We currently have an opening for a PhD position in the lab. If you are interested in pursuing some serious structural biology of photosynthetic and chloroplast processes please apply. Prerequisite is previous experience in cryoEM and/or phototrophs. stellenangebote.uni-marburg.de/jobposting/2...
Doctoral and Postdoctoral Researcher Positions in the Cluster of Excellence ‘Microbes for Climate’
stellenangebote.uni-marburg.de
Das größte bekannte #Enzym? Ein Team um @sophia-pa.bsky.social und @schullerjm.bsky.social vom @synmikro.bsky.social hat einen überzeugenden Kandidaten: einen katalytisch aktiven 8 MDa-Superkomplex aus einem Methan-produzierenden Archaeon … Mehr dazu: 👉https://www.laborjournal.de/editorials/3533.php
Some bacteria do not live as individuals. They build multicellular filaments and connect neighboring cells through tiny cell-cell junctions. Cyanobacteria are among the most beautiful examples 😍 In our new paper, we reveal first molecuar insights on the cyanobacterial septal junction architecture 🧵
Awesome work to determine the structure of a freakin 8MDa enzyme complex with over 600 FeS clusters! Sophia won the poster prize at the recent GRC C1 👏 www.nature.com/articles/s41...
Architecture of the 8 MDa Hdr–Vhu–Fwd super-assembly in class I methanogens - Nature
The structure of the Hdr–Vhu–Fwd super-assembly reveals a lineage-specific and modular 8 MDa complex with the ability to adapt to diverse anaerobic niches.
nature.com
ProLOEWE@proloewe.bsky.social · 4w agoHuge discovery from Marburg: Prof. Schuller (@synmikro.bsky.social),doctoral stud. @sophia-pa.bsky.social+colleagues have resolved1️⃣of the🧬🔬largest enzymes. Published in Nature, the study shows how methanogenic archaea generate energy under extreme conditions, offering🆕insights into the🌎carbon cycle.
Huge discovery from Marburg: Prof. Schuller (@synmikro.bsky.social),doctoral stud. @sophia-pa.bsky.social+colleagues have resolved1️⃣of the🧬🔬largest enzymes. Published in Nature, the study shows how methanogenic archaea generate energy under extreme conditions, offering🆕insights into the🌎carbon cycle.
Excited to share my paper! 🥳 Today in #Nature we reveal an 8 MDa Hdr electron bifurcating super-assembly in class I methanogens that couples the first and last steps of hydrogenotrophic methanogenesis. A lineage-specific adaptation to anaerobic niches. www.nature.com/articles/s41...
New preprint No7 - molecular architecture of the carbonyl branch enzyme in methanogens. Basically all enzymes of the pathway linked in a super assembly (2 MDa). One would expect a cryoEM study, but we miserably failed, so we used true integrative structural biology. www.biorxiv.org/cgi/content/...
Interface swapping orchestrates carbon transfer in the archaeal acetyl-CoA decarbonylase/synthase
The Wood-Ljungdahl pathway is one of biology's most ancient routes for carbon fixation and energy metabolism, used by organisms such as methanogenic archaea. One of its central metabolic complexes is ...
biorxiv.org
Okay the lab is now really living preprints to accelerate Science. It takes so long to publish a story in journals. So the only option to talk openly about our work are preprints. We currently have 6 preprints - check them out! More coming, one currently uploading and another one ready soon.
@trisre.bsky.social · last mo.1/ Happy to share our preprint! The Mtr complex catalyses the second-to-last step of the methanogenesis and is an essential bioenergetic machine in most methanogenic archaea. Anaerobic cryo-EM of Mtr reveals a nitrogenase-like metallocluster bound at its active site! www.biorxiv.org/content/10.6...
1/ Happy to share our preprint! The Mtr complex catalyses the second-to-last step of the methanogenesis and is an essential bioenergetic machine in most methanogenic archaea. Anaerobic cryo-EM of Mtr reveals a nitrogenase-like metallocluster bound at its active site! www.biorxiv.org/content/10.6...
Super excited to launch this search for a new endowed professor at the @biozentrum.unibas.ch! Join us to build a research cluster in Climate Biophysics! 🌍🌊🌾🔬🧪 This is a unique opportunity to create a community in Basel🇨🇭working together on this timely topic! ⏳🌡️ Questions? Please reach out! 👩🔬👨🔬
Biozentrum, University of Basel@biozentrum.unibas.ch · last mo.New Assistant (tenure-track) or Associate Professor position in Climate #Biophysics! Join our international research community to explore fundamental molecular mechanisms underlying climate-relevant biological processes. Apply by 7 Sept 2026! www.biozentrum.unibas.ch/de/open-posi...
