Danny Saban
@sabanlab.bsky.social
Professor Immunologist leveraging the eye as an organ model system to study #neuroimmunology #mucosalimmunology #immuneprivilege #macrophages #microglia #DC #neutrophils https://youtube.com/@danielrsaban?si=4cOtXhcsvyKDGuMe
ICYMI: The human cornea packs 7k nerve endings/mm², all from just a few hundred neurons. How that remarkable convergence is organized, and breaks down has long been difficult to resolve. Our NEI U01 consortium offers a tool-driven roadmap for what comes next iovs.arvojournals.org/article.aspx...
I defended my PhD 10 years ago today. That was the least remarkable thing that happened that day. Sharing something I wrote about it last year. Since then "the horrors persist but so do we." And with dignity.
Resident tissue #macrophages (RTM) are now recognized as integral regulators of tissue physiology, not transient immune sentinels. one fundamental question remains unresolved: why do some populations achieve lifelong self-maintenance, while others are replaced under steady-state conditions? 🧵1/11
Long-lived resident tissue macrophages govern intraocular pressure homeostasis by regulating extracellular matrix turnover, contributing to resistance-generating tissues that are dysfunctional in glaucoma @cp-immunity.bsky.social www.cell.com/immunity/ful... @dukeeyecenter.bsky.social
Preprint of National Eye Institute, U01-Funded Consortium Consensus on Ocular Surface Innervation is out ! "Corneal Innervation Research at a Crossroads: A Tool-Driven Roadmap for the Future "
#2016Nostalgia when we published our first #microglia paper ! www.nature.com/articles/sre...
Fate mapping reveals that microglia and recruited monocyte-derived macrophages are definitively distinguishable by phenotype in the retina - Scientific Reports
Scientific Reports - Fate mapping reveals that microglia and recruited monocyte-derived macrophages are definitively distinguishable by phenotype in the retina
nature.com
Surfers in Bondi Beach #Australia hold a tribute the victims of the attack last week. ❤️
Not to be missed! Our next #globalimmuno talk, today Wednesday, November 5th at 9am PST, noon EST, 5pm GMT by Dr. Daniel Saban. Title: “A Neuroimmune Niche that Underpins Touch Sensation” ZOOM LINK: us06web.zoom.us/webinar/regi... LIVE ON YOUTUBE: www.youtube.com/@GLOBALIMMUN...
Welcome! You are invited to join a webinar: GLOBAL IMMUNOTALKS: Virtual immunology seminar series . After registering, you will receive a confirmation email about joining the webinar.
Subscribe to our YouTube channel to stay updated and participate in the discussions: https://www.youtube.com/c/GLOBALIMMUNOTALKS We now offer: ✅ Live streaming on YouTube (in addition to Zoom) ✅ Asyn...
us06web.zoom.us
Welcome!
The Patani Laboratory@patanilab.bsky.social · 11mo agoDear Friends and Colleagues, we are finally on Bluesky! Our lab uses human stem cell models to understand brain, spinal cord and peripheral nerve diseases, focusing on RNA metabolism and cellular autonomy. We are based at NUS in Singapore at the Life Sciences Institute: www.nus.edu.sg/lsi/
#CSNeuroimmune25 Come learn about a novel neuro immune niche that underpins touch! Littleton Tues P2.38 13:00-14:30 youtu.be/BAtzNKj4wxA?si…
Supplemental Video 2_Littleton et al_2025
YouTube video by Daniel R. Saban
youtu.be
Getting ready for #CSNeuroimmune25 tomorrow in NYC! Excited to see everyone, and looking forward to some cool #neuroimmunology! @cp-neuron.bsky.social @cp-immunity.bsky.social www.cell-symposia.com/neuroimmunol...
