For the dozen people out there into urban planning and cloud computing arcana: Inclusionary availability zoning will finally solve our affordability problems.

Matthew Downhour @matthewdownhour.bsky.social · yesterday

Listen I’m fine with data centers as long as they meet some basic aesthetic criteria determined arbitrarily by a design board, fit into the scale and character of the neighborhood, don’t remove any trees, and have at least 30% below-market rate servers

Your periodic reminder that my 1991 SF Mission apt was $980/mo in today's dollars - an unaffordable sum for me then. This is what decades of NIMBY SF politics stole from you and our beloved city's creative spark

Yale President McInnis and the trustees are out of step with their faculty, including the current and present deans of the law school, in seeking a settlement from the Trump administration. Students and alumni also oppose. Who does Yale leadership actually represent? www.nytimes.com/2026/07/07/u...

Yale Law School Fights to Stop Trump Deal

nytimes.com

Hey look, our paper about the Single-cell Pediatric Cancer Atlas that we at @cancerdatalab.bsky.social have been working on for a while is out! www.cell.com/cell-genomic... It's a pretty good resource, if I do say so myself, and we are expanding: if you have data you want to share, get in touch!

The Single-Cell Pediatric Cancer Atlas: Data portal and open-source tools for single-cell transcriptomics of pediatric tumors

Hawkins et al. introduce the Single-Cell Pediatric Cancer Atlas: a uniformly processed collection of sc/snRNA-seq data from pediatric cancer samples and models. 700 samples from 55 pediatric cancer ty...

cell.com

very cool paper. Also contains an author that has the best name for a scientific consultancy that I have seen yet: “Middle Author Bioinformatics, LLC, Phoenix, AZ, USA Arkadiy Garber“

Vaughn Cooper@vscooper.micropopbio.org · last mo.

Important results of collab led by ⭐surgeon-microbiologist Ken Urish w/ @dariavantyne.bsky.social @ironark.bsky.social and us: Chronic suppression of a multidrug-resistant Pseudomonas aeruginosa in prosthetic joint infection using personalized bacteriophage treatment www.nature.com/articles/s41...

Fans of #RNA should check out the RNA Futures Meeting at UCSC in the fall, looks to be a great lineup of speakers, including Mark Akeson, Laurence Ettwiller, and Miten Jain: rnacenter.ucsc.edu/rna-futures-...

Thanks to @jmcoller.bsky.social for writing this important piece. Describes exactly what we stand to lose from the Lysenkoization of US science. 💪🏼

Leah Litman@leahlitman.bsky.social · 2mo ago

This piece is just maddening - in laying out the incredible destruction the Trump admin is doing to scientific research that might help to understand or cure … who knows what. We’ll never know since they’ve destroyed it. www.nytimes.com/2026/06/20/o...

One for the bioinformaticians

Spoke at The Australian Society for Microbiology 2026 Annual Meeting earlier this week. I covered our work on >100k carbapenemase-encoding genomes. Also here's a gimmick slide I spent way too much time on: "The Microbe's Digest". It's carba-pandemonium out there folks 🙏 @aussocmic.bsky.social

The end of Roe coincided with the near-complete destruction of feminist organizing or women's issues as a salient issue. Nobody in politics talks about abortion or gender equality, and the discourse is all about how "the Left is failing men". Hard to succinctly explain why but it's not salient.

Just how bad is housing affordability in Santa Cruz? Median house prices are currently 9.3x the median wage here, and though housing prices fluctuate, the average increase is 1.2% per year. Can any social scientists comment on my use of FHFA house price data and SAIPE household income?

Santa Cruz County is so NIMBY that it even $117k/year for a single person is considered "low-income." SC wages are far lower than SF or Silicon Valley, but HUD has to apply a special correction for exceptional housing-cost-to-income ratio. Even a median incomes qualifies for subsidized housing!

Next door in Silicon Valley@nextdoorsv.bsky.social · 2mo ago

Best of luck explaining to any normal person how it is that if you're a single person in true Silicon Valley making $113,700 or less, the government considers you to be "low income". Fun fact: the Governor of California has a salary of $246K - "moderate income" for a family of 4!

“Most Chinese scientists came to the U.S. with the hope of staying for their careers,” Innes says. “But now they are getting the clear message that the government doesn’t want them to be here.” 1/2 @policyhound.bsky.social 👏👏👏 www.science.org/content/arti...

Chinese postdocs in U.S. hit with a wave of prosecutions and deportations

The U.S. government has recently convicted multiple postdocs for improper shipments of biological materials. Some see a replay of the 2018 China Initiative

science.org

If you follow energy at all, you're probably familiar with the fact that the IEA and other energy analysts have a long record of underestimating the growth of solar and batteries. But did you know that they also have a long record of *overestimating* the growth of nuclear?

