Sara McArdle
@saramcardle.bsky.social
Staff Scientist at the La Jolla Institute Microscopy and Histology Facility. I love cat videos and microscopy images and I believe that Matlab is better than Python :)
A massive update: At least ~15 companies~ are selling scientists antibodies using faked validation data. We've documented 18,000+ manipulated images on 17,000+ products sold by leading laboratory suppliers including Thermo Fisher, Abcam, Santa Cruz Biotechnology, Millipore Sigma and Bio-Techne. 1/🧵
If you see this, quote the energy you bring to Bluesky
Christophe 🔬 Leterrier@christlet.bsky.social · 4w agoIf you see this, quote the energy you bring to Bluesky
2 more days to submit an abstract to the QBI Multiplexing conference! Come to beautiful San Diego to discuss all things multiplex immunofluorescence. Registration is still open for those who want to attend but not speak.
Sara McArdle@saramcardle.bsky.social · 2mo agoThere is still time to register for the QBI Multiplex Image Analysis and Computational Pathology workshop! Details below.
There is still time to register for the QBI Multiplex Image Analysis and Computational Pathology workshop! Details below.
Sara McArdle@saramcardle.bsky.social · 3mo agoAnnouncing a Multiplex Image Analysis and Computational Pathology workshop through the Quantitative BioImaging Society Talks on cell segmentation and phenotyping, data normalization, spatial analysis, and more! Hosted by @lji.org in San Diego, CA, Sept. 15-16 quantitativebioimaging.com/miacp2026/
I will arrive at your therapeutic area with a molecule so chiral, so offensive to your multi-parameter optimization algorithm, that your model will flag it as “not drug-like.” It will then proceed to work, in vivo. inpreparation.substack.com/p/go-ahead-a...
Go Ahead and Use AI to Design Drugs. It Will Only Help Me Dominate You.
A message of support for my fellow drug hunters
inpreparation.substack.com
From Segmentation to Pipelines: AI-Assisted Bioimage Analysis with Python 21-24 September 2026, Erasmus MC Rotterdam (The Netherlands) Application deadline: 25 July 2026 More information & signing up: courses.microscopie.nl?event_id=527
NL-BioImaging Advanced Image Analysis for Biologists 2026
courses.microscopie.nl
Announcing a Multiplex Image Analysis and Computational Pathology workshop through the Quantitative BioImaging Society Talks on cell segmentation and phenotyping, data normalization, spatial analysis, and more! Hosted by @lji.org in San Diego, CA, Sept. 15-16 quantitativebioimaging.com/miacp2026/
Multiplex Image Analysis & Computational Pathology - QBI Society
quantitativebioimaging.com
25 minutes of Photuris tremulans fireflies in Tennessee's smoky mountains.
The Thermo Fisher situation keeps getting worse. We've now collected 450+ problematic images presented as verification data in TF's antibody catalog. This includes: 🖌️ Dozens more images with duplications or painting 🖨️ Hundreds of blots that all share the same background (behold slideshow below)
The world’s largest sand battery got through Finland’s harshest winter in years. 2,000 tonnes of sand, heated to 500-600°C by cheap power, feeding district heating in Pornainen. And it worked. Result from one install: oil down 100%, emissions down 70%. Industrial process heat is the real prize.
More about the Cowlitz Tribe's beaver relocation program, which is among the largest in the West. "Beavers are amazing ecosystem engineers and create high-quality, complex wetland habitats that support biodiversity and ecosystem properties that can help buffer projected impacts of climate change.”
Check out baby beavers on ‘Kit Cam’ thanks to Cowlitz Indian Tribe
The Cowlitz Indian Tribe recently launched a new livestream featuring a mother beaver and four kits born April 16 as they wait to be relocated.
columbian.com
Birdsky! I need advice. This little bird has been sitting unnaturally still near my back door, and didn't even move when my kid excitedly banged on the glass. It's def alive, but I think not healthy? Is there anything I can do to help it?
I just called my reps with @5calls.org, you should too: 5calls.org
5 Calls
Spend 5 minutes. Make 5 calls. Make your voice heard.
5calls.org
Last week I shared results showing large variability between Imaris/Arivis/Aivia vs Python/ImageJ/CellProfiler. Much was due to small code issues (x/y swaps, microns vs pixels). After fixing, results are much closer—no big log-scale gaps. Some variability remains, but large errors weren’t real.
Love is in the air at Edinburgh zoo. Pebbling marks the start of the breeding season for Gentoo penguins. Kids at Edinburgh Children's Hospital Charity painted pebbles for the penguins to choose from and present to their mates.
Good morning from the harbor seal factory! We got several working harbor seal families ready to challenge the establishment! Here you can see a mother teaching their baby about the union. Get em started young! #UnionsForAll #SealSky 🦭 🦑
Videos are now available from the 2025 QuPath Training Course, from @iamichaelnelson.bsky.social, @zmikulski.bsky.social, and myself. Watch for multiplex tutorials! For image analysis inspiration! Or just watch to hear me speak like an overcaffeinated squirrel! www.youtube.com/playlist?lis...
