I tracked every keyword in 22 years of Cosyne abstracts to map how computational neuroscience evolved — from Bayesian brains to neural manifolds to LLMs — and where it's heading next.

22 years of Brain Science: what CoSyNe tells us about the evolution of Neuroscience

Tracking the intellectual DNA of Computational and Systems Neuroscience through its flagship meeting

open.substack.com

Synaptome architecture shapes regional dynamics in the mouse brain | doi.org/10.1371/jour... How do diverse synapses relate to the spatial patterning of whole-brain dynamics? Justine Hansen explores @plosbiology.org ⤵️

🚀 We are hiring: a PhD position is available in my lab (gozzilab.it) at @iitalk.bsky.social, Italy. Project: large-scale brain network mapping in behaving mice using functional ultrasound imaging (FUSI). 📅 Deadline: March 31 🔗 tinyurl.com/4jtetxa9 Reshares appreciated 😊

Wanna compare dynamics across neural data, RNNs, or dynamical systems? We got a fast and furious method🏎️ The 1st preprint of my PhD 🥳 fast dynamical similarity analysis (fastDSA): 📜: arxiv.org/abs/2511.22828 💻: github.com/CMC-lab/fast... I’ll be @cosynemeeting.bsky.social - happy to chat 😉

netneurotools: a trainee-oriented approach to network neuroscience | doi.org/10.1101/2025... Our lab’s internal toolkit for accomplishing everyday tasks in brain imaging ⤵️

✨ New preprint ✨ Introducing cuBNM, a toolbox we developed to run brain simulations *much* more efficiently on GPUs 🎉🚀 Preprint: www.biorxiv.org/content/10.1... Documentation: cubnm.readthedocs.io/en/stable/ GitHub: github.com/amnsbr/cubnm 1/n 🧵

Great review on The Genetics of Human Handedness: Microtubules and Beyond www.cell.com/trends/genet... - handedness is such an interesting phenotype!

Genetics of human handedness: microtubules and beyond

Handedness (i.e., the preference to use either the left or the right hand for fine motor tasks) is a widely investigated trait. Handedness heritability is consistently estimated to be 25%. After decad...

cell.com

Excited to share that our work introducing the Reproducible Brain Charts (RBC) data resource is now published in Neuron!! 🎉 📚 Read the paper: authors.elsevier.com/c/1lpaF3BtfH... 🧠 Explore the RBC dataset: reprobrainchart.github.io

Golia Shafiei@goliashf.bsky.social · last yr.

(1/18) Now out on BioRxiv‼️ Reproducible Brain Charts: An open data resource for mapping brain development and its associations with mental health | doi.org/10.1101/2025... Funded by National Institute of Mental Health (NIMH)

The effect of spherical projections on spin tests for brain maps | doi.org/10.1162/IMAG... Spin tests are the de facto null model for map-to-map comparisons in brain imaging. Why don't they perfectly control false positives? @vincebaz.bsky.social explores ⤵️

🚨 Excited to share the latest preprint form the lab ➡️https://tinyurl.com/32d3be9f Here we tackle a long-standing chicken-or-egg 🐣🥚question in #autism and developmental neuroscience ➡️ Is excitation–inhibition (E:I) imbalance a "cause" or a "consequence" of #autism? Check out what we found! 🧵1/n

Integrating and interpreting brain maps | doi.org/10.1016/j.ti... Imaging and recording technologies make it possible to map multiple biological features of the brain. How can these features be conceptually integrated into a coherent understanding of brain structure and function? ⤵️

My lab is at @ohbmofficial.bsky.social in Brisbane! Find us at the @gradientsworkshop.bsky.social - great talks by @wanb.bsky.social Katerina Manoli (and others) Then we are at the educational sessions where @claraweber.bsky.social will present @amnsbr.bsky.social work on E/I balance.

Very happy about this paper and what we learned from it!! Please see Amins thread for more juice 🧃 and let us know if you are also on the E/I journey and like to try our toolbox

Amin Saberi@amnsbr.bsky.social · last yr.

🧠⚖️📉 How does the cortical excitation-inhibition ratio mature during adolescence? We asked this in our new paper just out in #ScienceAdvances ✨ “Adolescent maturation of cortical excitation-inhibition ratio based on individualized biophysical network modeling” 📄 www.science.org/doi/full/10.... 🧵⤵️

Amazing new paper on individual development of E/I balance during adolescence, first-authored by @amnsbr.bsky.social! Read @ Science Advances: www.science.org/doi/10.1126/... Bonus: Amin developed a tool to run biophysical network modelling on GPUs – because why shouldn't he? cubnm.readthedocs.io

Adolescent maturation of cortical excitation-inhibition ratio based on individualized biophysical network modeling

Individualized simulations reveal a decrease in excitation-inhibition ratio in association areas throughout adolescence.

science.org

Amin Saberi@amnsbr.bsky.social · last yr.

🧠⚖️📉 How does the cortical excitation-inhibition ratio mature during adolescence? We asked this in our new paper just out in #ScienceAdvances ✨ “Adolescent maturation of cortical excitation-inhibition ratio based on individualized biophysical network modeling” 📄 www.science.org/doi/full/10.... 🧵⤵️

This is awesome!

Amin Saberi@amnsbr.bsky.social · last yr.

