Check out this cool new paper from Mike Rogers lab @garvaninstitute.bsky.social out in @cp-immunity.bsky.social! Their new model of MKD deficiency (aka Hyper IgD syndrome) as a "prenylopathy": NK cell degranulation defect -> compensatory increase IFN gamma -> autoinflammation. Can Rx with JAKi!

NK cell dysfunction and interferon gamma production underlie autoinflammation in mevalonate kinase deficiency

The mechanisms linking defective protein prenylation to systemic inflammation in mevalonate kinase deficiency remain unclear. Munoz et al. reveal that mice and humans with MKD have defective NK cells,...

cell.com

Resistance of IgG–FcR interactions to shear stress can be engineered, establishing a separate parameter for optimizing antibody effector functions beyond affinity alone. www.cell.com/immunity/pdf... Congratulations to Dr. Bowie Cheng and the whole team 🎉.

My new comprehensive review of Immune Memory to Vaccines is out! It has an emphasis on human vaccines. It is also accompanied by a full video lecture. Enjoy! @lji.org @cp-immunity.bsky.social authors.elsevier.com/sd/article/S...

Excited to share our new paper in @cp-immunity.bsky.social showing that "Germline-targeting HIV immunogen induces cross-neutralizing antibodies in outbred macaques" A promisingstep toward an HIV vaccine advancing soon to human clinical testing! Immunity www.cell.com/immunity/ful...

Germline-targeting HIV immunogen induces cross-neutralizing antibodies in outbred macaques

Inducing broadly neutralizing antibodies (bnAbs) remains a challenge in HIV vaccine development. Mishra et al. show that an engineered germline-targeting HIV trimer, Q23-APEX-GT2, primes rare V2-apex ...

cell.com

Two new KI studies published in @cp-immunity.bsky.social have mapped immune gene variation across multiple global populations and shown how these variations affect the ability to form neutralising antibodies, for example against the #influenza virus 🧪 #Immunology #Genetics news.ki.se/large-mappin...

Large mapping of hereditary differences in the immune system

Inherited variations in antibody genes can affect how we respond to infections and vaccines, show two new studies from Karolinska Institutet published in the journal Immunity. The researchers have map...

news.ki.se

New paper reveals how the human immune system fights #malaria caused by Plasmodium vivax, opening new avenues to develop #vaccines against the most widespread form of malaria. Published in @cp-immunity.bsky.social @burnetinstitute.bsky.social @wehi-research.bsky.social doi.org/10.1016/j.im...

Those who know me, know I’m not someone who changes his preferences & behaviors lightly. As Ron Swanson said, “I regret nothing. The end.” Well, let me tell you about our new study, out from The Perry Lab @mskcancercenter.bsky.social in @cp-immunity.bsky.social, which is the exception. /1

Excited to share my paper published today in @cp-immunity.bsky.social! We find that when CTLs integrate antigen and cytokine signaling, the timing of these cues matters - shedding light on an old question: Why do NK cells sometimes behave like CD8+ T cells? www.sciencedirect.com/science/arti...

Stepwise epigenetic signal integration drives adaptive programming of cytotoxic lymphocytes

Lymphocyte differentiation during infection depends on the integration of antigen and cytokine signals, yet how the timing and sequence of these cues …

sciencedirect.com

Commensal-derived trehalose monocorynomycolate triggers γδ T cell-driven protective ocular barrier immunity: Immunity www.cell.com/immunity/ful... @cp-immunity.bsky.social

State-specific enhancer landscapes govern microglial plasticity @cp-immunity.bsky.social www.cell.com/immunity/ful...

Thrilled to share our new paper on reactive microglial plasticity! Using long-term fate mapping and epigenetic profiling, we uncover the remarkable plasticity of reactive microglia across the lifespan and the enhancers and associated TFs that govern state transitions.

Immunity@cp-immunity.bsky.social · 7mo ago

Online now: State-specific enhancer landscapes govern microglial plasticity

So excited to share with you our latest work, result of my PhD with Dr.Rejane Rua at the @ciml.bsky.social! 🍾 If you want to brainstorm about bone channels and skull’s contribution to meningeal immunity, have a look! 🔬🧠

Immunity@cp-immunity.bsky.social · 7mo ago

Online now: Remodeling of skull bone channels regulates immune infiltration into the meninges during neuroinflammation

We are #absolutely #thrilled to #present @cp-immunity.bsky.social - Deep profiling of human T cells defines compartmentalized clones and phenotypic trajectories across blood and tonsils: Immunity www.cell.com/immunity/ful...

Deep profiling of human T cells defines compartmentalized clones and phenotypic trajectories across blood and tonsils

Human T cell responses are often studied using blood, yet most T cells reside in tissues. By comparing T cell receptor repertoires from millions of T cells from autologous tonsils and blood, Sureshcha...

cell.com

Immunity is now on LinkedIn! Follow us if you love #immunology! And if you don't already love immunology, maybe we'll change your mind 😀https://www.linkedin.com/company/immunity-cellpress

Immunity by Cell Press | LinkedIn

Immunity by Cell Press | 45 followers on LinkedIn. Cutting-edge research in immunology from around the world, and commentaries by thought leaders. | Immunity publishes the most important advances in i...

linkedin.com

Our new paper reveals that chronic active MS lesions feature CD8⁺ T cell niches with lipid-laden, inflamed microglia. IFN-γ drives cholesterol buildup, linking dysregulated lipid metabolism to inflammation and meurodeg. Check it out @cp-immunity.bsky.social www.sciencedirect.com/science/arti...

