The Thermo Fisher situation keeps getting worse. We've now collected 450+ problematic images presented as verification data in TF's antibody catalog. This includes: 🖌️ Dozens more images with duplications or painting 🖨️ Hundreds of blots that all share the same background (behold slideshow below)
Another great opportunity for genome integrity / replication stress aficionados to attend two excellent seminars with a simple click. Join us in a few days (Tue April 7th)! 👇
And in yesterday's journal club, we discussed this nice paper on transforming antibodies into intrabodies from @tim-stasevich.bsky.social et al. The authors put together a pipeline comprising ProteinMPNN to design a stabler protein sequence for the scaffold while keeping the antigen-binding loops.
AI-assisted protein design to rapidly convert antibody sequences to intrabodies targeting diverse peptides and histone modifications
AI-powered pipeline converts antibodies into functional intrabodies, enabling live-cell imaging of peptides and histone marks.
science.org
#JobOffer 💼 Professeur en stabilité du génome 📍Institut Jacques Monod 📆 1e septembre 2026 Les candidatures sont ouvertes jusqu'au 3 avril 2026 16h🔗 u-paris.fr/recrutement-...
Et je dois ajouter que nos travaux portent sur la structure et le mécanisme, mais le rôle immunitaire de ces protéines a été démontré par les équipes de @audeber.bsky.social et @enzopoirier.bsky.social
Une protéine humaine héritée des bactéries révèle un pan méconnu de notre immunité - Salle de presse de l'Inserm
Depuis quelques années, certains scientifiques explorent les liens inattendus entre les protéines humaines impliquées dans la défense de l’organisme et certains mécanismes immunitaires bactériens. C’e...
presse.inserm.fr
🔬 3ᵉ Symposium en Sciences de la Vie – Appel à communications ouvert ! Un rendez-vous incontournable pour présenter vos travaux et échanger avec des chercheurs expérimentés. 👉 Pour soumettre un résumé (Date limite : 3 avril) et vous inscrire, rendez-vous igdr-phd-symp26.sciencesconf.org?lang=en
📣 16th edition of the French 3R meeting “Replication, Recombination, Repair” - Last week for abstract submission! 📆 May 18 to 21, 2026 📍 Belambra Club Presqu’île du Ponant in La Grande-Motte, France 🔗 www.2026.3r-meeting.fr/page/home/
Home — Congrès des 3R
2026.3r-meeting.fr
Institut Jacques Monod@ijmonod.bsky.social · 6mo ago📣 16th edition of the French 3R meeting “Replication, Recombination, Repair” - Registrations are open! 📆 May 18 to 21, 2026 📍 Belambra Club Presqu’île du Ponant in La Grande-Motte, France 🔗 www.2026.3r-meeting.fr/page/home/
Thanks so much for highlighting our study! The tool is versatile and ready to uncover so much new knowledge 😀
The FEBS Journal@febsj.bsky.social · 6mo ago🌄 We'd like to suggest a great start into a new week with this highlighted study #Highlights2025 📕 A CRISPR-Cas9-based system for the dose-dependent study of DNA double-strand break sensing and repair 🧬 Discover the article, here ➡️ buff.ly/kDp40pZ #CRISPR #DNAbreak #DNArepair
I am happy to share our latest publication. In this work, we show that OGG1 association with DNA during lesion search involves local DNA distortion promoting base unstacking. This process is tightly controlled by conserved residues to ensure stable association without compromising fast scanning.
Cell Reports@cp-cellreports.bsky.social · 6mo agoA coordinated haptic mechanism ensures efficient DNA sampling by the 8-oxoguanine glycosylase OGG1
We are thrilled to share our latest publication in Cell Reports (Cell Press)! A huge thank you to everyone involved in this work! 📖 Read the full paper here: www.cell.com/cell-reports...
A coordinated haptic mechanism ensures efficient DNA sampling by the 8-oxoguanine glycosylase OGG1
Martinez et al. propose that OGG1 association with DNA during lesion seeking involves local DNA distortion promoting base unstacking. This process is tightly controlled by several conserved amino acid...
cell.com
Cell Reports@cp-cellreports.bsky.social · 6mo agoA coordinated haptic mechanism ensures efficient DNA sampling by the 8-oxoguanine glycosylase OGG1
In this study, we reveal that OGG1’s association with DNA during lesion searching involves local DNA distortion, promoting base unstacking. This process is tightly regulated by conserved amino acids encircling the double helix, ensuring stable binding without compromising rapid scanning.
A coordinated haptic mechanism ensures efficient DNA sampling by the 8-oxoguanine glycosylase OGG1
A coordinated haptic mechanism ensures efficient DNA sampling by the 8-oxoguanine glycosylase OGG1
Martinez et al. propose that OGG1 association with DNA during lesion seeking involves local DNA distortion promoting base unstacking. This process is tightly controlled by several conserved amino acids encircling the double helix, ensuring a sufficiently stable association during base interrogation while avoiding excessive engagement detrimental for fast scanning.
dlvr.it
✍️ The Cadoret Lab contributed to a new publication 📖 @natcomms.nature.com 📃 DNA methylation and lncRNA control asynchronous DNA replication at specific imprinted gene domains 🔗 www.nature.com/articles/s41...
🧬🔬@science.org A genetically encoded device for #transcriptome storage in mammalian cells | Science www.science.org/doi/10.1126/... @broadinstitute.org
A genetically encoded device for transcriptome storage in mammalian cells
Understanding how cells make decisions over time requires the ability to link past molecular states to future phenotypic outcomes. We present TimeVault, a genetically encoded system that records and s...
science.org
L'IGDR @igdrennes.bsky.social et la Faculté des Sciences de l'Université de Rennes annoncent l'ouverture d'un poste de Professeur des Universités en section CNU 65 "Régulations génétiques et épigénétiques" avec l'opportunité de rejoindre notre équipe @spartelab.bsky.social #PU #CNU65
The IGDR @igdrennes.bsky.social and the Faculty of Sciences at the University of Rennes announce an opening for a University Professor position in CNU Section 65 "Genetic and Epigenetic Regulations" with the opportunity to join our team @spartelab.bsky.social #PU #CNU65.