Fierce Biotech story about the "priorities" memo www.fiercebiotech.com/research/nih... 1/4
NIH chief calls for immediate research review, dangling threat of project termination
Jayanta Bhattacharya, M.D., Ph.D., director of the National Institutes of Health (NIH), has called on the agency’s scientific leadership to immediately review all of their current and planned resea | ...
fiercebiotech.com
Some say you either have "it" or you don't, and that creativity cannot be learned, but that really misses the point. Creativity is lost in the wrong environment. We need to recognize the "night science" aspect of our work and that we need to nurture it in our training. www.nature.com/articles/d41...
Can creativity in science be learnt? These researchers think so
Time pressure gets in the way of ideas. Developing ‘creative oases’ and small grants for risky ideas can encourage innovative thinking in science.
nature.com
Beautiful spatial transcriptomics of developing meninges and meningiomas. Hints into the origins of meningiomas arising from the dural border 🤩🧐
Cell atlas of the developing human meninges reveals a dura origin of meningioma
The vertebrate central nervous system is enveloped by the meninges, consisting of the pia, arachnoid, and dura layers. The arachnoid is hypothesised to give rise to the most common primary intracrania...
biorxiv.org
You don’t see #VisionResearch. But it sees you. Most of us don’t think about vision research. But millions live every day with the impact of it—when it’s there, and when it’s not. Vision research changes lives. bit.ly/3GXVIaZ #SeeWhatMatters #FundFederalVisionResearch
Previously unknown prenatally derived macrophage is uniquely involved in lipid metabolism and vascular maintenance and is decreased and dysfunctional in age-related macular degeneration @jem.org rupress.org/jem/article/...
Fortmann, Grant et al. show that prenatally derived #macrophages support choroidal health and decline in age-related #maculardegeneration rupress.org/jem/article/... 📘 In our Clinical #Immunology Collection: rupress.org/jem/collecti... #FOCIS2025
Wow.. this cover!! 😍 @jem.org looking jazzy this month! Take a look at the July issue here 👉 rupress.org/jem/issue/22...
Journal of Experimental Medicine@jem.org · last yr.Our July issue is here! rupress.org/jem/issue/22... The cover image depicts the spatial organization and cellular composition of the human choroid (posterior face) by multiplex immunofluorescence. From Fortmann et al. (doi.org/10.1084/jem....)
Excited to share our new work, led by an exceptional graduate student, Tornike Mamuladze, on the role of meningeal mast cells in regulation of brain/dura access points, with implications to CSF flow dynamics and meningitis || www.cell.com/cell/fulltex...
Mast cells regulate the brain-dura interface and CSF dynamics
Dural mast cells control cerebrospinal fluid dynamics at critical brain-dura interfaces, specifically arachnoid cuff exit points. Their activation limits pathogen brain entry via histamine-induced vas...
cell.com
If a foreign adversary snuck into our Federal budget and cut science research and education the way we’re cutting it ourselves — strategically undermining America’s long-term health, wealth, and security — we would likely consider it an act of war.
Excited to see this collection out! Thank you to all the authors and reviewers who contributed!
Immunity@cp-immunity.bsky.social · last yr.May issue is online! Explore reviews on the #neuroimmune axis! The beautiful cover was designed by Ella Marushchenko, working with @jonykipnis.bsky.social. A brain encased in a walnut shell that is cracking open symbolizes our growing understanding of #neuroimmunology www.cell.com/immunity/iss...
Nerve- and airway-associated interstitial macrophages mitigate SARS-CoV-2 pathogenesis via type I interferon signaling: Immunity www.cell.com/immunity/ful... our study out now in@cp-immunity.bsky.social #macrophages
Nerve- and airway-associated interstitial macrophages mitigate SARS-CoV-2 pathogenesis via type I interferon signaling
The local immunoregulatory mechanisms that safeguard the host from excessive lung infection inflammation remain unclear. Yeung, Yokota et al. uncover the essential role of nerve- and airway-associated...
cell.com
Sejiro Littleton takes home the coveted #GliaCamp best talk award 🥇. “Neuroimmune niche underpins touch.” He’s on the market for a postdoc position, for those who are asking! @MosemanLab @FilianoLab and students organized another wonderful camp ⛺️. @LongJun_Wu killer keynote@ - who can ask for more
