Researchers found that a synthetic gene-regulating compound called SynGR1 can recruit BRD4 to bypass gene-silencing structures without disrupting them and reactivate silenced genes. The findings point to new strategies for diseases like Friedrich’s ataxia and Huntington’s disease. 🧪 bit.ly/4hgkfb6

Restoring the silenced Friedreich’s ataxia gene through unconventional means

See how a synthetic gene regulating SynGR system desilenced the frataxin gene in Friedreich’s ataxia by shuttling BRD4 through HP1 condensates

bit.ly

We are actively looking for a NMR facility manager for our growing NMR needs in Syracuse! This facility hosts an 800 with TCI cryoprobe (perfect for disordered protein research) and 600 with Prodigy cryoprobe. Please share with your communities!

Magnetic Resonance News@nmr900.bsky.social · 2w ago

Instructional Support Specialist (NMR Specialist) College of Environmental Science and Forestry, Syracuse, New York esf.interviewexchange.com/jobofferdeta... #NMRjobs #NMRchat #NMR 🧲

Biomolecular condensates can function as inherent catalysts: Molecular Cell www.cell.com/molecular-ce...

Biomolecular condensates can function as inherent catalysts

Chen, Guo, Farag, Qian et al. present that biomolecular condensates formed by proteins lacking catalytic activity can mediate diverse hydrolysis reactions, highlighting the importance of condensate el...

cell.com

St. Jude researchers discovered that the tumor suppressor SPOP switches between an inactive "double-donut" structure and active filaments. The findings reveal how certain cancer mutations alter SPOP activity and may inform new therapeutic strategies. https://bit.ly/3R5c7zx

SPOP ‘double-donut’ structure closes the loop on unexplained cancer mutations

See how an inactive tumor suppressor SPOP ‘double-donut’ state is converted to an active filament state with Cullin-3 to ubiquitinate key proteins like BRD4

stjude.org

Our new paper on SPOP, a subunit of a Cullin-RING ubiquitin ligase that is heavily mutated in cancer patients. We are describing a large-scale, quaternary structural transition that converts an autoinhibited (double donut) state into the active state! kwnsfk27.r.eu-west-1.awstrack.me/L0/https:%2F...

Classic Glazed Donut

ALT: Classic Glazed Donut

static.klipy.com

Join us in a fun, crazy and interesting interdisciplinary research project that combines protein biophysics, evolutionary genomics, biomolecular archaeology, and textile research to resolve species identity and post-translational modifications in the structural proteins collagen and keratin

Matthew Collins@matthewcollins.bsky.social · 3w ago

Copenhagen job alert 🚨 GLOBE (@ucph.bsky.social) is hiring a 21-mo Postdoc in #Bioinformatics & #ComputationalProteomics Work with @lindorfflarsen.bsky.social, @fridowelker.bsky.social, @brandtgroup.bsky.social & more mapping collagen/keratin diversity across 1000s of genomes. 📅 Deadline Aug 31

What's happening in protein dynamics research right now? Jaime & Stephanie break down NIH policy changes, preprints & the conformational ensembles conference. New episode up: diffuse.science/posts/TTPD-15/ #StructuralBiology

It's nice when you benchmark your own method and find it good. But its even nicer when others benchmark your method and find it good. Table from doi.org/10.1101/2025... benchmarking our AF-CALVADOS approach (doi.org/10.1101/2025...)

Kresten Lindorff-Larsen@lindorfflarsen.bsky.social · 4mo ago

Run an MD simulation of any protein in the AlphaFold Protein Structure Database using AF-CALVADOS Thanks to @sobuelow.bsky.social AF-CALVADOS is now on Colab colab.research.google.com/github/KULL-...

Professor Lewis E. Kay @lek-lab.bsky.social University of Toronto/SickKids, has been promoted to Companion of the Order of Canada, the highest level of the Order of Canada, for his pioneering biomolecular NMR research, and training a new generation of scientists www.gg.ca/en/appointme... #NMRchat 🧲

(1/n) Very excited to share tri-lab collab (Mirny & Zechner) led by Harvey, Henrik & Jack: Q: How do enhancers & promoters interact in space (contact vs. action-at-a-distance) and time (stable vs. transient)? A: Transient E-P contact (~25-42 nm lasting ~10-20 sec): www.biorxiv.org/content/10.6...

