Excited to share that our review has been published in @angewandtechemie.bsky.social ! We summarize recent advances in deep-red to near-infrared light-driven radical generation and discuss future opportunities for low-energy photochemistry. doi.org/10.1002/anie...

Low‐Energy Photons in Radical Chemistry: From Deep‐Red to Near‐Infrared Radical Generation for Organic Synthesis

Low-energy photons from deep-red (DR) to near-infrared (NIR) light offer unique opportunities for sustainable photochemical synthesis but suffer from intrinsically limited reactivity. This Review sum...

doi.org

Congrats to Lingran, Kevin and Marcus (w/ help from HS student Jonah Luo!) for their [1+1+1] cyclopropane synthesis. The disappearing pyridine proved crucial to unravel the multicomponent coupling mechanism. tinyurl.com/4mn2uwp5

Third-year graduate student Larisa Pop developed this synthesis of the species-selective SDH inhibitor siccanin using computational tools to gain quick access to its local chemical space. tinyurl.com/3vt4vcdx

The single most defining thing Elon Musk has ever done is killing untold numbers of people by having DOGE illegally raid and disband USAID. Not rickets, not cars, not even the CSAMbot on X. It’s this, and so many media pundits just choose to unsee it.

USAID shutdown has led to hundreds of thousands of deaths | Harvard T.H. Chan School of Public Health

The Trump administration’s decision to shut down the U.S. Agency for International Development (USAID) has resulted in hundreds of thousands of deaths from infectious diseases and malnutrition, accord...

hsph.harvard.edu

Jamison Foser@jamisonfoser.bsky.social · 3mo ago

elon musk spends two-thirds of his time spreading racist pseudoscience and hating trans people and here is Ezra Klein in 2026 saying Musk is relentlessly focused on the only things that matter to him: EVs and going to Mars. I'm sorry but the guy's just very very dim

Findings from Prof. Chris Parker's lab show that post-translational modifications (PTMs) can determine whether proteins bind drug-like molecules. Published in Nature Chemical Biology, the study identified 400+ proteins whose druggability depends on modification state. More: https://ow.ly/3OQj50YVecw

Please RT! The Dept of Chemistry at UC Irvine invites applications for a tenured faculty position in Synthetic Organic Chemistry. Deadline: July 1, 2026. More information about the position can be found here: recruit.ap.uci.edu/JPF10109 @uciphyssci.bsky.social

Professor in Synthetic Organic Chemistry

University of California, Irvine is hiring. Apply now!

recruit.ap.uci.edu

A new method from the @shenvi.bsky.social lab enables the construction of branched molecular frameworks from simple alkenes via controlled MHAT chemistry, resolving a longstanding selectivity challenge and accelerating access to drug-relevant structures, as reported in @science.org.

New technique for synthesizing branched molecules could accelerate the development of future medicines

scripps.edu

Glad to share our new work: RitS (Right into the Saddle): a generative model for direct transition state (TS) prediction. 📄 Paper: chemrxiv.org/doi/full/10.26… 🤠 Code: github.com/isayevlab/RitS • Flow-matching model with explicit stereochemistry control • Direct TS generation from SMILEs #compchem

Congrats to Chunyu Li, Dr Xu-cheng Gan, Yu (Hannah) Irie and Dr Milo Smith for their paper appearing today in Science!

Jake Yeston@jakeyeston.bsky.social · 5mo ago

In @science.org for chemsky this week, @shenvi.bsky.social group report that lutidinium and manganese are the Goldilocks reagents to help nickel and cobalt cross-couple two different olefins www.science.org/doi/10.1126/...

What a thrill to see this out! Our prospective, scalable, and target-centric solution for molecular glue discovery. More thoughts and details here: www.linkedin.com/posts/activi... Paper here: www.nature.com/articles/s41...

