Christian Schlieker
@schliekerlab.bsky.social
Professor of Molecular Biophysics&Biochemistry and of Cell Biology at Yale. Fishing all Waters.
Looking forward to visiting!
Institut Jacques Monod@ijmonod.bsky.social · 2mo ago📢 Institut Jacques Monod Seminar 📅 June 26th 📍 IJM Invited by the @palancadelab.bsky.social Lab, Christian Schlieker ( @schliekerlab.bsky.social ) will present the IJM seminar "Biomolecular Condensates at the Nuclear Envelope: From Mechanism to Therapeutic Modulation" ➡️ buff.ly/uiGSbJp
Truly excited to serve as chair of MB&B and grateful to be part of such a great department! Looking forward to working with colleagues, students, and staff in this new role!
Yale MB&B@yalembb.bsky.social · 3mo agoMB&B is excited to announce that Christian Schlieker (@schliekerlab.bsky.social) will serve as MB&B’s next chair! A member of the department since 2009 and current Director of Undergraduate Studies, he will begin a three-year term on July 1, succeeding Ronald Breaker.
This was indeed a fantastic trip, thanks so much for hosting me! I very much enjoyed learning about fantastic science from you and your amazing @sumatalab.bsky.social team and the great IGBMC community!
Izabela Sumara@sumaralab.bsky.social · 9mo agoI had the great pleasure of hosting Christian Schlieker @schliekerlab.bsky.social for a seminar at IGBMC @igbmc.bsky.social Thank you 🙏, Christian, for sharing your inspiring science and ideas, and for such engaging discussions with PIs and my team. A truly wonderful visit! 🤩😁
looking forward to hosting Aaron Gitler @yalembb.bsky.social @yaleschoolofmed.bsky.social next Monday!
O'zapft is! Great times at our Octoberfest @yalembb.bsky.social yesterday with perfect weather and amazing home-brew!
Learn more about all the 2025 #LaskerAward winners—Dirk Görlich & Steven L. McKnight; Michael J. Welsh, Jesús (Tito) González, & Paul A. Negulescu; Lucy Shapiro 🧪 #Lasker2025 📖: laskerfoundation.org/winners/2025... 👀: laskerfoundation.org/the-2025-las...
2025 Winners - Lasker Foundation
winners
laskerfoundation.org
FOMO no more: NOMO and Calmin extend #mechanobiology to the ER. Julie Heffler and Jan Lammerding @LammerdingLab.bsky.social discuss recent studies from the @schliekerlab.bsky.social (doi.org/10.1083/jcb....) & @hennelab.bsky.social (doi.org/10.1016/j.ce...), in Spotlight: rupress.org/jcb/article/...
Heffler and @LammerdingLab.bsky.social discuss recent studies from the @schliekerlab.bsky.social (doi.org/10.1083/jcb....) and @hennelab.bsky.social (doi.org/10.1016/j.ce...) that identify two proteins serving as crucial mechanical elements in the endoplasmic reticulum. rupress.org/jcb/article/...
Thank you indeed-great read and excellent discussion on our recent papers identifying molecular mechanisms that (I) connect cellular forces to organelles and (II) enable elaborate membrane systems to respond to mechanical challenge
organelles.as
Henne lab@hennelab.bsky.social · 12mo agoThankful to @jcb.org and @lammerdinglab.bsky.social for highlighting our work together with work from @schliekerlab.bsky.social on the endoplasmic reticulum and proteins that influence ER shape and mechanical properties.
Congrats!!
Simone Reber@simonereber.bsky.social · 12mo agoFINALLY! Challenging to publish but we believe it is an important discovery: rdcu.be/eATFz 💚 Thanks to the team @biswashere.bsky.social, Omar Muñoz, ✨Q✨ C. Hoege, B. Lorton, R. Nikolay @matthewkraushar.bsky.social @dshechter.bsky.social @gucklab.bsky.social @vasilyzaburdaev.bsky.social 💚
Congrats Kim et al!
Journal of Cell Biology@jcb.org · last yr.New study showing the development of pan-Expansion Microscopy by Morgan et al. @luskinglab.bsky.social to reveal the molecular composition and structural plasticity of individual nuclear pore complexes including LINC complex-dependent dilation. rupress.org/jcb/article/...