New online: Structures of protein folding intermediates on the ribosome

Structures of protein folding intermediates on the ribosome

Nature Structural & Molecular Biology, Published online: 16 June 2026; doi:10.1038/s41594-026-01814-7Atomistic structural ensembles of protein folding intermediates on the ribosome are resolved by comprehensive 19F nuclear magnetic resonance analyses integrated with molecular dynamics simulations, providing insights into cotranslational folding pathways.

dlvr.it

Finally out in @Cellcellpress! Proteins with long IDRs are prone to misfolding during protein synthesis. This is prevented by mRNA 3′UTRs that act as mRNA-based IDR chaperones. www.cell.com/cell/fulltex...

mRNA 3′ UTRs chaperone intrinsically disordered regions to control protein activity

Highly conserved mRNA 3′ UTRs act as co-translational chaperones for intrinsically disordered regions (IDRs), preventing inter-domain misfolding and enabling biogenesis of fully active proteins.

cell.com

Extract: The Novo Nordisk Foundation Center for Protein Design at the University of Copenhagen seeks to appoint two group leaders in de novo protein design. Candidates should have strong backgrounds in computational and/or experimental protein design and an ambitious research and teaching plan.

Scientists at St. Jude developed patient-derived 3D tumor organoids and matched xenografts that preserve the molecular, genetic and cellular complexity of embryonal pediatric brain tumors. These models can speed functional assays and preclinical drug testing. https://ow.ly/vjSw50YK26w

3D tumor organoids give brain tumor researchers new scientific opportunities

Learn about brain tumor organoids developed by St. Jude scientists that preserve tumor diversity, enabling faster research and better access to research models

ow.ly

Run an MD simulation of any protein in the AlphaFold Protein Structure Database using AF-CALVADOS Thanks to @sobuelow.bsky.social AF-CALVADOS is now on Colab colab.research.google.com/github/KULL-...

Kresten Lindorff-Larsen@lindorfflarsen.bsky.social · 8mo ago

We (@sobuelow.bsky.social & @kejohansson.bsky.social) tested AF-CALVADOS using the recently described PeptoneBench SAXS benchmark that contains SAXS data for >400 proteins with different amounts of order and disorder. The results look pretty good 😇 so we are sharing here while updating the preprint📝

Do you want to be my boss? We are looking for a new Head of Department Our Department covers biology broadly, from molecular biophysics 🧬 to ecology 🌱 & biodiversity 🐋, and coordinates teaching in several BSc and MSc programmes🧑‍🎓 Located in Copenhagen, one of the world's most liveable cites 🚲 🌞 🌥️

Happy to announce that my institution, @irbbarcelona.org, is opening two group leader positions, 1 in chemical biology and 1 in structural biology, to strengthen our expertise in molecular sciences: please spread the word !

IRB Barcelona@irbbarcelona.org · 5mo ago

We are #hiring! #GroupLeader positions open at #IRBBarcelona in #ChemicalBiology and #StructuralBiology. Application deadline: May 22, 2026 𝗚𝗿𝗼𝘂𝗽 𝗟𝗲𝗮𝗱𝗲𝗿 𝗶𝗻 𝗖𝗵𝗲𝗺𝗶𝗰𝗮𝗹 𝗕𝗶𝗼𝗹𝗼𝗴𝘆 ➡️ https://shorturl.at/1tE3n 𝗚𝗿𝗼𝘂𝗽 𝗟𝗲𝗮𝗱𝗲𝗿 𝗶𝗻 𝗦𝘁𝗿𝘂𝗰𝘁𝘂𝗿𝗮𝗹 𝗕𝗶𝗼𝗹𝗼𝗴𝘆 ➡️ https://shorturl.at/eKiJn #IRBJobs #Jobs #AcademicSky

New preprint on how disagreement among variant effect predictors can help guide prioritization of proteins for experimental analysis Work led by Nicolas F Jonsson in a collaboration with Joe Marsh. Preprint: doi.org/10.64898/202... @vxh357.bsky.social @jmarshlab.bsky.social 1/6

bioRxiv Bioinfo@biorxiv-bioinfo.bsky.social · 5mo ago

Disagreement among variant effect predictors guides experimental prioritization of target proteins https://www.biorxiv.org/content/10.64898/2026.03.18.712765v1

We are hiring a postdoc in computational biophysics and machine learning studies of intrinsically disordered proteins We aim to study the function of IDPs by combining CG MD, ML and bioinformatics in collaboration with @tanjamittag.bsky.social & @rhp-lab.bsky.social tinyurl.com/REWIRE-PD

Our work on how oligomerization can enable selectively targeting intrinsic disorder with small molecules is now out in Science Advances: www.science.org/doi/10.1126/...). Congratulations Stase Bielskute and @borjaml.bsky.social and thanks to the collaborators and funders !

