Tessera
Folgen

Ted Satterthwaite

@ted-satterthwaite.bsky.social

McLure II Professor PennLINC | University of Pennsylvania www.pennlinc.io neurodevelopment, neuroimaging, neuroinformatics, & mental health

117 Posts1138 Follower444 Folgt
Sidhant Chopra@sidchop.bsky.social · last mo.

🧠 New work showing prominent and widespread 𝘪𝘯 𝘷𝘪𝘷𝘰 pre-synaptic terminal reductions in people with schizophrenia.🧠 nature.com/articles/s41... Strongest effects in left hemisphere, but synaptic loss didn't track with MRI grey matter alterations, but did align with..👇1/4

Widespread synaptic density loss in schizophrenia follows molecular and network architecture - Molecular Psychiatry

Molecular Psychiatry - Widespread synaptic density loss in schizophrenia follows molecular and network architecture

nature.com

Corey Horien@coreyhorien.bsky.social · last mo.

Pumped to share our latest work! Here, we peeked under the hood of fMRI-based predictive models to ask whether models of sustained attention and autism symptoms rely on overlapping functional connections. www.medrxiv.org/content/10.6... 1/2

Feature overlap in transdiagnostic connectome-based models of sustained attention and autism symptoms

Sustained attention is an important neurobiological process. Difficulties with attention play a key role in neurodevelopmental disorders, such as attention-deficit/hyperactivity disorder (ADHD) and au...

medrxiv.org

Lucinda Sisk@lucindasisk.bsky.social · 2mo ago

🧠‼️ Socioeconomic variables show the strongest associations with the brain out of 649 measures—surpassing cognition and mental health. Grateful for the chance to write a perspective with @ted-satterthwaite.bsky.social about @smarek0502.bsky.social and team's important findings! tinyurl.com/bdhk6bc8

Childhood environments shape the brain

Socioeconomic factors top the list of influences on children’s brain structure and function

science.org

Scott Marek@smarek0502.bsky.social · 2mo ago

What matters most for childhood brain organization? We analyzed 649 variables. The answer: Socioeconomics (SES); with brain patterns pointing at sleep & stress as drivers. Even brain-IQ associations were better explained by SES. In Science today: www.science.org/doi/10.1126/...

Scott Marek@smarek0502.bsky.social · 2mo ago

Thanks @ariellekeller.bsky.social ! And yes, please check out the amazing perspective by @lucindasisk.bsky.social and @ted-satterthwaite.bsky.social!

Arielle Keller@ariellekeller.bsky.social · 2mo ago

The evidence is clear: socioeconomic conditions play an *enormous* role in brain development Amazing work by @smarek0502.bsky.social &co doi.org/10.1126/science.aee6213 +perspective by @lucindasisk.bsky.social & @ted-satterthwaite.bsky.social doi.org/10.1126/science.aei3393 #neuroskyence #PsychSky

Ted Satterthwaite@ted-satterthwaite.bsky.social · 3mo ago

So excited to see this fabulous work by stellar MD-PhD student Briana Macedo now out as a preprint. Briana reports some of the strongest results I've ever seen -- very strong (25% variance, out-of-sample) associations between the childhood environment and white matter. Thread below!

Bbriana-mac.bsky.social@briana-mac.bsky.social · 3mo ago

How much does the childhood environment shape the brain? In our new preprint, we study the exposome (300+ environmental exposures) and link it to white matter structure in 8,000+ kids. 🧠✨ 🔗 Read the preprint: bit.ly/4wfsybZ 🧵 Thread below

Ted Satterthwaite@ted-satterthwaite.bsky.social · 4mo ago

Huzzah for @stevenmeisler.com, whose preprint on our new fully-processed ABCD dMRI data resource is now out. The super-clear results from this monumental effort will undoubtably change the way we approach studies of white matter development going forward.

Steven Meisler@stevenmeisler.com · 4mo ago

Diffusion MRI (dMRI) is a powerful tool to study white matter maturation. In our new preprint, we process and distribute a new resource of >24,000 ABCD dMRI scans using open source tools! We then evaluate how methods shape inferences about development. 🔗 www.biorxiv.org/content/10.6...

Ted Satterthwaite@ted-satterthwaite.bsky.social · 4mo ago

Incredible work by the absolutely stellar @bsevchik.bsky.social and @parkersingleton.bsky.social — the second installment of our open-science living meta-analysis of psychedelics for mental health.

Brooke Sevchik@bsevchik.bsky.social · 4mo ago

🍄 Our new living systematic review and meta-analysis on MDMA for PTSD is now live on medRxiv. Here's what we found and how we built upon our open science infrastructure to support it 🧵 www.medrxiv.org/content/10.6...

Ted Satterthwaite@ted-satterthwaite.bsky.social · 4mo ago

Beyond delighted to see this paper -- our first from the SYPRES initiative -- now out at @natmentalhealth.nature.com. Check out Parker's awesome thread below, w/ links to dashboard + all code + data.

Parker Singleton@parkersingleton.bsky.social · 4mo ago

🍄 Our new living systematic review and meta-analysis on psilocybin for depression is out now in Nature Mental Health. Here's what we found and the open science infrastructure we built to support it 🧵 Open-Access Link: rdcu.be/fbU5V

Thomas Yeo@bttyeo.bsky.social · 4mo ago

Updated preprint: doi.org/10.1101/2025... We have improved DELSSOME and showed that we can accelerate the estimation of two new biophysical models. By collating 12,005 individuals, we derive normative trajectories of cortical E/I ratio across the lifespan ...

doi.org

Thomas Yeo@bttyeo.bsky.social · last yr.

While the world burns, we cook up a new preprint! doi.org/10.1101/2025... Biophysical modeling is a key tool to derive mechanistic insights into the brain. These models are governed by biologically meaningful parameters (unlike artificial neural networks), but the dirty secret ... 1/N