Thanks to @acmedsci.bsky.social for funding our project on exploring the complex genetic architecture of Brugada syndrome.

Academy of Medical Sciences@acmedsci.bsky.social · 4mo ago

We’re pleased to share the latest round of our Springboard programme 👏 This year we're supporting 55 early career researchers across the UK whose bold ideas have the potential to save lives, by investing £6.7M in discovery-driven health research 💡 ➡️ bit.ly/4syNGa8

Via NFL Films, Caleb Williams’s craziest throws from his sophomore season

Brilliant. An expat im Dubai has a startling revelation, by @stephencollins.bsky.social

Happy birthday to one of my favourite haters, Charles Darwin

😂

Calling transphobia a 'gateway drug' to the far right undersells it. It's pure accelerant. Grimly fascinating to guess what crankery becomes any famous transphobe's secondary obsession, cos they all have one: 15 minute cities are fascism! Grok noncing is cool! ICE are good! We should kill all dogs!

HAPPY HOLIDAYS TO ALL OF YOU!🎄✨

📝 Excited to share our latest work, now out at European Heart Journal! We studied 252 SCN5A variants previously found in patients with Brugada Syndrome, an inherited arrhythmia disorder linked to sudden cardiac death. [1/4]

🚨🧬 Registrations for the IV Bootcamp are now open! Limited to 30 spots—first come, first served. Acces the link in this thread.

Yes, some people's legacies are complicated. For example, Watson. After all, though he was racist, don't forget his other traits. For example, he was also sexist. And also anti-semitic. And a data / idea thief. So let's not forget all the different facets.

A weekend of 10th anniversaries! Sorry to miss the party for St George's MSc Genomic Medicine. But an amazing meeting for the birthday of the Institute for Cardiomyopathies Heidelberg - great speakers, excellent science and a beautiful location.

"Titin and the mystery of cardiomyopathy incidence" - our editorial commentary on the recent mega-study of TTN-related dilated cardiomyopathy, with @seanjosephjurgens.bsky.social @escardio.bsky.social doi.org/10.1093/eurh... #cardiosky 🧬🫀

Titin and the mystery of cardiomyopathy incidence

This editorial refers to ‘Titin-related familial dilated cardiomyopathy: factors associated with disease onset’, by R. Johnson et al., https://doi.org/10.1

doi.org

📝Check out our review “Creating an atlas of variant effects to resolve variants of uncertain significance and guide cardiovascular medicine”, out in @natrevcardiol.nature.com. We review the use of Multiplexed Assays of Variant Effect and variant effect predictors in cardiovascular disease.

Our study on HCM intermediate effect variants (IEVs) is out today in Circulation, led by Juan Pablo Ochoa, Soledad García Hernandez and Luis De la Higuera Romero. IEVs are low frequency/penetrance variants with moderate effects sizes (OR:5-10). www.ahajournals.org/doi/10.1161/... #ESCcongress 🧬🫀

Redefining the Genetic Architecture of Hypertrophic Cardiomyopathy: Role of Intermediate Effect Variants | Circulation

Background: Hypertrophic cardiomyopathy (HCM) is a genetically heterogeneous disorder primarily linked to rare variants in sarcomere genes, though recently certain non-sarcomeric genes have emerged as...

ahajournals.org

This They Might Be Giants TONIGHT SHOW performance of "Birdhouse In Your Soul" from 1990 remains firmly lodged in my noggin thanks to the Tonight Show Band's full commitment and Doc Severinsen's incredible trumpeting... It took an already great song and made it transcendent.

🗓️ 🧬 I am happy to announce that our next Bootcamp of Genetics for cardiologists will be an special edition in English. It will take place on May 8th 2026 in Barcelona just the day before ESC HFA congress so you can make the most of your trip!

Metaphors don't come clearer than this...

UAE Exotic Falconry & Finance𓅃@falconryfinance.bsky.social · last yr.

Interview with Harvard's 2025 valedictorian, a Chinese national, while two American men fight over nothing in the background

TANK vs TESLA "We've crushed fascism before and we'll crush it again" - ⁠WW2 veteran Ken, 98, in the tank

Champions 😎

Superb!

The Mary Rose Museum@maryrosemuseum.bsky.social · last yr.

On the anniversary of the sinking of the Titanic, we thought we'd answer a question that's often asked, "If they raised the Mary Rose, why not raise the Titanic?" Allow our scaled diagram to explain...

This is high art

I was getting a bit irritated by ChatGPT increasingly hallucinating people when asked for peer reviewer suggestions. But I'm not sure its sarcastic response was necessary 😒

🧵 I’m excited to share our latest preprint! We studied 252 SCN5A variants found in patients with Brugada Syndrome by automated patch clamp. [1/7]

📝 Excited to share our latest article on hereditary transthyretin amyloidosis (ATTRv) caused by the Val142Ile variant in Spain Here's a summary thread by the authors: @revespcardiol.bsky.social

Pls retweet: ‼️ Skilled in bioinformatics? ⁉️ Join our cardiogenomics team @ AmsterdamUMC in lovely Amsterdam 🌷🌷 We have a vacancy for bioinformatician with prospect of permanent appointment. Info 👉🏻 werkenbij.amsterdamumc.org/en/vacatures... More about us and our approach here 👉🏻 tinyurl.com/5brcsazv

Does America have any idea what people around the world are thinking of it tonight? Where are the protests? Where is the opposition? Heartbreaking to see a nation's moral collapse like this.

The scenes in the Oval Office today will shame the US for decades. They’ll never be forgotten. A world leader, fighting for his country against the 21st century’s Nazis, came to the US and was attacked & abused by a gangster regime siding with the fascist invaders. A historic disgrace.

🧵 Polygenic scores in hypertrophic cardiomyopathy 📎 Paper: www.nature.com/articles/s41... in @naturegenet.bsky.social We created PGS using sumstats from our linked GWAS study www.nature.com/articles/s41..., evaluating it across a range of clinical settings in several cohorts. 1/n