Inflammation is a driver of age-related diseases (inflammaging) and this new NYT magazine article gets deep into the progress that is being made to track and block it gift link www.nytimes.com/interactive/...

Inflammation Keeps Us Alive. It's Also Making Us Sick. (Gift Article)

The discovery that chronic inflammation is a cause of myriad illnesses could be this century's biggest medical breakthrough.

nytimes.com

I love this so much. All biomedical research institutions should pay homage to our model organisms who have and will continue to save countless lives and advance our understanding of ourselves into the future!

Annika Barber@annikabarber.bsky.social · 3w ago

Took a selfie with the tiniest statue paying tribute to model organisms in science! 🧪 🐭 🐟 🪰🪱

Super excited about my talk today at PNIRS: Effects of Psilocybin on Biomarkers of Mitochondrial Stress and Inflammation in an open label pilot study of Parkinson’s Disease

Things that help calm the nervous system, quickly: - Box breathing (in for 4, hold for 4, out for 4, hold for 4, repeat) - Immerse your face in cold water (activates mammalian dive reflex) - Humming (stimulates vagus nerve) - Exercise (anything helps, outside even better) - Impeachment and removal

Wow! This is so cool

John Bistline@bistline.bsky.social · 4mo ago

This is my favorite climate change chart. Japanese monks, aristocrats, and emperors kept meticulous records of cherry blossom festivals for 1,200 years and accidentally built the world's longest climate dataset.

*Neuroscience and philosophy* Given the philosophical/conceptual naivete of all of neuroscience I will be retiring from my faculty position. I'm now looking for positions at philosophy departments and am happy to start at any level. I went from faculty to postdoc before and am ready again.

Lovely work on autoimmunity and its link to psychosis. I wonder what effect this modulation of NMDA receptors has on HALIPs? Less PPI would seem to be the opposite of a strong prior?

Katharina Schmack @kathaschmack.bsky.social · 4mo ago

🥁🎉The Psychosis Collective proudly presents our first preprint 𝐂𝐥𝐨𝐳𝐚𝐩𝐢𝐧𝐞 𝐬𝐮𝐩𝐩𝐫𝐞𝐬𝐬𝐞𝐬 𝐚𝐮𝐭𝐨𝐢𝐦𝐦𝐮𝐧𝐢𝐭𝐲 𝐝𝐫𝐢𝐯𝐢𝐧𝐠 𝐩𝐬𝐲𝐜𝐡𝐨𝐬𝐢𝐬-𝐥𝐢𝐤𝐞 𝐛𝐞𝐡𝐚𝐯𝐢𝐨𝐮𝐫 𝐢𝐧 𝐦𝐢𝐜𝐞 𝘈 𝘥𝘪𝘴𝘤𝘰𝘷𝘦𝘳𝘺 𝘫𝘰𝘶𝘳𝘯𝘦𝘺 𝘪𝘯 𝘵𝘩𝘳𝘦𝘦 𝘢𝘤𝘵𝘴 starring Le He & Harriet Feldman www.biorxiv.org/content/10.6... We wanted to understand how antipsychotics work. Thread🧵

Overall, I am very grateful to EIC Dost Ongur for letting me write the paper I wanted to write! Feedback very welcome—I submitted a medium size personalize grant on this topic in the Netherlands now to do this 'HPCing' in large-scale data.

Hey friends, my new paper was just published in JAMA Psychiatry. I draw on biological species classification to sketch a new framework for psychiatric nosology. Brief summary follows below. Full text link: jamanetwork.com/journals/jam... 🧪 #PsychSciSky #MentalHealth

Mental Disorders as Homeostatic Property Clusters

This narrative review explores the idea of understanding mental disorders according to homeostatic property clusters rather than through typical classification systems.

jamanetwork.com

𝗛𝗼𝘄 𝗱𝗼 𝗯𝗿𝗮𝗶𝗻 𝗮𝗿𝗲𝗮𝘀 𝗿𝗲𝗹𝗮𝘁𝗲𝗱 𝘁𝗼 𝗳𝘂𝗻𝗰𝘁𝗶𝗼𝗻? "High-resolution activity maps of PFC did NOT align with cytoarchitecturally defined subregions." Key tenet in neuroscience is that cytoarchitectonic boundaries correspond to functional ones. NB: study in the mouse #neuroskyence doi.org/10.1038/s415...