From Samples to Knowledge 2025: QuPath Training Course - YouTube
Recordings of the 2-day hands-on workshop at the La Jolla Institute for Immunology in February 2025. To follow along please use QuPath 0.6.0 or later.
youtube.com
Sara McArdle@saramcardle.bsky.social · 2y agoRegistration is OPEN for the 2025 QuPath Training Course on Feb 24-25 and an Advanced Users Meeting on Feb 26 at @lji.org . The year, the focus will be on Multiplex Immunofluorescence analysis. Hosted by Zbigniew Mikulski, @iamichaelnelson.bsky.social , and myself.
🔬 🖥️ Applications are open for the CSHL course Quantitative Imaging: From Acquisition to Analysis (April 6–21, 2026)! An intensive, hands-on course covering advanced fluorescence microscopy and quantitative image analysis using open-source tools. 🗓️ Apply online by Jan 30, 2026
Quantitative Imaging: From Acquisition to Analysis
Cold Spring Harbor Laboratory Meetings & Courses -- a private, non-profit institution with research programs in cancer, neuroscience, plant biology, genomics, bioinformatics.
meetings.cshl.edu
Quantitative Fluorescence Microscopy 2026: Registration Open! An international course in #fluorescence #microscopy and imaging for advanced grad students, postdoc trainees, imaging core managers and researchers who are incorporating the technology into their laboratories. 🧪 🐟🎸 🍎 👩🔬 🌎 🖥️ 🧬
Quantitative Fluorescence Microscopy 2026
mdibl.org
Holy CRAP. Retired engineer takes random pics of *kids*, without consent or attribution, bins them into “autistic” or “not autistic”, and uploads that “data” for free on Kaggle. Well over a HUNDRED papers are published, 38 in Springer Nature, 25 in IEEE, using it. And no reviewers objected? WTF.🧪
Springer Nature retracts, removes nearly 40 publications
The dataset contains images of children’s faces downloaded from websites about autism, which sparked concerns at Springer Nature about consent and reliability.
thetransmitter.org
XXL NEWS! Greg and Alex are coming to America in January 2026 to spread the word of the Taskmaster. Shows in Chicago, Boston, Philadelphia, Washington D.C. and New York! Sign up to the mailing list for pre-sale access. taskmaster.tv/taskmaster-l...
"Runctitiononal features"? "Medical fymblal"? "1 Tol Line storee"? This gets worse the longer you look at it. But it's got to be good, because it was published in Nature Scientific Reports last week: www.nature.com/articles/s41... h/t @asa.tsbalans.se
Python notebook from a two year old paper: Oh, no, I cannot run, there is a slight mismatch of a logging library. ImageJ plugin from 2001 running on Quantum Java 51 in 2078: Your 100 petabyte temporal hologram was successfully thresholded.
Just 4 days until the start of I2K and its 33 totally free image analysis tutorials and events! Please share with your "home networks", especially early career researchers - the videos will be amazing and high-impact no matter how many people attend live, BUT (1/x)
![Comic. Panels up to the 10-year point are grayed out. New panels since the Ten Years comic, which chronicles the first ten years of PERSON 1's journey with cancer: (1) [two people in bed] PERSON 1 (woman): One more chapter? PERSON 2 (man): Don’t we both have to get up early? PERSON 1: Nnnnnggggh PERSON 2: Sure, good point. (2) [many people wearing masks, walking while looking at graphs on their phones] (3) [birds landing on people] PERSON 2 in beanie and scarf: Hah! They like *my* seeds best. PERSON 1 in scarf holding phone with a bird sitting on it: Wait, how do I take a picture of this one? (4) [two people rowing boats with tree landscape] (5) [Person 1 carries overflowing stack of things to Person 2 in bed] PERSON 1: I brought you honey lemon tea, more pillows, a cinnamon roll, Tylenol, another blanket, a– PERSON 2: It was just Appendicitis, I’m really– PERSON 1: *It is my turn to take care of you and I am going to do it right!* (6) [Two people in car] (7) [still in car) PERSON 1: Oh my god. PERSON 2: Oh my god. (8) [car driving] PERSON 1: Pull over! PERSON 2: I am! (9) [both people get out of car] (10) [Large colored panel of aurora borealis over water with both people looking on] (11) [Person 1 sits against tree while Person 2 lies on the ground] PERSON 1: Fifteen years. No sign of the cancer. (12) I *am* having some weird symptoms. Joint pain. Fatigue. I think I’m losing my close-up vision. PERSON 2: Yeah. Me too. (13) PERSON 2: I think we’re getting old. (14) PERSON 1: I guess that’s okay. PERSON 2: It’s all I wanted.](https://cdn.bsky.app/img/feed_thumbnail/plain/did:plc:cz73r7iyiqn26upot4jtjdhk/bafkreihwhjblp5lyiwp63ouar7ocfea7evmckytoeo7rkfuoo4gw5rnrra)