Another great opportunity for genome integrity / replication stress aficionados to attend two excellent seminars with a simple click. Join us in a few days (Tue April 7th)! 👇

Pour les francophones : voici un article de communication du CNRS sur notre publication récente dans NSMB, avec @ahellab.bsky.social, @spartelab.bsky.social, et al, sur la structure et le mécanisme des sirtuines FAM118 ('SIRal') - de véritables « fossiles » apparentés aux protéines bactériennes.

🔬 3ᵉ Symposium en Sciences de la Vie – Appel à communications ouvert ! Un rendez-vous incontournable pour présenter vos travaux et échanger avec des chercheurs expérimentés. 👉 Pour soumettre un résumé (Date limite : 3 avril) et vous inscrire, rendez-vous igdr-phd-symp26.sciencesconf.org?lang=en

PhD in Rennes! Study how OGG1 repairs oxidative DNA damage using advanced microscopy. Join Sébastien Huet’s team at IGDR (Oct 2026). Master’s in cell biology/biophysics? Apply: sebastien.huet@univ-rennes.fr #PhD #CancerResearch #Microscopy

We are offering a 24-month post-doctoral position in our team, based in Rennes, France (@IGDR, @cedre-lab). Looking for a highly motivated researcher with expertise in deep learning and image analysis. emploi.cnrs.fr/Offres/CDD/U... #PostDoc #DeepLearning #ImageAnalysis #ResearchOpportunity

In this study, we reveal that OGG1’s association with DNA during lesion searching involves local DNA distortion, promoting base unstacking. This process is tightly regulated by conserved amino acids encircling the double helix, ensuring stable binding without compromising rapid scanning.

We are thrilled to share our latest publication in Cell Reports (Cell Press)! A huge thank you to everyone involved in this work! 📖 Read the full paper here: www.cell.com/cell-reports...

A coordinated haptic mechanism ensures efficient DNA sampling by the 8-oxoguanine glycosylase OGG1

Martinez et al. propose that OGG1 association with DNA during lesion seeking involves local DNA distortion promoting base unstacking. This process is tightly controlled by several conserved amino acid...

cell.com

Cell Reports@cp-cellreports.bsky.social · 6mo ago

A coordinated haptic mechanism ensures efficient DNA sampling by the 8-oxoguanine glycosylase OGG1

We are thrilled to share our latest publication in Cell Reports (Cell Press)! A huge thank you to everyone involved in this work! 📖 Read the full paper here: www.cell.com/cell-reports...

A coordinated haptic mechanism ensures efficient DNA sampling by the 8-oxoguanine glycosylase OGG1

Martinez et al. propose that OGG1 association with DNA during lesion seeking involves local DNA distortion promoting base unstacking. This process is tightly controlled by several conserved amino acid...

cell.com

Cell Reports@cp-cellreports.bsky.social · 6mo ago

A coordinated haptic mechanism ensures efficient DNA sampling by the 8-oxoguanine glycosylase OGG1

"Exciting opportunity! Our team is offering two PhD projects for this doctoral competition. Explore our innovative research topics and join us in pushing scientific boundaries. Applications open—don’t miss out! #PhD #Research #JoinUs"

Institut de Génétique & Développement de Rennes@igdrennes.bsky.social · 7mo ago

📢 Are you planning to do a #PhD in #Biology? Our doctoral competition is now open! Apply before 16 April, 11:59 p.m. 5 to 10 positions available ℹ️https://igdr.univ-rennes.fr/en/application-igdr-phd-program cc @cnrs-bretagneloire.bsky.social @insermgrandouest.bsky.social @rennesuniv.bsky.social

The IGDR @igdrennes.bsky.social and the Faculty of Sciences at the University of Rennes announce an opening for a University Professor position in CNU Section 65 "Genetic and Epigenetic Regulations" with the opportunity to join our team @spartelab.bsky.social #PU #CNU65.

