A childhood dream has come true – I was appointed Full Professor for Sustainable Biotechnology at the University of Düsseldorf @hhu.de : tinyurl.com/f43s74hp and as Director of the Institute for Molecular Enzyme Technology (IMET, www.iet.uni-duesseldorf.de/en/) at FZ Jülich @fz-juelich.de .

Mathematisch-Naturwissenschaftliche Fakultät

Heute ernannte Rektorin Prof. Dr. Anja Steinbeck den Biotechnologen Dr. Johannes Rebelein zum W3-Professor für Nachhaltige Biotechnologie. Rebelein wird damit auch Direktor des Instituts für Molekular...

tinyurl.com

Welcome to our new colleague Johannes Rebelein, head of the Institut of Sustainable Biotechnology @hhu.de and our new colleague at the Institute of Bio- and Geosciences 1 @fz-juelich.de. Welcome to @mibinet.bsky.social! www.chemie.hhu.de/en/latest-ne...

Mathematisch-Naturwissenschaftliche Fakultät

Heute ernannte Rektorin Prof. Dr. Anja Steinbeck den Biotechnologen Dr. Johannes Rebelein zum W3-Professor für Nachhaltige Biotechnologie. Rebelein wird damit auch Direktor des Instituts für Molekular...

chemie.hhu.de

Last Friday was the defense of my PhD thesis entitled "Structural basis of anaerobic enzymes mediated by noncanonical metalloclusters" after 4 yrs at the @synmikro.bsky.social 🎓🎓 Big thanks to my supervisor @schullerjm.bsky.social and the whole Schuller lab for their continuous and massive support!

Very cool story about the efficient transport and incorporation of non canonical amino acid!

Kathrin Lang@klanglab.bsky.social · 10mo ago

🚨Our paper is out! 🥳 Hijacking a bacterial ABC transporter for efficient genetic code expansion. Many congrats to everyone involved - a multi-year effort led by @taruniype.bsky.social @maxfottner.bsky.social www.nature.com/articles/s41... it all started years ago with a failed experiment 🧵👇 1/9

Our latest work on the nitrogenase-like methylthio-alkane reductase, which specifically reduces reduces carbon-sulfide bonds is now out @natcatal.nature.com: doi.org/10.1038/s419.... We find for the first time large #nitrogenase metalloclusters (P- and L-cluster) outside nitrogenases.

Methylthio-alkane reductases use nitrogenase metalloclusters for carbon–sulfur bond cleavage - Nature Catalysis

Methylthio-alkane reductases are recently discovered enzymes that can produce methanethiol and small hydrocarbons from methylated sulfur compounds. Now the cryo-EM structure of a methylthio-alkane red...

doi.org

Max Planck Institute for Terrestrial Microbiology@mpimicrobiomarburg.bsky.social · 10mo ago

Microbial enzymes hold the key to greener plastics! Rhodospirillum rubrum can produce ethylene without releasing CO₂. A team @rebeleinlab.bsky.social purified the enzyme and solved its structure, an important step towards #SustainableChemistry.

Fantastic work by the Ward lab to repurpose cytochrome #P450 enzymes for a new-to-nature asymmetric metal-catalysed H atom transfer! Just released @Nature : doi.org/10.1038/s415.... A must read!🧪

Repurposing haemoproteins for asymmetric metal-catalysed H atom transfer - Nature

Cytochrome P450 enzymes can be repurposed to catalyse asymmetric metal–hydride hydrogen atom transfer, a new-to-nature reaction.

doi.org

Great collaboration with @lennartschada.bsky.social on an #enzyme converting the #plastic component ethylene glycol and to a feedstock chemical for microbes. Offering new ways to use plastic biotechnologically. 🧪

Lennart Schada von Borzyskowski@lennartschada.bsky.social · last yr.

Ethylene glycol is widely used as monomer of the plastic PET. It is therefore highly relevant as sustainable feedstock for microbial biotechnology. In our new paper in @natcomms.nature.com, we characterize efficient enzymes for ethylene glycol oxidation: www.nature.com/articles/s41...

I am honored and excited that our research on #nitrogenases and the conversion of #CO2 to hydrocarbons is highlighted in the Yearbook 2024 of the Max Planck Society, see page 29. An English and a German version of the Yearbook are available in www.mpg.de/13631298/yea....

Yearbook Highlights

The Yearbook Highlights of the Max Planck Society

mpg.de

Max Planck Institute for Terrestrial Microbiology@mpimicrobiomarburg.bsky.social · last yr.

