Prof Steven Lee
@stevethechemist.bsky.social
Professor of Biophysical Chemistry - Cambridge University | Co-founder - ZOMP | Podcaster - TheScienceShed
This work was made possible thanks to the incredible contributions of Sophie Brasselet, @stevethechemist.bsky.social, @samofmidworld.bsky.social, Ezra Bruggeman, and @hannah-superres.bsky.social Have a look 👇 www.biorxiv.org/content/10.1...
SMOLM-LFM: ratiometric single molecule orientation without polarizers
Single-molecule orientation and localization microscopy (SMOLM) enables the determination of molecular orientation, wobbling, and position. However, most SMOLM implementations rely on complex point sp...
biorxiv.org
We are very pleased to announce Professor Steven Lee @stevethechemist.bsky.social as a winner of the RMS Scientific Achievement Award 2025 😀👏🔬 Steven is a world leading figure in cutting-edge, single-molecule #microscopy for biological discovery. Read more: rms.org.uk/resource/pro...
Very honoured to receive the 2025 Scientific Achievement Award from RMS. I am very grateful to *everyone* who has passed through our lab. Nothing happens without talented researchers who are willing to take bold ideas seriously. Thank you for that trust. www.rms.org.uk/resource/pro...
Professor Steven Lee receives 2025 Scientific Achievement Award
World leading figure in cutting-edge single-molecule microscopy for biological discovery
rms.org.uk
"Large-scale visualization of α-synuclein oligomers in Parkinson’s disease brain tissue," NatBME doi.org/10.1038/s41551-025-01496-4 A culmination of wild brainstorms, imaging marathons, analysis breakthroughs and setbacks, around the clock work before conferences, and new friends along the way! 🧠🎆
The Francis Crick Institute@crick.ac.uk · 10mo agoResearchers from the Crick, @ucl.ac.uk, @cam.ac.uk and @polymtl.bsky.social have directly observed the protein clusters believed to trigger Parkinson’s disease in human brain tissue, developing a new technique that could support future diagnostics and treatments. www.crick.ac.uk/news/2025-10...
www.nature.com/articles/s41... It's out at last! Work that I was totally privileged to be a part of led by @becs-andrews.bsky.social, with @jcbreiter.bsky.social @stevethechemist.bsky.social and funded by @asapresearch.parkinsonsroadmap.org
Large-scale visualization of α-synuclein oligomers in Parkinson’s disease brain tissue - Nature Biomedical Engineering
An optical detection and analysis platform quantifies aggregate density, distribution and size in fluorescently labelled post-mortem human brain tissue.
nature.com
Our work on visualising protein aggregates in human brain tissue in Parkinson's disease was published today in Nature Biomedical Engineering, well done to Becs, Bin and Christina for their hardwork! www.cam.ac.uk/research/new...
Parkinson’s ‘trigger’ directly observed in human brain tissue for the first time
Scientists have, for the first time, directly visualised and quantified the protein clusters believed to trigger Parkinson’s, marking a major advance in the
cam.ac.uk
Out now on biorxiv! Excited to share our latest collaborative work investigating the earliest stages of Parkinson’s disease. www.biorxiv.org/content/10.1... Thanks to all the amazing co-authors Melissa Grant-Peters @jsbeckwith.bsky.social @stevethechemist.bsky.social Mina Ryten Sonia Gandhi
Microglial activation and alpha-synuclein oligomers drive the early inflammatory phase of Parkinson's disease
Parkinson's disease (PD) is characterised by insoluble α-synuclein (αSyn) aggregates in Lewy bodies (LBs) within the substantia nigra, with cortical pathology appearing as the disease progresses. Late...
biorxiv.org
Single-Molecule Friends! Just 10 more days to apply for an exciting joint postdoc with @KlenermanLab, feel free to research out www.ch.cam.ac.uk/job/52425
Postdoctoral Research Associate in Single-Molecule Imaging and Super-Resolution Microscopy (Fixed Term) | Yusuf Hamied Department of Chemistry
Fixed-term: The funds for this post are available for 2 years in the first instance. Fixed-term: The funds for this post are available for 2 years in the first instance. Applications are invited for a...
ch.cam.ac.uk
Top-right image is from Ezra and the Lee lab's beautiful POLCAM work of actin fiber networks. The POLCAM software is much easier to use than full PSF fitting: doi.org/10.1038/s415...
POLCAM: instant molecular orientation microscopy for the life sciences - Nature Methods
Combining localization and polarization microscopy can yield detailed insights into subcellular structures. POLCAM uses a polarization camera and wide-field microscopy for rapid measurement of super-r...
doi.org
Build microscopes, solve immunology (kinda)... come and work with us! We have an exciting collaborative postdoc position in the group. www.cam.ac.uk/jobs/postdoc...
Postdoctoral Research Associate in Single-Molecule Imaging and Super-Resolution Microscopy (Fixed Term)
Fixed-term: The funds for this post are available for 2 years in the first instance. Fixed-term: The funds for this post are available for 2 years in the first instance. Applications are invited for
cam.ac.uk
You wont believe what happens next!?!? theevanslab.bsky.social! //run"(Insert_click_bate_that_Nick_will_fall_for"); soundcloud.com/the-science-...
S6 E1: Spies, Lies and Simeticone
Nick and Steve are back for the launch of Series 6 of The Science Shed! We're diving straight into a fresh batch of science-infused delights from a windowless room deep in the depths of UCL. Nick’s un
soundcloud.com
We back for the launch of Series 6 of The Science Shed! Nick’s uncovered some Cold War espionage, Steve’s brought along a surprise audio gift, and there’s plenty of snake oil to go around. Share to and repost! soundcloud.com/the-science-...
S6 E1: Spies, Lies and Simeticone
Nick and Steve are back for the launch of Series 6 of The Science Shed! We're diving straight into a fresh batch of science-infused delights from a windowless room deep in the depths of UCL. Nick’s un
soundcloud.com
A recent preprint by Team Wood describes a highly sensitive bioimaging method that allows for fluorescent signals to be detected in cell and tissue environments. 🧪🤖📈 🧬 www.biorxiv.org/content/10.1...
RASP: Optimal single fluorescent puncta detection in complex cellular backgrounds
bioRxiv - the preprint server for biology, operated by Cold Spring Harbor Laboratory, a research and educational institution
biorxiv.org