L'IGDR @igdrennes.bsky.social et la Faculté des Sciences de l'Université de Rennes annoncent l'ouverture d'un poste de Professeur des Universités en section CNU 65 "Régulations génétiques et épigénétiques" avec l'opportunité de rejoindre l'équipe SP@RTE @spartelab.bsky.social #PU #CNU65
MISO: a micro isolation method for single-particle cryo-EM grid preparation for extremely small sample amounts. www.nature.com/articles/s41...
MISO: microfluidic protein isolation enables single-particle cryo-EM structure determination from a single cell colony - Nature Methods
The micro isolation (MISO) method combines microfluidics-based protein purification with cryo-EM grid preparation, enabling cryo-EM structure determination of soluble and membrane proteins starting fr...
nature.com
Please check our collaborative paper with Marcin Suskiewicz and Sebastien Huet labs on FAM118 proteins – non-canonical sirtuins that form filaments and act as NADases in human and other vertebrate cells. www.nature.com/articles/s41...
Filament formation and NAD processing by noncanonical human FAM118 sirtuins - Nature Structural & Molecular Biology
Baretić and Missoury et al. identify vertebrate proteins FAM118B and FAM118A as sirtuins similar to bacterial antiphage enzymes and show that FAM118A/B processing of NAD involves head-to-tail filament...
nature.com
Very happy to share our collaborative project on FAM118 proteins - noncanonical sirtuins that form filaments and process NAD in human and other vertebrate cells.
Filament formation and NAD processing by noncanonical human FAM118 sirtuins
Nature Structural & Molecular Biology - Baretić and Missoury et al. identify vertebrate proteins FAM118B and FAM118A as sirtuins similar to bacterial antiphage enzymes and show that...
rdcu.be
Agreed! This review thoughtfully and comprehensively dives into the world of HPF1. The questions at the end are on point!
Karolin Luger@nucleosomepolice.bsky.social · 9mo agoBeautiful review from J. Rudolph on Histone PARylation factor 1: a review of its role in the DNA damage response url: academic.oup.com/nar/article/...
Beautiful review from J. Rudolph on Histone PARylation factor 1: a review of its role in the DNA damage response url: academic.oup.com/nar/article/...
Histone PARylation factor 1: a review of its role in the DNA damage response
Abstract. Although poly-(ADP ribose) polymerase 1 (PARP1) and PARylation of histones have been known for over 50 years and have been successfully targeted
academic.oup.com
#JobOffer 💼 Un poste susceptible d’être vacant de Professeur en stabilité des génomes devrait s’ouvrir pour la rentrée 2026 au sein de l’Institut Jacques Monod ➡️ Informations concernant ce poste et la procédure de candidature 🔗 www.ijm.fr/poste-de-pro...
Finally, someone has solved a real problem with AI! No more having to take a paper in the format for a journal that rejected you, and reformat it for a new journal. Well done!! formatmypaper.com
Ignacio Izeddin@izeddinresearch.bsky.social · 10mo agoSPT of DNA repair proteins after cell irradiation by Ashli Kobayashi @asaki-kobayashi.bsky.social and Romane Riou. Setup by Abbelight @abbelight.bsky.social and irradiator by Errol Laser @errol-laser.bsky.social. Look at that recruitment! #Mifobio2025 @gdrimabio.bsky.social
SPT of DNA repair proteins after cell irradiation by Ashli Kobayashi @asaki-kobayashi.bsky.social and Romane Riou. Setup by Abbelight @abbelight.bsky.social and irradiator by Errol Laser @errol-laser.bsky.social. Look at that recruitment! #Mifobio2025 @gdrimabio.bsky.social
New method paper: Bennie Lemmens et al @scilifelab.se describe 3D-SPARK, a super-resolution microscopy method that maps changes in DNA replication nanostructures in response to genetic perturbations or drugs, linking spatial cell biology with DNA synthesis dynamics www.embopress.org/doi/full/10....
New pre-print on the role of CCDC103/DNAAF19 in dynein assembly highlighting it's link to PCD. www.biorxiv.org/content/10.1...
CCDC103-mediated assembly of the R2C complex links RUVBL1-RUVBL2 to Primary Ciliary Dyskinesia
Primary ciliary dyskinesia (PCD) is a genetic disorder caused by defective cilia motility, powered by axonemal dynein motors. Assembly of these motors is facilitated by the molecular chaperone HSP90, ...
biorxiv.org
Exciting new study from new-PI Mohinder Pal on the role of CCDC103 and it's links to PCD as the most recent dynein assembly factor (DNAAF19). Congratulations to the entire team. @Mohinder Pal (currently not on Bluesky) @mike-wieczorek.bsky.social @laurencepearl.bsky.social
UK Cilia and Centrosome Network@ukcilianetwork.bsky.social · 11mo agoNew pre-print on the role of CCDC103/DNAAF19 in dynein assembly highlighting it's link to PCD. www.biorxiv.org/content/10.1...
Academic research generates almost all intellecutal innovation in the life sciences. With big pharma refusing to contribute, maybe it's time to stop giving them our research outputs cheaply, and instead having globally nationalised means of translating innovation? www.theguardian.com/business/202...
US drugmaker Merck scraps £1bn London research centre and cuts 125 science jobs
New blow to UK’s key life science sector as industry body says country is losing ground on investment and research
theguardian.com