Please use full factorial designs in preclinical psychedelic research! I'm guilty of not doing so in the past, but it will be critical for understanding their MOA going forward. We need to be able to directly compare effects in pathology to those healthy organisms

Excellent interview... VERY interesting insights on stress vs mitochodrial energy balance. I wonder how much impact on stress adaptation can be gained by increasing mitochondrial resilience w keto/low carb/ Fasting and the right amount of Exercise stress (hiit, resistance trng)

I had a fantastic discussion about our Allostatic Triage Model of Psychopathology (ATP Model) and the potential mitochondrial and metabolic effects of psychedelics with @metabolicmind.bsky.social Thanks so much for having me on! Check er out: youtu.be/-e49-DwCZ9A?...

Could Stress Be The Hidden Driver of Mental Illness?

YouTube video by Metabolic Mind

youtu.be

Congrats @carmensandi10.bsky.social !!

Bita Moghaddam@bita137.bsky.social · 9mo ago

Warm congratulations to @carmensandi10.bsky.social for winning the Mika Salpeter award. Incredibly well-deserved as I know of few other stellar neuroscientists who have advanced the careers of women in the field

Metabolism is an energetic circuitry that transcends cellular and organellar boundaries www.nature.com/articles/s42...

The neuron–astrocyte metabolic unit as a cornerstone of brain energy metabolism in health and disease - Nature Metabolism

Bolaños and Magistretti illustrate how intercellular metabolic cooperation underpins brain function and provide examples of how disruption of the neuron–astrocyte metabolic unit contributes to disease...

nature.com

Wait so midazolam is an antidepressant? Wut?

Eiko Fried@eikofried.bsky.social · 10mo ago

New 6-month depression RCT in n=65, serial Ketamine infusions as adjunctive care vs active placebo midazolam. Ketamine did not outperform primary nor any of the secondary efficacy, cognitive, economic, or quality-of-life outcomes. 🧪 #psychiary #PsychSciSky jamanetwork.com/journals/jam...

Hot off the press!

D. Parker Kelley, PhD@sequencemyneuro.bsky.social · 10mo ago

🚨Publication alert! 🚨 Why does stress drive psychopathology & transdiagnostic disease? We present the Allostatic Triage Model of Psychopathology (ATP Model), which explains stress-induced transdiagnostic disease pathogenesis through a bioenergetic lens. www.sciencedirect.com/science/arti...

The way we feel and the psychiatric symptoms some of us end up experiencing could emerge from the way energy flows, or fails to flow smoothly, in mitochondria. The ATP model (Allostatic Triage in Psychopathology) by Parker Kelley @sequencemyneuro.bsky.social www.sciencedirect.com/science/arti...

🚨Publication alert! 🚨 Why does stress drive psychopathology & transdiagnostic disease? We present the Allostatic Triage Model of Psychopathology (ATP Model), which explains stress-induced transdiagnostic disease pathogenesis through a bioenergetic lens. www.sciencedirect.com/science/arti...

Pα+ Psychedelic Bulletin #207 - Lykos Rebrands to Resilient - Pharma Pushes Back on Norway’s Ketamine Reimbursement Decision - AbbVie-Gilgamesh Deal Viewed as Validation - Psilocybin Rescheduling Petition Heads to HHS - Much, much more... psychedelicalpha.com/news/p%ce%b1...

Pα+ Psychedelic Bulletin #207: Lykos Rebrands to Resilient; Pharma Pushes Back on Norway’s Ketamine Reimbursement Decision; AbbVie-Gilgamesh Deal Viewed as Validation - Psychedelic Alpha

Lykos Therapeutics Rebrands to Resilient Pharmaceuticals • Pharma Pushes Back on Norway’s Off-Label Ketamine Decision • AbbVie–Gilgamesh Deal Viewed as Validation for Short-Acting Psychedelics •

psychedelicalpha.com

I'm near certain sLFOs are big for psychedelics.