The “Nuclear Energy Paradox”- Investigating nuclear imaginaries in energy projections

Current energy projections often envision an expansion of nuclear capacities to decarbonize future energy systems. However, this contrasts with the hi…

sciencedirect.com

"we're willing to trade kidnapped children for POWs" is a completely insane admission of guilt

UNITED24 Media@united24media.com · 3mo ago

🤯 Russia had proposed adding abducted Ukrainian children to prisoner-of-war exchange lists, Ukrainian FM Sybiha says. 🔗 united24media.com/latest-news/...

This newly-discovered DNA recognition system is a perfect fit for matching gene sequences that produce the same protein, by skipping over the wobble base in the protein code. Very cool system...

Alex Merz 🇺🇸🇨🇦🇺🇦@merz.bsky.social · 3mo ago

🤯

Have you wondered what the wet lab success rates are for current AI-driven protein design models? Look no further! In our new review, @kevinkaichuang.bsky.social @avapamini.bsky.social, @sarahalamdari.bsky.social, and I report wet lab success rates for *over 200* different protein design tasks 🧬💻

There was a time when the dictatorial and punitive power of Steve Jobs ensured that Apple would never let this sort of "I have two Outlooks" problem persist:

Currently trying to translate dinner discussion about Orban's defeat to our 7yo, and landed on the metaphor of JD Vance as Bowser Jr. This feels very right.

Ben Patton: "They [the Ukrainians] need us a lot less than we [the US] need them right now." US support to Ukraine has been cut off for more than a year, and in that year Ukraine has shifted the tide of the war. The US is blockading the Strait of Hormuz while Ukraine fights for freedom.

Kate from Kharkiv@kateinkharkiv.bsky.social · 4mo ago

PATTON: I don’t see how this war ends. Maybe Putin will eventually get blown up by one of oligarchs. But I really feel Ukrainians are in very strong position right now. They’re losing fraction of what Russians are losing. Russians have already taken something like 1.5 million casualties.

Very Ukrainian accent: "Oh Mr Vance, is it hard to negotiate peace? Is it difficult to come to a deal when both sides have fundamentally irreconcilable positions on key issues? Does not being able to trust your counterparty make things tricky? Why do you hate peace, Mr Vance?"

a man with a beard is sitting in a chair .

ALT: a man with a beard is sitting in a chair .

media.tenor.com

Nobel Laureate Jack Szostak “This country has given me endless opportunities…: The America we inhabit today bears almost no resemblance to the country I chose all those years ago” newsletter.ofthebrave.org/p/im-a-nobel...

I’m a Nobel Prize-winning immigrant. I can no longer recognize this country.

Attacks on science and immigrants are destroying America.

newsletter.ofthebrave.org

The neoantigen vaccine selection logic at the end of the OpenVax pipeline (code behind Mount Sinai PGV trials) is called Vaxrank inputs: HLA + VCF + RNA BAM outputs: vaccine design output Hadn't changed much since 2010s Just shipped 2.0 (new predictors, per-trial configs, &c)

Oh my god, this is my job!!! I can finally add something back to all the people who’ve given me knowledge

Chromosomes stuck behind the spindle are ticking time bombs for aneuploidy. We uncovered a mechanical rescue mechanism where microtubule pivoting repositions these high-risk chromosomes! Out last week in @natcomms.nature.com, here's a thread 🧵 shorturl.at/OD89x

I'm Josh Hawn, and I support this message.

Mayor Zohran Kwame Mamdani@mayor.nyc.gov · 4mo ago

Government must deliver for working people—and every dollar in our budget should work as hard as they do. That’s why I directed every agency to cut waste and help close our budget gap. Here’s some of what we found.

Everyone I know with practically any knowledge of global supply chains be like:

Endless Screaming@infinitescream.bsky.social · 5mo ago

AAAAAAAAAAAAAAAAAAAHHHHHHHH

“No for-profit company could possibly withstand all the false leads required by that process,” he recalled telling them, “all the weird, random science that never panned out.” Super grateful for this piece highlighting the threats to this country’s biomedical research infrastructure

Max Heiman@heiman.bsky.social · 5mo ago

NYT feature on their website's front page about our local C. elegans colleague Will Mair and NIH funding www.nytimes.com/2026/03/13/u...

Most cloud infrastructure engineering amounts to this, but is a bit less fun

Sundance@sundance.bikesky.social · 5mo ago

Zone 2 cardio. Mobility maxxing. There will be no further discussion.