It's finally here! So excited to start our FASEB Lipid Droplets: From Mechanisms to Disease SRC in beautiful Scottsdale, AZ. Welcome lipid folks to a great week of science! events.faseb.org/event/Lipid-...
Henne lab
@hennelab.bsky.social
We are a cell biology lab at UT Southwestern Medical Center in Dallas, TX. We study lipid droplets and the organization of metabolism in cells. For more, please see our lab website: https://labs.utsouthwestern.edu/henne-lab
Please re-post! Time is almost up to register for the 2026 FASEB Lipid Droplet Meeting. Abstracts are due May 31, 2026. See link below, and join us for an amazing SRC lipid meeting July 26-30! #LipidSRC events.faseb.org/event/Lipid-...
So happy to host Roberto Zoncu @robzonculab.bsky.social at UTSW, who gave a spectacular seminar as part of our LMND series on lipids and organelles in neurodegenerative diseases. Thank you for visiting us Roberto!
Publishing in JCB enables authors funded by National Institutes of Health (NIH), Howard Hughes Medical Institute (HHMI), and other funders an easy pathway to compliance. Learn more: 👉 rupress.org/pages/nih-hh...
Summer is approaching & so is the 2026 Lipid Droplets: From Mechanisms to Disease FASEB SRC (July 26-30 in Scottsdale, AZ)! Interested in lipids? Join this amazing summer research conference! Abstracts due May 31, Early registration June 14 events.faseb.org/event/Lipid-...
Check out our highlight of the most recent example of subcellular mitochondrial specialization in @currentbiology.bsky.social. Be sure to also check out the beautiful work from David Sherwood's lab www.cell.com/current-biol...
Mitochondrial biology: Specialized powerhouses pack a punch
A new study reveals that a specialized population of mitochondria in the Caenorhabditis elegans uterine anchor cell is remodeled and enriched in machinery needed for optimal local energy production to...
cell.com
Beyond delighted to share our amazing collaboration with Thierry Alquier's lab @alquierthierry.bsky.social on a conserved role for neuronal lipid droplets in regulating energy homeostasis in vivo led by Celena Cherian, Romane Manceau, Danie Majeur, and Colin Miller www.nature.com/articles/s42... /1
Neuronal lipid droplets play a conserved and sex-biased role in maintaining whole-body energy homeostasis - Nature Metabolism
In vivo regulation of neuronal lipid droplet formation mediates whole-body energy homeostasis in a sex-specific manner in Drosophila and mice.
nature.com
Updated preprint! Here, we identify an SREBP-dependent fatty acid sensing metabolic switch in Drosophila, enabling dramatic metabolic rewiring within adipose tissue that boosts carbohydrate metabolism in the absence of fat. read more here: doi.org/10.1101/2024...
So proud of Henne Lab graduate student Kaitlynn Gov for presenting her work at the @stjuderesearch.bsky.social St. Jude Children's Research Hospital National Graduate Student Symposium!
I'm excited to host the ASBMB LRD seminar series next Thurs 4/9 at 12pm ET. Please join for talks from @zakbaker.bsky.social (from @pagliarini-lab.bsky.social) and Sara Wong (from Adam Hughes' lab) on the intersection of mitochondria and lipid metabolism! Register here: www.asbmb.org/meetings-eve...
Lipid Research Division Seminar Series
April 9, 2026 | 12 p.m. Eastern
asbmb.org
I am so excited to co-organize the scientific program for ASBMB 2027 together with Amy Palmer @amypalmerzinc.bsky.social! Please join us in beautiful Boston April 3-6, 2027. Interested in organizing an ASBMB mini-symposia or workshop? Submit your proposals here!: www.asbmb.org/annual-meeti...
Proposals
asbmb.org
Amazing PhD @cristianrocharoa.bsky.social and I have collected our thoughts and questions (many!) on lipid scramblases in this review: www.sciencedirect.com/science/arti... If you are interested in lipid transport and metabolism, membrane asymmetry and membrane protein function, give it a read!
Lipid scrambling: New players, new questions, new opportunities
Nearly a quarter of the proteins encoded in most organisms are transmembrane proteins. Contrary to textbook description, many feature a hydrophilic gr…
sciencedirect.com
Please share!!! I am looking for a postdoctoral researcher to join us. Focus will be on exciting collaborative projects on lipids and membrane biology, pushing the boundaries of in silico "reconstitutions". Previous experience with molecular dynamics simulations of biological systems a strong plus!
With so many great reviews on LDs already out, do we need another? Sarah @cohenlaboratory.bsky.social and I were approached by @natrevmcb.nature.com to do a review on LD heterogeneity and inter-organelle contacts...topics in reviews, but not a focus. Fun project! www.nature.com/articles/s41...
Heterogeneity, dynamics and organelle interactions of lipid droplets - Nature Reviews Molecular Cell Biology
Lipid droplets have key roles in energy storage and lipid metabolism. This Review discusses tools used for assessing lipid droplet heterogeneity, and how their heterogeneous composition and interactio...
nature.com
I've been waiting for this Titeca et al. story from Anne-Claude Gavin's lab to come out: A systematic, comprehensive analysis of lipid transfer protein cargo selection, a truly massive undertaking. What a time to work in lipid biology. Cool stuff every few days. www.nature.com/articles/s41...