High-throughput ligand diversification to discover chemical inducers of proximity - Nature Chemical Biology

Molecular glue degraders have consistently been discovered retrospectively, despite their increasing importance. Herein, a high-throughput approach is described that modifies existing ligands into mol...

nature.com

Thrilled to share our new paper just published in @acsjacs.bsky.social: a modular, 11‑step total synthesis of lasalocid acid A—enabled by a new Pd‑catalyzed C-glycosylation reaction to construct C(sp³)–C(sp³) attached‑rings. Read the paper: pubs.acs.org/doi/10.1021/...

Simply outrageous!

How can we study target engagement and selectivity of covalent inhibitors? Which electrophilic probes are best suited to study a certain amino acid? Our study on "Profiling the proteome-wide selectivity of diverse electrophiles" is published in Nature Chemistry.(1/7) www.nature.com/articles/s41...

Profiling the proteome-wide selectivity of diverse electrophiles - Nature Chemistry

Covalent inhibitors are powerful entities in drug discovery. Now the amino acid selectivity and reactivity of a diverse electrophile library have been assessed proteome-wide using an unbiased workflow...

nature.com

Amazing paper from Krische, Carrow, White and Dotson out today in JACS. Cross-electrophile coupling to form biaryls using H2 as reductant. Wow. Check it out: pubs.acs.org/doi/pdf/10.1...

Hydrogen-Mediated Reductive Cross-Coupling of Aryl Iodides with Activated Aryl and Heteroaryl Bromides

Hydrogen-mediated reductive cross-couplings of aryl iodides with activated aryl and heteroaryl bromides are described, along with related homocouplings (Ullmann reactions) and vinylic reductive couplings that occur with cine-substitution. To corroborate key events in the catalytic cycle, Pd-to-Pd transmetalation and cross-selective reductive elimination, dianionic diarylpalladate complexes [Pd(Aryl)(μ-Br)Br]2[NPr4]2 bearing p-fluorophenyl, p-methoxyphenyl and p-nitrophenyl moieties were prepared. Stoichiometric reactions of these complexes in the presence of iodide demonstrate that Pd-to-Pd transmetalation by way of monomeric arylpalladates occurs at a greater rate than reductive elimination and that cross-selective C–C reductive elimination is favored for electronically distinct aryl partners. Hydrogen-mediated reductive cross-coupling of aryl iodides with α-bromostyrene occurs with cine-substitution (as observed in related formate-mediated processes), consistent with carbopalladation of α-bromostyrene by monomeric arylpalladates Pd(Aryl)I2[NBu4] that arise upon dissociation of [Pd(Aryl)(μ-I)I]2[NBu4]2.

pubs.acs.org

Happy to share the final version of this work out in ACS CS. Inspired by ‘binding-focused’ chemoproteomic methods, we developed a ‘function-focused’ strategy to agnostically identify degradable proteins. This was a big team effort led by @inesforrest.bsky.social and in collaboration with AbbVie.

Proteome-Wide Discovery of Degradable Proteins Using Bifunctional Molecules

Targeted protein degradation (TPD) is an emergent therapeutic strategy with the potential to circumvent challenges associated with targets unamenable to conventional pharmacological inhibition. Among ...

pubs.acs.org

During these uncertain times, I’m very happy to see that my institution, @scripps.edu has an open tenure-track Assistant Professor position. Any field in Chemistry or Biology is welcome. I’d especially love to see fellow neuroscientists apply. Please repost! apply.interfolio.com/174756

Congrats to Florian, Stone and Sam for publication of Part 1 in our collaboration with Laura Bohn's lab to explore the pharmacology of GB18, a Galbulimima alkaloid that we identified as a novel opioid in 2022. pubs.acs.org/doi/10.1021/acscentsci.5c00573

www.nytimes.com/2025/05/31/o... “It was Elon Musk who first insisted that ‘no one has died.’ Now Rubio has doubled down.” “While testifying before Congress, Rubio claimed that the Trump administration’s dismantling of USAID had not cost any lives. This is ludicrous. The only debate..”

Opinion | Really, Secretary Rubio? I’m Lying About the Kids Dying Under Trump?

nytimes.com

Excited to present our newest preprint on the structure-function relationship of anaphylatoxin complement receptors. A casual number of 19 structures deciphering ligand recognition mechanisms, G protein/arrestin and species specific signaling. Please check it out! 🧪💊 www.biorxiv.org/content/bior...