Cole Korponay@ckorponay.bsky.social · 11mo ago

An exciting 🆕 extension of our sLFO/FC inflation work (www.nature.com/articles/s41...) Extracting the sLFO signal from BOLD data not only sharpens FC estimates.. ..the sLFO itself - via links to arousal - captures variability in trait + state drug use phenotypes: tinyurl.com/msanmrnc #neuroimaging

Just delighted to see this out in the world !! This is the first installment of SYPRES -- our living meta-analysis + open data resource focused on psychedelics. Led by the incomparable @parkersingleton.bsky.social and @bsevchik.bsky.social. Check it out + and give us your feedback!!!

Parker Singleton@parkersingleton.bsky.social · 12mo ago

🍄 Our new living systematic review and meta-analysis on psilocybin for depression is out. Here's what we found and the open science infrastructure we built to support it 🧪🧵 www.medrxiv.org/content/10.1...

It is impossible to explain to civilians how it feels to finally, FINALLY, land a clearly within-payline NIH grant score and then have it go unfunded because of all this regime bullshit. You all have my sympathies. Unfair doesn’t even begin to describe it.

🍄 Our new living systematic review and meta-analysis on psilocybin for depression is out. Here's what we found and the open science infrastructure we built to support it 🧪🧵 www.medrxiv.org/content/10.1...

Such a beautiful project! This is the exact sort of framework we need to advance progress going forward.

Parker Singleton@parkersingleton.bsky.social · 12mo ago

🍄 Our new living systematic review and meta-analysis on psilocybin for depression is out. Here's what we found and the open science infrastructure we built to support it 🧪🧵 www.medrxiv.org/content/10.1...

Dispatch: The Neurobiology of Psychedelics Gordon Research Conference — Circuitry, Consciousness, and Clinical Horizons (Part 2) Reporting by @jasteralaina.bsky.social. The entire Dispatch is now free to read. psychedelicalpha.com/news/dispatc...

Dispatch: The Neurobiology of Psychedelics Gordon Research Conference — Circuitry, Consciousness, and Clinical Horizons (Part 2) - Psychedelic Alpha

In this second Dispatch from the inaugural Neurobiology of Psychedelics Gordon Research Conference, Dr. Alaina Jaster recaps Days 2 through 4, highlighting cutting-edge research on neuroplasticity…

psychedelicalpha.com

Since its founding in 2021 by myself and Zarmeen Zahid as Your Brain on Science, it's expanded into Psychedelic Brain Science, to encompass the larger goal of including all things psychedelic including research, policy and culture. Now we’re expanding further to provide services! Check it out!

Psychedelic Brain Science@psychedbrainsci.bsky.social · last yr.

Psychedelic Brain Science is officially an LLC! To celebrate we’re launching Psychedelic Brain Science Consulting where a variety of services will be offered including workshops, one-on-one coaching, general consulting, independent analysis, and more! For details visit our website!

I’m elated to share our latest publication - out now in @natmentalhealth.nature.com! www.nature.com/articles/s44... - tour de force by @leahbanellis.bsky.social @brainandstomach.bsky.social and the rest of the VMP team!

Stomach–brain coupling indexes a dimensional signature of mental health - Nature Mental Health

Using a relatively large and diverse sample of mostly young adults, this study by Banellis, Rebollo and colleagues examines associations between regional stomach–brain coupling and mental health and i...

nature.com

Check out my keynote & Day 1 dispatch of #GRCPsychedelics 🧠 via @psychedelicalpha.bsky.social psychedelicalpha.com/news/dispatc...

Dispatch: The Neurobiology of Psychedelics Gordon Research Conference — Plasticity, Psychotherapy, and Perception (Part 1) - Psychedelic Alpha

Here, we share Dr. Alaina Jaster’s observations from the inaugural Neurobiology of Psychedelics Gordon Research Conference, where leading scientists gathered to explore various realms of psychedelic…

psychedelicalpha.com

Had a blast at the first ever #GRCPsychedelics - thanks so much to Chairs @alexkwan.bsky.social @vyazovskiy.bsky.social & Vice Chairs @melissaherman.bsky.social @viditavaidya.bsky.social for bringing our community together 🫶 Per usual, I took no pics - but luckily Missy had it covered for me 😂