how the affinity and kinetics data in the EV‑A71 2A OpenBind release were produced - from target selection to large‑scale structure and binding measurements. https://loom.ly/gZY5ylY #StructuralBiology #Biophysics #OpenScience #AI

Czech biotech stands on stronger foundations than many still assume. Nearly 430 entities, CZK 97.5bn in annual revenue, and growing investor attention show real momentum. But further growth will depend on one thing: turning strong science into investable, scalable projects. #Biotech #Czechia

Tomas Pluskal @pluskal-lab.org on plants, their products and AI #pps2026

This article is wild. The asteroid Bennu contains enough amino acid variety to construct a metabolism. A highly limited amino acid library from asteroid Bennu yields wide-ranging protein folds | Nature Communications

A highly limited amino acid library from asteroid Bennu yields wide-ranging protein folds - Nature Communications

The origins of life are steeped in mystery, but the AI revolution could transform this field. Here, the authors use AI-based protein design software to uncover a broad range of protein folds that can be formed from small, primordial amino acid libraries constrained by asteroid and prebiotic chemistry data.

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Now published in NSMB! Paper: doi.org/10.1038/s415... Full PDF: rdcu.be/fhBtI Overview of additions since the preprint👇 (1/5)

Evaluating generalization in protein–ligand cofolding methods - Nature Structural & Molecular Biology

This work introduces the Runs N’ Poses dataset for benchmarking deep learning methods on the protein–ligand complex prediction task. It shows that current methods rely on memorization, challenging the...

doi.org

Peter Škrinjar@peterskrinjar.bsky.social · last yr.

Excited to share our latest preprint evaluating AlphaFold3, Boltz-1, Chai-1 and Protenix for predicting protein-ligand interactions, featuring our newly introduced benchmark dataset 🌹Runs N’ Poses🌹! www.biorxiv.org/content/10.1... 🧵👇 (1/n)

A while back, Andrej Karpathy said the app store will be replaced by generated, disposable software," and Amjad Masad predicted that the value of all application software will go to zero I think this "ephemeral software hypothesis" is wrong, though, and I want to explain why:

FT comments section this morning - saying what everyone else is thinking, right?

PDB Reaches a New Milestone: more than 250,000 entries

PDB Reaches a New Milestone

The PDB now contains more than 250,000 entries

rcsb.org

ProteinTTT is now easy to run on Hugging Face Spaces and Google Colab. We’ll also be presenting the paper at ICLR 2026 🇧🇷 🤗 Hugging Face Space: huggingface.co/spaces/pimen... ⚙️ Google Colab: colab.research.google.com/drive/1l_h7c... 🧵👇

Very happy @roman-bushuiev.bsky.social and I joined the amazing team led by @hannes-stark.bsky.social to work on BoltzGen, a generative model for binder design based on Boltz-2. Excited what it will enable!

Hannes Stark@hannes-stark.bsky.social · 9mo ago

Excited to release BoltzGen which brings SOTA folding performance to binder design! The best part of this project is collaborating with a broad network of leading wetlabs that test BoltzGen at an unprecedented scale, showing success on many novel targets and pushing the model to its limits!

We train machine learning models on millions of proteins. But when it comes to making predictions, do we need them to understand all proteins at once? Often, we need an accurate model for the specific protein we are studying or designing. We address this with ProteinTTT arxiv.org/abs/2411.02109 1/🧵

Finally, Mol* with a human face

RCSB Protein Data Bank@rcsbpdb.bsky.social · 11mo ago

MolViewSpec: describe, share, and reproduce Mol* molecular scenes with a simple extension

today #3Dprint protein is ferritin (PDB: 6I36) available here: www.printables.com/model/141627...

I am very proud of the final outcome of this project, mainly driven by Corinna Brungs and supported by numerous labs who donated compounds for analysis.

IOCB Prague@iocbprague.bsky.social · 11mo ago

The @pluskal-lab.org is helping colleagues around the world identify unknown compounds. A #research article about their vast #massspec library has been published in @natmethods.nature.com with Corinna Brungs & @robinschmidt.bsky.social as the first two authors. See more ► www.uochb.cz/en/news/732

🌿 The Botanical Garden of Charles University’s Faculty of Science turns 250! Founded in 1775, it is one of Central Europe’s oldest university gardens. Join us for a special anniversary program 15–21 Sept 2025. 🎉 @unikarlova.cuni.cz @botanickazahradauk.bsky.social

There is a new version of Runs N' Poses preprint by @peterskrinjar.bsky.social and @ninjani.bsky.social comparing Boltz-2 to Boltz-1 and to other co-folding methods by extension (though not yet to classical docking). @mdc-biocat.bsky.social - how did comparison of Boltz-2 to PocketVina turn out?