Bittersweet graduation this year. These two earned their PhDs working to understand components of traditional medicine (Salvinorin A and the GB alkaloids), each earned a Science paper and graduated in 4y. Now they are highly skilled scientists with Merck and Janssen, trained with federal funds.

Gave a talk at my parents’ retirement community to describe how science is done, and what is at stake. There was a ton of interest, and anyone can do this. Get the word out about how science affects everyone. I’m happy to share slides with anyone who asks- just get in touch! youtu.be/BY_SFgi-Cig

Kara Marshall PHD-History of Science in America - Trilogy at Tehaleh 04/27/25

YouTube video by Steve Lawson

youtu.be

Musk Said No One Has Died Since Aid Was Cut. That Isn’t True. www.nytimes.com/interactive/...

Opinion | Musk Said No One Has Died Since Aid Was Cut. That Isn’t True.

A journey through the front lines of global poverty shows that when the world’s richest men slash aid for the world’s poorest children, the result is sickness, starvation and death.

nytimes.com

Our latest @angewandtechemie.bsky.social paper!🎉 We introduce a 2-stage dication pool strategy for the anti-Markovnikov hydrofunctionalization of alkenes via thianthrenium intermediates, expanding the scope of nucleophiles. Huge congrats to @sbencee.bsky.social & the team!👏 doi.org/10.1002/anie...

It's finally out – actually out and in print! Many thanks to @jcornlab.bsky.social @matthiasmuhar.bsky.social @jakobfarnung.bsky.social and all the fantastic collaborators. What started as pure curiosity lead to an amazing find! www.nature.com/articles/s41...

C-terminal amides mark proteins for degradation via SCF–FBXO31 - Nature

SCF–FBXO31 scans proteins for C-terminal amidation and marks them for subsequent proteasomal degradation.

nature.com

It’s been a tough few weeks. My 10yo daughter was diagnosed with a very rare, aggressive cancer called interdigitating dendritic cell sarcoma (IDCS). I’m reaching out to identify clinicians/patients who have encountered pediatric IDCS or other (non-LCH) dendritic or histiocytic sarcomas cases.

Check out our recent efforts in chemrxiv to expand the chemical tractability of the proteome through NP-inspired photoaffinity probes chemrxiv.org/engage/chemr...

New reactive groups for covalent inhibitors are key to expanding target scope. Natural products give inspiration for privileged structures. In Chemical Science, the group of @tbpoulsen.bsky.social synthesized cyclohelminthol I–IV and characterized their reactivity. (1/8) pubs.rsc.org/en/cont...

Total syntheses of cyclohelminthol I–IV reveal a new cysteine-selective covalent reactive group

Biocompatible covalent reactive groups (CRGs) play pivotal roles in several areas of chemical biology and the life sciences, including targeted covalent inhibitor design and preparation of advanced biologic drugs, such as antibody–drug conjugates. In this study, we present the discovery that the small, chlorinated

pubs.rsc.org

My first science post here on BlueSky is a long one. Setting the contrarian tone from the very beginning, I take strong issue with the recent op-ed by Charles Piller published in the January 24th NY Times on #Alzheimer's disease (nam12.safelinks.protection.outlook.com?url=https%3A...)

Opinion | The Devastating Legacy of Lies in Alzheimer’s Science

Fraud in research needs to end.

nam12.safelinks.protection.outlook.com

Check out the summary of the newest paper from our lab. Just out in Chemical Science #chembio #chemicalbiology

Anders Kiib@aekiib.bsky.social · 2y ago

I am excited to share that the latest project from the @tbpoulsen.bsky.social group, detailing the syntheses and biological evaluation of the four natural products cyclohelminthol I-IV is now available in Chemical Science! doi.org/10.1039/D4SC... A short "Bluetorial" below #ChemSky #ChemBio 1/7

Saturdays at the lab. Paper reviews, free Farmers Open seats.