Simone Mozzachiodi
@simonemozzachiodi.bsky.social
Postdoc in Kiran Patil's lab at Cambridge, UK. Previously PhD student at Gianni Liti's lab in Nice, France. Interested in microbes (genomes, evolution, communities and metabolism)
Could laboratory evolution of microbes strengthen pollinator resilience to chemical exposure? Happy to share the latest preprint from our lab: www.biorxiv.org/content/10.6... Fantastic work by @simonemozzachiodi.bsky.social @davidbaracchi.bsky.social @skamrad.bsky.social et al.
Our article "Common xenobiotics modulate gut microbial responses to low‑calorie sweeteners in vitro" is out! link.springer.com/article/10.1... With @kiranrpatil.bsky.social, @indraroux.bsky.social, @rbradley.bsky.social, @skamrad.bsky.social, @simonemozzachiodi.bsky.social, @itsbinir.bsky.social.
Common xenobiotics modulate gut microbial responses to low‑calorie sweeteners in vitro - Molecular Systems Biology
The gut microbiota is implicated in adverse effects associated with low-calorie sweeteners. Yet, the direct impact of sweeteners on gut bacteria remains largely uncharacterized. Here, we report intera...
link.springer.com
Latest preprint from our lab reports a hitherto hidden consequence of drug bioaccumulation: disruption of RNA-protein interactions by antidepressant duloxetine in bacterial as well as human cells. Implications for MoA, toxicity, and for targeting RNA-protein interactions. In collab wt Lilley lab
bioRxiv SysBio@biorxiv-sysbio.bsky.social · 2w agoNetwork-scale disruption of RNA-protein interactions by a bioaccumulating small-molecule drug https://www.biorxiv.org/content/10.64898/2026.07.23.740326v1
Great collaboration with Dr. Na Liu and Dr. Jun Ma's teams! It was a fun journey to expand our research footprint into cancer-associated microorganisms. Special thanks to @simonemozzachiodi.bsky.social for critically reading our manuscript and providing valuable feedback. 🧬🦠
Evomics Lab@evomicslab.bsky.social · 3w agoGlad to see this joint work on nasopharyngeal microbiota culturomics published in #ScienceTranslationalMedicine, featured as a cover story! By building this local bacterial catalog, we characterized a Fusobacterium-Prevotella mutualism in nasopharyngeal tumors. www.science.org/doi/10.1126/...
Happy to share our story on the impact of #chemicals on #fungi and #pollinators. We started from a broad screening of agrochemicals toxicity and ended up using #laboratoryevolution to mitigate the negative effect of a common pesticide on #pollinators and their #microbiomes. See below Kiran's post 👇🏻
Kiran R. Patil@kiranrpatil.bsky.social · 3w agoCould laboratory evolution of microbes strengthen pollinator resilience to chemical exposure? Happy to share the latest preprint from our lab: www.biorxiv.org/content/10.6... Fantastic work by @simonemozzachiodi.bsky.social @davidbaracchi.bsky.social @skamrad.bsky.social et al.
New online! Fungal diversity, ecology and functions in soil ecosystems
Fungal diversity, ecology and functions in soil ecosystems
Nature Reviews Microbiology, Published online: 21 May 2026; doi:10.1038/s41579-026-01321-yIn this Review, Rillig explores the diversity of fungi in the soil ecosystem, their ecological interactions and diverse ecological roles in terrestrial ecosystems as well as anthropogenic factors that affect soil fungi.
dlvr.it
Happy to share our review on non-model microbes and microbial communities in biotechnology! With @sonjablasche.bsky.social @indraroux.bsky.social @kiranrpatil.bsky.social see below 👇🏼
Indra Roux@indraroux.bsky.social · 5mo agoOne of the biggest challenges in microbial biotechnology? Unlocking the potential of non-model microbes and synthetic communities! Glad to share our review @sonjablasche.bsky.social @simonemozzachiodi.bsky.social @kiranrpatil.bsky.social @cambridgebiosci.bsky.social🧵(1/7) doi.org/10.1016/j.co...