Fresh from the press! 📰Check out the article by Dr. Johannes Rebelein @rebeleinlab.bsky.social on page 29: 'From waste to valuable materials'. #sustainability #carboncapture #nitrogenase

A must read for anybody interested in the evolution of life and how to construct phylogenies using structures. Outstanding work by @georghochberg.bsky.social and co-worker. Congrats!

@georghochberg.bsky.social · last yr.

New paper from the lab from Sriram Garg in my group. We introduce a general substitution matrix for structural phylogenetics. I think this is a big deal, so read on below if you think deep history is important. academic.oup.com/mbe/advance-...

New paper from the lab from Sriram Garg in my group. We introduce a general substitution matrix for structural phylogenetics. I think this is a big deal, so read on below if you think deep history is important. academic.oup.com/mbe/advance-...

A general substitution matrix for structural phylogenetics.

Abstract. Sequence-based maximum likelihood (ML) phylogenetics is a widely used method for inferring evolutionary relationships, which has illuminated the

academic.oup.com

Leveraging spectroscopic and structural approaches we obtained new insights into the role of #ferredoxins in N2 fixation. Just published in Chemistry – A European Journal: doi.org/10.1002/chem...! Great work by Holly Addison. Fantastic collaboration with Antonio Pierik on the EPR characterization.

Two Key Ferredoxins for Nitrogen Fixation Have Different Specificities and Biophysical Properties

Two ferredoxins, FdC and FdN, are collectively essential for the process of nitrogen fixation by the iron nitrogenase in R. capsulatus. We explore the biophysical factors, through spectroscopic and s....

doi.org

Marburg rules. I see @rebeleinlab.bsky.social @schullerjm.bsky.social @georghochberg.bsky.social in the crowd 😘

Olalla Vázquez@olallalab.bsky.social · last yr.

YES!!!Excellent initiative #Microbes-for-Climate #M4C🦠FUNDED💲💰☺️🤩 The best?🤔The people❤️ Endless gratitude to Tobi & Anke - amazing role models❤️ Love the "thanks BBQ no matter what" spirit from the "Präsidium"! @unimarburg.bsky.social - sure it tasted better as we got it😉😂 #ProfLife #LovelyMarburg🏰❤️

Out now in @chemicalscience.rsc.org: We apply 2DIR spectroscopy to study [FeFe] hydrogenase for the first time. Check it out! pubs.rsc.org/en/content/a...

The National Climate Assessment — already in the works for months — was gutted earlier this week, when President Trump’s administration dismissed hundreds of scientists working on it.. The National Nature Assessment was cancelled on his first day back in office.. 🧪🦠 www.nature.com/articles/d41...

Trump gutted two landmark environmental reports — can researchers save them?

Scientists working on disrupted national climate and nature assessments aren’t giving up.

nature.com

I think a lot about what Carl Sagan said in one of his final interviews.

*** Only a few days left to apply *** Postdoc position at the University of Marburg (Germany), funded within our ERC Advanced Grant "C-SWITCH" Spatiotemporal regulation of cellular processes by CTP-switches in bacteria Apply by 04 May: stellenangebote.uni-marburg.de/jobposting/2...

My dept in London at Imperial (Bioengineering) is recruiting a group leader at Professor level 🧑‍🎓 Please RT. It's a great place with world-class expertise in all sorts of biomedical & biological engineering topics like synthetic biology. It's also not in the USA. www.imperial.ac.uk/jobs/search-...

Exciting work from @frunzkelab.bsky.social and @borjana-a.bsky.social at @fz-juelich.de

Julia Frunzke@frunzkelab.bsky.social · last yr.

New preprint from @erdrich-science.bsky.social of our collaborative project with @borjana-a.bsky.social, @fz-juelich.de and @guidogrossmann.bsky.social @hhu.de: "Phage biocontrol reduces the burden on plant immunity through suppression of bacterial virulence" www.biorxiv.org/content/10.1...

New preprint from @erdrich-science.bsky.social of our collaborative project with @borjana-a.bsky.social, @fz-juelich.de and @guidogrossmann.bsky.social @hhu.de: "Phage biocontrol reduces the burden on plant immunity through suppression of bacterial virulence" www.biorxiv.org/content/10.1...