🧠⚖️📉 How does the cortical excitation-inhibition ratio mature during adolescence? We asked this in our new paper just out in #ScienceAdvances ✨ “Adolescent maturation of cortical excitation-inhibition ratio based on individualized biophysical network modeling” 📄 www.science.org/doi/full/10.... 🧵⤵️

⭐ new paper Maturation of cortical excitation-inhibition (EI) in adolescence now in Science Advances 💥 A true tour de force of multimodal MRI, connectomics & GPU-powered 🤖!! biophysical modelling by hiball superheroes 🦸‍♂️🦸‍♀️🦸‍♂️ @amnsbr.bsky.social @sofievalk.bsky.social @sbe.bsky.social

Amin Saberi@amnsbr.bsky.social · last yr.

🧠⚖️📉 How does the cortical excitation-inhibition ratio mature during adolescence? We asked this in our new paper just out in #ScienceAdvances ✨ “Adolescent maturation of cortical excitation-inhibition ratio based on individualized biophysical network modeling” 📄 www.science.org/doi/full/10.... 🧵⤵️

🧠⚖️📉 How does the cortical excitation-inhibition ratio mature during adolescence? We asked this in our new paper just out in #ScienceAdvances ✨ “Adolescent maturation of cortical excitation-inhibition ratio based on individualized biophysical network modeling” 📄 www.science.org/doi/full/10.... 🧵⤵️

Adolescent maturation of cortical excitation-inhibition ratio based on individualized biophysical network modeling

Individualized simulations reveal a decrease in excitation-inhibition ratio in association areas throughout adolescence.

science.org

We are seeking a scientific coordinator for my research group at the Max Planck Institute for Human Cognitive and Brain Sciences in Leipzig 😊🧠🌈 Could be ideal for a gap year between MSc and PhD or PhD and postdoc! Please out more here: recruitingapp-5218.de.umantis.com/Vacancies/43...?

⭐ preprint ⭐ In-vivo evidence for increased tau deposition in temporal lobe epilepsy ➡️ Using [¹⁸F]MK-6240 PET, we show increased tau in young and middle aged TLE ➡️ Tau aggregation potential mechanism of disease progression & cognitive decline ➡️ pdf bit.ly/4mmlTYH by Raul Cruces & a super team

The gradients workshop is happening soon! Please join us on June 23rd in Brisbane for a full day of gradient fun! 🌈 ✅ Amazing speaker line up ✅ Poster presentation ✅ Flash talks for selected abstracts Deets on program, abstract submission, and registration 👉 gradients-workshop.github.io

Our #metaanalysis (n = 231) in JAMAPsych reveals consistent brain abnormalities across #sleep disorders involving affective and cognitive hubs in sgACC, amygdala/hippocampus Short-term sleep deprivation shows a distinct picture, affecting the thalamus jamanetwork.com/journals/jam...

in press @natcomms.nature.com 🌟 "Multimodal gradients unify local and global cortical organization" 7T MRI + cytoarchitectonics reveal a sensory-paralimbic axis of areal specialization & integration led by superstar Yezhou Wang & a terrific team of friends & colleagues ▶️ doi.org/10.1038/s414...

✨ What makes the brain's functional organization different in each #TLE patient? 🧠 ✨ We used a large sample (298 healthy adults, 282 TLE, 45 disease controls) + normative modeling to capture individualized functional disruptions. 🔎 #epilepsy #neuroimaging #precisionmedicine doi.org/10.1101/2025...

Personalized Biomarkers of Multiscale Functional Alterations in Temporal Lobe Epilepsy

Temporal lobe epilepsy (TLE) presents with substantial inter-patient variability in clinical and neuroimaging manifestations. This multicenter study examined inter-individual differences in spatial pa...

doi.org

Top-down feedback is ubiquitous in the brain and computationally distinct, but rarely modeled in deep neural networks. What happens when a DNN has biologically-inspired top-down feedback? 🧠📈 Our new paper explores this: elifesciences.org/reviewed-pre...

While the world burns, we cook up a new preprint! doi.org/10.1101/2025... Biophysical modeling is a key tool to derive mechanistic insights into the brain. These models are governed by biologically meaningful parameters (unlike artificial neural networks), but the dirty secret ... 1/N

Our study is now out in @naturecomms.bsky.social! Here, we integrate large-scale registry musicality data from twins to investigate the genetics of music enjoyment 🧬🎶🧑‍🤝‍🧑

Simon Fisher@profsimonfisher.bsky.social · last yr.

“What an odd thing“ wrote Oliver Sacks “to see an entire species playing with listening to meaningless tonal patterns, preoccupied for much of their time by what they call ‘music’...“. Our new paper, led by ace student @giacomobignardi.bsky.social, unpacks this puzzle from a genetic perspective. 🧪

Our open-source multimodal precision MRI dataset is officially out! 🧲🧠🧲 www.nature.com/articles/s41... osf.io/mhq3f/ @borismontreal.bsky.social @jroyer.bsky.social @themindwanders.bsky.social @jordandekraker.bsky.social

Multimodal precision MRI of the individual human brain at ultra-high fields - Scientific Data

Scientific Data - Multimodal precision MRI of the individual human brain at ultra-high fields

nature.com

📢 We have a new #NeuroAI postdoctoral position in the lab! If you have a strong background in #NeuroAI or computational neuroscience, I’d love to hear from you. (Repost please) 🧠📈🤖

Brain function fluctuates daily—but what drives these changes? direct.mit.edu/imag/article... super proud of Deniz Yilmaz and Bianca Serio and thankful for the open data of @emilyjacobs.bsky.social and Laura Pritschet 🌈👫 studying hormonal fluctuations in functional gradients ❤️‍🔥