Single-cell spatial transcriptomic profiling defines a pathogenic inflammatory niche in chronic active multiple sclerosis lesions

Compartmentalized inflammation is a key driver of multiple sclerosis (MS) progression, but the mechanisms sustaining its persistence remain unclear. A…

sciencedirect.com

How is the persistence of compartmentalized inflammation sustained in MS? Our new study in @cp-immunity.bsky.social offers some hints. cell.com/immunity/ful... Thanks and congratulations to all contributors

For those of you joining us for the editors panel at #RTN2025, please bring your questions! We have more editors than I've ever seen at a single meeting, so this is your chance to get answers to all of your burning questions! @genelayinstitute.bsky.social @rtnconference.bsky.social

Looking forward to #RTN2025 today! Excited for some #neuroimmunology! If you'll be there, please look for me and say hello! @genelayinstitute.bsky.social @rtnconference.bsky.social genelayinstitute.org/rtn/#program

#CSNeuroimmune25 @danmucida.bsky.social talking about food allergy and neuroimmune response to helminth infection @cp-neuron.bsky.social

#CSNeuroimmune25 Come learn about a novel neuro immune niche that underpins touch! Littleton Tues P2.38 13:00-14:30 youtu.be/BAtzNKj4wxA?si…

Supplemental Video 2_Littleton et al_2025

YouTube video by Daniel R. Saban

youtu.be

Getting ready for #CSNeuroimmune25 tomorrow in NYC! Excited to see everyone, and looking forward to some cool #neuroimmunology! @cp-neuron.bsky.social @cp-immunity.bsky.social www.cell-symposia.com/neuroimmunol...

Happy to share that our work "Amyloid-β induces lipid droplet-mediated microglial dysfunction via the enzyme DGAT2 in Alzheimer’s disease" is out now @cp-immunity.bsky.social! ➡️ www.cell.com/immunity/ful...

Amyloid-β induces lipid droplet-mediated microglial dysfunction via the enzyme DGAT2 in Alzheimer’s disease

Why microglia stop reducing amyloid deposits from Alzheimer’s disease (AD) brains is unknown. Prakash, Manchanda, et al. show that microglia increase their lipid droplets and lose their phagocytic cap...

cell.com

It was a privilege and a pleasure for both myself and @menezesnmaria.bsky.social‬ to preview a great upcoming article in @cp-immunity.bsky.social‬ by @kamphorstlab.bsky.social‬ showing an unexpected inhibitory role for ICOS in exhausted CD8+ T cells. www.cell.com/immunity/abs...

The high (I)COSt of costimulation for exhausted T cells

ICOS agonists are being investigated for cancer immunotherapy based on the idea that they will reinvigorate exhausted CD8+ T cell anti-cancer immunity. Humblin et al. unexpectedly find the opposite—th...

cell.com

Thanks to Dr. Pinho-Ribeiro for previewing our latest work in the current issue of Immunity. @cp-immunity.bsky.social @kavithascranton.bsky.social Neural tuners of lung immunity: Immunity cell.com/immunity/ful... cell.com/immunity/ful...

Neural tuners of lung immunity

Pulmonary immunity must strike a precise balance between protecting the delicate mucosal tissue from environmental threats and preserving its vital gas-exchange function. In this issue of Immunity, Li...

cell.com

#EpigeneticPower! 💥 #NewPaperAlert! We show @cp-immunity.bsky.social that endogenous oxidized lipids decide whether host survives or dies during #sepsis, #ARDS, or Staph infection! Ox lipids bind & inhibit #AKT, boosting inhibitory H3K27 methylation via EZH2 & blocking #IL10!

Epigenetic silencing of interleukin-10 by host-derived oxidized phospholipids supports a lethal inflammatory response to infections

Upon pathogen detection, phagocytes trigger immunity. This process induces tissue stress and the formation of host-derived molecules that further tune immune responses. We show that host-derived oxidi...

dlvr.it

A new function for an ancient innate immune stimulus. Zanoni et al report that oxidized lipids control IL-10 expression, impacting host defense and disease. Kudos to the authors on this important discovery www.sciencedirect.com/science/arti...

Epigenetic silencing of interleukin-10 by host-derived oxidized phospholipids supports a lethal inflammatory response to infections

Phagocytes initiate immunity to invading microorganisms by detecting pathogen-associated molecular patterns via pattern recognition receptors. Pathoge…

sciencedirect.com

#ChromatinPower #WhatADay! After our paper @cp-immunity.bsky.social (free link 👉 authors.elsevier.com/a/1lS0g3qNrU-i…) happy for our tiny contribution to @xuzhoulab.bsky.social Medzhitov &co amazing paper @cp-cell.bsky.social showing pH controls inflammation via chromatin remodeling! Free link👇

Optogenetic vagal nerve stimulation attenuates heart failure by limiting the generation of monocyte-derived inflammatory CCRL2+ macrophages: @cp-immunity.bsky.social www.cell.com/immunity/ful...

Optogenetic vagal nerve stimulation attenuates heart failure by limiting the generation f monocyte-derived inflammatory CCRL2+ macrophages

Parasympathetic neuronal dysfunction is associated with heart failure, yet the underlying mechanism is poorly understood. Here, Li et al. demonstrate that optogenetic activation of the vagus nerve pre...

cell.com

Early discounted registration ends June 27th for #CSNeuroimmune25, Sept 7–9, NYC! Explore cutting-edge #neuroimmunology and engage with experts in the field. Keynotes: David Julius & Susan Kaech hubs.li/Q03qS95l0 @cp-neuron.bsky.social @kavithascranton.bsky.social @cellpress.bsky.social

The R136S mutation in the APOE3 gene confers resilience against tau pathology via inhibition of the cGAS-STING-IFN pathway @cp-immunity.bsky.social www.cell.com/immunity/ful...