✨Thanks to amazing students @tobiaskletter.bsky.social, postdocs @biswashere.bsky.social & collaborators @vasilyzaburdaev.bsky.social & ALMF @embl.org ✨ 👉Cytoplasmic material properties control spindle architecture and scaling 👉 out today @natcellbio.nature.com rdcu.be/eqPr8
Cell state-specific cytoplasmic density controls spindle architecture and scaling
Nature Cell Biology - Kletter et al. show that cell state-specific cytoplasmic density controls spindle architecture and scaling in neural differentiation, suggesting that the physical properties...
rdcu.be
our genome-wide CRISPR screen revealed strong ties between microcephaly-related genes and aberrant condensates revealing unexpected cellular pathology! Our chemical-genetic platform could accelerate the hunt for treatments for neurodegenerative and neurodevelopmental disorders!
Christian Schlieker@schliekerlab.bsky.social · last yr.We’ve pioneered a disease-agnostic screening platform for aberrant biomolecular condensates—cellular structures linked to incurable neurological diseases. We screened genes and FDA-approved drugs that modulate disease-relevant nuclear condensates: www.biorxiv.org/cgi/content/...
🔬 Key findings: -RNF26 and ZNF335 protect against harmful protein buildup. -identification of compounds that have potential to counteract toxic condensates. -Links to zinc biology, autophagy, and oxidative stress offer new therapeutic angles.
Christian Schlieker@schliekerlab.bsky.social · last yr.We’ve pioneered a disease-agnostic screening platform for aberrant biomolecular condensates—cellular structures linked to incurable neurological diseases. We screened genes and FDA-approved drugs that modulate disease-relevant nuclear condensates: www.biorxiv.org/cgi/content/...
We’ve pioneered a disease-agnostic screening platform for aberrant biomolecular condensates—cellular structures linked to incurable neurological diseases. We screened genes and FDA-approved drugs that modulate disease-relevant nuclear condensates: www.biorxiv.org/cgi/content/...
we are beyond proud that our @yalembb.bsky.social @schliekerlab.bsky.social undergraduate researcher Sophia graduated as the sole @Yale Colleague '25 graduate with an exceptional distinction in the major! Congrats Sophia for this richly deserved honor!
Important to celebrate trainee victories: excited to have Holly Merta's @hollymerta.bsky.social paper out! We use TurboID sub-organelle proteomics to map the ER network. We find calmin/CLMN, an ER-to-actin tether regulating focal adhesions & cell motility. www.sciencedirect.com/science/arti...
Spatial proteomics of ER tubules reveals CLMN, an ER-actin tether at focal adhesions that promotes cell migration
The endoplasmic reticulum (ER) is structurally and functionally diverse, yet how its functions are organized within morphological subdomains is incomp…
sciencedirect.com
We are excited to announce a tenure-track or tenured faculty position in Computational Biophysics and Biochemistry, exploring the intricate molecular and cellular processes and the complex interactions of their macromolecular components. Join us in MB&B! Apply now at apply.interfolio.com/162132
In a great collaboration with @hummerlab.bsky.social and the Kräusslich lab: HIV capsid doesn't break at the NPC; instead, it cracks open the NPC itself! Details in Cell: authors.elsevier.com/sd/article/S... @mpibp.bsky.social @uniheidelberg.bsky.social A thread below:
How did microtubules adapt to support life across 🐸 species at divergent thermal niches? Now online & OA @currentbiology.bsky.social Thanks to Ella, Luca, @biswashere.bsky.social & Carolyn @mpiib-berlin.mpg.de @BirkbeckUoL 🙌 Enjoy reading! 👉 www.cell.com/current-biol...
Mechanistic basis of temperature adaptation in microtubule dynamics across frog species
Despite tubulin’s evolutionary conservation, microtubule dynamics are highly temperature sensitive. Troman et al. use natural tubulin variants from closely related Xenopus species to show that a decrease in tubulin’s apparent activation energy and weakening of lateral lattice contacts stabilize microtubules in cold-adapted frogs.
cell.com
