22/23 I also want to thank Christian Klämbt, Carsten Grasshof and @rwedlichsoldner.bsky.social , and especially @luschnig.bsky.social , for all their support during the grant application. And thank you to Stefan and his entire group for all the help and support as I set up my new lab!

23/23 So, let’s see where this journey takes us! I’ll keep y‘all updated. 😊 For job postings in the future, check my website: www.bischofflab.com/jobs

Exciting preprint from @hessofarhan.bsky.social! Mechanical stress has a new sensor! IRE1 detects ER membrane tension and drives protein synthesis independently of its canonical UPR role, reshaping cell and organelle mechanobiology. www.researchsquare.com/article/rs-1...

Yeast cells utilize a TORC2 feedback loop for plasma membrane adaptation to mechanical stress, with increased sterol transport from plasma membrane to endoplasmic reticulum activating TORC2 signaling Robbie Loewith, Aurélien Roux @rouxlab.bsky.social and coworkers www.embopress.org/doi/full/10....

🚨 Lipid Time! 🚨 Excited to share our latest story now on @biorxiv-biochem.bsky.social ! Our brilliant PhD student @manpreet0700.bsky.social , together with @walter-nickel-bzh.bsky.social and myself, shows how PI(4,5)P₂ asymmetry in the plasma membrane drives the unconventional secretion of FGF2! 👇👇👇

Plasma membrane transbilayer asymmetry of PI(4,5)P2 drives unconventional secretion of Fibroblast Growth Factor 2

Unconventional secretion of Fibroblast Growth Factor 2 (FGF2) is based upon direct self-translocation across the plasma membrane, a process that involves the transient formation of a lipidic membrane ...

biorxiv.org

This yielded beautiful tomograms that showed that microvillar actin is first reabsorbed from the microvillar base, gets repositioned underneath the plasma membrane of the cell body, and is then remodeled from a set of bundles into a meshwork, with the typical architecture of a cortex.

Previous preprint is now published in RSC Chemical Biology. If you are interested in plasma membrane labeling, see the paper! 👇 pubs.rsc.org/en/content/a...

Plasma membrane labelling efficiency, internalization and partitioning of functionalized fluorescent lipids as a function of lipid structure

Labeling the plasma membrane for advanced imaging remains a significant challenge. For time-lapse live cell imaging, probe internalization and photobleaching are major limitations affecting most membr...

pubs.rsc.org

Erdinc Sezgin@sciezgin.bsky.social · last yr.

New paper out! Would you like to fluorescently label the plasma membrane in live, fixed or permeabilized cells? I tested different lipid structures and labelling approaches to decide what makes a good membrane labelling probe for such imaging experiments! www.biorxiv.org/content/10.1...

New: Using F-tractin to visualize #actin in living cells? Dmitry Shatskiy, Athul Sivan, Roland Wedlich-Söldner, and Alexander Belyy @alexanderbelyy.bsky.social determined the F-tractin-F-actin structure and showed that this probe is nearly identical to #Lifeact. https://buff.ly/3EIqAur #cytoskeleton

It's been a while in the making, but finally out:😂🥳 We’re excited to share our new work with H. Pavenstädt, D. Braun, M. Krahn, P. Bieling and @raunser-lab.bsky.social on INF2 and global actin remodeling! Read the story here: www.biorxiv.org/content/10.6... #Actin #Cytoskeleton #CellBiology #INF2

Very interesting conference report on how to communicate science effectively in an increasingly polarized world: pubmed.ncbi.nlm.nih.gov/41025353/

Proud to share our study on #LipidDroplet #Motility #Mitochondria #MembraneContactSite now in Cell Reports @cp-cellreports.bsky.social! Big thanks to @rwedlichsoldner.bsky.social, @flofroehlich.bsky.social, @ruferbus.bsky.social, Daniel Kümmel lab, Thomas Becker lab! www.cell.com/cell-reports...

The Myo2 adaptor Ldm1 and its receptor Ldo16 mediate actin-dependent lipid droplet motility

Zhao et al. identify the molecular machinery for lipid droplet motility, consisting of the type V myosin Myo2, the Myo2 adaptor protein Ldm1, and its surface receptor Ldo16. They uncover a molecular l...

cell.com

🐍Heute ist der Welttag der Schlange!

RiffReporter@riffreporter.bsky.social · last yr.

Giftig, schleimig, böse? Über #Schlangen gibt es viele Vorurteile. Ist etwas dran? Und wozu brauchen wir Schlangen überhaupt? Das hat @susannewedlich.bsky.social zum Welttag der Schlange aufgeschrieben: #archiv https://t1p.de/de877

🦠 Kieselalgen sind die wohl schönsten Schleimer der Welt. 🌊 Ich hab aufgeschrieben, wie wichtig sie im Wattenmeer sind (Sauerstoff, Biomasse, Kraftnahrung für Zugvögel)- und was sich jetzt vielleicht verschiebt: #Watt #klimakrise #Zugvögel Keine Paywall: www.riffreporter.de/de/umwelt/ki...