Crazy biochemistry is the norm for @schullerjm.bsky.social, but here I wanna say I have witnessed up close the amazing effort from @tomaspascoa.bsky.social and @tamb-o.bsky.social to chase the BCRII complex in situ 🤩 Big congrats to Lena Appel and @rnfr2d2.bsky.social for the cryoEM structure too 👏🏽
Tomas Pascoa@tomaspascoa.bsky.social · 4mo ago5/ But one key component was still missing: the high-potential acceptor 🤔🔍 Earlier studies proposed that BCRII is membrane-attached and transfers electrons to menaquinone Using in situ #cryoET, we instead found BCRII dispersed throughout the cytoplasm, pointing to a soluble high-potential acceptor
Across scales from cells🦠 to atoms⚛️ – We reveal how anaerobic #bacteria break down very stable aromatic compounds found e.g. in oil spills 🛢️ #Bioremediation #TeamTomo 🧪 🧶🧬 🔬 Awesome collab with Lena, Matthias, @schullerjm.bsky.social @rnfr2d2.bsky.social @tomaspascoa.bsky.social @tamb-o.bsky.social
Tomas Pascoa@tomaspascoa.bsky.social · 4mo ago1/ Excited to share our preprint! 🥳 Degradation of aromatic compounds, including BTEX pollutants, requires highly endergonic aromatic ring reduction. Using #cryoEM and in situ #cryoET, we show how BCRII couples electron bifurcation modules in one giant redox machine www.biorxiv.org/content/10.6...
Thanks for the fun collaboration into this fascinating “oil eating” biomachine. I learned a lot! 🧪 #TeamTomo
Anuj@rnfr2d2.bsky.social · 4mo agoHow do “LEGO-like” electron-bifurcating modules combine to drive degradation in BTEX-contaminated ecosystems? Check out our latest preprint, where we use cryo-EM and cryo-ET to reveal how the 1 MDa BCRII complex powers extremely endergonic aromatic ring reduction. www.biorxiv.org/content/10.6...
Amazing paper. A megadalton enzyme complex that: - combines both electron bifurcation AND confurcation steps - has a new type of iron-sulfur cluster - a new kind of weird electron transfer path - super charges electrons to reduce aromatic rings - also powers respiration 😳
Ben Engel@cellarchlab.com · 4mo agoAcross scales from cells🦠 to atoms⚛️ – We reveal how anaerobic #bacteria break down very stable aromatic compounds found e.g. in oil spills 🛢️ #Bioremediation #TeamTomo 🧪 🧶🧬 🔬 Awesome collab with Lena, Matthias, @schullerjm.bsky.social @rnfr2d2.bsky.social @tomaspascoa.bsky.social @tamb-o.bsky.social
How do “LEGO-like” electron-bifurcating modules combine to drive degradation in BTEX-contaminated ecosystems? Check out our latest preprint, where we use cryo-EM and cryo-ET to reveal how the 1 MDa BCRII complex powers extremely endergonic aromatic ring reduction. www.biorxiv.org/content/10.6...
biorxiv.org
Happy to present our latest story: the BCRII complex with the Boll and @cellarchlab.com . Months of processing by @rnfr2d2.bsky.social. Also @tomaspascoa.bsky.social and @tamb-o.bsky.social managed an in-situ tour de force. And Lena Appel did amazing biochemistry. This story has it all. Enjoy it.
Tomas Pascoa@tomaspascoa.bsky.social · 4mo ago1/ Excited to share our preprint! 🥳 Degradation of aromatic compounds, including BTEX pollutants, requires highly endergonic aromatic ring reduction. Using #cryoEM and in situ #cryoET, we show how BCRII couples electron bifurcation modules in one giant redox machine www.biorxiv.org/content/10.6...
1/ Excited to share our preprint! 🥳 Degradation of aromatic compounds, including BTEX pollutants, requires highly endergonic aromatic ring reduction. Using #cryoEM and in situ #cryoET, we show how BCRII couples electron bifurcation modules in one giant redox machine www.biorxiv.org/content/10.6...