Oligomerization enables the selective targeting of an intrinsically disordered region by a small molecule

The druggability of intrinsically disordered regions.

science.org

IDPSeminars is back TOMORROW! Come see @tanjamittag.bsky.social and @xsalvatella1.bsky.social ! Not to be missed!!

Pleased to share the final version of this behemoth of a paper, now finally published. I guess I can retire now? www.nature.com/articles/s41... More functional data, many thousands of words removed, and a few other updates from last year's preprint.

Sequence and chemical specificity define the functional landscape of intrinsically disordered regions - Nature Cell Biology

Langstein-Skora, Schmid, Huth et al. propose that intrinsically disordered region functionality can be driven by the interplay between linear binding motifs and contextual chemical characteristics suc...

nature.com

Alex Holehouse@alexholehouse.bsky.social · 2y ago

We’re pleased to share our substantially updated (more below on that…) version of our manuscript exploring the relationship between conservation in sequence/function for intrinsically disordered regions (IDRs) www.biorxiv.org/content/10.1...

It was a pleasure to write the review on the role of phase separation in transcription together with you, @bsabari.bsky.social, Mikayla and Ambuja. I learnt a lot!

Ben Sabari@bsabari.bsky.social · 6mo ago

I am excited to share a new review @cp-molcell.bsky.social written in collaboration with @tanjamittag.bsky.social , Mikayla Eppert, and Ambuja Navalkar where we review the current evidence for and against the role of density transitions in regulating transcription www.cell.com/molecular-ce...

Faculty retreat of @stjuderesearch.bsky.social today. We see evidence everywhere of how Jim Downing shaped the vision for St. Jude over the last twenty years. The results are cutting edge fundamental science, St. Jude Global and important new initiatives. Inspiring!

New preprint with work led by @asrauh.bsky.social in which we explore how double mutant cycles could be used to study molecular interactions in condensates, and highlight difficulties in extracting information about interactions from mutational experiments www.biorxiv.org/content/10.6...

bioRxiv Biophysics@biorxiv-biophys.bsky.social · 6mo ago

On the Use of Double Mutant Cycles to Probe the Molecular Interactions in Biomolecular Condensates https://www.biorxiv.org/content/10.64898/2026.02.03.703500v1

Does targeting enzymes and substrates in a condensate lead to rate enhancement? No. Here, we investigate how the condensate environment can inhibit an enzyme reaction. Spoiler: Mass-transport limitations. We find a strong correlation between diffusion and reaction rates. doi.org/10.64898/202...

I am recruiting postdoctoral fellows to develop new research directions in the lab. We study transcriptional regulation through biomolecular condensates in development and disease, with an emphasis on first-principles and mechanistic discovery. Please repost or share with colleagues.

Second preprint of the year in which @sarahgersing.bsky.social from @rhp-lab.bsky.social mapped the effects of >7500 variants in glucokinase (GCK) on the interaction with the glucokinase regulatory protein so that we now have a 3D GCK scan (abundance, interaction, activity) doi.org/10.64898/202...

Rasmus Hartmann-Petersen@rhp-lab.bsky.social · 7mo ago

New preprint! Led by @sarahgersing.bsky.social we map how 7,500+ variants in glucokinase (GCK) affect binding to GKRP and disentangle this from stability. We now have activity, abundance, and interaction scores for 7,128 GCK variants - a resource for understanding phenotypes and glucose homeostasis.

Are you a junior scientist working in theoretical biophysics? @zamakany.bsky.social and I are organizing another workshop this fall here at @hhmijanelia.bsky.social. Travel and the workshop expenses are all covered! tinyurl.com/yc66fawc

IDPSeminars is BACK THIS WEEK! Talks from Andrea Soranno and @bokaizhulab.bsky.social on Thursday! 1 pm EST / 7 PM European time! Sign up here: forms.gle/3yCHeYvuuqLh... And check out the full Spring 2026 schedule at idpseminars.com!