Einzellige Schleimer: Kieselalgen halten das Watt zusammen

Die dünne Haut des Wattbodens verbirgt eine unsichtbare Welt. Kunstvoll gestaltete Kieselalgen geben dem Ökosystem Biomasse, Sauerstoff und Stabilität.

riffreporter.de

Guter Journalismus zB über die Klima- und die Biodiversitätskrise ist wichtig. Das Team von @riffreporter.bsky.social leistet hier fantastische Arbeit. Und ihr könnt dazu beitragen, dass das weiter möglich ist. www.startnext.com/riffreporter

Wenn Bücher groß werden: Vor 6 Jahren ist am 31.10. mein "Das Buch vom Schleim" 🐌 erschienen: www.matthes-seitz-berlin.de/buch/das-buc... Seit dem 31.10. läuft nun im Museum der Medizingeschichte der Charité die Ausstellung SCHLEIM, die ich mitkuratieren durfte: bmm-charite.de/ausstellunge...

Das Buch vom Schleim

Matthes & Seitz Berlin - Im Grunde genommen ist Schleim nur Wasser in molekularen Ketten. Doch was heißt das schon. Das auf den ersten Blick so bescheidene Material ist ein Phänomen, das Raum und Zeit...

matthes-seitz-berlin.de

The next #DGZ Focus Workshop on #Cilia & #Centrosomes will take place November 25 (end of October is our DGZ meeting in HD). Join us for a great speaker line-up, and big thanks to David Mick @mick-lab.bsky.social & Dagmar Wachten @wachtenlab.bsky.social for organizing!

Großer Erfolg für Lina Herhaus: Die Leiterin der MICROSTAR-Nachwuchsgruppe „Zelluläre Immunsignale“ am HZI erhält einen Exploration Grant der Boehringer Ingelheim Stiftung & den Walther Flemming Award der DGZ für ihre innovative Forschung am Immunsystem. www.helmholtz-hzi.de/media-center...

Kudos to @eliasbarrigalab.bsky.social for the Innovation DGZ Prize for his work on #CellMigration A great Chilean 🇨🇱 in #STEM 💪🏽🔥 @dgz.bsky.social #DGZ50

We start the second day of the #BiomembraneDays25 with impressive results on phase separation in the yeast plasma membrane by Roland Wedlich-Söldner

Our study explains why yeast cells lacking Neo1 are neomycin sensitive, which targets PI4P when it is exposed on the outer leaflet of the plasma membrane. We show that Neo1 flips PI4P, offering key mechanistic insight into how phosphoinositide membrane asymmetry is maintained. @vuartsci.bsky.social

Very excited to announce the #DGZ awardees 2025. We look forward to welcoming all award winners to our meeting in Heidelberg, where they will present their work!

We are excited to announce the details for this year’s #DGZ International Meeting, a very special one as we are celebrating 50 years of DGZ! Join us in October in Heidelberg, where the DGZ was founded in 1975. Check the speakers line-up etc. at the poster. Registration: shorturl.at/EHUzb #DGZ50

JCS interview with Sandra ahead of our DGZ meeting in Heidelberg where we will celebrate 50 years of DGZ. shorturl.at/rCQg5

Sandra Iden@sandraiden.bsky.social · 11mo ago

Recent interview for @jcellsci.bsky.social. Thx for important services JCS & @biologists.bsky.social provide to the cell science community. Glad we could share aspects on #50yearDGZ @dgz.bsky.social, @dfg.de @hetcci.bsky.social SPP2493, #CGBM & my great team @uni-saarland.de shorturl.at/rCQg5

Join us for the next @DGZ_info Focus Workshop on #celladhesion and #extracellularmatrix, Tuesday April 30 at noon in Zoom, organized by Carsten Grashoff and @WickstromLab. Speakers: Srishti Rangarajan @uni_muenster, @IngoThievessen, @amaia_cipitria, @JNuchel

In eigener Sache: Es geht so nicht mehr Der #WiardaBlog hat sich zu einer einschlägigen Adresse der Berichterstattung zur Bildungs- und Wissenschaftspolitik entwickelt. Doch wirtschaftlich steht die Idee seiner freien Zugänglichkeit vor dem Scheitern. www.jmwiarda.de/2024/03/05/i...

Join us for the CRC 1348 meeting on "Molecular Mechanisms of Membrane Organization", May 22-24 2024 in Münster, Germany. For further information and free registration please visit our Meeting Website: crc1348.ycode.site

Join us for the CRC 1348 meeting on "Molecular Mechanisms of Membrane Organization", May 22-24 2024 in Münster, Germany. For further information and free registration please visit our Meeting Website: crc1348.ycode.site

Join us tomorrow, Feb 27, at noon CET, for the next virtual @DGZ_info Focus Workshop on “Imaging for Cell Biology”! #cellbiology #DGZ #imaging #microscopy

Mark your calendars: International @SFB1348 Meeting @uni_muenster May 22-24, 2024. REGISTER NOW! crc1348.ycode.site

Fantastic Focus Workshop today on Mitosis and Meiosis - with talks by Martin Würz, Jörg Mansfeld and Marcel Ernst. New format with 15 min talks and lots of discussion worked really well. See you all for next time on February 27th!