Abstract deadline extended to Jan 31 for the EMBO–AS Workshop (Apr 24–27) Evolving together: From genomics to biological interactions. We’re close to capacity (~80% full, aiming for 200), with 70 abstracts already submitted. If you are considering going, submit here: coms.app/gw26-19/
🆕 Vacancy! We're looking for a Research Scientist to work on novel platforms for sustainable myco-food production and precision fermentation. 💷 £37,500 to £40,240 🗓️ Apply by 30 November 2025 ➡️ buff.ly/6LKIB1y
The #Yeast2025 meeting has finally reached its end after four days of exciting talks, posters and networking activities. Stay tuned for the upcoming special issue about the conference! More infos will follow in the next coming weeks. 🙂
@pjboynton.bsky.social advertises our upcoming special issue about the #Yeast2025 conference in Paris
Superhappy to share the last paper from my PhD in @litinice.bsky.social lab. We evolved yeasts with humanized telomeric repeats and discovered that they adapt through amplification of telomere-binding proteins and inactivation of the DNA damage response. www.biorxiv.org/content/10.1...
The adaptive molecular landscape of reprogrammed telomeric sequences
Telomeric sequences vary across the tree of life and intimately co-evolve with telomere-binding protein complexes. However, the molecular mechanisms allowing organisms to adapt to new telomeric sequen...
biorxiv.org
Excited to share some key details on our latest research in @natmicrobiol.nature.com reporting intra-cellular accumulation of #PFAS (aka forever chemicals) by certain human gut bacteria. #microsky #mevosky #microbiomesky www.nature.com/articles/s41...
Latest study from the lab is online today (and another will be out tomorrow, stay tuned:)). We profiled effect of >1700 chemicals (drugs, pesticides,...) on secretion of amines (involved in gut-brain and gut-immune axis. ) by human gut bacteria. Brilliant work by @skamrad.bsky.social and Tara Davis
MRC Toxicology Unit@mrc-tu.bsky.social · last yr.Stephan Kamrad and Tara Davis in the Patil lab at the MRC Toxicology Unit have identified that some drugs and environmental contaminants alter gut bacterial amine metabolism. Find out more here: buff.ly/5akzsgs @kiranrpatil.bsky.social @skamrad.bsky.social
incredible work by an incredible scientist (and friend)! very beautiful figures too www.cell.com/cell-systems...
The molecular landscape of cellular metal ion biology
Aulakh et al. systematically investigated how metal ion availability impacts yeast biochemistry. Their metallomic, proteomic, and genetic screens reveal the widespread metal concentration dependence o...
cell.com
In the latest #Yeast research article of the series #FantasticYeasts, Pei-Jie Han, Feng-Yan Bai & team describe a new yeast species isolated from a Chinese forest: Saccharomycopsis yichangensis, that can prey on Saccharomyces cerevisiae and other yeasts 😲 onlinelibrary.wiley.com/doi/10.1002/...
Saccharomycopsis yichangensis sp. nov., a Novel Predacious Yeast Species Isolated From Soil
Saccharomycopsis yichangensis sp. nov. occurs in soil from a subtropical forest in central China. This novel species is homothallic and produces asci containing four spheroidal ascospores, which can ...
onlinelibrary.wiley.com
Check out our new preprint! We systematically map proteomic and metabolomic interactions between >100 pairs of gut bacteria, detecting metabolic interactions and functionally-related clusters of proteins. www.biorxiv.org/content/10.1... @kiranrpatil.bsky.social
Interspecies interactions drive bacterial proteome reorganisation and emergent metabolism
Species in microbial communities must respond to the presence of others to stave off resource competition or to capitalise on new resources that may become available due to additional metabolic activi...
biorxiv.org
Hi everyone! "Yeast" is looking for its next journal cover for the upcoming 2025 issues. If you have beautiful yeast images that you would like to see on our front cover, please send them to YEAST@wiley.com Have a nice day 🙂
🧬 Save the date! The EMBO Workshop "The Immune System of Bacteria" will uncover groundbreaking insights into bacterial defense systems. Join us April 8-10, 2025, at Institut Pasteur, Paris. Submit your abstracts by Feb. 28 👉 https://www.sisb2025.conferences-pasteur.org/home
Building on our discovery of #LesionSegregation, @mikespencerchapman.bsky.social and colleagues from @sangerinstitute.bsky.social find that some DNA lesions can persist in humans for months or years! "Prolonged persistence of mutagenic DNA lesions in somatic cells" www.nature.com/articles/s41...
Prolonged persistence of mutagenic DNA lesions in somatic cells - Nature
Persistent DNA lesions can occur throughout the human lifespan and can remain in the genome of affected cells for several years and generate a substantial proportion of the mutational burden.
nature.com