Phage biocontrol reduces the burden on plant immunity through suppression of bacterial virulence

Bacteriophages are increasingly recognized as key players in modulating plant-microbe interactions, including their potential in the biocontrol of plant pathogenic bacteria. In this study, we investig...

biorxiv.org

Exciting work by Ribbe & Hu lab demonstrating the in vivo reduction of N2 by L-cluster containing Nif(EN)2 inside E. coli: www.science.org/doi/10.1126/... This finding suggests a smaller minimal gene set for the heterologous expression of #nitrogenase and an easier route to synthetic #N2-fixation

Heterologous synthesis of a simplified nitrogenase analog in Escherichia coli

Heterologous synthesis of a nitrogenase analog (NifH/NifEN) in E. coli enables N2 reduction and incorporation of N into biomass.

science.org

Great work Adrian!

Adrian Bunzel@bunzela.bsky.social · last yr.

🚨Out now in Angewandte Chemie: AI.zymes - A modular platform for evolutionary enzyme design. AI.zymes integrates established and emerging bioengineering tools into a coherent pipeline for #enzymedesign. 📄Paper: doi.org/10.1002/anie... 💻GitHub: github.com/bunzela/AIzy...

Enabling next-generation anaerobic cultivation through biotechnology to advance functional microbiome research www.nature.com/articles/s41... #jcampubs

Enabling next-generation anaerobic cultivation through biotechnology to advance functional microbiome research - Nature Biotechnology

Overcoming key hurdles for the development of next-generation anaerobic cultivation methods could have major impacts on microbial community research and applications.

nature.com

Gab es dazu wirklich KEINE Berichterstattung? Eine Google-News Suche zu CO2-Konzentration liefert nur Ergebnisse zu einem UN-Bericht aus 2024. Keine Studie, keine News? Außer natürlich bei BIP, Inflation, Arbeitslosigkeit... 😬 Bitte gerne Links darunter posten.

Reinhard Steurer@steurer.bsky.social · last yr.

Wahnsinn. Dieser nie dagewesene Anstieg der CO2-Konzentration in einem Jahr ist jenseits aller Erwartungen und müsste in zig Sondersendungen erörtert werden, wenn wir als Gesellschaft noch bei Trost wären. Müsste... gml.noaa.gov/ccgg/trends/...

Energy from air? No problem! In our new preprint, we reconstitute the machinery that allows microbes to endure starvation. By using the trace amounts of hydrogen in air alone, they produce plenty of chemical energy (2 ATP) to get by. The only byproduct? Water. www.biorxiv.org/content/10.1...

Hydrogenase-driven ATP synthesis from air

All cells require a continuous supply of the universal energy currency, adenosine triphosphate (ATP), to drive countless cellular reactions. The universally conserved F1Fo-ATP synthase regenerates ATP...

biorxiv.org

Towards community-driven visual proteomics! Excited to finally share this large-scale curated & annotated dataset of 1829 high-quality #cryoET tomograms of the little green alga that just keeps giving— Chlamydomonas! 🧪🧶🧬🌾🌊🌍 Preprint📜: www.biorxiv.org/content/10.1... A short thread🧵👇

One of the largest open questions in anaerobic metabolism solved. The best work of my lab yet, performed by the incredible hard working, talented and motivated coworkers: @fidelormz.bsky.social , @sophia-pa.bsky.social and @rnfr2d2.bsky.social. I am a proud PI today! www.nature.com/articles/s41...

Structure of the ATP-driven methyl-coenzyme M reductase activation complex - Nature

The structure and function of the MCR activation complex from Methanococcus maripaludis were revealed, demonstrating its ATP-dependent ability to activate MCR and form methane while uncovering a uniqu...

nature.com

This is an excellent explanation about the implications of finding #nitrogenase #metalloclusters in the MCR activation complex

@georghochberg.bsky.social · last yr.

This is a wild paper. The anaerobic biochemistry is definitely worth your while (and beyond me to explain), but let me try to explain why this is also an evolutionary bombshell. This is about how nitrogen fixation evolved as we know it.

I'm truly excited to announce our new publication in @nature.com unraveling a central picture of the Methyl-coenzyme M reductase (MCR) activation machinery and it's strong ATP dependency - kudos to @rnfr2d2.bsky.social for the fantastic illustration! LINK: www.nature.com/articles/s41...

Structure of the ATP-driven methyl-coenzyme M reductase activation complex pubmed.ncbi.nlm.nih.gov/40240609/ #cryoEM

Had a blast at VAAM 2025 in Bochum @vaam-microbes.bsky.social. Holly Addison and Frederik Schmidt gave fantastic talks about our work electron transport to #nitrogenase and nitrogenase #catalysis