I will probably be hiring either a PhD or a Postdoc in the near future. If you are interested in deep biochemical history or molecular mechanisms of evolution please get in touch.
Congratulations 🎉 Anuj. This is well earned and I am a proud supervisor. There is much more coming. @rnfr2d2.bsky.social will present a paradigm shifting story this year at the GRC C1 and EBEC.
Anuj@rnfr2d2.bsky.social · 4mo agoI am truly honoured and delighted to receive the GBM #PhDAward from @gbmev.bsky.social Grateful to @schullerjm.bsky.social and Prof. Volker Müller for their continuous support and guidance! www.uni-marburg.de/en/prfolder-...
Carbonic anhydrase catalyses the interconversion of CO2 and HCO3- and helps increasing the net-CO2 concentration inside cells. Why? CO2-reducing enzymes like RuBisCO are notoriously slow and ineffective. However, import of HCO3- is typically coupled to ATP consumption...
Thrilled to be able to finally post my first adventure into secondary metabolism!: Flavoaffinins, Elusive Cellulose-Binding Natural Products from an Anaerobic Bacterium pubs.acs.org/doi/full/10.... Co-authors: Ruocheng Yu, f. undergrad Jessie Lee, @katherinem.bsky.social , and Emily Balskus!
pubs.acs.org
Last Friday was the defense of my PhD thesis entitled "Structural basis of anaerobic enzymes mediated by noncanonical metalloclusters" after 4 yrs at the @synmikro.bsky.social 🎓🎓 Big thanks to my supervisor @schullerjm.bsky.social and the whole Schuller lab for their continuous and massive support!
The largest challenge of the day. Try to assemble 5 structural biology papers (each more than 100 pages incl. Supplements) in a single pdf with less than 15MB to upload as a document for a prize nomination for a student. Not sure compression algorithms are that good...
📢 Postdoc position: Cell Biology of Cyanobacteria in my group, as part of the Excellence Cluster "Microbes for Climate" (M4C) in Marburg, Germany. More information at shorturl.at/wNnDT (see Project 2) 🔗Apply at shorturl.at/VsEDl 📅Deadline: Nov 16, 2025 Please repost. #Postdoc
A new preprint from the lab. I won't do a tweetorial until this is peer reviewed, but I think it's a banger, led by @JedNzy. It's about Rubisco and what chaperones are really for. He's on the market, get him while you can. www.biorxiv.org/content/10.1...
Origin of chaperone dependence and assembly complexity in Rubisco biogenesis
Molecular chaperones assist with the folding and assembly of protein clients. Consequently, they are essential to diverse cellular functions. In most aerobic photosynthetic organisms such as B-cyanoba...
biorxiv.org
Die aller♥️lichsten Glückwünsche🍾🥂auch von uns an Jan Schuller, Wissenschaftler👨🏼🔬bei LOEWE-Tree-M & zuvor bereits beim ehem. LOEWE-Zentrum SYNMIKRO, zu seinem #Explorationsstipendium der Boehringer Ingelheim Stiftung! @synmikro.bsky.social @loewe-tree-m.bsky.social.
Universität Marburg@unimarburg.bsky.social · 11mo agoDr. Jan Schuller erhält renommiertes Boehringer Ingelheim Stiftung (BIS) Stipendium. Im Fokus: Wie schädliche #Darmbakterien ohne #Sauerstoff Energie gewinnen – die Funktionsweise von #Clostridioides difficile uni-marburg.de/eOYjSV Foto: R K Wegst #Mikrobiologie #Kryo-Elektronenmikroskopie
‼️ Exciting new preprint from a close collaboration with Kylie Walters' group. Our study maps the binding sites of key regulators of the proteasome in situ. www.biorxiv.org/content/10.1...
Structures of dynamic interactors at native proteasomes by PhIX-MS and cryoelectron microscopy
Proteasome function depends on a network of transient interactions that remain structurally and functionally unresolved. We developed PhIX-MS (Photo-induced In situ Crosslinking-Mass Spectrometry), a ...
biorxiv.org
Thank you Knut and Alice Wallenberg Foundation for producing this wonderful video on our research, and for the generous long-term support on our work. youtu.be/A12FvTn812Q
He wants to reveal the secret behind the body's battery
YouTube video by Wallenbergstiftelserna
youtu.be
#PhDposition #OrganicChemistry #ChemBio - deadline 03.08 - please RT ❤️ Application online stellenangebote.uni-marburg.de/jobposting/d...