L'IGDR @igdrennes.bsky.social et la Faculté des Sciences de l'Université de Rennes annoncent l'ouverture d'un poste de Professeur des Universités en section CNU 65 "Régulations génétiques et épigénétiques" avec l'opportunité de rejoindre notre équipe @spartelab.bsky.social #PU #CNU65

L'IGDR @igdrennes.bsky.social et la Faculté des Sciences de l'Université de Rennes annoncent l'ouverture d'un poste de Professeur des Universités en section CNU 65 "Régulations génétiques et épigénétiques" avec l'opportunité de rejoindre l'équipe SP@RTE @spartelab.bsky.social #PU #CNU65

The IGDR @igdrennes.bsky.social and the Faculty of Sciences at the University of Rennes announce an opening for a University Professor position in CNU Section 65 "Genetic and Epigenetic Regulations" with the opportunity to join the SP@RTE team @spartelab.bsky.social #PU #CNU65.

Very happy to share our collaborative project on FAM118 proteins - noncanonical sirtuins that form filaments and process NAD in human and other vertebrate cells.

Filament formation and NAD processing by noncanonical human FAM118 sirtuins

Nature Structural & Molecular Biology - Baretić and Missoury et al. identify vertebrate proteins FAM118B and FAM118A as sirtuins similar to bacterial antiphage enzymes and show that...

rdcu.be

Ignacio Izeddin@izeddinresearch.bsky.social · 10mo ago

SPT of DNA repair proteins after cell irradiation by Ashli Kobayashi @asaki-kobayashi.bsky.social and Romane Riou. Setup by Abbelight @abbelight.bsky.social and irradiator by Errol Laser @errol-laser.bsky.social. Look at that recruitment! #Mifobio2025 @gdrimabio.bsky.social

SPT of DNA repair proteins after cell irradiation by Ashli Kobayashi @asaki-kobayashi.bsky.social and Romane Riou. Setup by Abbelight @abbelight.bsky.social and irradiator by Errol Laser @errol-laser.bsky.social. Look at that recruitment! #Mifobio2025 @gdrimabio.bsky.social

A postdoc position is available in our lab to study ADP-ribosylation and ubiquitylation signalling! We are looking for someone with experience in structural biology and biochemistry. The application deadline is June 20th. my.corehr.com/pls/uoxrecru...

We have another postdoc position available to work on interplay between ADP-ribosylation and ubiquitination in regulation of genome stability. For this post expertise in cell biology is required. my.corehr.com/pls/uoxrecru...

Very happy that our SIAH1 article - published online in February - was now chosen for the cover of the new issue of the @febsj.bsky.social . Thank you @spartelab.bsky.social for the wonderful collaboration and the lovely cellular images. febs.onlinelibrary.wiley.com/toc/17424658...

Two year postdoc position available in the Sparte lab at IGDR to investigate the crosstalk between ADP-ribosylation and SUMOylation signaling at stressed replication forks

#ScientificResult | A collaborative work by the Huet group at IGDR and the Suskiewicz team at CBM discovers how SIAH1 polymerization could improve the clearing of protein aggregates involved in certain neurodegenerative diseases. igdr.univ-rennes.fr/en/proteins-... pubmed.ncbi.nlm.nih.gov/39910688/

📢Are you planning to do a #PhD in #Biology? There's still a month to apply at #IGDR PhD call! Apply before April 21st, 1:00 pm 7 to 9 positions ℹ️https://igdr.univ-rennes.fr/en/application-igdr-phd-program cc @cnrs-bretagneloire.bsky.social @insermgrandouest.bsky.social @rennesuniv.bsky.social

Here is a link to the article: onlinelibrary.wiley.com/share/author... We're very happy to see it published in a society journal, The FEBS J. It's another great collaboration with the team from Rennes led by Sébastien Huet @spartelab.bsky.social . Thanks to @ercresearch.bsky.social for funding.

Happy to share our new study showing that the Ub E3 ligase SIAH1, known to dimerise via its C-term SBD, also dimerises via its N-term RING. When these tendencies combine, full-length SIAH1 forms multimers, which might explain its clustering in cells & preference for aggregated/multimeric substrates.

This is a cover design that wasn't accepted, showing SIAH1 multimers on top of cells (SIAH1 red, actin green). We were not able to visualise SIAH1 chains in vitro, as we could only purify N- or C-term halves of SIAH1 separately: the blue chains are made from combined dimeric structures of each half.

What better occasion for our first post on Bluesky than this? Congratulations to Dr. Eva Pinto for successfully defending her thesis, "Study of ADP-ribose-dependent chromatin remodeling processes occurring at early stages of the DNA damage response." 🧬🔬