Matthieu da Costa@mdc-biocat.bsky.social · 11mo ago

With the release of Boltz 2, is there already a review comparing the efficiency of different (new) docking tools? (I’ve already tried Pocket Vina, which is actually quite good for high-throughput)

YouTube link for MLCB2025 is up! Starting in 30 min. www.youtube.com/live/19I7xTh...

Machine Learning in Computational Biology 2025

YouTube video by Machine Learning in Computational Biology

youtube.com

Day 3 opened with Kenneth Atz @Roche tackling the holy grail of #CADD: P-L binding #affinity prediction. By reframing limits of data & models, we can focus on the next solvable challenges - a sharp reminder of complexity & progress ahead. #CECAM @cecamevents.bsky.social @iocbprague.bsky.social

This afternoon at our @cecamevents.bsky.social Workshop in Prague: Talks by Ulf Ryde, Ran Friedman & Charles-Alexandre Mattelaer explored QM methods for binding affinity, energy decomposition & binding geometries. Great discussions on rigorous QM in drug design! #compchem @iocbprague.bsky.social

Morning session of our #CECAM Workshop in Prague featured @gdefabritiis.bsky.social presenting a ML force field for drug discovery, Julien Michel on electrostatic embedding for ML/MM free energy calcs, and Carlos Cruz Marin on ML models for logP. @iocbprague.bsky.social @cecamevents.bsky.social

Closing Day2 with exciting talks: M.Lepsik on #SQM scoring on AI-generated structures,M.Hennemann on local properties at P-L interfaces & I.Gordiy on enhanced sampling with ML potentials.Inspiring end before our social dinner! @cecamevents.bsky.social @iocbprague.bsky.social @iocbtech.bsky.social

We opened Day 2 of our #CECAM flagship workshop in Prague with the CECAM director Andrea Cavalli, highlighting steered #MD, dynamical docking & the complexity of binding energetics, and the challenges ahead. 🚀 #CECAMinPrague @iocbprague.bsky.social @cecamevents.bsky.social @iocbtech.bsky.social

Day 1 of our #CECAM Flagship Workshop in Prague started strong! Talks by Kennie Merz, Jan Řezáč, Markus Hermann & Hamza Ibrahim sparked great discussion on #QM, #ML & #DrugDesign Thanks to @iocbprague.bsky.social, @iocbtech.bsky.social & @cecamevents.bsky.social for support! #compchem #SQM

Tomorrow we kick off our #CECAM Flagship Workshop on Quantum Chemistry for Drug Design (Sept 8–10, Prague). 3 days of cutting-edge talks bridging #QM #ML & #drugdesign with world-class speakers shorturl.at/5sooU #compchem #SQM @iocbtech.bsky.social @cecamevents.bsky.social @iocbprague.bsky.social

CATH turns 30 years old 🥳 They celebrate with a Symposium on September 16th! I'll be presenting our work: "An Atlas of Energetic Evolutionary Constraints Across Protein Families" Unbelievable selection of speakers! So if you are around London, you can register to attend: tinyurl.com/2pnk8hj5

Exciting to see our protein binder design pipeline BindCraft published in its final form in @Nature ! This has been an amazing collaborative effort with Lennart, Christian, @sokrypton.org, Bruno and many other amazing lab members and collaborators. www.nature.com/articles/s41...

😂

Iain@iainnd.bsky.social · 11mo ago

Look what they did to Notepad. Shut the fuck up. This is Notepad. You are not welcome here. Oh yeah "Let me use Copilot for Notepad". "I'm going to sign into my account for Notepad". What the fuck are you talking about. It's Notepad.

The first day of our bioML symposium at @iocbprague.bsky.social went very well. It is amazing to see how fast this field is moving forward. Thanks to everyone for the fantastic talks! 🤖🧬

Our significantly expanded preprint is out. In it we show that pancreatic cancer cells can transfer ribosomes via tunnelling nanotubes and rescue protein synthesis when co-cultured with cells with impaired ribosomal biogenesis. 🧪 (Includes some #bayesian #rstats inspired by @rmcelreath.bsky.social)

Ribosome transfer via tunnelling nanotubes rescues protein synthesis in pancreatic cancer cells

Background: Pancreatic ductal adenocarcinoma (PDAC) is considered as one of the deadliest types of cancer. Tunnelling nanotubes (TNTs) are thin, membranous, intercellular communication structures obse...

biorxiv.org