Systematic analyses of lipid mobilization by human lipid transfer proteins - Nature
Nature - Systematic analyses of lipid mobilization by human lipid transfer proteins
nature.com
Thrilled to share our latest study, led by @reikatei.bsky.social, in @natchembio.nature.com! We began by asking a simple question—how do cells know if they have too much of a lipid in a particular membrane, and how do they respond to rectify this imbalance? www.nature.com/articles/s41... More info 👇
Membrane editing with proximity labeling reveals regulators of lipid homeostasis - Nature Chemical Biology
Coupling an optogenetic lipid-modifying enzyme with proximity labeling reveals protein networks and mechanisms regulating lipid homeostasis in the membranes of target organelles.
nature.com
Registration is open for the FASEB #LipidDroplet meeting in Scottsdale, July 26-30! This is THE premier North American conference on LDs, you do not want to miss it!
Henne lab@hennelab.bsky.social · 7mo agoInterested in lipids? Join us @ the 2026 FASEB Lipid Droplet: From Mechanisms to Disease Conference (July 26-30, Scottsdale, AZ). Registration is now open! events.faseb.org/event/Lipid-... We are co-locating with the FASEB Phospholipids SRC! Register for one to enjoy BOTH meetings!
Interested in lipids? Join us @ the 2026 FASEB Lipid Droplet: From Mechanisms to Disease Conference (July 26-30, Scottsdale, AZ). Registration is now open! events.faseb.org/event/Lipid-... We are co-locating with the FASEB Phospholipids SRC! Register for one to enjoy BOTH meetings!
💥I am excited to present our first research paper from the lab about caveolae lipid trafficking 🎉 Led by my fantastic PhD candidate @estherocket.bsky.social Here we looked into caveolae mediated dietary lipid uptake and how this process is mechanistically facilitated 👇 1/n
bioRxivpreprint@biorxivpreprint.bsky.social · 8mo agoLipid-induced Caveolin1-Lipid droplet trafficking is associated with lipid droplet growth https://www.biorxiv.org/content/10.64898/2025.12.10.693432v1
Attending #CellBio2025? Come see the Cohen Lab - Monday will be a busy day for us, including my theatrical debut in WICB "Scripts of Success" skits!
Thrilled to share our latest work showing that the bridge lipid transport protein ATG2A transfers diacylglycerol (DAG), and some TAG/PA, from the ER to LDs, thereby recruiting DGAT2 to drive local TAG synthesis, promoting LD expansion while protecting ER membranes. www.nature.com/articles/s41...
ATG2A-mediated DAG transfer recruits DGAT2 for lipid droplet growth - Nature Structural & Molecular Biology
Elhan et al. show that ATG2A acts with DGAT2, the enzyme producing triacylglycerol (TAG), in lipid droplet growth. By delivering diacylglycerol to lipid droplets, ATG2A not only fuels TAG production b...
nature.com
Check out our @ascbiology.bsky.social #CellBio2025 Minisymposium on ER Homeostasis. With THIS speaker lineup, this event will be as dynamic, transformative and productive as the ER itself! So don’t 𝗦𝗧𝗥𝗘𝗦𝗦, 𝙩𝙧𝙖𝙣𝙨𝙡𝙤𝙘𝙖𝙩𝙚 yourselves over and join us to 𝗡𝗘𝗧𝗪𝗢𝗥𝗞 in world of the ER. (All PUNS intended.)
Proud to share our study on #LipidDroplet #Motility #Mitochondria #MembraneContactSite now in Cell Reports @cp-cellreports.bsky.social! Big thanks to @rwedlichsoldner.bsky.social, @flofroehlich.bsky.social, @ruferbus.bsky.social, Daniel Kümmel lab, Thomas Becker lab! www.cell.com/cell-reports...
The Myo2 adaptor Ldm1 and its receptor Ldo16 mediate actin-dependent lipid droplet motility
Zhao et al. identify the molecular machinery for lipid droplet motility, consisting of the type V myosin Myo2, the Myo2 adaptor protein Ldm1, and its surface receptor Ldo16. They uncover a molecular l...
cell.com
Fat storage in the body relies on specialized structures called lipid droplets. In a new Science study, researchers identified the microprotein adipogenin as a regulator of adipocyte lipid droplet size, revealing a key mechanism in lipid homeostasis. Learn more this week: https://scim.ag/4nFEGO7
New paper in Science identifying adipogenin as a critical seipin regulator in LD biogenesis. So glad our lab could help a little in this monumental study. Congrats to all authors! www.science.org/doi/10.1126/...
Adipogenin promotes the development of lipid droplets by binding a dodecameric seipin complex
The microprotein adipogenin (Adig) is predominantly expressed in adipose tissues. Here, we found that Adig interacts with seipin to form a stable, rigid complex. We present the structure of the seipin...
science.org
Excited to share our study out in @natcellbio.nature.com! Led by @mikelangelipid.bsky.social, we identify the first #LipidDroplet lipid quality control pathway: LD-localized FSP1 protects stored lipids from oxidative damage and prevents LD-initiated #ferroptosis. www.nature.com/articles/s41...
FSP1-mediated lipid droplet quality control prevents neutral lipid peroxidation and ferroptosis - Nature Cell Biology
Lange et al. identify a lipid droplet quality control pathway in which FSP1 safeguards stored neutral lipids from lipid peroxidation, thereby preventing the induction of ferroptosis.
nature.com
Looking forward to #UNCResearchWeek! I'll be presenting my lab's work on #organelles in physiology and neurodegenerative disease on Monday, October 20
Great Endoplasmic Reticulum meeting in Paris organized by the amazing Eric Chevet @ericchevet.bsky.social! It was wonderful to also hang out with James Olzmann @olzmannlab.bsky.social and Rachid Thiam @abdourachidthiam.bsky.social.
Another great EMBO #LipidDroplets workshop in Sant Feliu de Guixols! Many thanks to Maria Bohnert, Robin Klemm, and Bianca Schrul for the wonderful organization!
